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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-methyl-5-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3,4-oxadiazole —— C15H16N4O2S
    2-methyl-5-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3,4-oxadiazole
    —— 2-methylsulfanyl-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole —— C12H14N2OS
    2-methylsulfanyl-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C17H19N3O2S
    2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-methyl-5-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3,4-oxadiazole —— C15H16N4O2S
    2-methyl-5-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]-1,3,4-oxadiazole
    —— 1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-(3,4-dimethylphenyl)sulfanylethanone —— C16H23NO2S
    1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-(3,4-dimethylphenyl)sulfanylethanone
    —— N-cyclohexyl-N-methyl-2-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C20H27N3O2S
    N-cyclohexyl-N-methyl-2-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-ethyl-N-(2-methylprop-2-enyl)-2-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H25N3O2S
    N-ethyl-N-(2-methylprop-2-enyl)-2-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 4-[[(2S)-oxolan-2-yl]methyl]-3-[(1R)-1-phenylethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C15H19N3O2S
    4-[[(2S)-oxolan-2-yl]methyl]-3-[(1R)-1-phenylethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— (2S)-N-cyclopropyl-2-(2,4-dimethylphenyl)sulfanylpropanamide —— C14H19NOS
    (2S)-N-cyclopropyl-2-(2,4-dimethylphenyl)sulfanylpropanamide
    —— 1-(2,5-dimethyl-1-prop-2-enylpyrrol-3-yl)-2-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C22H25N3O2S
    1-(2,5-dimethyl-1-prop-2-enylpyrrol-3-yl)-2-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— N-cyclohexyl-N-methyl-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C16H26N4O3S
    N-cyclohexyl-N-methyl-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 3-(2-ethoxyethylsulfanyl)-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C11H19N3O3S
    3-(2-ethoxyethylsulfanyl)-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
    —— 3-anilino-5-(4-chloro-benzylthio)-1,2,4-triazole 334538-50-0 C15H13ClN4S
    3-anilino-5-(4-chloro-benzylthio)-1,2,4-triazole
    —— 3-[2-(1-adamantyl)ethylsulfanyl]-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C19H29N3O2S
    3-[2-(1-adamantyl)ethylsulfanyl]-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
    —— 3-Methoxy-1-methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-1H-pyrazole —— C14H15F3N2OS
    3-Methoxy-1-methyl-4-(4-methylsulfanyl-benzyl)-5-trifluoromethyl-1H-pyrazole
    —— N-[(1R,2R,3R)-2,3-dimethylcyclohexyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C17H22N4O2S
    N-[(1R,2R,3R)-2,3-dimethylcyclohexyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-[(1R)-1-(4-ethylphenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C19H20N4O2S
    N-[(1R)-1-(4-ethylphenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-[(1R)-1-(4-chlorophenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C17H15ClN4O2S
    N-[(1R)-1-(4-chlorophenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C17H16FN3O3S
    N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-2-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,2,2-trifluoroethyl)propanamide —— C15H17F3N4O2S
    (2R)-2-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,2,2-trifluoroethyl)propanamide
    —— 3-[[2-(2-methylanilino)-1,3-thiazol-4-yl]methylsulfanyl]-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C18H21N5O2S2
    3-[[2-(2-methylanilino)-1,3-thiazol-4-yl]methylsulfanyl]-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
    —— (2S)-2-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,2,2-trifluoroethyl)propanamide —— C15H17F3N4O2S
    (2S)-2-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,2,2-trifluoroethyl)propanamide
    —— 4-butyl-3-[2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C14H24N4O3S
    4-butyl-3-[2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C17H15ClN4O2S
    N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-N-[(1S,2R)-2-methylcyclohexyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C17H22N4O2S
