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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-2-(1-methylimidazol-2-yl)sulfanyl-3-(4-methylphenyl)propanenitrile —— C14H15N3S
    (2R)-2-(1-methylimidazol-2-yl)sulfanyl-3-(4-methylphenyl)propanenitrile
    —— 1-[1-[2-(Cyclohexen-1-yl)ethyl]-2,5-dimethylpyrrol-3-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone —— C18H25N5OS
    1-[1-[2-(Cyclohexen-1-yl)ethyl]-2,5-dimethylpyrrol-3-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone
    —— (2R)-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3-(4-methylphenyl)propanenitrile —— C18H14FN3OS
    (2R)-2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3-(4-methylphenyl)propanenitrile
    —— 2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]acetamide —— C16H18N4O3S2
    2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]acetamide
    —— 1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[(4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C15H18N4O2S
    1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[(4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(cyclohexen-1-yl)-N-ethylacetamide —— C19H23N3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(cyclohexen-1-yl)-N-ethylacetamide
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-[2-(pyridin-2-ylmethyl)pyrazol-3-yl]pyridine-3-carboxamide —— C23H21N5OS
    2-(3,4-dimethylphenyl)sulfanyl-N-[2-(pyridin-2-ylmethyl)pyrazol-3-yl]pyridine-3-carboxamide
    —— N-cyclopropyl-2-[[5-(furan-2-yl)-4-(2-methylpropyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C15H20N4O2S
    N-cyclopropyl-2-[[5-(furan-2-yl)-4-(2-methylpropyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 3-methyl-7-({[5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}methyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C14H10N4O2S3
    3-methyl-7-({[5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}methyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 1-Methyl-4-(6-naphthalen-2-ylsulfanylpyridin-3-yl)sulfonylpiperazine —— C20H21N3O2S2
    1-Methyl-4-(6-naphthalen-2-ylsulfanylpyridin-3-yl)sulfonylpiperazine
    —— (2S)-2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-3-(4-methylphenyl)propanenitrile —— C21H22N4S
    (2S)-2-[(5-benzyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-3-(4-methylphenyl)propanenitrile
    —— 1-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-3-(2-morpholin-4-ium-4-ylethyl)thiourea —— C15H23N4OS2+
    1-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-3-(2-morpholin-4-ium-4-ylethyl)thiourea
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[(2R,6S)-2,6-dimethylpiperidin-1-yl]pyridine-3-carboxamide —— C21H27N3OS
    2-(2,5-dimethylphenyl)sulfanyl-N-[(2R,6S)-2,6-dimethylpiperidin-1-yl]pyridine-3-carboxamide
    —— (3R)-3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyloxolan-2-one —— C10H7ClF3NO2S
    (3R)-3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyloxolan-2-one
    —— 2-Benzyl-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,3,4-oxadiazole —— C19H15N3OS2
    2-Benzyl-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-[[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylmethyl]-5-phenyl-1,3,4-oxadiazole —— C15H9ClF3N3OS
    2-[[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylmethyl]-5-phenyl-1,3,4-oxadiazole
    —— 1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-(1H-1,2,4-triazol-5-ylsulfanyl)ethanone —— C17H14ClN5O2S
    1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-(1H-1,2,4-triazol-5-ylsulfanyl)ethanone
    —— 5-(3-methylbut-2-enylsulfanyl)-N-phenyl-1,3,4-thiadiazol-2-amine —— C13H15N3S2
    5-(3-methylbut-2-enylsulfanyl)-N-phenyl-1,3,4-thiadiazol-2-amine
    —— (1S)-1-(4-ethylphenyl)-2-phenylsulfanylethanol —— C16H18OS
    (1S)-1-(4-ethylphenyl)-2-phenylsulfanylethanol
    —— (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-cyclopropylpropanamide —— C14H16N4OS2
    (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-cyclopropylpropanamide
    —— 2-[(5-Anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-thiophen-2-ylethanone —— C14H11N3OS3
    2-[(5-Anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-thiophen-2-ylethanone
    —— (5R)-5-(4-methylsulfanylphenyl)-3-phenyl-2,5-dihydro-1,2,4-oxadiazole —— C15H14N2OS
    (5R)-5-(4-methylsulfanylphenyl)-3-phenyl-2,5-dihydro-1,2,4-oxadiazole
    —— (7S)-3-[(2-fluorophenyl)methyl]-7-methyl-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C19H17FN4S
    (7S)-3-[(2-fluorophenyl)methyl]-7-methyl-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— 2-[[5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-pentan-2-yl]acetamide —— C15H18BrN3O2S
    2-[[5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-pentan-2-yl]acetamide
    —— (2R)-N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C19H25N5OS2
    (2R)-N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 4-[(5-Anilino-1,3,4-thiadiazol-2-yl)sulfanyl]butanenitrile —— C12H12N4S2
    4-[(5-Anilino-1,3,4-thiadiazol-2-yl)sulfanyl]butanenitrile
    —— 5-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-phenyl-1,3,4-thiadiazol-2-amine —— C17H12ClN5OS2
    5-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-N-phenyl-1,3,4-thiadiazol-2-amine
    —— (2R)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-1-yl)propan-1-one —— C19H27N5OS2
    (2R)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-1-yl)propan-1-one
    —— 2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-cyclohexyl-N-ethylacetamide —— C18H24N4OS2
    2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-cyclohexyl-N-ethylacetamide
    —— 2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(2-cyanoethyl)acetamide —— C13H13N5OS2
    2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(2-cyanoethyl)acetamide
    —— (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-(4-ethylpiperazin-4-ium-1-yl)propan-1-one —— C17H24N5OS2+
    (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-(4-ethylpiperazin-4-ium-1-yl)propan-1-one
    —— ethyl (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-2-phenylacetate —— C18H17N3O2S2
    ethyl (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-2-phenylacetate
    —— 2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C18H20N4OS3
    2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— 5-[[(4R)-1,3-dioxan-4-yl]methylsulfanyl]-N-(4-ethylphenyl)-1,3,4-thiadiazol-2-amine —— C15H19N3O2S2
    5-[[(4R)-1,3-dioxan-4-yl]methylsulfanyl]-N-(4-ethylphenyl)-1,3,4-thiadiazol-2-amine
    —— 1-(4-Acetylpiperazin-1-yl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C18H23N5O2S2
    1-(4-Acetylpiperazin-1-yl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— Propan-2-yl 2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]acetate —— C13H15N3O2S2
    Propan-2-yl 2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]acetate
    —— (2R)-N-(1-cyanocyclohexyl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C20H25N5OS2
    (2R)-N-(1-cyanocyclohexyl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 5-[(3-fluorophenyl)methylsulfanyl]-N-phenyl-1,3,4-thiadiazol-2-amine —— C15H12FN3S2
    5-[(3-fluorophenyl)methylsulfanyl]-N-phenyl-1,3,4-thiadiazol-2-amine
    —— 4-[[5-(4-Ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanenitrile —— C14H16N4S2
    4-[[5-(4-Ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butanenitrile
    —— 2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1R)-1-(2,4-difluorophenyl)ethyl]acetamide —— C18H16F2N4OS2
    2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1R)-1-(2,4-difluorophenyl)ethyl]acetamide
    —— (2S)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-cyclohexyl-N-ethylpropanamide —— C19H26N4OS2
    (2S)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-cyclohexyl-N-ethylpropanamide
    —— (2S)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-pyrrolidin-1-ylpropan-1-one —— C15H18N4OS2
    (2S)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-pyrrolidin-1-ylpropan-1-one
    —— 2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide —— C18H20N4O2S2
    2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide
    —— 2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1S)-1-cyano-1-cyclopropylethyl]acetamide —— C16H17N5OS2
    2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1S)-1-cyano-1-cyclopropylethyl]acetamide
    —— Butyl 2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetate —— C14H19N3O2S2
    Butyl 2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetate
    —— N-(2,5-dimethylphenyl)-2-(5H-[1,2,4]triazino[6,5-b][1,4]benzothiazin-3-ylsulfanyl)acetamide —— C19H17N5OS2
    N-(2,5-dimethylphenyl)-2-(5H-[1,2,4]triazino[6,5-b][1,4]benzothiazin-3-ylsulfanyl)acetamide
    —— 2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-[1-(2-methoxyethyl)-2,5-dimethylpyrrol-3-yl]ethanone —— C20H23N3O3S
    2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-[1-(2-methoxyethyl)-2,5-dimethylpyrrol-3-yl]ethanone
    —— 4-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-2-phenyl-1,3-thiazole —— C20H18N4S2
    4-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-2-phenyl-1,3-thiazole
    —— (2S)-N-(1-cyanocyclohexyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C18H20N4OS3
    (2S)-N-(1-cyanocyclohexyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— N'-acetyl-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetohydrazide —— C13H14N4O3S
    N'-acetyl-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetohydrazide