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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-(2-Anilinovinyl)-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]sulfanyl}-4-isothiazolecarbonitrile —— C18H10ClF3N4S2
    5-(2-Anilinovinyl)-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]sulfanyl}-4-isothiazolecarbonitrile
    —— (1'R,5'R,6'S)-2'-amino-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile —— C16H14N4O2S
    (1'R,5'R,6'S)-2'-amino-6'-(4-methylsulfanylphenyl)spiro[1,3-dioxolane-2,4'-3-azabicyclo[3.1.0]hex-2-ene]-1',5'-dicarbonitrile
    —— 1-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-5-nitrophenyl]-N-(4-nonoxyphenyl)methanimine —— C25H31N5O3S
    1-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-5-nitrophenyl]-N-(4-nonoxyphenyl)methanimine
    —— N-[(Z)-[2-(4-chlorophenyl)sulfanylphenyl]methylideneamino]-4,6-dimorpholin-4-yl-1,3,5-triazin-2-amine —— C24H26ClN7O2S
    N-[(Z)-[2-(4-chlorophenyl)sulfanylphenyl]methylideneamino]-4,6-dimorpholin-4-yl-1,3,5-triazin-2-amine
    —— N-[(E)-(5-phenylsulfanylfuran-2-yl)methylideneamino]octanamide —— C19H24N2O2S
    N-[(E)-(5-phenylsulfanylfuran-2-yl)methylideneamino]octanamide
    —— N-[(Z)-(5-phenylsulfanylfuran-2-yl)methylideneamino]octanamide —— C19H24N2O2S
    N-[(Z)-(5-phenylsulfanylfuran-2-yl)methylideneamino]octanamide
    —— N-(4-butylphenyl)-1-[5-[[5-(naphthalen-1-ylmethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]furan-2-yl]methanimine —— C34H30N4OS
    N-(4-butylphenyl)-1-[5-[[5-(naphthalen-1-ylmethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]furan-2-yl]methanimine
    —— ethyl 2-[4-(dimethylamino)benzylidene]-7-methyl-5-[4-(methylsulfanyl)phenyl]-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate —— C26H27N3O3S2
    ethyl 2-[4-(dimethylamino)benzylidene]-7-methyl-5-[4-(methylsulfanyl)phenyl]-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
    —— N-(2,6-diethylphenyl)-2-[[6-[(3-nitro-4-pyridin-2-ylsulfanylphenyl)methylideneamino]-1,3-benzothiazol-2-yl]sulfanyl]acetamide —— C31H27N5O3S3
    N-(2,6-diethylphenyl)-2-[[6-[(3-nitro-4-pyridin-2-ylsulfanylphenyl)methylideneamino]-1,3-benzothiazol-2-yl]sulfanyl]acetamide
    —— N-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide —— C15H20N6OS
    N-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide
    —— [(Z)-[3,3-dimethyl-1-(1-oxidopyridin-1-ium-2-yl)sulfanylbutan-2-ylidene]amino] N-methylcarbamate —— C13H19N3O3S
    [(Z)-[3,3-dimethyl-1-(1-oxidopyridin-1-ium-2-yl)sulfanylbutan-2-ylidene]amino] N-methylcarbamate
    —— (2E)-2-cyano-N-(oxolan-2-ylmethyl)-3-(5-phenylthio(2-furyl))prop-2-enamide —— C19H18N2O3S
    (2E)-2-cyano-N-(oxolan-2-ylmethyl)-3-(5-phenylthio(2-furyl))prop-2-enamide
    —— (E)-3-(4-chloroanilino)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylpent-2-enoic acid —— C17H13Cl2F3N2O2S
    (E)-3-(4-chloroanilino)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylpent-2-enoic acid
    —— (Z)-3-(4-chloroanilino)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylpent-2-enoic acid —— C17H13Cl2F3N2O2S
    (Z)-3-(4-chloroanilino)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylpent-2-enoic acid
    —— N-(2-methylphenyl)-2-[(5Z)-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide —— C26H21N3O5S2
    N-(2-methylphenyl)-2-[(5Z)-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
    —— 2,6-ditert-butyl-4-[2,3,5-trifluoro-6-[2-[(R)-sulfanyl-[4-(trifluoromethyl)anilino]methyl]hydrazinyl]pyridin-4-yl]sulfanylphenol —— C27H30F6N4OS2
    2,6-ditert-butyl-4-[2,3,5-trifluoro-6-[2-[(R)-sulfanyl-[4-(trifluoromethyl)anilino]methyl]hydrazinyl]pyridin-4-yl]sulfanylphenol
    —— 2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]sulfonyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline —— C23H25N7O7S2
    2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]sulfonyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline
    —— 2-[(2S,4R)-2,4-dimethylpiperidin-1-yl]sulfonyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline —— C24H27N7O6S2
    2-[(2S,4R)-2,4-dimethylpiperidin-1-yl]sulfonyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline
    —— N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-2-(4-methylpiperidin-1-yl)sulfonyl-4-nitroaniline —— C23H25N7O6S2
    N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-2-(4-methylpiperidin-1-yl)sulfonyl-4-nitroaniline
    —— 2-[(2R,3R)-2,3-dimethylpiperidin-1-yl]sulfonyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline —— C24H27N7O6S2
    2-[(2R,3R)-2,3-dimethylpiperidin-1-yl]sulfonyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline
    —— 2-[(2R,3R)-2,3-dimethylpiperidin-1-yl]sulfonyl-N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline —— C24H27N7O6S2
    2-[(2R,3R)-2,3-dimethylpiperidin-1-yl]sulfonyl-N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline
    —— 2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]sulfonyl-4-nitro-N-[(E)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline —— C28H26N6O7S2
    2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]sulfonyl-4-nitro-N-[(E)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline
    —— 2-[(2S,4S)-2,4-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(E)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline —— C29H28N6O6S2
    2-[(2S,4S)-2,4-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(E)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline
    —— 2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]sulfonyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline —— C23H25N7O7S2
    2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]sulfonyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline
    —— 2-[(2R,3R)-2,3-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(Z)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline —— C29H28N6O6S2
    2-[(2R,3R)-2,3-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(Z)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline
    —— (2Z)-2-{4-[(4-chlorophenyl)sulfanyl]benzylidene}[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one —— C22H13ClN2OS2
    (2Z)-2-{4-[(4-chlorophenyl)sulfanyl]benzylidene}[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one
    —— 2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]sulfonyl-4-nitro-N-[(Z)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline —— C28H26N6O7S2
    2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]sulfonyl-4-nitro-N-[(Z)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline
    —— 2-[(2S,4R)-2,4-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(E)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline —— C29H28N6O6S2
    2-[(2S,4R)-2,4-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(E)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline
    —— N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-2-(4-methylpiperidin-1-yl)sulfonyl-4-nitroaniline —— C23H25N7O6S2
    N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-2-(4-methylpiperidin-1-yl)sulfonyl-4-nitroaniline
    —— 2-[(2R,3S)-2,3-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(Z)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline —— C29H28N6O6S2
    2-[(2R,3S)-2,3-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(Z)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline
    —— 2-[(2R,3S)-2,3-dimethylpiperidin-1-yl]sulfonyl-N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline —— C24H27N7O6S2
    2-[(2R,3S)-2,3-dimethylpiperidin-1-yl]sulfonyl-N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline
    —— 2-[(2S,4R)-2,4-dimethylpiperidin-1-yl]sulfonyl-N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline —— C24H27N7O6S2
    2-[(2S,4R)-2,4-dimethylpiperidin-1-yl]sulfonyl-N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline
    —— 2-[(2S,4S)-2,4-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(Z)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline —— C29H28N6O6S2
    2-[(2S,4S)-2,4-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(Z)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline
    —— 2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]sulfonyl-4-nitro-N-[(E)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline —— C28H26N6O7S2
    2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]sulfonyl-4-nitro-N-[(E)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline
    —— 2-[(2S,4S)-2,4-dimethylpiperidin-1-yl]sulfonyl-N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline —— C24H27N7O6S2
    2-[(2S,4S)-2,4-dimethylpiperidin-1-yl]sulfonyl-N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline
    —— 2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]sulfonyl-N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline —— C23H25N7O7S2
    2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]sulfonyl-N-[(Z)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline
    —— N-[(E)-[4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylideneamino]-2-(4-methylpiperidin-1-yl)sulfonyl-4-nitroaniline —— C26H24N6O6S3
    N-[(E)-[4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylideneamino]-2-(4-methylpiperidin-1-yl)sulfonyl-4-nitroaniline
    —— 2-[(2S,4R)-2,4-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(Z)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline —— C29H28N6O6S2
    2-[(2S,4R)-2,4-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(Z)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-(4-chlorophenyl)methylideneamino]-5-[(4-chlorophenyl)sulfanylmethyl]triazole-4-carboxamide —— C19H14Cl2N8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-(4-chlorophenyl)methylideneamino]-5-[(4-chlorophenyl)sulfanylmethyl]triazole-4-carboxamide
    —— 2-[(5S,7S)-3-(methylsulfanylcarbonylamino)-1-adamantyl]acetic acid —— C14H21NO3S
    2-[(5S,7S)-3-(methylsulfanylcarbonylamino)-1-adamantyl]acetic acid
    —— 2-[(5R,7R)-3-(methylsulfanylcarbonylamino)-1-adamantyl]acetic acid —— C14H21NO3S
    2-[(5R,7R)-3-(methylsulfanylcarbonylamino)-1-adamantyl]acetic acid
    —— 2-[(2R,3R)-2,3-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(E)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline —— C29H28N6O6S2
    2-[(2R,3R)-2,3-dimethylpiperidin-1-yl]sulfonyl-4-nitro-N-[(E)-(3-nitro-4-quinolin-8-ylsulfanylphenyl)methylideneamino]aniline
    —— 2-[(2R,3S)-2,3-dimethylpiperidin-1-yl]sulfonyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline —— C24H27N7O6S2
    2-[(2R,3S)-2,3-dimethylpiperidin-1-yl]sulfonyl-N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-4-nitroaniline
    —— 2-[[6-[[4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-3-nitrophenyl]methylideneamino]-1,3-benzothiazol-2-yl]sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C24H22N6O4S4
    2-[[6-[[4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-3-nitrophenyl]methylideneamino]-1,3-benzothiazol-2-yl]sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— N-[2-[(2,5-dichlorophenyl)methylsulfanyl]-1,3-benzothiazol-6-yl]-1-[4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-3-nitrophenyl]methanimine —— C24H15Cl2N5O2S4
    N-[2-[(2,5-dichlorophenyl)methylsulfanyl]-1,3-benzothiazol-6-yl]-1-[4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-3-nitrophenyl]methanimine
    —— 2-[[6-[[4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-3-nitrophenyl]methylideneamino]-1,3-benzothiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C24H22N6O4S4
    2-[[6-[[4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-3-nitrophenyl]methylideneamino]-1,3-benzothiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— 2-hydroxy-N-[(Z)-[5-(4-oxo-3-phenylquinazolin-2-yl)sulfanylfuran-2-yl]methylideneamino]benzamide —— C26H18N4O4S
    2-hydroxy-N-[(Z)-[5-(4-oxo-3-phenylquinazolin-2-yl)sulfanylfuran-2-yl]methylideneamino]benzamide
    —— 5-[(Z)-2-(4-chloroanilino)ethenyl]-3-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]-1,2-thiazole-4-carbonitrile —— C17H13ClN4S3
    5-[(Z)-2-(4-chloroanilino)ethenyl]-3-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]-1,2-thiazole-4-carbonitrile
    —— N-(2,6-dimethylphenyl)-2-[[6-[(3-nitro-4-pyridin-2-ylsulfanylphenyl)methylideneamino]-1,3-benzothiazol-2-yl]sulfanyl]acetamide —— C29H23N5O3S3
    N-(2,6-dimethylphenyl)-2-[[6-[(3-nitro-4-pyridin-2-ylsulfanylphenyl)methylideneamino]-1,3-benzothiazol-2-yl]sulfanyl]acetamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-benzylideneamino]-5-[(4-methylphenyl)sulfanylmethyl]triazole-4-carboxamide —— C20H18N8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-benzylideneamino]-5-[(4-methylphenyl)sulfanylmethyl]triazole-4-carboxamide