    (2R)-N-[(1S,2R)-2-methylcyclohexyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— N-methyl-N-[(2-methylphenyl)methyl]-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C18H24N4O3S
    N-methyl-N-[(2-methylphenyl)methyl]-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[(1R,2R,3S)-2,3-dimethylcyclohexyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C17H22N4O2S
    N-[(1R,2R,3S)-2,3-dimethylcyclohexyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 4-butyl-3-[2-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C14H24N4O3S
    4-butyl-3-[2-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C17H15ClN4O2S
    N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(2-methylphenyl)ethyl]acetamide —— C19H22N4OS2
    2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(2-methylphenyl)ethyl]acetamide
    —— (2S)-N-cyclohexyl-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C16H20N4O2S
    (2S)-N-cyclohexyl-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-[(1S)-1-phenylethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H18N4O2S
    (2S)-N-[(1S)-1-phenylethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— 2-[(4-amino-5-tert-butyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(4-chlorophenyl)ethyl]acetamide —— C16H22ClN5OS
    2-[(4-amino-5-tert-butyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(4-chlorophenyl)ethyl]acetamide
    —— N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C17H15FN4O2S
    N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-[(1R)-1-phenylethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C17H16N4O2S
    N-[(1R)-1-phenylethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 2-(2-methylfuran-3-yl)-5-[(1R)-1-phenylethyl]sulfanyl-1,3,4-oxadiazole —— C15H14N2O2S
    2-(2-methylfuran-3-yl)-5-[(1R)-1-phenylethyl]sulfanyl-1,3,4-oxadiazole
    —— N-[(1S,2R,3R)-2,3-dimethylcyclohexyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C17H22N4O2S
    N-[(1S,2R,3R)-2,3-dimethylcyclohexyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(2,2,2-trifluoroethyl)propanamide —— C12H11F3N4O2S
    (2R)-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(2,2,2-trifluoroethyl)propanamide
    —— (2R)-N-[(1R)-1-phenylethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H18N4O2S
    (2R)-N-[(1R)-1-phenylethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H17FN4O2S
    (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (2R)-N-[(1S)-1-phenylethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H18N4O2S
    (2R)-N-[(1S)-1-phenylethyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-[(2R)-2-phenylpropyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C19H20N4O2S
    (2S)-N-[(2R)-2-phenylpropyl]-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— 4-[[(2R)-oxolan-2-yl]methyl]-3-[(1R)-1-phenylethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C15H19N3O2S
    4-[[(2R)-oxolan-2-yl]methyl]-3-[(1R)-1-phenylethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— (2S)-N-(1-cyanocyclohexyl)-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C17H19N5O2S
    (2S)-N-(1-cyanocyclohexyl)-2-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2,2,2-trifluoroethyl)propanamide —— C13H15F3N4OS2
    (2S)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2,2,2-trifluoroethyl)propanamide
    —— 3-anilino-5-(3,5-dimethyl-benzylthio)-1,2,4-triazole 334538-75-9 C17H18N4S
    3-anilino-5-(3,5-dimethyl-benzylthio)-1,2,4-triazole
    —— 2-[(4-amino-5-tert-butyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(4-chlorophenyl)ethyl]acetamide —— C16H22ClN5OS
    2-[(4-amino-5-tert-butyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(4-chlorophenyl)ethyl]acetamide
    —— 2-(2-methylfuran-3-yl)-5-[(1S)-1-phenylethyl]sulfanyl-1,3,4-oxadiazole —— C15H14N2O2S
    2-(2-methylfuran-3-yl)-5-[(1S)-1-phenylethyl]sulfanyl-1,3,4-oxadiazole
    —— N-methyl-N-[(2-methylphenyl)methyl]-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C18H24N4O3S
    N-methyl-N-[(2-methylphenyl)methyl]-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 3-(2-methylfuran-3-yl)-5-[(1S)-1-phenylethyl]sulfanyl-1,2,4-triazol-4-amine —— C15H16N4OS
    3-(2-methylfuran-3-yl)-5-[(1S)-1-phenylethyl]sulfanyl-1,2,4-triazol-4-amine