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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(E)-[(E)-2-bromo-3-phenylprop-2-enylidene]amino]-2-(6-methyl-2-methylsulfanylpyrimidin-4-yl)oxyacetamide —— C17H17BrN4O2S
    N-[(E)-[(E)-2-bromo-3-phenylprop-2-enylidene]amino]-2-(6-methyl-2-methylsulfanylpyrimidin-4-yl)oxyacetamide
    —— N-[3-[5-[2-nitro-4-(trifluoromethyl)phenyl]sulfanyl-4-phenyl-1,2,4-triazol-3-yl]propyl]acetamide —— C20H18F3N5O3S
    N-[3-[5-[2-nitro-4-(trifluoromethyl)phenyl]sulfanyl-4-phenyl-1,2,4-triazol-3-yl]propyl]acetamide
    —— N-(2-methylpropyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C12H16N4OS2
    N-(2-methylpropyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 3,3-Dimethyl-1-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]butan-2-one —— C9H14N2OS2
    3,3-Dimethyl-1-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]butan-2-one
    —— 6-Tert-butyl-2-prop-2-enylsulfanyl-4-(trifluoromethyl)pyridine-3-carbonitrile —— C14H15F3N2S
    6-Tert-butyl-2-prop-2-enylsulfanyl-4-(trifluoromethyl)pyridine-3-carbonitrile
    —— 2-[[3,6-Bis(2-methylphenyl)-7-oxo-2-sulfanylidene-[1,3]thiazolo[4,5-d]pyrimidin-5-yl]sulfanyl]acetonitrile —— C21H16N4OS3
    2-[[3,6-Bis(2-methylphenyl)-7-oxo-2-sulfanylidene-[1,3]thiazolo[4,5-d]pyrimidin-5-yl]sulfanyl]acetonitrile
    —— 2-[(Z)-but-2-enyl]sulfonyl-N-(2-cyclohexylethyl)acetamide —— C14H25NO3S
    2-[(Z)-but-2-enyl]sulfonyl-N-(2-cyclohexylethyl)acetamide
    —— (Z)-4-[[5-[[(2S)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]but-2-enenitrile —— C11H14N4OS2
    (Z)-4-[[5-[[(2S)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]but-2-enenitrile
    —— (Z)-4-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]but-2-enenitrile —— C11H14N4OS2
    (Z)-4-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]but-2-enenitrile
    —— 2-(2-chlorophenyl)sulfanyl-N-(4-phenylbutan-2-yl)acetamide —— C18H20ClNOS
    2-(2-chlorophenyl)sulfanyl-N-(4-phenylbutan-2-yl)acetamide
    —— 4-Chloro-5-ethoxy-2-(6-ethoxy-2-methylsulfanylpyrimidin-4-yl)pyridazin-3-one —— C13H15ClN4O3S
    4-Chloro-5-ethoxy-2-(6-ethoxy-2-methylsulfanylpyrimidin-4-yl)pyridazin-3-one
    —— Ethyl 2-{[3-(3,4-dimethylphenyl)-6-(2-methylphenyl)-7-oxo-2-sulfanylidene-2H,3H,6H,7H-[1,3]thiazolo[4,5-D]pyrimidin-5-YL]sulfanyl}acetate —— C24H23N3O3S3
    Ethyl 2-{[3-(3,4-dimethylphenyl)-6-(2-methylphenyl)-7-oxo-2-sulfanylidene-2H,3H,6H,7H-[1,3]thiazolo[4,5-D]pyrimidin-5-YL]sulfanyl}acetate
    —— 4-ethyl-5-methyl-2-(2-oxo-2-pyrrolidin-1-ylethyl)sulfanyl-1H-pyrimidin-6-one —— C13H19N3O2S
    4-ethyl-5-methyl-2-(2-oxo-2-pyrrolidin-1-ylethyl)sulfanyl-1H-pyrimidin-6-one
    —— 2-(3-cyano-6-thiophen-2-ylpyridin-2-yl)sulfanyl-N-octylacetamide —— C20H25N3OS2
    2-(3-cyano-6-thiophen-2-ylpyridin-2-yl)sulfanyl-N-octylacetamide
    —— 5-(Benzylsulfanyl)-3-[(furan-2-YL)methyl]-6-phenyl-2-sulfanylidene-2H,3H,6H,7H-[1,3]thiazolo[4,5-D]pyrimidin-7-one —— C23H17N3O2S3
    5-(Benzylsulfanyl)-3-[(furan-2-YL)methyl]-6-phenyl-2-sulfanylidene-2H,3H,6H,7H-[1,3]thiazolo[4,5-D]pyrimidin-7-one
    —— 1-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]-N-(1H-1,2,4-triazol-4-ium-4-yl)methanimine —— C13H12N7O2S+
    1-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]-N-(1H-1,2,4-triazol-4-ium-4-yl)methanimine
    —— 2-((3-(2-chlorophenyl)-1,2,4-thiadiazol-5-yl)thio)-N-cyclopentylacetamide —— C15H16ClN3OS2
    2-((3-(2-chlorophenyl)-1,2,4-thiadiazol-5-yl)thio)-N-cyclopentylacetamide
    —— 3-(4-Fluorophenyl)-5-imino-6-[(4-methylsulfanylphenyl)methylidene]-[1,3]thiazolo[3,2-a]pyrimidin-7-one —— C20H14FN3OS2
    3-(4-Fluorophenyl)-5-imino-6-[(4-methylsulfanylphenyl)methylidene]-[1,3]thiazolo[3,2-a]pyrimidin-7-one
    —— 6-tert-butyl-4-[(E)-[(1S)-cyclohex-3-en-1-yl]methylideneamino]-3-methylsulfanyl-1,2,4-triazin-5-one —— C15H22N4OS
    6-tert-butyl-4-[(E)-[(1S)-cyclohex-3-en-1-yl]methylideneamino]-3-methylsulfanyl-1,2,4-triazin-5-one
    —— 1-Cyclohexyl-3-(1,3-dihydroxy-2-methylpropan-2-yl)thiourea —— C11H22N2O2S
    1-Cyclohexyl-3-(1,3-dihydroxy-2-methylpropan-2-yl)thiourea
    —— 6-tert-butyl-4-[(E)-[(1R)-cyclohex-3-en-1-yl]methylideneamino]-3-methylsulfanyl-1,2,4-triazin-5-one —— C15H22N4OS
    6-tert-butyl-4-[(E)-[(1R)-cyclohex-3-en-1-yl]methylideneamino]-3-methylsulfanyl-1,2,4-triazin-5-one
    —— [2-Tert-butyl-4-(4-chlorophenyl)sulfanyl-5-methylpyrazol-3-yl] 2-phenylacetate —— C22H23ClN2O2S
    [2-Tert-butyl-4-(4-chlorophenyl)sulfanyl-5-methylpyrazol-3-yl] 2-phenylacetate
    —— [2-Tert-butyl-4-(4-chlorophenyl)sulfanyl-5-methylpyrazol-3-yl] benzoate —— C21H21ClN2O2S
    [2-Tert-butyl-4-(4-chlorophenyl)sulfanyl-5-methylpyrazol-3-yl] benzoate
    —— 3-Pyridin-2-ylsulfanylpropanamide —— C8H10N2OS
    3-Pyridin-2-ylsulfanylpropanamide
    —— 3-[(Z)-but-2-enyl]sulfanyl-4-methyl-1,2,4-triazole —— C7H11N3S
    3-[(Z)-but-2-enyl]sulfanyl-4-methyl-1,2,4-triazole
    —— 1-Cyclopentyl-3-propylthiourea —— C9H18N2S
    1-Cyclopentyl-3-propylthiourea
    —— 1-[[4-(4-Chlorophenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile —— C26H16ClN7S
    1-[[4-(4-Chlorophenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile
    —— N-(1,1-dioxothiolan-3-yl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C17H22N4O3S3
    N-(1,1-dioxothiolan-3-yl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— N-(1-adamantyl)-2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C20H22ClN3OS3
    N-(1-adamantyl)-2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-(1-{[2-(benzylsulfanyl)-6-methylpyrimidin-4-yl]oxy}-2,2,2-trichloroethyl)-2,2-dimethylpropanamide —— C19H22Cl3N3O2S
    N-(1-{[2-(benzylsulfanyl)-6-methylpyrimidin-4-yl]oxy}-2,2,2-trichloroethyl)-2,2-dimethylpropanamide
    —— N-benzyl-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-tert-butylacetamide —— C26H28N4OS2
    N-benzyl-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-tert-butylacetamide
    —— (Z)-3-(2-chloroimidazo[1,2-a]pyridin-3-yl)-N-(2-methyl-4-pyrimidin-2-ylsulfanylphenyl)prop-2-enamide —— C21H16ClN5OS
    (Z)-3-(2-chloroimidazo[1,2-a]pyridin-3-yl)-N-(2-methyl-4-pyrimidin-2-ylsulfanylphenyl)prop-2-enamide
    —— (2S)-N-[(Z)-3-chloroprop-2-enyl]-N-methyl-1-methylsulfonylpropan-2-amine —— C8H16ClNO2S
    (2S)-N-[(Z)-3-chloroprop-2-enyl]-N-methyl-1-methylsulfonylpropan-2-amine
    —— 1-(3-benzylsulfanyl-1H-1,2,4-triazol-5-yl)-3-[chloro(ethoxy)phosphoryl]urea —— C12H15ClN5O3PS
    1-(3-benzylsulfanyl-1H-1,2,4-triazol-5-yl)-3-[chloro(ethoxy)phosphoryl]urea
    —— 1-allyl-3-[2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-ylsulfanyl)-benzyl]-urea 745827-41-2 C20H23N5OS
    1-allyl-3-[2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-ylsulfanyl)-benzyl]-urea
    —— 5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-phenylsulfanylaniline —— C20H26ClN3S
    5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-phenylsulfanylaniline
    —— N-(1-ethylpropyl)-5-(6-isopropyl-2-methoxypyridin-3-yl)-6-methyl-3-(methylthio)pyrazin-2-amine 666254-35-9 C20H30N4OS
    N-(1-ethylpropyl)-5-(6-isopropyl-2-methoxypyridin-3-yl)-6-methyl-3-(methylthio)pyrazin-2-amine
    —— 2-(4-bromophenyl)sulfanyl-5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-methoxyethyl)benzamide —— C23H29BrN2O4S2
    2-(4-bromophenyl)sulfanyl-5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-methoxyethyl)benzamide
    —— 2-(4-bromophenyl)sulfanyl-5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(3-ethoxypropyl)benzamide —— C25H33BrN2O4S2
    2-(4-bromophenyl)sulfanyl-5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(3-ethoxypropyl)benzamide
    —— 5-(4-Fluorophenyl)sulfanyl-1-[(4-methoxyphenyl)methyl]pyrazolo[3,4-b]pyridine —— C20H16FN3OS
    5-(4-Fluorophenyl)sulfanyl-1-[(4-methoxyphenyl)methyl]pyrazolo[3,4-b]pyridine
    —— 2-(4-bromophenyl)sulfanyl-5-[(3S,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(3-ethoxypropyl)benzamide —— C25H33BrN2O4S2
    2-(4-bromophenyl)sulfanyl-5-[(3S,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(3-ethoxypropyl)benzamide
    —— 2-(4-bromophenyl)sulfanyl-N-[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]-5-morpholin-4-ylsulfonylbenzamide —— C25H23BrN2O6S2
    2-(4-bromophenyl)sulfanyl-N-[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]-5-morpholin-4-ylsulfonylbenzamide
    —— 3-bromo-4-(3,5-dimethylphenyl)sulfanyl-5-ethyl-6-methyl-1H-pyridin-2-one —— C16H18BrNOS
    3-bromo-4-(3,5-dimethylphenyl)sulfanyl-5-ethyl-6-methyl-1H-pyridin-2-one
    —— 2-(4-bromophenyl)sulfanyl-5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-morpholin-4-ylethyl)benzamide —— C26H34BrN3O4S2
    2-(4-bromophenyl)sulfanyl-5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-morpholin-4-ylethyl)benzamide
    —— 2-(4-bromophenyl)sulfanyl-5-[(3S,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-morpholin-4-ylethyl)benzamide —— C26H34BrN3O4S2
    2-(4-bromophenyl)sulfanyl-5-[(3S,5S)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-morpholin-4-ylethyl)benzamide
    —— 2-(4-bromophenyl)sulfanyl-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-methoxyethyl)benzamide —— C23H29BrN2O4S2
    2-(4-bromophenyl)sulfanyl-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-methoxyethyl)benzamide
    —— 2-(4-bromophenyl)sulfanyl-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(3-ethoxypropyl)benzamide —— C25H33BrN2O4S2
    2-(4-bromophenyl)sulfanyl-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(3-ethoxypropyl)benzamide
    —— 2-(4-bromophenyl)sulfanyl-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-morpholin-4-ylethyl)benzamide —— C26H34BrN3O4S2
    2-(4-bromophenyl)sulfanyl-5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]sulfonyl-N-(2-morpholin-4-ylethyl)benzamide
    —— 2-(4-bromophenyl)sulfanyl-N-[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]-5-morpholin-4-ylsulfonylbenzamide —— C25H23BrN2O6S2
    2-(4-bromophenyl)sulfanyl-N-[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]-5-morpholin-4-ylsulfonylbenzamide
    —— N-[(1R)-2,2-dichloro-1-(4-methylphenyl)sulfanylethyl]propanamide —— C12H15Cl2NOS
    N-[(1R)-2,2-dichloro-1-(4-methylphenyl)sulfanylethyl]propanamide