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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(S)-[(1R,2S)-2-methylcyclopropyl]-phenylmethyl]-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H20N4OS
    N-[(S)-[(1R,2S)-2-methylcyclopropyl]-phenylmethyl]-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2R)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one —— C14H17N3OS2
    (2R)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one
    —— 2-[2-(4-Chlorophenyl)sulfanylethylsulfanyl]-5-(2-methylphenyl)-1,3,4-oxadiazole —— C17H15ClN2OS2
    2-[2-(4-Chlorophenyl)sulfanylethylsulfanyl]-5-(2-methylphenyl)-1,3,4-oxadiazole
    —— N-[(1R,3R)-3-methoxy-2,2,3-trimethylcyclobutyl]-2-pyridin-4-ylsulfanylacetamide —— C15H22N2O2S
    N-[(1R,3R)-3-methoxy-2,2,3-trimethylcyclobutyl]-2-pyridin-4-ylsulfanylacetamide
    —— (2S)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one —— C14H17N3OS2
    (2S)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one
    —— 1-[(3-methylpyridin-2-yl)methyl]-3-[(2S)-2-phenylsulfanylpropyl]urea —— C17H21N3OS
    1-[(3-methylpyridin-2-yl)methyl]-3-[(2S)-2-phenylsulfanylpropyl]urea
    —— 1-[(3-methylpyridin-2-yl)methyl]-3-[(2R)-2-phenylsulfanylpropyl]urea —— C17H21N3OS
    1-[(3-methylpyridin-2-yl)methyl]-3-[(2R)-2-phenylsulfanylpropyl]urea
    —— 5-[(2-chlorophenyl)methylsulfanyl]-N-(3-methylphenyl)-1,3,4-thiadiazol-2-amine —— C16H14ClN3S2
    5-[(2-chlorophenyl)methylsulfanyl]-N-(3-methylphenyl)-1,3,4-thiadiazol-2-amine
    —— N-[(3R)-1-benzylpyrrolidin-1-ium-3-yl]-2-phenylsulfanylpyridine-3-carboxamide —— C23H24N3OS+
    N-[(3R)-1-benzylpyrrolidin-1-ium-3-yl]-2-phenylsulfanylpyridine-3-carboxamide
    —— 2-Naphthalen-2-ylsulfanylpyrimidine —— C14H10N2S
    2-Naphthalen-2-ylsulfanylpyrimidine
    —— N-[(1R,3S)-3-methoxy-2,2,3-trimethylcyclobutyl]-2-pyridin-4-ylsulfanylacetamide —— C15H22N2O2S
    N-[(1R,3S)-3-methoxy-2,2,3-trimethylcyclobutyl]-2-pyridin-4-ylsulfanylacetamide
    —— N-[(1S,3S)-3-methoxy-2,2,3-trimethylcyclobutyl]-2-pyridin-4-ylsulfanylacetamide —— C15H22N2O2S
    N-[(1S,3S)-3-methoxy-2,2,3-trimethylcyclobutyl]-2-pyridin-4-ylsulfanylacetamide
    —— N-[(1S,3R)-3-methoxy-2,2,3-trimethylcyclobutyl]-2-pyridin-4-ylsulfanylacetamide —— C15H22N2O2S
    N-[(1S,3R)-3-methoxy-2,2,3-trimethylcyclobutyl]-2-pyridin-4-ylsulfanylacetamide
    —— N'-[2-(3-chloro-4-fluorophenyl)sulfanylacetyl]-2-[(3R)-1,1-dioxothiolan-3-yl]acetohydrazide —— C14H16ClFN2O4S2
    N'-[2-(3-chloro-4-fluorophenyl)sulfanylacetyl]-2-[(3R)-1,1-dioxothiolan-3-yl]acetohydrazide
    —— 5-ethylsulfanyl-3-(2-thienyl)-1H-1,2,4-triazole —— C8H9N3S2
    5-ethylsulfanyl-3-(2-thienyl)-1H-1,2,4-triazole
    —— 4,6-Dimethyl-2-[2-oxo-2-[4-(thiophen-2-ylmethyl)piperazin-4-ium-1-yl]ethyl]sulfanylpyridine-3-carbonitrile —— C19H23N4OS2+
    4,6-Dimethyl-2-[2-oxo-2-[4-(thiophen-2-ylmethyl)piperazin-4-ium-1-yl]ethyl]sulfanylpyridine-3-carbonitrile
    —— N-[[4-(dimethylamino)phenyl]methyl]-2-(2-methylphenyl)sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C23H30N2O2S
    N-[[4-(dimethylamino)phenyl]methyl]-2-(2-methylphenyl)sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— 4,6-Dimethyl-2-[2-oxo-2-[4-(thiophen-2-ylmethyl)piperazin-1-yl]ethyl]sulfanylpyridine-3-carbonitrile —— C19H22N4OS2
    4,6-Dimethyl-2-[2-oxo-2-[4-(thiophen-2-ylmethyl)piperazin-1-yl]ethyl]sulfanylpyridine-3-carbonitrile
    —— 1-(5-Chlorothiophen-2-yl)-2-[[5-(prop-2-enylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C11H10ClN3OS3
    1-(5-Chlorothiophen-2-yl)-2-[[5-(prop-2-enylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— [(1S)-2-[[2-(2-cyanophenyl)sulfanylbenzoyl]amino]-1-thiophen-2-ylethyl]-dimethylazanium —— C22H22N3OS2+
    [(1S)-2-[[2-(2-cyanophenyl)sulfanylbenzoyl]amino]-1-thiophen-2-ylethyl]-dimethylazanium
    —— 2-[[4-(4-Methylphenyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]pyridine-3-carbonitrile —— C19H18N6OS
    2-[[4-(4-Methylphenyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]pyridine-3-carbonitrile
    —— 2-[(5-cyclohexyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C17H26N4O3S2
    2-[(5-cyclohexyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— 2-phenylsulfanyl-N-[2-(thiophen-2-ylmethyl)pyrazol-3-yl]pyridine-3-carboxamide —— C20H16N4OS2
    2-phenylsulfanyl-N-[2-(thiophen-2-ylmethyl)pyrazol-3-yl]pyridine-3-carboxamide
    —— 4-[(4-benzylsulfonylpiperazin-1-yl)methyl]-2-methylsulfanyl-1H-pyrimidin-6-one —— C17H22N4O3S2
    4-[(4-benzylsulfonylpiperazin-1-yl)methyl]-2-methylsulfanyl-1H-pyrimidin-6-one
    —— 4-Cyclohexyl-3-methyl-5-propan-2-ylsulfanyl-1,2,4-triazole —— C12H21N3S
    4-Cyclohexyl-3-methyl-5-propan-2-ylsulfanyl-1,2,4-triazole
    —— 2-[(5-cyclohexyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethanone —— C19H30N4O2S
    2-[(5-cyclohexyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethanone
    —— 2-[(5-cyclohexyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]ethanone —— C19H30N4O2S
    2-[(5-cyclohexyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]ethanone
    —— [(2R)-but-3-yn-2-yl] (3R)-2,3-dihydro-1-benzothiophene-3-carboxylate —— C13H12O2S
    [(2R)-but-3-yn-2-yl] (3R)-2,3-dihydro-1-benzothiophene-3-carboxylate
    —— [(2R)-but-3-yn-2-yl] (3S)-2,3-dihydro-1-benzothiophene-3-carboxylate —— C13H12O2S
    [(2R)-but-3-yn-2-yl] (3S)-2,3-dihydro-1-benzothiophene-3-carboxylate
    —— [(2S)-but-3-yn-2-yl] (3R)-2,3-dihydro-1-benzothiophene-3-carboxylate —— C13H12O2S
    [(2S)-but-3-yn-2-yl] (3R)-2,3-dihydro-1-benzothiophene-3-carboxylate
    —— [(2S)-but-3-yn-2-yl] (3S)-2,3-dihydro-1-benzothiophene-3-carboxylate —— C13H12O2S
    [(2S)-but-3-yn-2-yl] (3S)-2,3-dihydro-1-benzothiophene-3-carboxylate
    —— (2S)-4-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C17H15N5OS3
    (2S)-4-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— [2-oxo-2-(1H-pyrrol-2-yl)ethyl] (2S)-2-phenyl-2-phenylsulfanylacetate —— C20H17NO3S
    [2-oxo-2-(1H-pyrrol-2-yl)ethyl] (2S)-2-phenyl-2-phenylsulfanylacetate
    —— (2R)-4-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C17H15N5OS3
    (2R)-4-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— N-(cyclohexen-1-yl)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propylacetamide —— C17H21N3O3S
    N-(cyclohexen-1-yl)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propylacetamide
    —— (1S,3S)-N-methyl-3-methylsulfanyl-N-(2-methylsulfonylethyl)cyclopentan-1-amine —— C10H21NO2S2
    (1S,3S)-N-methyl-3-methylsulfanyl-N-(2-methylsulfonylethyl)cyclopentan-1-amine
    —— 3-[2-[(3R)-3-(phenylsulfanylmethyl)pyrrolidin-1-yl]ethyl]-1,3-oxazolidin-2-one —— C16H22N2O2S
    3-[2-[(3R)-3-(phenylsulfanylmethyl)pyrrolidin-1-yl]ethyl]-1,3-oxazolidin-2-one
    —— 2-[[5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(1S,5R)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethanone —— C19H30N4O2S
    2-[[5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(1S,5R)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethanone
    —— 2-methyl-1-[(3S)-3-(phenylsulfanylmethyl)pyrrolidin-1-yl]propan-2-ol —— C15H23NOS
    2-methyl-1-[(3S)-3-(phenylsulfanylmethyl)pyrrolidin-1-yl]propan-2-ol
    —— (1R,3S)-N-methyl-3-methylsulfanyl-N-(2-methylsulfonylethyl)cyclopentan-1-amine —— C10H21NO2S2
    (1R,3S)-N-methyl-3-methylsulfanyl-N-(2-methylsulfonylethyl)cyclopentan-1-amine
    —— 3-[2-[(3S)-3-(phenylsulfanylmethyl)pyrrolidin-1-yl]ethyl]-1,3-oxazolidin-2-one —— C16H22N2O2S
    3-[2-[(3S)-3-(phenylsulfanylmethyl)pyrrolidin-1-yl]ethyl]-1,3-oxazolidin-2-one
    —— 2-methyl-1-[(3R)-3-(phenylsulfanylmethyl)pyrrolidin-1-yl]propan-2-ol —— C15H23NOS
    2-methyl-1-[(3R)-3-(phenylsulfanylmethyl)pyrrolidin-1-yl]propan-2-ol
    —— 2-[[5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(1R,5S)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethanone —— C19H31N4O2S+
    2-[[5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(1R,5S)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethanone
    —— [2-[(3-Chlorophenyl)methylamino]-2-oxoethyl] 2-(4-fluorophenyl)sulfanylacetate —— C17H15ClFNO3S
    [2-[(3-Chlorophenyl)methylamino]-2-oxoethyl] 2-(4-fluorophenyl)sulfanylacetate
    —— 3-[[5-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1H-1,2,4-triazol-5-amine —— C13H14N6OS2
    3-[[5-(4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1H-1,2,4-triazol-5-amine
    —— N-[(2R)-2-(5-chlorothiophen-2-yl)-2-hydroxyethyl]-2-phenylsulfanylacetamide —— C14H14ClNO2S2
    N-[(2R)-2-(5-chlorothiophen-2-yl)-2-hydroxyethyl]-2-phenylsulfanylacetamide
    —— N-[(2S)-2-(5-chlorothiophen-2-yl)-2-hydroxyethyl]-2-phenylsulfanylacetamide —— C14H14ClNO2S2
    N-[(2S)-2-(5-chlorothiophen-2-yl)-2-hydroxyethyl]-2-phenylsulfanylacetamide
    —— 2-(2,5-Dichlorophenyl)sulfanyl-5-pyrrolidin-1-ylsulfonylpyridine —— C15H14Cl2N2O2S2
    2-(2,5-Dichlorophenyl)sulfanyl-5-pyrrolidin-1-ylsulfonylpyridine
    —— (5-Chloro-6-oxo-1-phenylpyridazin-4-yl) pyrrolidine-1-carbodithioate —— C15H14ClN3OS2
    (5-Chloro-6-oxo-1-phenylpyridazin-4-yl) pyrrolidine-1-carbodithioate
    —— [2-(2-Benzoylhydrazinyl)-2-oxoethyl] 2-phenylsulfanylpyridine-3-carboxylate —— C21H17N3O4S
    [2-(2-Benzoylhydrazinyl)-2-oxoethyl] 2-phenylsulfanylpyridine-3-carboxylate