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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-4-phenylbutan-2-yl]acetamide —— C15H20N4OS
    2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-4-phenylbutan-2-yl]acetamide
    —— (2R)-N-(cyclohexylmethyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C13H22N4OS
    (2R)-N-(cyclohexylmethyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(1R)-1-(4-chlorophenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C13H15ClN4OS
    N-[(1R)-1-(4-chlorophenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C13H15ClN4OS
    N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2S)-N-(cyclohexylmethyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C13H22N4OS
    (2S)-N-(cyclohexylmethyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C13H15ClN4OS
    N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-phenylethyl]acetamide —— C13H16N4OS
    2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-phenylethyl]acetamide
    —— methyl 2-[6-oxo-2-[(2R)-1-oxo-1-[[(2R)-4-phenylbutan-2-yl]amino]propan-2-yl]sulfanyl-1H-pyrimidin-4-yl]acetate —— C20H25N3O4S
    methyl 2-[6-oxo-2-[(2R)-1-oxo-1-[[(2R)-4-phenylbutan-2-yl]amino]propan-2-yl]sulfanyl-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-(cyclohexylmethylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C16H23N3O4S
    methyl 2-[2-[2-(cyclohexylmethylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[6-oxo-2-[2-oxo-2-(2-oxopyrrolidin-1-yl)ethyl]sulfanyl-1H-pyrimidin-4-yl]acetate —— C13H15N3O5S
    methyl 2-[6-oxo-2-[2-oxo-2-(2-oxopyrrolidin-1-yl)ethyl]sulfanyl-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-[cyclopropylmethyl(propyl)amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C16H23N3O4S
    methyl 2-[2-[2-[cyclopropylmethyl(propyl)amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(1S)-1-(4-fluorophenyl)ethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C15H15FN2O3S
    methyl 2-[2-[(1S)-1-(4-fluorophenyl)ethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-(cycloheptylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C16H23N3O4S
    methyl 2-[2-[2-(cycloheptylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[6-oxo-2-[2-oxo-2-[[(2S)-4-phenylbutan-2-yl]amino]ethyl]sulfanyl-1H-pyrimidin-4-yl]acetate —— C19H23N3O4S
    methyl 2-[6-oxo-2-[2-oxo-2-[[(2S)-4-phenylbutan-2-yl]amino]ethyl]sulfanyl-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-(cyclohexylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C15H21N3O4S
    methyl 2-[2-[2-(cyclohexylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— ethyl (2R)-2-[[4-(2-methoxy-2-oxoethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]-2-phenylacetate —— C17H18N2O5S
    ethyl (2R)-2-[[4-(2-methoxy-2-oxoethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]-2-phenylacetate
    —— methyl 2-[2-[2-(1-adamantylmethylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C20H27N3O4S
    methyl 2-[2-[2-(1-adamantylmethylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[6-oxo-2-[(3S)-2-oxooxolan-3-yl]sulfanyl-1H-pyrimidin-4-yl]acetate —— C11H12N2O5S
    methyl 2-[6-oxo-2-[(3S)-2-oxooxolan-3-yl]sulfanyl-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-[cyclohexyl(methyl)amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C16H23N3O4S
    methyl 2-[2-[2-[cyclohexyl(methyl)amino]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— 1-[1-[(4-Fluorophenyl)methyl]-2,5-dimethylpyrrol-3-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C18H19FN4OS
    1-[1-[(4-Fluorophenyl)methyl]-2,5-dimethylpyrrol-3-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— (2S)-N-cyclopentyl-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C11H18N4OS
    (2S)-N-cyclopentyl-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— methyl 2-[6-oxo-2-[2-oxo-2-[[(2S)-pentan-2-yl]amino]ethyl]sulfanyl-1H-pyrimidin-4-yl]acetate —— C14H21N3O4S
    methyl 2-[6-oxo-2-[2-oxo-2-[[(2S)-pentan-2-yl]amino]ethyl]sulfanyl-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[6-oxo-2-[(2R)-1-oxo-1-[[(2S)-4-phenylbutan-2-yl]amino]propan-2-yl]sulfanyl-1H-pyrimidin-4-yl]acetate —— C20H25N3O4S
    methyl 2-[6-oxo-2-[(2R)-1-oxo-1-[[(2S)-4-phenylbutan-2-yl]amino]propan-2-yl]sulfanyl-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-(cyclopropylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C12H15N3O4S
    methyl 2-[2-[2-(cyclopropylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— 4-[[2-(4-bromophenyl)sulfanylethylamino]methylidene]-5-(hydroxymethyl)-2-methylpyridin-3-one —— C16H17BrN2O2S
    4-[[2-(4-bromophenyl)sulfanylethylamino]methylidene]-5-(hydroxymethyl)-2-methylpyridin-3-one
    —— (2S)-N-[2-(cyclohexen-1-yl)ethyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanamide —— C13H19N3OS2
    (2S)-N-[2-(cyclohexen-1-yl)ethyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanamide
    —— 5-(hydroxymethyl)-2-methyl-4-[[3-[4-(2-methylpropyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propylamino]methylidene]pyridin-3-one —— C18H27N5O2S
    5-(hydroxymethyl)-2-methyl-4-[[3-[4-(2-methylpropyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propylamino]methylidene]pyridin-3-one
    —— 4-[[5-(3,4-Dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butan-2-one —— C14H17N3OS2
    4-[[5-(3,4-Dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]butan-2-one
    —— 1-[[5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3,3-dimethylbutan-2-one —— C14H15BrN2O2S
    1-[[5-(2-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-3,3-dimethylbutan-2-one
    —— 2-(4-Methylphenyl)sulfanyl-1-(4-methylpiperazin-4-ium-1-yl)ethanone —— C14H21N2OS+
    2-(4-Methylphenyl)sulfanyl-1-(4-methylpiperazin-4-ium-1-yl)ethanone
    —— 3-((2-Methylbenzyl)thio)-6-(pyridin-4-yl)pyridazine —— C17H15N3S
    3-((2-Methylbenzyl)thio)-6-(pyridin-4-yl)pyridazine
    —— (2R)-2-[[5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-pyrrolidin-1-ylpropan-1-one —— C15H16BrN3O2S
    (2R)-2-[[5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-pyrrolidin-1-ylpropan-1-one
    —— (2S)-N-cyclopentyl-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]propanamide —— C12H18N2OS2
    (2S)-N-cyclopentyl-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]propanamide
    —— 2-(2-bromophenyl)-5-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12BrClN2OS
    2-(2-bromophenyl)-5-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-[[5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-cyano-1-cyclopropylethyl]acetamide —— C16H15BrN4O2S
    2-[[5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-cyano-1-cyclopropylethyl]acetamide
    —— 1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)ethanone —— C17H13ClN4O2S2
    1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)ethanone
    —— 2-(2-bromophenyl)-5-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12BrClN2OS
    2-(2-bromophenyl)-5-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— tert-butyl N-[(1S,2R)-2-methyl-1-[5-[(3-methylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]butyl]carbamate —— C20H29N3O3S
    tert-butyl N-[(1S,2R)-2-methyl-1-[5-[(3-methylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]butyl]carbamate
    —— N-(1-adamantylmethyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide —— C17H24N2OS2
    N-(1-adamantylmethyl)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]acetamide
    —— 1-[(3S)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]ethanone —— C20H19N3O2S2
    1-[(3S)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]ethanone
    —— ethyl 2,4-dimethyl-5-[(2R)-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanoyl]-1H-pyrrole-3-carboxylate —— C14H17N3O3S2
    ethyl 2,4-dimethyl-5-[(2R)-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanoyl]-1H-pyrrole-3-carboxylate
    —— tert-butyl N-[(1S,2R)-1-[5-[(2-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]carbamate —— C19H26ClN3O3S
    tert-butyl N-[(1S,2R)-1-[5-[(2-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]carbamate
    —— N-cyclopropyl-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide —— C7H9N3OS2
    N-cyclopropyl-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide
    —— tert-butyl N-[(1S,2R)-1-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]carbamate —— C19H26ClN3O3S
    tert-butyl N-[(1S,2R)-1-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]carbamate
    —— 2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]-N-(2-phenylsulfanylphenyl)acetamide —— C18H16N2OS3
    2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]-N-(2-phenylsulfanylphenyl)acetamide
    —— 3-Methyl-7-[(4-methyl-1,3-thiazol-2-yl)sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C12H11N3OS3
    3-Methyl-7-[(4-methyl-1,3-thiazol-2-yl)sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— ethyl 2,4-dimethyl-5-[(2S)-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanoyl]-1H-pyrrole-3-carboxylate —— C14H17N3O3S2
    ethyl 2,4-dimethyl-5-[(2S)-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanoyl]-1H-pyrrole-3-carboxylate
    —— ethyl 2,4-dimethyl-5-[(2S)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate —— C16H20N2O3S2
    ethyl 2,4-dimethyl-5-[(2S)-2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate
    —— Ethyl 4-[1,4-dimethyl-5-[(4-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylbutanoate —— C20H26N2O3S
    Ethyl 4-[1,4-dimethyl-5-[(4-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylbutanoate
    —— 2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylbutyl]acetamide —— C21H24N4OS2
    2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylbutyl]acetamide