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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— [(1S)-1-[5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]-2-methylpropyl]azanium —— C12H23N4O2S+
    [(1S)-1-[5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]-2-methylpropyl]azanium
    —— 2-[(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl]-N-(1-cyanocyclohexyl)-N-methylacetamide —— C19H24N4OS
    2-[(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl]-N-(1-cyanocyclohexyl)-N-methylacetamide
    —— 2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-(cyclohexylmethyl)acetamide —— C18H25N3OS
    2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-(cyclohexylmethyl)acetamide
    —— (2S)-2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-(cyclohexylmethyl)propanamide —— C19H27N3OS
    (2S)-2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-(cyclohexylmethyl)propanamide
    —— 2-[(3-Chlorophenyl)methylsulfanyl]-4,5,6-trimethylpyridine-3-carbonitrile —— C16H15ClN2S
    2-[(3-Chlorophenyl)methylsulfanyl]-4,5,6-trimethylpyridine-3-carbonitrile
    —— 4,5,6-Trimethyl-2-[(5-oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methylsulfanyl]pyridine-3-carbonitrile —— C16H14N4OS2
    4,5,6-Trimethyl-2-[(5-oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methylsulfanyl]pyridine-3-carbonitrile
    —— (2S)-N-benzyl-2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-methylpropanamide —— C20H23N3OS
    (2S)-N-benzyl-2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-methylpropanamide
    —— N-[(2R)-butan-2-yl]-2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanylacetamide —— C15H21N3OS
    N-[(2R)-butan-2-yl]-2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanylacetamide
    —— [(2R)-1-oxo-1-pyrrolidin-1-ylpropan-2-yl] 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate —— C17H26N4O3S2
    [(2R)-1-oxo-1-pyrrolidin-1-ylpropan-2-yl] 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate
    —— [2-Oxo-2-(1,2,5-trimethylpyrrol-3-yl)ethyl] 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate —— C19H26N4O3S2
    [2-Oxo-2-(1,2,5-trimethylpyrrol-3-yl)ethyl] 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate
    —— [2-[[(1R,2S)-2-methylcyclohexyl]amino]-2-oxoethyl] 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate —— C19H30N4O3S2
    [2-[[(1R,2S)-2-methylcyclohexyl]amino]-2-oxoethyl] 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate
    —— 1-[2,5-Dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrol-3-yl]-2-(2-fluorophenyl)sulfanylethanone —— C18H17FN2O2S
    1-[2,5-Dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrol-3-yl]-2-(2-fluorophenyl)sulfanylethanone
    —— [(1S)-2-oxocyclohexyl] 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate —— C16H23N3O3S2
    [(1S)-2-oxocyclohexyl] 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate
    —— [2-[[(2S)-butan-2-yl]amino]-2-oxoethyl] 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate —— C16H26N4O3S2
    [2-[[(2S)-butan-2-yl]amino]-2-oxoethyl] 2-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetate
    —— N-[2-(2-fluorophenyl)sulfanylacetyl]-1-methylpyrrole-2-carboxamide —— C14H13FN2O2S
    N-[2-(2-fluorophenyl)sulfanylacetyl]-1-methylpyrrole-2-carboxamide
    —— N-[(2-chlorophenyl)methyl]-2-[[5-(2-methoxyethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H17ClN4O2S2
    N-[(2-chlorophenyl)methyl]-2-[[5-(2-methoxyethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-(1-adamantylmethyl)-2-(2-fluorophenyl)sulfanylacetamide —— C19H24FNOS
    N-(1-adamantylmethyl)-2-(2-fluorophenyl)sulfanylacetamide
    —— 2-(2-Fluorophenyl)sulfanyl-1-[1-(furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]ethanone —— C19H18FNO2S
    2-(2-Fluorophenyl)sulfanyl-1-[1-(furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]ethanone
    —— ethyl 5-[(2R)-2-(2-fluorophenyl)sulfanylpropanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C18H20FNO3S
    ethyl 5-[(2R)-2-(2-fluorophenyl)sulfanylpropanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C14H21N3O4S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— tert-butyl N-[(1S,2R)-1-[5-[(3-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]carbamate —— C19H26FN3O3S
    tert-butyl N-[(1S,2R)-1-[5-[(3-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]carbamate
    —— [(1S)-1-(5-ethylsulfanyl-1,3,4-oxadiazol-2-yl)-3-methylbutyl]azanium —— C9H18N3OS+
    [(1S)-1-(5-ethylsulfanyl-1,3,4-oxadiazol-2-yl)-3-methylbutyl]azanium
    —— 1-(4-Ethylpiperazin-4-ium-1-yl)-3-(4-methylphenyl)sulfanylpropan-1-one —— C16H25N2OS+
    1-(4-Ethylpiperazin-4-ium-1-yl)-3-(4-methylphenyl)sulfanylpropan-1-one
    —— 1-(5-chlorothiophen-2-yl)-2-[[(1R,8S)-8,11,11-trimethyl-3,4,6-triazatricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-5-yl]sulfanyl]ethanone —— C17H18ClN3OS2
    1-(5-chlorothiophen-2-yl)-2-[[(1R,8S)-8,11,11-trimethyl-3,4,6-triazatricyclo[6.2.1.02,7]undeca-2(7),3,5-trien-5-yl]sulfanyl]ethanone
    —— 2-[7-(3,5-dimethylphenyl)-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl]sulfanyl-N-methylacetamide —— C19H21N5O3S
    2-[7-(3,5-dimethylphenyl)-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl]sulfanyl-N-methylacetamide
    —— 2-(7-butyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C19H27N5O4S
    2-(7-butyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 2-[7-(2-fluorophenyl)-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl]sulfanyl-N-methylacetamide —— C17H16FN5O3S
    2-[7-(2-fluorophenyl)-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl]sulfanyl-N-methylacetamide
    —— 2-(7-cyclohexyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N,N-diethylacetamide —— C20H29N5O3S
    2-(7-cyclohexyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N,N-diethylacetamide
    —— 2-[1,3-dimethyl-7-(2-methylphenyl)-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl]sulfanyl-N-propan-2-ylacetamide —— C20H23N5O3S
    2-[1,3-dimethyl-7-(2-methylphenyl)-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl]sulfanyl-N-propan-2-ylacetamide
    —— 2-[1,3-dimethyl-7-(2-methylpropyl)-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl]sulfanyl-N-propan-2-ylacetamide —— C17H25N5O3S
    2-[1,3-dimethyl-7-(2-methylpropyl)-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl]sulfanyl-N-propan-2-ylacetamide
    —— methyl 2,4-dimethyl-5-[(2R)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate —— C14H17N3O3S2
    methyl 2,4-dimethyl-5-[(2R)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate
    —— N-[(1S,2R,3R)-2,3-dimethylcyclohexyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H21N3OS2
    N-[(1S,2R,3R)-2,3-dimethylcyclohexyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[(1R,2R,3R)-2,3-dimethylcyclohexyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H21N3OS2
    N-[(1R,2R,3R)-2,3-dimethylcyclohexyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C14H16FN3OS2
    (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (1R,6S,7S,9S)-12-imino-9-(4-methylsulfanylphenyl)-10,11-dioxatricyclo[5.3.2.01,6]dodecane-7,8,8-tricarbonitrile —— C20H18N4O2S
    (1R,6S,7S,9S)-12-imino-9-(4-methylsulfanylphenyl)-10,11-dioxatricyclo[5.3.2.01,6]dodecane-7,8,8-tricarbonitrile
    —— methyl 2,4-dimethyl-5-[(2S)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate —— C14H17N3O3S2
    methyl 2,4-dimethyl-5-[(2S)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate
    —— N-[(2S)-butan-2-yl]-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H21N3O3S3
    N-[(2S)-butan-2-yl]-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 2-[[5-(Furan-2-yl)-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C13H10N3O4S-
    2-[[5-(Furan-2-yl)-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— tert-butyl N-[(1S,2R)-1-[5-[(2-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]carbamate —— C19H26FN3O3S
    tert-butyl N-[(1S,2R)-1-[5-[(2-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]carbamate
    —— N-[(1R,2R)-2-methylcyclohexyl]-2-phenylsulfanylacetamide —— C15H21NOS
    N-[(1R,2R)-2-methylcyclohexyl]-2-phenylsulfanylacetamide
    —— N-(4-phenyl-1,3-thiazol-2-yl)-N-prop-2-enyl-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C24H26N2OS2
    N-(4-phenyl-1,3-thiazol-2-yl)-N-prop-2-enyl-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— (1R)-1-[5-[[5-(5-bromothiophen-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-4-(2-morpholin-4-ylethyl)-1,2,4-triazol-3-yl]-N,N-dimethylpropan-1-amine —— C20H28BrN7O2S2
    (1R)-1-[5-[[5-(5-bromothiophen-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-4-(2-morpholin-4-ylethyl)-1,2,4-triazol-3-yl]-N,N-dimethylpropan-1-amine
    —— N-[(1R)-1-(3-chlorophenyl)ethyl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C20H24ClNOS
    N-[(1R)-1-(3-chlorophenyl)ethyl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— N-(1-adamantyl)-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C22H31NOS
    N-(1-adamantyl)-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— 2-(2,3,5,6-Tetramethylphenyl)sulfanylacetamide —— C12H17NOS
    2-(2,3,5,6-Tetramethylphenyl)sulfanylacetamide
    —— N-[(1R)-1-phenylethyl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C20H25NOS
    N-[(1R)-1-phenylethyl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— 5-chloro-4-methylsulfanyl-1H-pyridazin-6-one —— C5H5ClN2OS
    5-chloro-4-methylsulfanyl-1H-pyridazin-6-one
    —— 1-(1-Adamantyl)-2-(2,3,5,6-tetramethylphenyl)sulfanylethanone —— C22H30OS
    1-(1-Adamantyl)-2-(2,3,5,6-tetramethylphenyl)sulfanylethanone
    —— 2-[(2,3,4,5,6-Pentafluorophenyl)sulfanylmethyl]-5-phenyl-1,3,4-oxadiazole —— C15H7F5N2OS
    2-[(2,3,4,5,6-Pentafluorophenyl)sulfanylmethyl]-5-phenyl-1,3,4-oxadiazole
    —— N-(4-methylcyclohexyl)-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C19H29NOS
    N-(4-methylcyclohexyl)-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide