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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-[(4-Cyclopropyl-5-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-thiophen-3-yl-1,2,4-oxadiazole —— C13H13N5OS2
    5-[(4-Cyclopropyl-5-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-thiophen-3-yl-1,2,4-oxadiazole
    —— (2S)-N-(2-methoxyethyl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C17H23N3O3S2
    (2S)-N-(2-methoxyethyl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— (2S)-2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-[(2-chlorophenyl)methyl]propanamide —— C12H14ClN5OS
    (2S)-2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-[(2-chlorophenyl)methyl]propanamide
    —— (2R)-N-[(2-chlorophenyl)methyl]-2-[[4-ethyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C19H21ClN4O2S
    (2R)-N-[(2-chlorophenyl)methyl]-2-[[4-ethyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— N-[(2,4-dimethylphenyl)methyl]-N-methyl-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H21N3O3S
    N-[(2,4-dimethylphenyl)methyl]-N-methyl-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— (5-Methyl-1,2-oxazol-3-yl)methyl 2-(2-cyanophenyl)sulfanylbenzoate —— C19H14N2O3S
    (5-Methyl-1,2-oxazol-3-yl)methyl 2-(2-cyanophenyl)sulfanylbenzoate
    —— N-[(1R)-2-(dimethylamino)-1-phenylethyl]-2-(2-methylphenyl)sulfanylacetamide —— C19H24N2OS
    N-[(1R)-2-(dimethylamino)-1-phenylethyl]-2-(2-methylphenyl)sulfanylacetamide
    —— (2R)-2-[[4-amino-5-[(4-fluorophenyl)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-ethylpropanamide —— C14H18FN5OS
    (2R)-2-[[4-amino-5-[(4-fluorophenyl)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-ethylpropanamide
    —— 3-[(4-fluorophenyl)methyl]-5-[(1R)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,2,4-triazol-4-amine —— C19H16F2N6OS
    3-[(4-fluorophenyl)methyl]-5-[(1R)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,2,4-triazol-4-amine
    —— (2S)-2-[[4-amino-5-[(4-fluorophenyl)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-ethylpropanamide —— C14H18FN5OS
    (2S)-2-[[4-amino-5-[(4-fluorophenyl)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-ethylpropanamide
    —— (2S)-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethylpropanamide —— C13H15ClN4OS2
    (2S)-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethylpropanamide
    —— (2R)-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dimethylpropanamide —— C13H15ClN4OS2
    (2R)-2-[[5-(3-chloroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dimethylpropanamide
    —— [(2S)-1-(ethylamino)-1-oxopropan-2-yl] (2R)-2-(4-methylphenyl)sulfanylpropanoate —— C15H21NO3S
    [(2S)-1-(ethylamino)-1-oxopropan-2-yl] (2R)-2-(4-methylphenyl)sulfanylpropanoate
    —— (2S)-2-[[5-[(2R)-1-(dimethylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dimethylpropanamide —— C12H20N4O2S3
    (2S)-2-[[5-[(2R)-1-(dimethylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dimethylpropanamide
    —— [2-[2-(4-Methylphenyl)sulfanylethylamino]-2-oxoethyl] 1-ethyl-2,5-dimethylpyrrole-3-carboxylate —— C20H26N2O3S
    [2-[2-(4-Methylphenyl)sulfanylethylamino]-2-oxoethyl] 1-ethyl-2,5-dimethylpyrrole-3-carboxylate
    —— (2S)-2-[[5-[(2S)-1-(dimethylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dimethylpropanamide —— C12H20N4O2S3
    (2S)-2-[[5-[(2S)-1-(dimethylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dimethylpropanamide
    —— 2-[[5-(Propylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one —— C16H19N5OS3
    2-[[5-(Propylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one
    —— N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C15H19ClN4OS2
    N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (2S)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C16H21FN4OS2
    (2S)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 1-(2,5-Dimethyl-1-propan-2-ylpyrrol-3-yl)-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C16H24N4OS2
    1-(2,5-Dimethyl-1-propan-2-ylpyrrol-3-yl)-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C16H21FN4OS2
    (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 5-[(4-methylsulfanylphenyl)methylsulfanyl]-N-propyl-1,3,4-thiadiazol-2-amine —— C13H17N3S3
    5-[(4-methylsulfanylphenyl)methylsulfanyl]-N-propyl-1,3,4-thiadiazol-2-amine
    —— N-[(1S,2R)-2-methylcyclohexyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H24N4OS2
    N-[(1S,2R)-2-methylcyclohexyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 1-[1-(Furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C18H22N4O2S2
    1-[1-(Furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— N-[(4-fluorophenyl)methyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H17FN4OS2
    N-[(4-fluorophenyl)methyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-(2-phenylsulfanylphenyl)-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C19H20N4OS3
    N-(2-phenylsulfanylphenyl)-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— ethyl 2,4-dimethyl-5-[2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]-1H-pyrrole-3-carboxylate —— C16H22N4O3S2
    ethyl 2,4-dimethyl-5-[2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]-1H-pyrrole-3-carboxylate
    —— N-[(1R)-1-(1-adamantyl)ethyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C19H30N4OS2
    N-[(1R)-1-(1-adamantyl)ethyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 7-[[5-(Propylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C12H13N5OS3
    7-[[5-(Propylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 1-(2,5-Dimethyl-1-prop-2-enylpyrrol-3-yl)-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C16H22N4OS2
    1-(2,5-Dimethyl-1-prop-2-enylpyrrol-3-yl)-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 1-(1-Adamantyl)-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C17H25N3OS2
    1-(1-Adamantyl)-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— N-(1-adamantyl)-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H26N4OS2
    N-(1-adamantyl)-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-benzyl-N-methyl-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C15H20N4OS2
    N-benzyl-N-methyl-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[(1S)-1-phenylethyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C15H20N4OS2
    N-[(1S)-1-phenylethyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[(4-chlorophenyl)methyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H17ClN4OS2
    N-[(4-chlorophenyl)methyl]-2-[[5-(propylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 4-chloropyridine-2-carboxylate —— C20H15ClN2O3S
    [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 4-chloropyridine-2-carboxylate
    —— (2R)-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-phenylbutyl]propanamide —— C21H31N5O2S
    (2R)-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-phenylbutyl]propanamide
    —— (2S)-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-3-(4-methylphenyl)propanenitrile —— C18H23N5OS
    (2S)-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-3-(4-methylphenyl)propanenitrile
    —— N-[(1R)-1-(3,4-dimethylphenyl)ethyl]-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C20H29N5O2S
    N-[(1R)-1-(3,4-dimethylphenyl)ethyl]-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-(4-methylphenyl)sulfanylethyl]acetamide —— C19H27N5O2S2
    2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-(4-methylphenyl)sulfanylethyl]acetamide
    —— N-[(2,4-dimethylphenyl)methyl]-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-methylacetamide —— C20H29N5O2S
    N-[(2,4-dimethylphenyl)methyl]-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-methylacetamide
    —— 4-[4-ethyl-5-[(1S)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C19H24N6O2S
    4-[4-ethyl-5-[(1S)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 4-[4-ethyl-5-[(1R)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C19H24N6O2S
    4-[4-ethyl-5-[(1R)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-methyl-N-[(1S)-1-phenylethyl]acetamide —— C19H27N5O2S
    2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-methyl-N-[(1S)-1-phenylethyl]acetamide
    —— 2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C16H23N5O2S2
    2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— 4-[4-ethyl-5-[(1R)-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C18H22N6O2S
    4-[4-ethyl-5-[(1R)-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-3-methyl-1-phenylbutyl]acetamide —— C21H31N5O2S
    2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-3-methyl-1-phenylbutyl]acetamide
    —— 2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-3-methyl-1-phenylbutyl]acetamide —— C21H31N5O2S
    2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-3-methyl-1-phenylbutyl]acetamide
    —— N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C18H24ClN5O2S
    N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[[(1R,2R)-2-methylcyclohexyl]carbamoyl]acetamide —— C18H30N6O3S
    2-[(4-ethyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[[(1R,2R)-2-methylcyclohexyl]carbamoyl]acetamide