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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-N-cyclopropyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C15H18N4OS2
    (2R)-N-cyclopropyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2R)-1-[3-(4-chlorophenyl)sulfanylpropylamino]propan-2-ol —— C12H18ClNOS
    (2R)-1-[3-(4-chlorophenyl)sulfanylpropylamino]propan-2-ol
    —— (2S)-2-(4-methylphenyl)sulfanyl-N-(3-phenylpropyl)propanamide —— C19H23NOS
    (2S)-2-(4-methylphenyl)sulfanyl-N-(3-phenylpropyl)propanamide
    —— (5S)-2-(1-adamantyl)-5-(4-fluorophenyl)-5,6-dihydro-[1,2,4]triazolo[5,1-b][1,3]thiazin-7-one —— C21H22FN3OS
    (5S)-2-(1-adamantyl)-5-(4-fluorophenyl)-5,6-dihydro-[1,2,4]triazolo[5,1-b][1,3]thiazin-7-one
    —— (2S)-N-(1-adamantyl)-2-(4-methylphenyl)sulfanylpropanamide —— C20H27NOS
    (2S)-N-(1-adamantyl)-2-(4-methylphenyl)sulfanylpropanamide
    —— (2S)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanamide —— C18H22FN3O2S
    (2S)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanamide
    —— (2S)-2-ethanimidoyl-3-oxo-4-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]butanenitrile —— C13H16N4O2S
    (2S)-2-ethanimidoyl-3-oxo-4-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]butanenitrile
    —— 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-4-propyl-1H-pyrimidin-6-one —— C13H17N3O2S
    2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-4-propyl-1H-pyrimidin-6-one
    —— 2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)acetamide —— C11H13N3O4S
    2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)acetamide
    —— (2S)-1-[3-(4-chlorophenyl)sulfanylpropylamino]propan-2-ol —— C12H18ClNOS
    (2S)-1-[3-(4-chlorophenyl)sulfanylpropylamino]propan-2-ol
    —— N-[(1S)-1-(2,4-difluorophenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H13F2N3O3S
    N-[(1S)-1-(2,4-difluorophenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 4-propyl-2-[(2-thiophen-2-yl-1,3-oxazol-4-yl)methylsulfanyl]-1H-pyrimidin-6-one —— C15H15N3O2S2
    4-propyl-2-[(2-thiophen-2-yl-1,3-oxazol-4-yl)methylsulfanyl]-1H-pyrimidin-6-one
    —— 4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanyl]-2-ethanimidoyl-3-oxobutanenitrile —— C21H17N5OS
    4-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanyl]-2-ethanimidoyl-3-oxobutanenitrile
    —— (2S)-N-cyclopropyl-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C12H13N3O3S
    (2S)-N-cyclopropyl-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— 2-[2-oxo-2-(5-phenyl-3,4-dihydropyrazol-2-yl)ethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one —— C18H20N4O2S
    2-[2-oxo-2-(5-phenyl-3,4-dihydropyrazol-2-yl)ethyl]sulfanyl-4-propyl-1H-pyrimidin-6-one
    —— (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanamide —— C18H22FN3O2S
    (2R)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanamide
    —— N-[(1S)-1-cyano-1-cyclopropylethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C15H20N4O2S
    N-[(1S)-1-cyano-1-cyclopropylethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— (2S)-N-(cyclohexylmethyl)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C16H21N3O3S
    (2S)-N-(cyclohexylmethyl)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— methyl 5-[(2R)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C17H17N3O5S
    methyl 5-[(2R)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— methyl (2R)-2-[1,4-dimethyl-5-[(4-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylpropanoate —— C18H22N2O3S
    methyl (2R)-2-[1,4-dimethyl-5-[(4-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylpropanoate
    —— N-cyclohexyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C19H29N3O4S2
    N-cyclohexyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(1R)-1-(2,4-difluorophenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H13F2N3O3S
    N-[(1R)-1-(2,4-difluorophenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-(Furan-2-yl)-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,3,4-oxadiazole —— C15H10N4O3S
    2-(Furan-2-yl)-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-(4-Bromophenyl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3,4-oxadiazole —— C15H9BrN4O3S
    2-(4-Bromophenyl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3,4-oxadiazole
    —— 1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylethanone —— C20H16ClN3O3S
    1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylethanone
    —— 1-[(1S,2S,6S)-3-acetyl-4,6-dihydroxy-6-methyl-2-(4-methylsulfanylphenyl)cyclohex-3-en-1-yl]ethanone —— C18H22O4S
    1-[(1S,2S,6S)-3-acetyl-4,6-dihydroxy-6-methyl-2-(4-methylsulfanylphenyl)cyclohex-3-en-1-yl]ethanone
    —— (2S)-N-(cyclohexylcarbamoyl)-2-(1-methylimidazol-2-yl)sulfanylpropanamide —— C14H22N4O2S
    (2S)-N-(cyclohexylcarbamoyl)-2-(1-methylimidazol-2-yl)sulfanylpropanamide
    —— 2-(1-Methylimidazol-2-yl)sulfanyl-1-(1,2,5-trimethylpyrrol-3-yl)ethanone —— C13H17N3OS
    2-(1-Methylimidazol-2-yl)sulfanyl-1-(1,2,5-trimethylpyrrol-3-yl)ethanone
    —— 1-[2,5-dimethyl-1-[[(2S)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-(1-methylimidazol-2-yl)sulfanylethanone —— C17H23N3O2S
    1-[2,5-dimethyl-1-[[(2S)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-(1-methylimidazol-2-yl)sulfanylethanone
    —— N-[2-(4-chlorophenyl)ethyl]-2-(1-methylimidazol-2-yl)sulfanylacetamide —— C14H16ClN3OS
    N-[2-(4-chlorophenyl)ethyl]-2-(1-methylimidazol-2-yl)sulfanylacetamide
    —— 3-Benzyl-5-[(4-bromo-2-fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazole —— C17H15BrFN3S
    3-Benzyl-5-[(4-bromo-2-fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazole
    —— (2S)-3-methylbutane-2-thiol —— C5H12S
    (2S)-3-methylbutane-2-thiol
    —— 2-{[(4-Fluorophenyl)methyl]sulfanyl}-3,6-dimethyl-5-[(3-methylphenyl)methyl]-3,4-dihydropyrimidin-4-one —— C21H21FN2OS
    2-{[(4-Fluorophenyl)methyl]sulfanyl}-3,6-dimethyl-5-[(3-methylphenyl)methyl]-3,4-dihydropyrimidin-4-one
    —— 4-Methyl-3-[(4-methylsulfanylphenyl)methylsulfanyl]-5-(thiophen-2-ylmethyl)-1,2,4-triazole —— C16H17N3S3
    4-Methyl-3-[(4-methylsulfanylphenyl)methylsulfanyl]-5-(thiophen-2-ylmethyl)-1,2,4-triazole
    —— [(2S)-1-(cyclopentylamino)-1-oxopropan-2-yl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C18H24N4O4S
    [(2S)-1-(cyclopentylamino)-1-oxopropan-2-yl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— [2-[[(2S)-butan-2-yl]amino]-2-oxoethyl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C16H22N4O4S
    [2-[[(2S)-butan-2-yl]amino]-2-oxoethyl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— [2-[[(1R)-1-cyano-1-cyclopropylethyl]amino]-2-oxoethyl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C18H21N5O4S
    [2-[[(1R)-1-cyano-1-cyclopropylethyl]amino]-2-oxoethyl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— [(2R)-1-[cyclohexyl(methyl)amino]-1-oxopropan-2-yl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C20H28N4O4S
    [(2R)-1-[cyclohexyl(methyl)amino]-1-oxopropan-2-yl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— 2-{[(4-Chlorophenyl)methyl]sulfanyl}-3,6-dimethyl-5-[(3-methylphenyl)methyl]-3,4-dihydropyrimidin-4-one —— C21H21ClN2OS
    2-{[(4-Chlorophenyl)methyl]sulfanyl}-3,6-dimethyl-5-[(3-methylphenyl)methyl]-3,4-dihydropyrimidin-4-one
    —— [2-oxo-2-[[(2R)-pentan-2-yl]amino]ethyl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C17H24N4O4S
    [2-oxo-2-[[(2R)-pentan-2-yl]amino]ethyl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— 2-(2-Fluorophenyl)sulfanylethyl 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C18H18FN3O3S2
    2-(2-Fluorophenyl)sulfanylethyl 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— [2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C18H24N4O5S
    [2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl] 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— (2R)-2-(4-methylphenyl)sulfanyl-N-(2-morpholin-4-ium-4-ylethyl)propanamide —— C16H25N2O2S+
    (2R)-2-(4-methylphenyl)sulfanyl-N-(2-morpholin-4-ium-4-ylethyl)propanamide
    —— (2R)-2-(4-chlorophenyl)sulfanyl-N-(3-morpholin-4-ium-4-ylpropyl)propanamide —— C16H24ClN2O2S+
    (2R)-2-(4-chlorophenyl)sulfanyl-N-(3-morpholin-4-ium-4-ylpropyl)propanamide
    —— methyl (4R)-1,6-dimethyl-4-(4-methylsulfanylphenyl)-2-oxo-3,4-dihydropyridine-5-carboxylate —— C16H19NO3S
    methyl (4R)-1,6-dimethyl-4-(4-methylsulfanylphenyl)-2-oxo-3,4-dihydropyridine-5-carboxylate
    —— [2-[[(1S)-1-(3-chlorophenyl)ethyl]amino]-2-oxoethyl] 2-(2,4-dimethylphenyl)sulfanylacetate —— C20H22ClNO3S
    [2-[[(1S)-1-(3-chlorophenyl)ethyl]amino]-2-oxoethyl] 2-(2,4-dimethylphenyl)sulfanylacetate
    —— [2-Oxo-2-(thiophen-2-ylmethylamino)ethyl] 2-(2-fluorophenyl)sulfanylacetate —— C15H14FNO3S2
    [2-Oxo-2-(thiophen-2-ylmethylamino)ethyl] 2-(2-fluorophenyl)sulfanylacetate
    —— [2-(Cyclohexylamino)-2-oxoethyl] 2-(2-fluorophenyl)sulfanylacetate —— C16H20FNO3S
    [2-(Cyclohexylamino)-2-oxoethyl] 2-(2-fluorophenyl)sulfanylacetate
    —— [2-(4-Methylphenyl)-1,3-thiazol-4-yl]methyl 2-(2-fluorophenyl)sulfanylacetate —— C19H16FNO2S2
    [2-(4-Methylphenyl)-1,3-thiazol-4-yl]methyl 2-(2-fluorophenyl)sulfanylacetate
    —— [(2S)-1-oxo-1-[[(2S)-4-phenylbutan-2-yl]amino]propan-2-yl] 2-(2-fluorophenyl)sulfanylacetate —— C21H24FNO3S
    [(2S)-1-oxo-1-[[(2S)-4-phenylbutan-2-yl]amino]propan-2-yl] 2-(2-fluorophenyl)sulfanylacetate