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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-tert-butylacetamide —— C19H27N5O2S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-tert-butylacetamide
    —— (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanenitrile —— C16H19N5OS
    (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanenitrile
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-1-methylpyrazole-4-carboxamide —— C16H24N6OS
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-1-methylpyrazole-4-carboxamide
    —— 1-benzyl-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]pyrazole-4-carboxamide —— C22H28N6OS
    1-benzyl-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]pyrazole-4-carboxamide
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-pentan-3-ylacetamide —— C20H29N5O2S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-pentan-3-ylacetamide
    —— 4-[4-Benzyl-5-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]-1,2,4-triazol-3-yl]morpholine —— C18H21N5OS2
    4-[4-Benzyl-5-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]-1,2,4-triazol-3-yl]morpholine
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide —— C22H27N5O2S
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C20H27N5O3S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— 2-[(4-Benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-1-pyrrolidin-1-ylethanone —— C19H25N5O2S
    2-[(4-Benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-1-pyrrolidin-1-ylethanone
    —— (2R)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-propan-2-ylpropanamide —— C19H27N5O2S
    (2R)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-propan-2-ylpropanamide
    —— (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-cyclohexylpropanamide —— C22H31N5O2S
    (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-cyclohexylpropanamide
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxyethyl)acetamide —— C18H25N5O3S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxyethyl)acetamide
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-cyclopentylacetamide —— C20H27N5O2S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-cyclopentylacetamide
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-3-phenylpropanamide —— C20H28N4OS
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-3-phenylpropanamide
    —— (2R)-2-(2,5-difluorophenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]propanamide —— C17H16F3NOS
    (2R)-2-(2,5-difluorophenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]propanamide
    —— 2-(2,5-Difluorophenyl)sulfanyl-1-[2,5-dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]ethanone —— C17H14F2N2OS2
    2-(2,5-Difluorophenyl)sulfanyl-1-[2,5-dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]ethanone
    —— 2-(2,5-difluorophenyl)sulfanyl-N-[(1S,2S)-2-methylcyclohexyl]acetamide —— C15H19F2NOS
    2-(2,5-difluorophenyl)sulfanyl-N-[(1S,2S)-2-methylcyclohexyl]acetamide
    —— 6-Amino-5-[2-(2,5-difluorophenyl)sulfanylacetyl]-1-propylpyrimidine-2,4-dione —— C15H15F2N3O3S
    6-Amino-5-[2-(2,5-difluorophenyl)sulfanylacetyl]-1-propylpyrimidine-2,4-dione
    —— 4-(2,5-Difluorophenyl)sulfanyl-2-ethanimidoyl-3-oxobutanenitrile —— C12H10F2N2OS
    4-(2,5-Difluorophenyl)sulfanyl-2-ethanimidoyl-3-oxobutanenitrile
    —— ethyl (E)-3-[(3-benzylsulfanyl-1,2,4-thiadiazol-5-yl)amino]-2-cyanoprop-2-enoate —— C15H14N4O2S2
    ethyl (E)-3-[(3-benzylsulfanyl-1,2,4-thiadiazol-5-yl)amino]-2-cyanoprop-2-enoate
    —— 2-(2,5-difluorophenyl)sulfanyl-N-[(1S,2R)-2-methylcyclohexyl]acetamide —— C15H19F2NOS
    2-(2,5-difluorophenyl)sulfanyl-N-[(1S,2R)-2-methylcyclohexyl]acetamide
    —— (2R)-N-benzyl-2-(2,5-difluorophenyl)sulfanylpropanamide —— C16H15F2NOS
    (2R)-N-benzyl-2-(2,5-difluorophenyl)sulfanylpropanamide
    —— 2-[[(3-Benzylsulfanyl-1,2,4-thiadiazol-5-yl)amino]methylidene]propanedinitrile —— C13H9N5S2
    2-[[(3-Benzylsulfanyl-1,2,4-thiadiazol-5-yl)amino]methylidene]propanedinitrile
    —— 1-[2-(4-Chlorophenyl)sulfanylphenyl]-3-[3-(dimethylamino)propyl]thiourea —— C18H22ClN3S2
    1-[2-(4-Chlorophenyl)sulfanylphenyl]-3-[3-(dimethylamino)propyl]thiourea
    —— 1-(4-Acetylpiperazin-1-yl)-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C16H17FN4O3S
    1-(4-Acetylpiperazin-1-yl)-2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 2-[4-[(Z)-[3-[(4-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]iminomethyl]-N-methylanilino]ethanol —— C19H20ClN5OS
    2-[4-[(Z)-[3-[(4-chlorophenyl)methylsulfanyl]-1,2,4-triazol-4-yl]iminomethyl]-N-methylanilino]ethanol
    —— 3-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-4-propyl-1H-1,2,4-triazol-5-one —— C14H14ClN5O2S
    3-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-4-propyl-1H-1,2,4-triazol-5-one
    —— 2-[[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]sulfanyl]-1-(5-phenyl-3,4-dihydropyrazol-2-yl)ethanone —— C20H16FN3OS2
    2-[[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]sulfanyl]-1-(5-phenyl-3,4-dihydropyrazol-2-yl)ethanone
    —— 4-ethyl-3-[[(2S)-oxan-2-yl]methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazole —— C14H19N3OS2
    4-ethyl-3-[[(2S)-oxan-2-yl]methylsulfanyl]-5-thiophen-2-yl-1,2,4-triazole
    —— 2-[[4-amino-5-(3,5-dimethylpyrazol-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]-N-methylacetamide —— C19H26N8OS
    2-[[4-amino-5-(3,5-dimethylpyrazol-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]-N-methylacetamide
    —— 2-(3-cyanopyridin-2-yl)sulfanyl-N-[3-(N-methylanilino)propyl]acetamide —— C18H20N4OS
    2-(3-cyanopyridin-2-yl)sulfanyl-N-[3-(N-methylanilino)propyl]acetamide
    —— 2-(3-cyanopyridin-2-yl)sulfanyl-N-[[4-(dimethylamino)phenyl]methyl]-N-methylacetamide —— C18H20N4OS
    2-(3-cyanopyridin-2-yl)sulfanyl-N-[[4-(dimethylamino)phenyl]methyl]-N-methylacetamide
    —— [2-[[4-(dimethylamino)phenyl]methylamino]-2-oxoethyl] (E)-3-phenylsulfanylprop-2-enoate —— C20H22N2O3S
    [2-[[4-(dimethylamino)phenyl]methylamino]-2-oxoethyl] (E)-3-phenylsulfanylprop-2-enoate
    —— methyl 2-[2-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C13H17N3O5S
    methyl 2-[2-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(2R)-1-amino-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C10H13N3O4S
    methyl 2-[2-[(2R)-1-amino-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[(2R)-1-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C18H20FN3O4S
    methyl 2-[2-[(2R)-1-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-1-oxopropan-2-yl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 5-[(2S)-2-[[4-(2-methoxy-2-oxoethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C18H21N3O6S
    methyl 5-[(2S)-2-[[4-(2-methoxy-2-oxoethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-3-(4-methylphenyl)propanenitrile —— C18H16N4S2
    (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-3-(4-methylphenyl)propanenitrile
    —— methyl 2-[6-oxo-2-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1H-pyrimidin-4-yl]acetate —— C17H15N3O3S2
    methyl 2-[6-oxo-2-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1H-pyrimidin-4-yl]acetate
    —— 2-[(4-Propan-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one —— C16H19N5OS2
    2-[(4-Propan-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one
    —— methyl 2-[2-[2-[1-(2-methoxyethyl)-2,5-dimethylpyrrol-3-yl]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C18H23N3O5S
    methyl 2-[2-[2-[1-(2-methoxyethyl)-2,5-dimethylpyrrol-3-yl]-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-(2-methylpropylsulfanyl)-6-oxo-1H-pyrimidin-4-yl]acetate —— C11H16N2O3S
    methyl 2-[2-(2-methylpropylsulfanyl)-6-oxo-1H-pyrimidin-4-yl]acetate
    —— methyl 2-[2-[2-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C17H19N3O5S
    methyl 2-[2-[2-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— 2-[[5-[[(3S)-1,1-dioxothiolan-3-yl]methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[2-(2-fluorophenyl)ethyl]acetamide —— C17H20FN3O4S2
    2-[[5-[[(3S)-1,1-dioxothiolan-3-yl]methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[2-(2-fluorophenyl)ethyl]acetamide
    —— 2-(4-Fluorophenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-oxadiazole —— C15H9FN4O2S2
    2-(4-Fluorophenyl)-5-[(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— ethyl 5-[2-[[4-(2-methoxy-2-oxoethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]acetyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C18H21N3O6S
    ethyl 5-[2-[[4-(2-methoxy-2-oxoethyl)-6-oxo-1H-pyrimidin-2-yl]sulfanyl]acetyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— 1-(2,5-dimethyl-1-propylpyrrol-3-yl)-2-[[5-[[(3S)-1,1-dioxothiolan-3-yl]methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C18H25N3O4S2
    1-(2,5-dimethyl-1-propylpyrrol-3-yl)-2-[[5-[[(3S)-1,1-dioxothiolan-3-yl]methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— methyl 2-[2-[2-(3-methylbutylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate —— C14H21N3O4S
    methyl 2-[2-[2-(3-methylbutylamino)-2-oxoethyl]sulfanyl-6-oxo-1H-pyrimidin-4-yl]acetate
    —— 2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-prop-2-enyl-N-(thiophen-2-ylmethyl)acetamide —— C18H18N4OS3
    2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-prop-2-enyl-N-(thiophen-2-ylmethyl)acetamide
    —— 2-[[5-[[(3R)-1,1-dioxothiolan-3-yl]methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide —— C16H25N3O4S2
    2-[[5-[[(3R)-1,1-dioxothiolan-3-yl]methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide