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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[2-(4-fluorophenyl)ethyl]acetamide —— C14H16FN3OS3
    2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[2-(4-fluorophenyl)ethyl]acetamide
    —— [(1S)-2-[[2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetyl]amino]-1-phenylethyl]-dimethylazanium —— C16H23N4OS3+
    [(1S)-2-[[2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetyl]amino]-1-phenylethyl]-dimethylazanium
    —— 2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2R)-2-phenylpropyl]acetamide —— C15H19N3OS3
    2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2R)-2-phenylpropyl]acetamide
    —— N-[(2S)-2-(dimethylamino)-2-phenylethyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C16H22N4OS3
    N-[(2S)-2-(dimethylamino)-2-phenylethyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 1-[2,5-Dimethyl-1-(thiophen-2-ylmethyl)pyrrol-3-yl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C17H19N3OS4
    1-[2,5-Dimethyl-1-(thiophen-2-ylmethyl)pyrrol-3-yl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— N-[(1R)-1-(3,4-dimethylphenyl)ethyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C16H21N3OS3
    N-[(1R)-1-(3,4-dimethylphenyl)ethyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2S)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C13H20N4OS3
    (2S)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— N-[(3-chlorophenyl)methyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H14ClN3OS3
    N-[(3-chlorophenyl)methyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 2-(4-Chlorophenyl)-5-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C13H11ClN4OS3
    2-(4-Chlorophenyl)-5-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— N-[(2S)-butan-2-yl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C10H17N3OS3
    N-[(2S)-butan-2-yl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-N-cyclopropyl-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C10H15N3OS3
    (2R)-N-cyclopropyl-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— N-[2-(4-chlorophenyl)ethyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C14H16ClN3OS3
    N-[2-(4-chlorophenyl)ethyl]-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2S)-N-(1-adamantyl)-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C17H25N3OS3
    (2S)-N-(1-adamantyl)-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— N-[(2R,3S)-2-methyloxolan-3-yl]-1-phenylsulfanylcyclopentane-1-carboxamide —— C17H23NO2S
    N-[(2R,3S)-2-methyloxolan-3-yl]-1-phenylsulfanylcyclopentane-1-carboxamide
    —— N-[(2R,3R)-2-methyloxolan-3-yl]-1-phenylsulfanylcyclopentane-1-carboxamide —— C17H23NO2S
    N-[(2R,3R)-2-methyloxolan-3-yl]-1-phenylsulfanylcyclopentane-1-carboxamide
    —— N-[(2S,3R)-2-methyloxolan-3-yl]-1-phenylsulfanylcyclopentane-1-carboxamide —— C17H23NO2S
    N-[(2S,3R)-2-methyloxolan-3-yl]-1-phenylsulfanylcyclopentane-1-carboxamide
    —— N-[(2S,3S)-2-methyloxolan-3-yl]-1-phenylsulfanylcyclopentane-1-carboxamide —— C17H23NO2S
    N-[(2S,3S)-2-methyloxolan-3-yl]-1-phenylsulfanylcyclopentane-1-carboxamide
    —— (2S)-N-[(4-methylcyclohexyl)methyl]-2-[(S)-methylsulfinyl]propan-1-amine —— C12H25NOS
    (2S)-N-[(4-methylcyclohexyl)methyl]-2-[(S)-methylsulfinyl]propan-1-amine
    —— N,N-diethyl-2-((6-(furan-2-yl)pyridazin-3-yl)thio)ethanamine —— C14H19N3OS
    N,N-diethyl-2-((6-(furan-2-yl)pyridazin-3-yl)thio)ethanamine
    —— Diethyl-[2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylethyl]azanium —— C14H20N3OS+
    Diethyl-[2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylethyl]azanium
    —— (2R)-1-ethylsulfonyl-N-[(4-methylcyclohexyl)methyl]propan-2-amine —— C13H27NO2S
    (2R)-1-ethylsulfonyl-N-[(4-methylcyclohexyl)methyl]propan-2-amine
    —— 3-(Furan-2-yl)-6-(2-piperidin-1-ium-1-ylethylsulfanyl)pyridazine —— C15H20N3OS+
    3-(Furan-2-yl)-6-(2-piperidin-1-ium-1-ylethylsulfanyl)pyridazine
    —— 2-((6-(Furan-2-yl)pyridazin-3-yl)thio)acetonitrile —— C10H7N3OS
    2-((6-(Furan-2-yl)pyridazin-3-yl)thio)acetonitrile
    —— (2R)-2-[(6-benzylsulfanylpyrazin-2-yl)-methylamino]propan-1-ol —— C15H19N3OS
    (2R)-2-[(6-benzylsulfanylpyrazin-2-yl)-methylamino]propan-1-ol
    —— (2R)-N-[(4-methylcyclohexyl)methyl]-2-[(S)-methylsulfinyl]propan-1-amine —— C12H25NOS
    (2R)-N-[(4-methylcyclohexyl)methyl]-2-[(S)-methylsulfinyl]propan-1-amine
    —— (2R)-N-[(4-methylcyclohexyl)methyl]-4-methylsulfonylbutan-2-amine —— C13H27NO2S
    (2R)-N-[(4-methylcyclohexyl)methyl]-4-methylsulfonylbutan-2-amine
    —— N,N-diethyl-2-((6-(pyridin-4-yl)pyridazin-3-yl)thio)ethanamine —— C15H20N4S
    N,N-diethyl-2-((6-(pyridin-4-yl)pyridazin-3-yl)thio)ethanamine
    —— 2-(4-Chlorophenyl)-4-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazole —— C15H15ClN4S2
    2-(4-Chlorophenyl)-4-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazole
    —— (2S)-N-[(4-methylcyclohexyl)methyl]-4-methylsulfonylbutan-2-amine —— C13H27NO2S
    (2S)-N-[(4-methylcyclohexyl)methyl]-4-methylsulfonylbutan-2-amine
    —— (2R)-N-[(4-methylcyclohexyl)methyl]-2-[(R)-methylsulfinyl]propan-1-amine —— C12H25NOS
    (2R)-N-[(4-methylcyclohexyl)methyl]-2-[(R)-methylsulfinyl]propan-1-amine
    —— (2S)-1-ethylsulfonyl-N-[(4-methylcyclohexyl)methyl]propan-2-amine —— C13H27NO2S
    (2S)-1-ethylsulfonyl-N-[(4-methylcyclohexyl)methyl]propan-2-amine
    —— Diethyl-[2-(6-thiophen-2-ylpyridazin-3-yl)sulfanylethyl]azanium —— C14H20N3S2+
    Diethyl-[2-(6-thiophen-2-ylpyridazin-3-yl)sulfanylethyl]azanium
    —— (2S)-N-[(4-methylcyclohexyl)methyl]-2-[(R)-methylsulfinyl]propan-1-amine —— C12H25NOS
    (2S)-N-[(4-methylcyclohexyl)methyl]-2-[(R)-methylsulfinyl]propan-1-amine
    —— (2S)-2-[(6-benzylsulfanylpyrazin-2-yl)-methylamino]propan-1-ol —— C15H19N3OS
    (2S)-2-[(6-benzylsulfanylpyrazin-2-yl)-methylamino]propan-1-ol
    —— 1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(2R,3R)-2-methyloxolan-3-yl]urea —— C14H19FN2O2S
    1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(2R,3R)-2-methyloxolan-3-yl]urea
    —— 1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(2S,3S)-2-methyloxolan-3-yl]urea —— C14H19FN2O2S
    1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(2S,3S)-2-methyloxolan-3-yl]urea
    —— 1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(2R,3S)-2-methyloxolan-3-yl]urea —— C14H19FN2O2S
    1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(2R,3S)-2-methyloxolan-3-yl]urea
    —— 1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(2S,3R)-2-methyloxolan-3-yl]urea —— C14H19FN2O2S
    1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(2S,3R)-2-methyloxolan-3-yl]urea
    —— (2R)-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]cyclohexan-1-one —— C15H16N2O2S
    (2R)-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]cyclohexan-1-one
    —— N-[(4-chlorophenyl)methyl]-N-methyl-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H18ClN3O2S
    N-[(4-chlorophenyl)methyl]-N-methyl-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(2-Methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-thiophen-2-ylethanone —— C15H12N2O2S2
    2-[[5-(2-Methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-thiophen-2-ylethanone
    —— (2S)-N-(furan-2-ylmethyl)-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C17H17N3O3S
    (2S)-N-(furan-2-ylmethyl)-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— N-[(1R)-1-(1-adamantyl)ethyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C23H29N3O2S
    N-[(1R)-1-(1-adamantyl)ethyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— methyl (2S)-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate —— C13H14N2O3S
    methyl (2S)-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate
    —— N-[2-(4-fluorophenyl)ethyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H18FN3O2S
    N-[2-(4-fluorophenyl)ethyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(1S,2S)-2-methylcyclohexyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H23N3O2S
    N-[(1S,2S)-2-methylcyclohexyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[2-(4-Fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-(3-methylphenyl)-1,3,4-oxadiazole —— C19H14FN3OS2
    2-[[2-(4-Fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-(3-methylphenyl)-1,3,4-oxadiazole
    —— 1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C17H21N3O3S
    1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— N-carbamoyl-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C12H12N4O3S
    N-carbamoyl-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C21H25N3O3S
    1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone