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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— [2-[(4-Fluorophenyl)methylamino]-2-oxoethyl] 3-(4-chlorophenyl)sulfanylpropanoate —— C18H17ClFNO3S
    [2-[(4-Fluorophenyl)methylamino]-2-oxoethyl] 3-(4-chlorophenyl)sulfanylpropanoate
    —— N-[2-[(3-methylthiophen-2-yl)methyl]pyrazol-3-yl]-2-phenylsulfanylpyridine-3-carboxamide —— C21H18N4OS2
    N-[2-[(3-methylthiophen-2-yl)methyl]pyrazol-3-yl]-2-phenylsulfanylpyridine-3-carboxamide
    —— 2-[(4-Chlorophenyl)thio]ethyl carbamimidothioate 959958-01-1 C9H11ClN2S2
    2-[(4-Chlorophenyl)thio]ethyl carbamimidothioate
    —— dimethyl-[(1S)-2-[[2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetyl]amino]-1-phenylethyl]azanium —— C17H22N3O2S+
    dimethyl-[(1S)-2-[[2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetyl]amino]-1-phenylethyl]azanium
    —— 2-(2-fluorophenyl)sulfanyl-N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]acetamide —— C13H16FNO3S2
    2-(2-fluorophenyl)sulfanyl-N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]acetamide
    —— (E)-N'-[2-(4-chlorophenyl)sulfanylacetyl]-3-thiophen-2-ylprop-2-enehydrazide —— C15H13ClN2O2S2
    (E)-N'-[2-(4-chlorophenyl)sulfanylacetyl]-3-thiophen-2-ylprop-2-enehydrazide
    —— (2R)-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-(1-methyltetrazol-5-yl)sulfanylpropan-1-one —— C11H19N5O2S
    (2R)-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-(1-methyltetrazol-5-yl)sulfanylpropan-1-one
    —— 2-(4-methylphenyl)sulfanyl-N-[(1R)-1-phenylethyl]pyridine-3-carboxamide —— C21H20N2OS
    2-(4-methylphenyl)sulfanyl-N-[(1R)-1-phenylethyl]pyridine-3-carboxamide
    —— [(2S)-1-amino-1-oxopropan-2-yl] 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylbenzoate —— C18H17N3O3S2
    [(2S)-1-amino-1-oxopropan-2-yl] 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylbenzoate
    —— N-(1-adamantyl)-2-[[4-amino-5-[(2R)-2-phenylpropyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C23H31N5OS
    N-(1-adamantyl)-2-[[4-amino-5-[(2R)-2-phenylpropyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 2-(2-chlorophenyl)sulfanyl-1-[(3R)-3-(1,2,4-oxadiazol-3-yl)morpholin-4-yl]ethanone —— C14H14ClN3O3S
    2-(2-chlorophenyl)sulfanyl-1-[(3R)-3-(1,2,4-oxadiazol-3-yl)morpholin-4-yl]ethanone
    —— 5-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-1-methyltetrazole —— C10H11ClN4S
    5-[(1R)-1-(2-chlorophenyl)ethyl]sulfanyl-1-methyltetrazole
    —— 1-[(3S)-3-(furan-2-yl)-5-(5-methylfuran-2-yl)-3,4-dihydropyrazol-2-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone —— C16H16N6O3S
    1-[(3S)-3-(furan-2-yl)-5-(5-methylfuran-2-yl)-3,4-dihydropyrazol-2-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone
    —— 1-[2,5-Dimethyl-1-(3-methylbutyl)pyrrol-3-yl]-2-[[5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C20H31N4O2S+
    1-[2,5-Dimethyl-1-(3-methylbutyl)pyrrol-3-yl]-2-[[5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— N-cyclopropyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C12H17N3O3S3
    N-cyclopropyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 1-butyl-5-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]tetrazole —— C12H15N7S2
    1-butyl-5-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]tetrazole
    —— 2-(3,4-dimethylphenyl)-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-oxadiazole —— C18H16N4O2S2
    2-(3,4-dimethylphenyl)-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 4-propyl-3-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-1,2,4-triazol-5-one —— C13H15N5O2S2
    4-propyl-3-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-1,2,4-triazol-5-one
    —— 2-phenyl-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12N4O2S2
    2-phenyl-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-phenyl-5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12N4O2S2
    2-phenyl-5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— N-benzyl-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C17H15N5OS3
    N-benzyl-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— 1-Butyl-5-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]tetrazole —— C14H19N7OS
    1-Butyl-5-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]tetrazole
    —— 2-[(1R)-1-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-5-thiophen-2-yl-1,3,4-oxadiazole —— C16H15N5O2S2
    2-[(1R)-1-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-5-thiophen-2-yl-1,3,4-oxadiazole
    —— 2-[(1R)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-5-thiophen-2-yl-1,3,4-oxadiazole —— C16H15N5OS3
    2-[(1R)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-5-thiophen-2-yl-1,3,4-oxadiazole
    —— 2-[(1R)-1-(4-chlorophenyl)sulfanylethyl]-5-thiophen-2-yl-1,3,4-oxadiazole —— C14H11ClN2OS2
    2-[(1R)-1-(4-chlorophenyl)sulfanylethyl]-5-thiophen-2-yl-1,3,4-oxadiazole
    —— 3-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-1,2,4-triazol-5-amine —— C10H10N6OS2
    3-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-1,2,4-triazol-5-amine
    —— N-[(1R)-1-(1-adamantyl)ethyl]-2-[[5-(butylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C20H32N4OS2
    N-[(1R)-1-(1-adamantyl)ethyl]-2-[[5-(butylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-(2-methylphenyl)-5-prop-2-enylsulfanyl-1,3,4-thiadiazol-2-amine —— C12H13N3S2
    N-(2-methylphenyl)-5-prop-2-enylsulfanyl-1,3,4-thiadiazol-2-amine
    —— 5-[(1-butyltetrazol-5-yl)methylsulfanyl]-N-(3,4-dimethylphenyl)-1,3,4-thiadiazol-2-amine —— C16H21N7S2
    5-[(1-butyltetrazol-5-yl)methylsulfanyl]-N-(3,4-dimethylphenyl)-1,3,4-thiadiazol-2-amine
    —— N-(2-methylphenyl)-5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C17H15N5OS3
    N-(2-methylphenyl)-5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— N-(2-cyanoethyl)-N-methyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C15H17N5OS2
    N-(2-cyanoethyl)-N-methyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-(2-methylphenyl)-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C17H15N5OS3
    N-(2-methylphenyl)-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— N-(3-methylphenyl)-5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C17H15N5OS3
    N-(3-methylphenyl)-5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— N-(cyclopenten-1-yl)-2-[[5-[4-(diethylamino)phenyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-ethylacetamide —— C21H28N4O2S
    N-(cyclopenten-1-yl)-2-[[5-[4-(diethylamino)phenyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-ethylacetamide
    —— 3-[4,6-dimethyl-2-(methylsulfanyl)pyrimidin-5-yl]-N-[(4-fluorophenyl)methyl]propanamide —— C17H20FN3OS
    3-[4,6-dimethyl-2-(methylsulfanyl)pyrimidin-5-yl]-N-[(4-fluorophenyl)methyl]propanamide
    —— (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C20H21FN4OS2
    (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2S)-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(methylcarbamoyl)propanamide —— C13H14FN5O2S2
    (2S)-2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(methylcarbamoyl)propanamide
    —— N-[(1S)-1-cyano-1-cyclopropylethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H19N5OS2
    N-[(1S)-1-cyano-1-cyclopropylethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-(cyclopropylmethyl)-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propylacetamide —— C19H26N4OS2
    N-(cyclopropylmethyl)-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propylacetamide
    —— 3-(2-Piperidin-1-ium-1-ylethylsulfanyl)-1-piperidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile —— C22H34N4S+2
    3-(2-Piperidin-1-ium-1-ylethylsulfanyl)-1-piperidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-4-carbonitrile
    —— methyl (2S)-2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]butanoate —— C19H25N3O3S
    methyl (2S)-2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]butanoate
    —— 3-{[3-(Dimethylamino)propyl]sulfanyl}-1-(piperidin-1-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C20H30N4S
    3-{[3-(Dimethylamino)propyl]sulfanyl}-1-(piperidin-1-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
    —— 3-[(4-Cyano-1-piperidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]propyl-dimethylazanium —— C20H32N4S+2
    3-[(4-Cyano-1-piperidin-1-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]propyl-dimethylazanium
    —— 3-{[2-(Dimethylamino)ethyl]sulfanyl}-1-(piperidin-1-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C19H28N4S
    3-{[2-(Dimethylamino)ethyl]sulfanyl}-1-(piperidin-1-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
    —— 3-{[3-(Dimethylamino)propyl]sulfanyl}-1-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C19H28N4OS
    3-{[3-(Dimethylamino)propyl]sulfanyl}-1-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
    —— 4-Methyl-6-(2-morpholin-4-ium-4-ylethylsulfanyl)-2-phenylpyrimidine-5-carbonitrile —— C18H21N4OS+
    4-Methyl-6-(2-morpholin-4-ium-4-ylethylsulfanyl)-2-phenylpyrimidine-5-carbonitrile
    —— 3-[(4-Cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]propyl-dimethylazanium —— C19H30N4OS+2
    3-[(4-Cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]propyl-dimethylazanium
    —— 1-(4-Methylpiperidin-1-yl)-3-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C22H32N4S
    1-(4-Methylpiperidin-1-yl)-3-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
    —— 1-(Piperidin-1-yl)-3-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C21H30N4S
    1-(Piperidin-1-yl)-3-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile
    —— 3-{[2-(Morpholin-4-yl)-2-oxoethyl]sulfanyl}-1-(piperidin-1-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile —— C21H28N4O2S
    3-{[2-(Morpholin-4-yl)-2-oxoethyl]sulfanyl}-1-(piperidin-1-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile