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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-5-(4-methoxyphenyl)-N-[(5-phenylsulfanylfuran-2-yl)methyl]-1,2-oxazole-3-carboxamide —— C26H24N2O6S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-5-(4-methoxyphenyl)-N-[(5-phenylsulfanylfuran-2-yl)methyl]-1,2-oxazole-3-carboxamide
    —— 2-[5-[[2-[(4-fluorophenyl)methylsulfanyl]-1-methyl-4-oxopyrimidin-5-yl]methyl]-2-oxopyrimidin-1-yl]-N-methyl-N-octylacetamide —— C28H36FN5O3S
    2-[5-[[2-[(4-fluorophenyl)methylsulfanyl]-1-methyl-4-oxopyrimidin-5-yl]methyl]-2-oxopyrimidin-1-yl]-N-methyl-N-octylacetamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-5-(4-methoxyphenyl)-N-[(5-phenylsulfanylfuran-2-yl)methyl]-1,2-oxazole-3-carboxamide —— C26H24N2O6S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-5-(4-methoxyphenyl)-N-[(5-phenylsulfanylfuran-2-yl)methyl]-1,2-oxazole-3-carboxamide
    —— 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-oxopyrazin-1-yl]-N-[(3-methylsulfanyl-1-oxidopyridin-1-ium-2-yl)methyl]acetamide —— C20H19ClF2N6O3S
    2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-oxopyrazin-1-yl]-N-[(3-methylsulfanyl-1-oxidopyridin-1-ium-2-yl)methyl]acetamide
    —— [(2R)-3,3-dimethylbutan-2-yl]oxy-methyl-oxo-sulfanylidene-λ6-sulfane —— C7H16O2S2
    [(2R)-3,3-dimethylbutan-2-yl]oxy-methyl-oxo-sulfanylidene-λ6-sulfane
    —— (2S)-3-dodecylsulfonyl-2-methylpropanamide —— C16H33NO3S
    (2S)-3-dodecylsulfonyl-2-methylpropanamide
    —— 2-[3-[4-[[4-(2,3-Difluorophenyl)-2,5-dioxopyrrol-3-yl]amino]phenyl]sulfanylphenyl]acetic acid —— C24H16F2N2O4S
    2-[3-[4-[[4-(2,3-Difluorophenyl)-2,5-dioxopyrrol-3-yl]amino]phenyl]sulfanylphenyl]acetic acid
    —— 1-(2,6-Dichlorophenyl)-6-(2,4-difluorophenyl)sulfanylquinazoline-2,4-dione —— C20H10Cl2F2N2O2S
    1-(2,6-Dichlorophenyl)-6-(2,4-difluorophenyl)sulfanylquinazoline-2,4-dione
    —— N-[2-[[5-[[(2,3-difluorophenyl)methyl]thio]-2,3-dihydro-2-oxothiazolo[4,5-d]pyrimidin-7-yl]amino]ethyl]methanesulfonamide —— C15H15F2N5O3S3
    N-[2-[[5-[[(2,3-difluorophenyl)methyl]thio]-2,3-dihydro-2-oxothiazolo[4,5-d]pyrimidin-7-yl]amino]ethyl]methanesulfonamide
    —— (Z)-3-((Z)-Benzylidene)-6-((5-((2-(dimethylamino)ethyl)thio)thiophen-2-yl)methylene)piperazine-2,5-dione hydrochloride —— C20H22ClN3O2S2
    (Z)-3-((Z)-Benzylidene)-6-((5-((2-(dimethylamino)ethyl)thio)thiophen-2-yl)methylene)piperazine-2,5-dione hydrochloride
    —— 1,2-Diethyl-3-[5-[[5-(1-methyl-6-oxopyridin-3-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]pyrimidin-4-yl]guanidine —— C18H22N8O2S
    1,2-Diethyl-3-[5-[[5-(1-methyl-6-oxopyridin-3-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]pyrimidin-4-yl]guanidine
    —— 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-(2-hydroxyethoxy)ethyl]amino] thiazolo[4,5-d]pyrimidin-2(3H)-one —— C16H16F2N4O3S2
    5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-(2-hydroxyethoxy)ethyl]amino] thiazolo[4,5-d]pyrimidin-2(3H)-one
    —— 4-Methyl-2-methylsulfanyl-13-nitro-3,8,9,10,11,16b-hexahydro-7H-6-oxa-12-thia-1,3-diaza-dibenzo[a,c]cyclododecen-5-one —— C18H21N3O4S2
    4-Methyl-2-methylsulfanyl-13-nitro-3,8,9,10,11,16b-hexahydro-7H-6-oxa-12-thia-1,3-diaza-dibenzo[a,c]cyclododecen-5-one
    —— 1-[(3,5-Difluorophenyl)methyl]-6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-pyrimidine-2,4-dione —— C21H20F2N2O2S
    1-[(3,5-Difluorophenyl)methyl]-6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-pyrimidine-2,4-dione
    —— [2-[2-[(dimethylamino)methyl]phenyl]sulfanyl-5-(123I)iodanylphenyl]methanol —— C16H18INOS
    [2-[2-[(dimethylamino)methyl]phenyl]sulfanyl-5-(123I)iodanylphenyl]methanol
    —— 4-(3-Chlorophenyl)sulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline —— C16H8ClF3N4S
    4-(3-Chlorophenyl)sulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
    —— 1-(3-Chlorophenyl)-4-methyl-6-oxo-5-phenylsulfanylpyridazine-3-carboxamide —— C18H14ClN3O2S
    1-(3-Chlorophenyl)-4-methyl-6-oxo-5-phenylsulfanylpyridazine-3-carboxamide
    —— 5-[4-[(2S)-4-hydroxy-2-methyloxan-4-yl]thiophen-2-yl]sulfanyl-1-methyl-3H-indol-2-one —— C19H21NO3S2
    5-[4-[(2S)-4-hydroxy-2-methyloxan-4-yl]thiophen-2-yl]sulfanyl-1-methyl-3H-indol-2-one
    —— 4-[4-(4-Chloro-phenyl)-thiazol-2-yl]-5-methylsulfanyl-thiophene-2-carboxamidine —— C15H12ClN3S3
    4-[4-(4-Chloro-phenyl)-thiazol-2-yl]-5-methylsulfanyl-thiophene-2-carboxamidine
    —— 2-[Dibromo(fluoro)methyl]sulfanyl-[1,3]thiazolo[4,5-b]pyridine —— C7H3Br2FN2S2
    2-[Dibromo(fluoro)methyl]sulfanyl-[1,3]thiazolo[4,5-b]pyridine
    —— 3-Amino-4-(3-naphthalen-2-ylsulfanylanilino)cyclobut-3-ene-1,2-dione —— C20H14N2O2S
    3-Amino-4-(3-naphthalen-2-ylsulfanylanilino)cyclobut-3-ene-1,2-dione
    —— 3-Chloro-4-(2,3-dichlorophenyl)sulfanylaniline —— C12H8Cl3NS
    3-Chloro-4-(2,3-dichlorophenyl)sulfanylaniline
    —— 3-Chloro-4-(2,3-dichlorophenyl)sulfanylaniline;hydrochloride —— C12H9Cl4NS
    3-Chloro-4-(2,3-dichlorophenyl)sulfanylaniline;hydrochloride
    —— 2-[(2,5-dimethyl-1,2,4-triazol-3-yl)sulfanylmethyl]-N,N-dimethylaniline;dihydrochloride —— C13H20Cl2N4S
    2-[(2,5-dimethyl-1,2,4-triazol-3-yl)sulfanylmethyl]-N,N-dimethylaniline;dihydrochloride
    —— (1R,5R,6R)-6-[4-(3-Phenyl-prop-2-ynylsulfanyl)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[3.2.1]octane —— C18H19N3S2
    (1R,5R,6R)-6-[4-(3-Phenyl-prop-2-ynylsulfanyl)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[3.2.1]octane
    —— 4-[2-(2-Thiophen-3-ylsulfanylethoxy)ethylsulfanyl]phenol —— C14H16O2S3
    4-[2-(2-Thiophen-3-ylsulfanylethoxy)ethylsulfanyl]phenol
    —— Tert-butyl-hydroxy-[[5-(4-methoxyphenyl)sulfanylthiophen-2-yl]methyl]azanium —— C16H22NO2S2+
    Tert-butyl-hydroxy-[[5-(4-methoxyphenyl)sulfanylthiophen-2-yl]methyl]azanium
    —— 3-[(6R)-2-azabicyclo[2.2.2]octan-6-yl]-4-hexylsulfanyl-1,2,5-thiadiazole —— C15H25N3S2
    3-[(6R)-2-azabicyclo[2.2.2]octan-6-yl]-4-hexylsulfanyl-1,2,5-thiadiazole
    —— N-(4-methylphenyl)-3-(2-phenylethylsulfanyl)-1H-1,2,4-triazol-5-amine —— C17H18N4S
    N-(4-methylphenyl)-3-(2-phenylethylsulfanyl)-1H-1,2,4-triazol-5-amine
    —— (2S)-N-[(Z)-[4-(dimethylamino)phenyl]methylideneamino]-2-[[5-[(2S)-1-[(2Z)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C26H32N8O2S3
    (2S)-N-[(Z)-[4-(dimethylamino)phenyl]methylideneamino]-2-[[5-[(2S)-1-[(2Z)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 5-(4-methylsulfanylphenyl)-6-pyridin-4-yl-2,3-dihydro-1H-imidazo[1,2-a]imidazole —— C17H16N4S
    5-(4-methylsulfanylphenyl)-6-pyridin-4-yl-2,3-dihydro-1H-imidazo[1,2-a]imidazole
    —— N-(4-methylphenyl)-3-(5-methylthiophen-2-yl)sulfanyl-1H-1,2,4-triazol-5-amine —— C14H14N4S2
    N-(4-methylphenyl)-3-(5-methylthiophen-2-yl)sulfanyl-1H-1,2,4-triazol-5-amine
    —— (2R)-N-[(Z)-[4-(dimethylamino)phenyl]methylideneamino]-2-[[5-[(2S)-1-[(2Z)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C26H32N8O2S3
    (2R)-N-[(Z)-[4-(dimethylamino)phenyl]methylideneamino]-2-[[5-[(2S)-1-[(2Z)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2R)-N-[(Z)-[4-(dimethylamino)phenyl]methylideneamino]-2-[[5-[(2R)-1-[(2Z)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C26H32N8O2S3
    (2R)-N-[(Z)-[4-(dimethylamino)phenyl]methylideneamino]-2-[[5-[(2R)-1-[(2Z)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinyl]-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 3-anilino-5-(2-methyl-thiazol-4-ylmethylthio)-1,2,4-triazole 334538-65-7 C13H13N5S2
    3-anilino-5-(2-methyl-thiazol-4-ylmethylthio)-1,2,4-triazole
    —— 3-Chloro-4-(2,4-dimethylphenyl)sulfanylaniline —— C14H14ClNS
    3-Chloro-4-(2,4-dimethylphenyl)sulfanylaniline
    —— 3-(4-fluorophenyl)thio-2,3-dihydro-1,1-dioxidebenzo[b]thiophene 246169-05-1 C14H11FO2S2
    3-(4-fluorophenyl)thio-2,3-dihydro-1,1-dioxidebenzo[b]thiophene
    —— 4-[2-[2-(1H-1,2,4-triazol-5-ylsulfanyl)ethoxy]ethylsulfanyl]phenol —— C12H15N3O2S2
    4-[2-[2-(1H-1,2,4-triazol-5-ylsulfanyl)ethoxy]ethylsulfanyl]phenol
    —— 3-Chloro-4-(2,4-dimethylphenyl)sulfanylaniline;hydrochloride —— C14H15Cl2NS
    3-Chloro-4-(2,4-dimethylphenyl)sulfanylaniline;hydrochloride
    —— (1S)-1-[5-(benzylsulfanyl)-4H-1,2,4-triazol-3-yl]-3-(methylsulfanyl)propan-1-amine —— C13H18N4S2
    (1S)-1-[5-(benzylsulfanyl)-4H-1,2,4-triazol-3-yl]-3-(methylsulfanyl)propan-1-amine
    —— 2,4-Dichloro-6-(2-hydroxyphenyl)sulfanylphenol —— C12H8Cl2O2S
    2,4-Dichloro-6-(2-hydroxyphenyl)sulfanylphenol
    —— 3-(furan-2-ylsulfanyl)-N-(4-methylphenyl)-1H-1,2,4-triazol-5-amine —— C13H12N4OS
    3-(furan-2-ylsulfanyl)-N-(4-methylphenyl)-1H-1,2,4-triazol-5-amine
    —— 3-anilino-5-(pyridin-2-ylmethylthio)-1,2,4-triazole 334538-66-8 C14H13N5S
    3-anilino-5-(pyridin-2-ylmethylthio)-1,2,4-triazole
    —— (2Z,5R)-2-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-7-methyl-3-oxo-N,5-diphenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide —— C31H22ClN3O3S2
    (2Z,5R)-2-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-7-methyl-3-oxo-N,5-diphenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide
    —— (2Z,5R)-7-methyl-2-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methylidene]-3-oxo-N,5-diphenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide —— C32H25N3O3S2
    (2Z,5R)-7-methyl-2-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methylidene]-3-oxo-N,5-diphenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide
    —— (2Z,5S)-2-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-7-methyl-3-oxo-N,5-diphenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide —— C31H22ClN3O3S2
    (2Z,5S)-2-[[5-(4-chlorophenyl)sulfanylfuran-2-yl]methylidene]-7-methyl-3-oxo-N,5-diphenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide
    —— (2Z,5S)-7-methyl-2-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methylidene]-3-oxo-N,5-diphenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide —— C32H25N3O3S2
    (2Z,5S)-7-methyl-2-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methylidene]-3-oxo-N,5-diphenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide
    —— N-(5-methyl-1H-pyrazol-3-yl)-2-(phenylsulfanylmethyl)-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-4-amine —— C20H23N5S
    N-(5-methyl-1H-pyrazol-3-yl)-2-(phenylsulfanylmethyl)-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-4-amine
    —— 1-N',3-N'-bis(cyclopropanecarbothioyl)-1-N',3-N',2,2-tetramethylpropanedihydrazide —— C15H24N4O2S2
    1-N',3-N'-bis(cyclopropanecarbothioyl)-1-N',3-N',2,2-tetramethylpropanedihydrazide
    —— 4-[(1R,3S)-3-amino-1-(3-fluorothiophen-2-yl)-4-hydroxybutyl]sulfanyl-6-methoxypyridine-3-carbonitrile —— C15H16FN3O2S2
    4-[(1R,3S)-3-amino-1-(3-fluorothiophen-2-yl)-4-hydroxybutyl]sulfanyl-6-methoxypyridine-3-carbonitrile