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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— ethyl 2,5-dimethyl-4-[2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]-1H-pyrrole-3-carboxylate —— C17H21N3O3S3
    ethyl 2,5-dimethyl-4-[2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]-1H-pyrrole-3-carboxylate
    —— methyl 2,4-dimethyl-5-[(2S)-2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate —— C17H21N3O3S3
    methyl 2,4-dimethyl-5-[(2S)-2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate
    —— 2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-phenylethyl]acetamide —— C16H19N3OS3
    2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-phenylethyl]acetamide
    —— 2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]-N-methylacetamide —— C16H22N6O2S
    2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]-N-methylacetamide
    —— 3-[5-[2-[2,5-Dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrol-3-yl]-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide —— C19H24N6O3S
    3-[5-[2-[2,5-Dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrol-3-yl]-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide
    —— 3-[5-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide —— C13H15BrN4O2S2
    3-[5-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide
    —— 2-[(4-amino-5-tert-butyl-1,2,4-triazol-3-yl)sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]acetamide —— C17H26N6OS
    2-[(4-amino-5-tert-butyl-1,2,4-triazol-3-yl)sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]acetamide
    —— 2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methylbutan-2-yl)acetamide —— C17H24N4OS2
    2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methylbutan-2-yl)acetamide
    —— 3-[5-[2-(1-Benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide —— C22H27N5O2S
    3-[5-[2-(1-Benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide
    —— 3-[4-Ethyl-5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,2,4-triazol-3-yl]propanamide —— C18H21N5OS2
    3-[4-Ethyl-5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,2,4-triazol-3-yl]propanamide
    —— 2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-(furan-2-yl)ethyl]acetamide —— C18H20N4O2S2
    2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-(furan-2-yl)ethyl]acetamide
    —— (2R)-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C15H17N3O4S2
    (2R)-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— methyl N-[(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoyl]carbamate —— C13H13N3O4S
    methyl N-[(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoyl]carbamate
    —— 3-[5-[2-[[(1S)-1-(3-chlorophenyl)ethyl]amino]-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide —— C17H22ClN5O2S
    3-[5-[2-[[(1S)-1-(3-chlorophenyl)ethyl]amino]-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide
    —— (2S)-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C16H16N4O4S2
    (2S)-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (2R)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-propylpropanamide —— C14H17N3O2S
    (2R)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-propylpropanamide
    —— 3-[4-Ethyl-5-[2-oxo-2-(1,2,5-trimethylpyrrol-3-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide —— C16H23N5O2S
    3-[4-Ethyl-5-[2-oxo-2-(1,2,5-trimethylpyrrol-3-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide
    —— 3-[5-[2-(1-Adamantyl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide —— C19H28N4O2S
    3-[5-[2-(1-Adamantyl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide
    —— 3-[5-[(4-Chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]propanamide —— C14H17ClN4OS
    3-[5-[(4-Chlorophenyl)methylsulfanyl]-4-ethyl-1,2,4-triazol-3-yl]propanamide
    —— (2R)-N-(2-methylpropyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C15H19N3O2S
    (2R)-N-(2-methylpropyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— 3-[4-Ethyl-5-[2-oxo-2-(pentan-3-ylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide —— C14H25N5O2S
    3-[4-Ethyl-5-[2-oxo-2-(pentan-3-ylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide
    —— (2R)-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C17H21N3O4S2
    (2R)-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— 3-[5-[2-[2,5-Dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide —— C18H22N6O2S2
    3-[5-[2-[2,5-Dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide
    —— (2R)-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C16H16N4O4S2
    (2R)-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— 3-[4-Ethyl-5-[(4-oxo-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-2-yl)methylsulfanyl]-1,2,4-triazol-3-yl]propanamide —— C18H22N6O2S2
    3-[4-Ethyl-5-[(4-oxo-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-2-yl)methylsulfanyl]-1,2,4-triazol-3-yl]propanamide
    —— ethyl 5-[(2S)-2-[[5-(3-amino-3-oxopropyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C19H27N5O4S
    ethyl 5-[(2S)-2-[[5-(3-amino-3-oxopropyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— ethyl 2,4-dimethyl-5-[(2S)-2-(3-methylsulfanylanilino)propanoyl]-1H-pyrrole-3-carboxylate —— C19H24N2O3S
    ethyl 2,4-dimethyl-5-[(2S)-2-(3-methylsulfanylanilino)propanoyl]-1H-pyrrole-3-carboxylate
    —— ethyl 5-[(2R)-2-[4-(difluoromethylsulfanyl)anilino]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C19H22F2N2O3S
    ethyl 5-[(2R)-2-[4-(difluoromethylsulfanyl)anilino]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— (2R)-2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N,N-dimethylpropanamide —— C15H20N4OS2
    (2R)-2-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N,N-dimethylpropanamide
    —— methyl 5-[(2S)-2-[4-(difluoromethylsulfanyl)anilino]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C18H20F2N2O3S
    methyl 5-[(2S)-2-[4-(difluoromethylsulfanyl)anilino]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— 2-(3-chlorophenyl)-5-[(1R)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,3,4-oxadiazole —— C19H15ClN4O2S
    2-(3-chlorophenyl)-5-[(1R)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-[(5-Anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-(5-methylthiophen-2-yl)ethanone —— C15H13N3OS3
    2-[(5-Anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-(5-methylthiophen-2-yl)ethanone
    —— (2R)-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-ethylpropanamide —— C13H14ClN3O2S
    (2R)-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-ethylpropanamide
    —— ethyl 4-[[5-oxo-4-(2-phenylethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]butanoate —— C16H21N3O3S
    ethyl 4-[[5-oxo-4-(2-phenylethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]butanoate
    —— 3-[[(1R)-2,2-dichlorocyclopropyl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one —— C14H15Cl2N3OS
    3-[[(1R)-2,2-dichlorocyclopropyl]methylsulfanyl]-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one
    —— 2-({[5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-YL]sulfanyl}methyl)-6,7,8,9-tetrahydro-4H-pyrimido[2,1-B][1,3]benzothiazol-4-one —— C19H15FN4O2S2
    2-({[5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-YL]sulfanyl}methyl)-6,7,8,9-tetrahydro-4H-pyrimido[2,1-B][1,3]benzothiazol-4-one
    —— N-[2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]acetamide —— C11H13N3O3S
    N-[2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]acetamide
    —— 2-(2-fluorophenyl)sulfanyl-N-[3-(N-methylanilino)propyl]acetamide —— C18H21FN2OS
    2-(2-fluorophenyl)sulfanyl-N-[3-(N-methylanilino)propyl]acetamide
    —— N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-5-nitro-2-(1H-1,2,4-triazol-5-ylsulfanyl)benzamide —— C18H15N5O4S
    N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-5-nitro-2-(1H-1,2,4-triazol-5-ylsulfanyl)benzamide
    —— 2-(2,5-dimethylfuran-3-yl)-5-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanylmethyl)-1,3,4-oxadiazole —— C16H19N5O2S
    2-(2,5-dimethylfuran-3-yl)-5-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanylmethyl)-1,3,4-oxadiazole
    —— 2-(4-Chlorophenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-oxadiazole —— C15H9ClN4O2S2
    2-(4-Chlorophenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— N-[2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]ethyl]acetamide —— C13H14N2OS2
    N-[2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]ethyl]acetamide
    —— N-[(2-chlorophenyl)methyl]-2-[(4-methylsulfanylphenyl)methylsulfanyl]acetamide —— C17H18ClNOS2
    N-[(2-chlorophenyl)methyl]-2-[(4-methylsulfanylphenyl)methylsulfanyl]acetamide
    —— (2R)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-prop-2-enylpropanamide —— C16H20N4OS2
    (2R)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-prop-2-enylpropanamide
    —— 2-[[5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)acetamide —— C15H12BrN3O3S
    2-[[5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)acetamide
    —— 2-(2-Bromophenyl)-5-[(3-methylphenyl)methylsulfanyl]-1,3,4-oxadiazole —— C16H13BrN2OS
    2-(2-Bromophenyl)-5-[(3-methylphenyl)methylsulfanyl]-1,3,4-oxadiazole
    —— (2S)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-prop-2-enylpropanamide —— C16H20N4OS2
    (2S)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-prop-2-enylpropanamide
    —— (2S)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2-chlorophenyl)methyl]propanamide —— C18H17ClN4OS2
    (2S)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(2-chlorophenyl)methyl]propanamide
    —— (2S)-2-[[5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]cyclohexan-1-one —— C14H13BrN2O2S
    (2S)-2-[[5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]cyclohexan-1-one
    —— 3-[[5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanenitrile —— C11H8BrN3OS
    3-[[5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanenitrile