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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[5-(furan-2-ylmethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(3-phenylpropyl)acetamide —— C18H20N4O2S2
    2-[[5-(furan-2-ylmethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(3-phenylpropyl)acetamide
    —— (2S)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-(3,4-difluorophenyl)sulfanylpropanamide —— C15H18F2N2OS
    (2S)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-(3,4-difluorophenyl)sulfanylpropanamide
    —— N-(furan-2-ylmethyl)-2-[[5-(furan-2-ylmethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C14H14N4O3S2
    N-(furan-2-ylmethyl)-2-[[5-(furan-2-ylmethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide —— C16H21N3O2S
    (2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide
    —— N'-acetyl-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetohydrazide —— C14H16N4O3S
    N'-acetyl-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetohydrazide
    —— 2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylbutyl]acetamide —— C22H25N3O2S
    2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylbutyl]acetamide
    —— N-(1-cyanocyclopentyl)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H20N4O2S
    N-(1-cyanocyclopentyl)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylbutyl]propanamide —— C23H27N3O2S
    (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylbutyl]propanamide
    —— (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide —— C16H21N3O2S
    (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide
    —— 2-(3,5-Dimethylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-oxadiazole —— C17H14N4O2S2
    2-(3,5-Dimethylphenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-[(5-Phenyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one —— C19H16N4O2S2
    2-[(5-Phenyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one
    —— N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H22N4O2S
    N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[(3-Chlorophenyl)methylsulfanyl]-5-(3,5-dimethylphenyl)-1,3,4-oxadiazole —— C17H15ClN2OS
    2-[(3-Chlorophenyl)methylsulfanyl]-5-(3,5-dimethylphenyl)-1,3,4-oxadiazole
    —— 2-(3,5-Dimethylphenyl)-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,3,4-oxadiazole —— C20H17N3OS2
    2-(3,5-Dimethylphenyl)-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— N-[2-(cyclohexen-1-yl)ethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C20H25N3O2S
    N-[2-(cyclohexen-1-yl)ethyl]-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C16H18ClN3O2S3
    2-[[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— [(1R)-1-[4-benzyl-5-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]propyl]-dimethylazanium —— C18H25F3N5OS+
    [(1R)-1-[4-benzyl-5-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]propyl]-dimethylazanium
    —— 2-[[4-benzyl-5-[(1S)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide —— C18H24F3N5OS
    2-[[4-benzyl-5-[(1S)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide
    —— 5-[(4-Bromophenyl)sulfanylmethyl]-3-thiophen-2-yl-1,2,4-oxadiazole —— C13H9BrN2OS2
    5-[(4-Bromophenyl)sulfanylmethyl]-3-thiophen-2-yl-1,2,4-oxadiazole
    —— 2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2-fluorophenyl)methyl]-N-methylacetamide —— C19H19FN4OS2
    2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2-fluorophenyl)methyl]-N-methylacetamide
    —— 2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[2-(3-chlorophenyl)ethyl]acetamide —— C19H19ClN4OS2
    2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[2-(3-chlorophenyl)ethyl]acetamide
    —— 1-(Azocan-1-yl)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C18H24N4OS2
    1-(Azocan-1-yl)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 2-[(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)methylsulfanyl]-5-(3,4-dimethylphenyl)-1,3,4-oxadiazole —— C20H19ClN2O3S
    2-[(6-chloro-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)methylsulfanyl]-5-(3,4-dimethylphenyl)-1,3,4-oxadiazole
    —— (2R)-N-ethyl-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C8H13N3OS3
    (2R)-N-ethyl-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-ethyl-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C8H13N3OS3
    (2S)-N-ethyl-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— [(2R)-1-(ethylamino)-1-oxopropan-2-yl] 2-(3,4-dimethylphenyl)sulfanylpyridine-3-carboxylate —— C19H22N2O3S
    [(2R)-1-(ethylamino)-1-oxopropan-2-yl] 2-(3,4-dimethylphenyl)sulfanylpyridine-3-carboxylate
    —— 2-(3,4-dimethylphenyl)-5-[(1R)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,3,4-oxadiazole —— C20H17FN4O2S
    2-(3,4-dimethylphenyl)-5-[(1R)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,3,4-oxadiazole
    —— [(2S)-1-(ethylamino)-1-oxopropan-2-yl] 2-(2-chlorophenyl)sulfanylpyridine-3-carboxylate —— C17H17ClN2O3S
    [(2S)-1-(ethylamino)-1-oxopropan-2-yl] 2-(2-chlorophenyl)sulfanylpyridine-3-carboxylate
    —— N-[(3-chlorophenyl)methyl]-2-[(4-methylsulfanylphenyl)methylsulfanyl]acetamide —— C17H18ClNOS2
    N-[(3-chlorophenyl)methyl]-2-[(4-methylsulfanylphenyl)methylsulfanyl]acetamide
    —— [(2R)-1-(dimethylamino)-1-oxopropan-2-yl] 2-(4-methylphenyl)sulfanylpyridine-3-carboxylate —— C18H20N2O3S
    [(2R)-1-(dimethylamino)-1-oxopropan-2-yl] 2-(4-methylphenyl)sulfanylpyridine-3-carboxylate
    —— [(2R)-1-(ethylamino)-1-oxopropan-2-yl] 2-(2-chlorophenyl)sulfanylpyridine-3-carboxylate —— C17H17ClN2O3S
    [(2R)-1-(ethylamino)-1-oxopropan-2-yl] 2-(2-chlorophenyl)sulfanylpyridine-3-carboxylate
    —— 6-Amino-5-[2-(2,5-dimethylphenyl)sulfanylacetyl]-1-methylpyrimidine-2,4-dione —— C15H17N3O3S
    6-Amino-5-[2-(2,5-dimethylphenyl)sulfanylacetyl]-1-methylpyrimidine-2,4-dione
    —— 6-Amino-5-[2-(2,4-dimethylphenyl)sulfanylacetyl]-1-methylpyrimidine-2,4-dione —— C15H17N3O3S
    6-Amino-5-[2-(2,4-dimethylphenyl)sulfanylacetyl]-1-methylpyrimidine-2,4-dione
    —— [2-(2-Methoxyethylamino)-2-oxoethyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate —— C16H23NO4S
    [2-(2-Methoxyethylamino)-2-oxoethyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate
    —— [2-Oxo-2-(propan-2-ylamino)ethyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate —— C16H23NO3S
    [2-Oxo-2-(propan-2-ylamino)ethyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate
    —— (8aR)-7-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6,8a-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C9H9N5OS3
    (8aR)-7-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6,8a-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— Methyl 3-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoate —— C13H15N3O2S2
    Methyl 3-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoate
    —— 2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2-chlorophenyl)methyl]acetamide —— C19H26ClN5OS
    2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(2-chlorophenyl)methyl]acetamide
    —— (2R)-3-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-methylpropanenitrile —— C13H14N4S2
    (2R)-3-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-methylpropanenitrile
    —— (2S)-2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-cyclopropylpropanamide —— C16H27N5OS
    (2S)-2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-cyclopropylpropanamide
    —— 2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(4-chlorophenyl)ethyl]acetamide —— C20H28ClN5OS
    2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(4-chlorophenyl)ethyl]acetamide
    —— N-(1-adamantyl)-2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C22H35N5OS
    N-(1-adamantyl)-2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-(3-chlorophenyl)ethyl]acetamide —— C20H28ClN5OS
    2-[[4-amino-5-(2-cyclohexylethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-(3-chlorophenyl)ethyl]acetamide
    —— (3S,4R)-1,1-dioxo-4-pyrimidin-2-ylsulfanylthiolan-3-ol —— C8H10N2O3S2
    (3S,4R)-1,1-dioxo-4-pyrimidin-2-ylsulfanylthiolan-3-ol
    —— N-(2-methyl-4-oxopentan-2-yl)-3-pyrimidin-2-ylsulfanylpropanamide —— C13H19N3O2S
    N-(2-methyl-4-oxopentan-2-yl)-3-pyrimidin-2-ylsulfanylpropanamide
    —— N-benzyl-2-[(4-pentyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H22N4OS
    N-benzyl-2-[(4-pentyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-[2-(4-chlorophenyl)ethyl]-2-[(4-pentyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C17H23ClN4OS
    N-[2-(4-chlorophenyl)ethyl]-2-[(4-pentyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(4-pentyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C18H25FN4OS
    (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(4-pentyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-(1-cyanocyclopentyl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H22N4O2S2
    N-(1-cyanocyclopentyl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 1-(5-chlorothiophen-2-yl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C17H15ClN2O2S3
    1-(5-chlorothiophen-2-yl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone