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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)-4-[[5-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]butanenitrile —— C20H15N5OS3
    (2R)-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)-4-[[5-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]butanenitrile
    —— (2R)-4-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile —— C16H11F3N6OS2
    (2R)-4-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile
    —— [(E)-2-methyl-4-phenylsulfanylbut-2-enyl] methanesulfonate —— C12H16O3S2
    [(E)-2-methyl-4-phenylsulfanylbut-2-enyl] methanesulfonate
    —— methyl (E)-3-phenylsulfanylnon-2-enoate —— C16H22O2S
    methyl (E)-3-phenylsulfanylnon-2-enoate
    —— (2S)-4-[[4-amino-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile —— C20H16N6O2S2
    (2S)-4-[[4-amino-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile
    —— (2S)-4-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile —— C16H11F3N6OS2
    (2S)-4-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile
    —— (2S)-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)-4-[[5-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]butanenitrile —— C20H15N5OS3
    (2S)-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)-4-[[5-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]butanenitrile
    —— (2E)-2-hydroxyimino-3-(4-methylphenyl)sulfanylpropanoic acid —— C10H11NO3S
    (2E)-2-hydroxyimino-3-(4-methylphenyl)sulfanylpropanoic acid
    —— (Tetrahydrofuran-2-ylmethyl)dithiocarbamic acid phenyl ester 370065-41-1 C12H15NOS2
    (Tetrahydrofuran-2-ylmethyl)dithiocarbamic acid phenyl ester
    —— Propan-2-yl 2-chloro-2-ethylsulfanylcarbonyloxyacetate —— C8H13ClO4S
    Propan-2-yl 2-chloro-2-ethylsulfanylcarbonyloxyacetate
    —— 5-mercapto-2-(phenylthio)-pentanoic acid 378242-57-0 C11H14O2S2
    5-mercapto-2-(phenylthio)-pentanoic acid
    —— (4-Aminobutylsulfinimidoyl)formic acid —— C5H12N2O2S
    (4-Aminobutylsulfinimidoyl)formic acid
    —— 1-(2-Methyl-cyclopent-1-enylmethyl)-3-(2-hydroxy-ethyl)-thiourea —— C10H18N2OS
    1-(2-Methyl-cyclopent-1-enylmethyl)-3-(2-hydroxy-ethyl)-thiourea
    —— Acylglycineboronic acid, 13 —— C8H11BN2O3S
    Acylglycineboronic acid, 13
    —— (2S)-4-[[5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile —— C20H14N4O2S3
    (2S)-4-[[5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile
    —— (3R)-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-1,1-dioxothiolane-3-carboxamide —— C11H17N3O3S3
    (3R)-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-1,1-dioxothiolane-3-carboxamide
    —— (2R)-4-[[5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile —— C20H14N4O2S3
    (2R)-4-[[5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile
    —— (3S)-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-1,1-dioxothiolane-3-carboxamide —— C11H17N3O3S3
    (3S)-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-1,1-dioxothiolane-3-carboxamide
    —— 3-[5-[1-[3,4-Bis(difluoromethoxy)phenyl]-2-pyridin-4-ylethyl]pyridin-2-yl]sulfanylbenzenesulfonamide —— C26H21F4N3O4S2
    3-[5-[1-[3,4-Bis(difluoromethoxy)phenyl]-2-pyridin-4-ylethyl]pyridin-2-yl]sulfanylbenzenesulfonamide
    —— N-[1-benzyl-3-[[3-[2-(diethylamino)ethylsulfanyl]anilino]methyl]cyclopent-2-en-1-yl]-3,3,3-trichloropropanamide —— C28H36Cl3N3OS
    N-[1-benzyl-3-[[3-[2-(diethylamino)ethylsulfanyl]anilino]methyl]cyclopent-2-en-1-yl]-3,3,3-trichloropropanamide
    —— 4-(2-tert-butyl-4,5-dichlorophenyl)-3-(2-nitro-4-pentan-3-ylphenyl)sulfanyl-1H-1,2,4-triazol-5-one —— C23H26Cl2N4O3S
    4-(2-tert-butyl-4,5-dichlorophenyl)-3-(2-nitro-4-pentan-3-ylphenyl)sulfanyl-1H-1,2,4-triazol-5-one
    —— 2-[3-methyl-5-[2-[[(1R)-3-methyl-1-phenylbutyl]amino]-2-oxoethyl]sulfanyl-1,2,4-triazol-4-yl]acetamide —— C18H25N5O2S
    2-[3-methyl-5-[2-[[(1R)-3-methyl-1-phenylbutyl]amino]-2-oxoethyl]sulfanyl-1,2,4-triazol-4-yl]acetamide
    —— (Z)-7-[(1S,2R,3S,5R)-6,6-dimethyl-2-[(5-thiophen-2-ylsulfanylthiophene-2-carbonyl)amino]-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acid —— C25H31NO3S3
    (Z)-7-[(1S,2R,3S,5R)-6,6-dimethyl-2-[(5-thiophen-2-ylsulfanylthiophene-2-carbonyl)amino]-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acid
    —— 4-(4-Chlorophenyl)-2-[[5-[(4-chlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methylsulfanylmethyl]-1,3-thiazole —— C21H18Cl2N4S3
    4-(4-Chlorophenyl)-2-[[5-[(4-chlorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methylsulfanylmethyl]-1,3-thiazole
    —— 1-[3-(Methylthio)-2-pyridylmethylcarbamoylmethyl]-3-[2,2-difluoro-2-(2-pyridyl)ethylamino]-6-chloropyrazine-2(1H)-one —— C20H19ClF2N6O2S
    1-[3-(Methylthio)-2-pyridylmethylcarbamoylmethyl]-3-[2,2-difluoro-2-(2-pyridyl)ethylamino]-6-chloropyrazine-2(1H)-one
    —— (2R)-2-but-3-enoxy-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide —— C15H16ClN3O2S2
    (2R)-2-but-3-enoxy-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide
    —— (3S)-1-(2,2-dimethylpropanoyl)-N-[4-(4-methoxyphenyl)sulfanylphenyl]piperidine-3-carboxamide —— C24H30N2O3S
    (3S)-1-(2,2-dimethylpropanoyl)-N-[4-(4-methoxyphenyl)sulfanylphenyl]piperidine-3-carboxamide
    —— (2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-[2-(trifluoromethyl)phenoxy]propanamide —— C18H13ClF3N3O2S2
    (2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-[2-(trifluoromethyl)phenoxy]propanamide
    —— N-[6-(4-fluorophenyl)hexyl]-2-[[2-[(6-methylpyridin-3-yl)methyl]-6-oxo-1H-pyrimidin-5-yl]sulfanyl]acetamide —— C25H29FN4O2S
    N-[6-(4-fluorophenyl)hexyl]-2-[[2-[(6-methylpyridin-3-yl)methyl]-6-oxo-1H-pyrimidin-5-yl]sulfanyl]acetamide
    —— (3R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-1-[(2S)-2-methylbutanoyl]piperidine-3-carboxamide —— C19H23ClN4O2S2
    (3R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-1-[(2S)-2-methylbutanoyl]piperidine-3-carboxamide
    —— (1R,2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(3-fluorophenyl)cyclopropane-1-carboxamide —— C18H13ClFN3OS2
    (1R,2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(3-fluorophenyl)cyclopropane-1-carboxamide
    —— (2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-ethylsulfanyl-3-methylbutanamide —— C15H18ClN3OS3
    (2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-ethylsulfanyl-3-methylbutanamide
    —— (1S,2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(5-methylthiophen-2-yl)cyclopropane-1-carboxamide —— C17H14ClN3OS3
    (1S,2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(5-methylthiophen-2-yl)cyclopropane-1-carboxamide
    —— (2R)-2-butoxy-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide —— C15H18ClN3O2S2
    (2R)-2-butoxy-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide
    —— 2-[3-methyl-5-[2-[[(1S)-3-methyl-1-phenylbutyl]amino]-2-oxoethyl]sulfanyl-1,2,4-triazol-4-yl]acetamide —— C18H25N5O2S
    2-[3-methyl-5-[2-[[(1S)-3-methyl-1-phenylbutyl]amino]-2-oxoethyl]sulfanyl-1,2,4-triazol-4-yl]acetamide
    —— (2S)-2-butoxy-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide —— C15H18ClN3O2S2
    (2S)-2-butoxy-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide
    —— (1R,2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(5-methylthiophen-2-yl)cyclopropane-1-carboxamide —— C17H14ClN3OS3
    (1R,2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(5-methylthiophen-2-yl)cyclopropane-1-carboxamide
    —— (2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(3-methylbutoxy)propanamide —— C16H20ClN3O2S2
    (2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(3-methylbutoxy)propanamide
    —— (2S)-2-but-3-enoxy-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide —— C15H16ClN3O2S2
    (2S)-2-but-3-enoxy-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]propanamide
    —— (2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(3,5-dimethylpyrazol-1-yl)propanamide —— C16H16ClN5OS2
    (2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(3,5-dimethylpyrazol-1-yl)propanamide
    —— (2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-ethylsulfanyl-3-methylbutanamide —— C15H18ClN3OS3
    (2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-ethylsulfanyl-3-methylbutanamide
    —— (3R)-1-(cyclopropanecarbonyl)-N-[4-(4-methoxyphenyl)sulfanylphenyl]piperidine-3-carboxamide —— C23H26N2O3S
    (3R)-1-(cyclopropanecarbonyl)-N-[4-(4-methoxyphenyl)sulfanylphenyl]piperidine-3-carboxamide
    —— 5-methyl-7-(2-methylpropyl)-2-(1-naphtalenylmethyl)-3-(2-pyridinylthio)thieno[2,3-d]pyridazin-4(5H)-one —— C27H25N3OS2
    5-methyl-7-(2-methylpropyl)-2-(1-naphtalenylmethyl)-3-(2-pyridinylthio)thieno[2,3-d]pyridazin-4(5H)-one
    —— (2R)-2-(3,5-dimethylpyrazol-1-yl)-N-[4-(4-methoxyphenyl)sulfanylphenyl]propanamide —— C21H23N3O2S
    (2R)-2-(3,5-dimethylpyrazol-1-yl)-N-[4-(4-methoxyphenyl)sulfanylphenyl]propanamide
    —— (1S,2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(3-fluorophenyl)cyclopropane-1-carboxamide —— C18H13ClFN3OS2
    (1S,2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(3-fluorophenyl)cyclopropane-1-carboxamide
    —— (2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-[2-(trifluoromethyl)phenoxy]propanamide —— C18H13ClF3N3O2S2
    (2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-[2-(trifluoromethyl)phenoxy]propanamide
    —— (1R,2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(5-methylthiophen-2-yl)cyclopropane-1-carboxamide —— C17H14ClN3OS3
    (1R,2R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(5-methylthiophen-2-yl)cyclopropane-1-carboxamide
    —— (2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-cyclopentyloxy-2-phenylacetamide —— C21H20ClN3O2S2
    (2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-cyclopentyloxy-2-phenylacetamide
    —— (3R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-1-[(2R)-2-methylbutanoyl]piperidine-3-carboxamide —— C19H23ClN4O2S2
    (3R)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-1-[(2R)-2-methylbutanoyl]piperidine-3-carboxamide
    —— (1S,2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(5-methylthiophen-2-yl)cyclopropane-1-carboxamide —— C17H14ClN3OS3
    (1S,2S)-N-[3-chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)phenyl]-2-(5-methylthiophen-2-yl)cyclopropane-1-carboxamide