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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methylpropyl)propanamide —— C17H23N3O2S
    (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methylpropyl)propanamide
    —— (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide —— C20H20FN3O2S
    (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide
    —— (2S)-N-(1-cyanocyclohexyl)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-methylpropanamide —— C21H26N4O2S
    (2S)-N-(1-cyanocyclohexyl)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-methylpropanamide
    —— (2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide —— C20H20FN3O2S
    (2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide
    —— (2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethylpropanamide —— C19H25N3O4S2
    (2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethylpropanamide
    —— (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-prop-2-enylpropanamide —— C16H19N3O2S
    (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-prop-2-enylpropanamide
    —— [(2R)-1-(2-methoxyethylamino)-1-oxopropan-2-yl] 3-[2-(difluoromethylsulfanyl)-4,6-dimethylpyrimidin-5-yl]propanoate —— C16H23F2N3O4S
    [(2R)-1-(2-methoxyethylamino)-1-oxopropan-2-yl] 3-[2-(difluoromethylsulfanyl)-4,6-dimethylpyrimidin-5-yl]propanoate
    —— 3-(3,4-difluorophenyl)sulfanyl-N-[[4-(dimethylamino)phenyl]methyl]propanamide —— C18H20F2N2OS
    3-(3,4-difluorophenyl)sulfanyl-N-[[4-(dimethylamino)phenyl]methyl]propanamide
    —— [(2S)-1-(2-methoxyethylamino)-1-oxopropan-2-yl] 3-[2-(difluoromethylsulfanyl)-4,6-dimethylpyrimidin-5-yl]propanoate —— C16H23F2N3O4S
    [(2S)-1-(2-methoxyethylamino)-1-oxopropan-2-yl] 3-[2-(difluoromethylsulfanyl)-4,6-dimethylpyrimidin-5-yl]propanoate
    —— N-[[4-(dimethylamino)phenyl]methyl]-2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H23N5O2S
    N-[[4-(dimethylamino)phenyl]methyl]-2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[[4-(dimethylamino)phenyl]methyl]-3-(3,4-dimethylphenyl)sulfanylpropanamide —— C20H26N2OS
    N-[[4-(dimethylamino)phenyl]methyl]-3-(3,4-dimethylphenyl)sulfanylpropanamide
    —— methyl N-[(2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanoyl]carbamate —— C18H23N5O4S
    methyl N-[(2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanoyl]carbamate
    —— (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-cyanoethyl)-N-methylpropanamide —— C20H26N6O2S
    (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-cyanoethyl)-N-methylpropanamide
    —— (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methylpropyl)propanamide —— C20H29N5O2S
    (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methylpropyl)propanamide
    —— methyl N-[(2R)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanoyl]carbamate —— C18H23N5O4S
    methyl N-[(2R)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanoyl]carbamate
    —— (2R)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxyethyl)propanamide —— C19H27N5O3S
    (2R)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxyethyl)propanamide
    —— (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxyethyl)propanamide —— C19H27N5O3S
    (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxyethyl)propanamide
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]acetamide —— C19H19ClN4O2S
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]acetamide
    —— 3-(4-chlorophenyl)sulfanyl-N-[[4-(dimethylamino)phenyl]methyl]propanamide —— C18H21ClN2OS
    3-(4-chlorophenyl)sulfanyl-N-[[4-(dimethylamino)phenyl]methyl]propanamide
    —— N-[[4-(dimethylamino)phenyl]methyl]-3-phenylsulfanylpropanamide —— C18H22N2OS
    N-[[4-(dimethylamino)phenyl]methyl]-3-phenylsulfanylpropanamide
    —— 2-(2-methylphenyl)sulfanyl-N-[(2R)-2-phenylpropyl]acetamide —— C18H21NOS
    2-(2-methylphenyl)sulfanyl-N-[(2R)-2-phenylpropyl]acetamide
    —— 2-(4-fluorophenyl)sulfanyl-N-[(2S)-2-phenylpropyl]acetamide —— C17H18FNOS
    2-(4-fluorophenyl)sulfanyl-N-[(2S)-2-phenylpropyl]acetamide
    —— N-butyl-2-[[5-(4-butylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C18H26N4OS2
    N-butyl-2-[[5-(4-butylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (5Z)-5-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-2-(4-methylanilino)-1,3-thiazol-4-one —— C21H15ClN2O2S2
    (5Z)-5-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-2-(4-methylanilino)-1,3-thiazol-4-one
    —— 1-(4-Benzylsulfonylpiperazin-1-yl)-3-(4-methylphenyl)sulfanylpropan-1-one —— C21H26N2O3S2
    1-(4-Benzylsulfonylpiperazin-1-yl)-3-(4-methylphenyl)sulfanylpropan-1-one
    —— 1-(4-Benzylsulfonylpiperazin-1-yl)-3-phenylsulfanylpropan-1-one —— C20H24N2O3S2
    1-(4-Benzylsulfonylpiperazin-1-yl)-3-phenylsulfanylpropan-1-one
    —— 1-(4-Benzylsulfonylpiperazin-1-yl)-2-(4-fluorophenyl)sulfanylethanone —— C19H21FN2O3S2
    1-(4-Benzylsulfonylpiperazin-1-yl)-2-(4-fluorophenyl)sulfanylethanone
    —— 1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C20H19N3O3S2
    1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 4-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-1,2,4-triazolidine-3,5-dithione —— C10H10N4S3
    4-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-1,2,4-triazolidine-3,5-dithione
    —— N'-[1-(2,4-dimethylpyrrol-3-ylidene)ethyl]-3-(4-fluorophenyl)sulfanylpropanehydrazide —— C17H20FN3OS
    N'-[1-(2,4-dimethylpyrrol-3-ylidene)ethyl]-3-(4-fluorophenyl)sulfanylpropanehydrazide
    —— N-[(Z)-(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)methylideneamino]-3-(4-fluorophenyl)sulfanylpropanamide —— C19H18ClFN2O3S
    N-[(Z)-(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)methylideneamino]-3-(4-fluorophenyl)sulfanylpropanamide
    —— N-[(Z)-[2,5-dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]methylideneamino]-3-(4-fluorophenyl)sulfanylpropanamide —— C19H19FN4OS2
    N-[(Z)-[2,5-dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]methylideneamino]-3-(4-fluorophenyl)sulfanylpropanamide
    —— N-[(Z)-[(E)-3-(1-benzyltriazol-4-yl)prop-2-enylidene]amino]-2-(2-fluorophenyl)sulfanylacetamide —— C20H18FN5OS
    N-[(Z)-[(E)-3-(1-benzyltriazol-4-yl)prop-2-enylidene]amino]-2-(2-fluorophenyl)sulfanylacetamide
    —— 1-(5-chlorothiophen-2-yl)-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C13H14ClN3O2S3
    1-(5-chlorothiophen-2-yl)-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— N-[(1S)-1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-methylpropyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C18H23N3O3S2
    N-[(1S)-1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-methylpropyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[[(2S)-oxolan-2-yl]methyl]-5-[(5-phenyl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C17H18N4O2S2
    N-[[(2S)-oxolan-2-yl]methyl]-5-[(5-phenyl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-cycloheptyl-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H26N4O2S2
    N-cycloheptyl-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[(1R)-1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-methylpropyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C18H23N3O3S2
    N-[(1R)-1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-methylpropyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— [2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl] 2-phenylsulfanylpyridine-3-carboxylate —— C23H20N2O3S
    [2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl] 2-phenylsulfanylpyridine-3-carboxylate
    —— 2-(4,6-diaminopyrimidin-2-yl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-methylacetamide —— C11H17N5O3S2
    2-(4,6-diaminopyrimidin-2-yl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]-N-methylacetamide
    —— 2-(4,6-diaminopyrimidin-2-yl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-methylacetamide —— C11H17N5O3S2
    2-(4,6-diaminopyrimidin-2-yl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-methylacetamide
    —— 2-[2-[(3S)-3-(furan-2-yl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-oxoethyl]sulfanylpyridine-3-carbonitrile —— C19H14N4O2S2
    2-[2-[(3S)-3-(furan-2-yl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-oxoethyl]sulfanylpyridine-3-carbonitrile
    —— N-ethyl-5-[[5-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C17H16N6O2S2
    N-ethyl-5-[[5-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 7-[[5-(2-Methoxyethylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C13H15N5O2S3
    7-[[5-(2-Methoxyethylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 1-methyl-N-[2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]pyrrole-2-carboxamide —— C15H19N5O3S2
    1-methyl-N-[2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]pyrrole-2-carboxamide
    —— 2-[(2,5-Difluorophenyl)sulfanylmethyl]-5-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,3,4-oxadiazole —— C19H13F2N3O2S
    2-[(2,5-Difluorophenyl)sulfanylmethyl]-5-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,3,4-oxadiazole
    —— 2-(4-bromophenyl)sulfanyl-N-[(2-methylphenyl)methyl]acetamide —— C16H16BrNOS
    2-(4-bromophenyl)sulfanyl-N-[(2-methylphenyl)methyl]acetamide
    —— 2-(4-bromophenyl)sulfanyl-N-[[4-(dimethylamino)phenyl]methyl]acetamide —— C17H19BrN2OS
    2-(4-bromophenyl)sulfanyl-N-[[4-(dimethylamino)phenyl]methyl]acetamide
    —— N-[(3-chlorophenyl)methyl]-N-methyl-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide —— C12H13ClN4OS
    N-[(3-chlorophenyl)methyl]-N-methyl-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide
    —— 2-(4-bromophenyl)sulfanyl-N-[(1S)-1-(furan-2-yl)ethyl]acetamide —— C14H14BrNO2S
    2-(4-bromophenyl)sulfanyl-N-[(1S)-1-(furan-2-yl)ethyl]acetamide