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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(7S)-3-[(4-fluorophenyl)methyl]-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C17H13FN4O2S2
    2-[(7S)-3-[(4-fluorophenyl)methyl]-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— (2S)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylcyclopentan-1-one —— C11H12N4OS2
    (2S)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylcyclopentan-1-one
    —— 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-[4-[[(2S)-oxolan-2-yl]methyl]piperazin-4-ium-1-yl]ethanone —— C17H27N4O2S+
    2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-[4-[[(2S)-oxolan-2-yl]methyl]piperazin-4-ium-1-yl]ethanone
    —— 2-[(7S)-3-ethyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C14H14N4O2S
    2-[(7S)-3-ethyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-[4-[[(2S)-oxolan-2-yl]methyl]piperazin-1-yl]ethanone —— C17H26N4O2S
    2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-[4-[[(2S)-oxolan-2-yl]methyl]piperazin-1-yl]ethanone
    —— 2-[(7R)-3-[(4-fluorophenyl)methyl]-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C17H12FN4O2S2-
    2-[(7R)-3-[(4-fluorophenyl)methyl]-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 4-methyl-3-[(1R)-1-phenylethyl]sulfanyl-5-(trifluoromethyl)-1,2,4-triazole —— C12H12F3N3S
    4-methyl-3-[(1R)-1-phenylethyl]sulfanyl-5-(trifluoromethyl)-1,2,4-triazole
    —— 2-[(7R)-3-ethyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C14H14N4O2S
    2-[(7R)-3-ethyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— (2S)-2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-cyclopentylpropanamide —— C17H23N3OS
    (2S)-2-(3-cyano-4,5,6-trimethylpyridin-2-yl)sulfanyl-N-cyclopentylpropanamide
    —— 6-(2-Bromophenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C16H11BrN4S2
    6-(2-Bromophenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 3-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-pyridin-3-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C12H9N7S3
    3-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-pyridin-3-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(4-Chlorophenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C13H9ClN6S3
    6-(4-Chlorophenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-[(1R)-1-phenylbutyl]-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C20H20N4S2
    6-[(1R)-1-phenylbutyl]-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(3-Fluorophenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C13H9FN6S3
    6-(3-Fluorophenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(2-Methylphenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C14H12N6S3
    6-(2-Methylphenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(3-Chlorophenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C13H9ClN6S3
    6-(3-Chlorophenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(3,4-Dimethylphenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C18H16N4S2
    6-(3,4-Dimethylphenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(3-Chlorophenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C16H11ClN4S2
    6-(3-Chlorophenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(2-Fluorophenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C13H9FN6S3
    6-(2-Fluorophenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 4-Amino-2-[(5-thiophen-2-yl-1,2-oxazol-3-yl)methylsulfanyl]pyrimidine-5-carbonitrile —— C13H9N5OS2
    4-Amino-2-[(5-thiophen-2-yl-1,2-oxazol-3-yl)methylsulfanyl]pyrimidine-5-carbonitrile
    —— 6-(4-Bromophenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C16H11BrN4S2
    6-(4-Bromophenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— (5E)-3-(2-morpholin-4-ylethyl)-2-sulfanylidene-5-[[4-(trifluoromethylsulfanyl)phenyl]methylidene]-1,3-thiazolidin-4-one —— C17H17F3N2O2S3
    (5E)-3-(2-morpholin-4-ylethyl)-2-sulfanylidene-5-[[4-(trifluoromethylsulfanyl)phenyl]methylidene]-1,3-thiazolidin-4-one
    —— N-[2-[(5E)-5-[(2-fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-[(5-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C19H20FN5O3S2
    N-[2-[(5E)-5-[(2-fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethyl]-2-[(5-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (5E)-5-[(4-methylsulfanylphenyl)methylidene]-3-(2-morpholin-4-ylethyl)-2-sulfanylidene-1,3-thiazolidin-4-one —— C17H20N2O2S3
    (5E)-5-[(4-methylsulfanylphenyl)methylidene]-3-(2-morpholin-4-ylethyl)-2-sulfanylidene-1,3-thiazolidin-4-one
    —— 6-(3-Bromophenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C16H11BrN4S2
    6-(3-Bromophenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 2-[(7S)-3-[(4-fluorophenyl)methyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C19H14FN4O2S-
    2-[(7S)-3-[(4-fluorophenyl)methyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 2-[(7S)-6-(4-chlorophenyl)-3-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C16H10ClN4O2S2-
    2-[(7S)-6-(4-chlorophenyl)-3-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 2-[(1R)-1-(1-cyclopropyltetrazol-5-yl)sulfanylethyl]-5-phenyl-1,3,4-oxadiazole —— C14H14N6OS
    2-[(1R)-1-(1-cyclopropyltetrazol-5-yl)sulfanylethyl]-5-phenyl-1,3,4-oxadiazole
    —— 2-[(7R)-3-[(4-fluorophenyl)methyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C19H15FN4O2S
    2-[(7R)-3-[(4-fluorophenyl)methyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7S)-3-ethyl-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C15H16N4O2S
    2-[(7S)-3-ethyl-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7R)-3-[(4-fluorophenyl)methyl]-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C20H17FN4O2S
    2-[(7R)-3-[(4-fluorophenyl)methyl]-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7R)-6-(4-chlorophenyl)-3-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C16H10ClN4O2S2-
    2-[(7R)-6-(4-chlorophenyl)-3-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 2-(1-cyclopropyltetrazol-5-yl)sulfanyl-N-[(3-fluorophenyl)methyl]-N-methylacetamide —— C14H16FN5OS
    2-(1-cyclopropyltetrazol-5-yl)sulfanyl-N-[(3-fluorophenyl)methyl]-N-methylacetamide
    —— 1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]ethanone —— C18H22N2O2S2
    1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]ethanone
    —— 2-[(7R)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C12H8ClN4O2S-
    2-[(7R)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 2-[(7R)-6-(4-chlorophenyl)-3-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C16H11ClN4O2S2
    2-[(7R)-6-(4-chlorophenyl)-3-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 3-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-phenyl-1,2-oxazole —— C16H17N5OS
    3-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-phenyl-1,2-oxazole
    —— 2-[4-(3-Ethoxypropyl)-5-[2-(2-methylpropylamino)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]acetamide —— C15H27N5O3S
    2-[4-(3-Ethoxypropyl)-5-[2-(2-methylpropylamino)-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]acetamide
    —— 2-[(3R)-1,1-dioxothiolan-3-yl]-N'-[2-(2,4,6-trimethylphenyl)sulfanylacetyl]acetohydrazide —— C17H24N2O4S2
    2-[(3R)-1,1-dioxothiolan-3-yl]-N'-[2-(2,4,6-trimethylphenyl)sulfanylacetyl]acetohydrazide
    —— 3-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-thiophen-2-yl-1,2-oxazole —— C14H15N5OS2
    3-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-thiophen-2-yl-1,2-oxazole
    —— [2-[4-(2,5-dimethylphenyl)sulfanylanilino]-2-oxoethyl] (Z)-3-(1,3-dimethyl-2,4-dioxopyrimidin-5-yl)prop-2-enoate —— C25H25N3O5S
    [2-[4-(2,5-dimethylphenyl)sulfanylanilino]-2-oxoethyl] (Z)-3-(1,3-dimethyl-2,4-dioxopyrimidin-5-yl)prop-2-enoate
    —— 2-[(7R)-3-ethyl-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C15H15N4O2S-
    2-[(7R)-3-ethyl-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— N-(cyclohexen-1-yl)-N-(2-methoxyethyl)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylacetamide —— C17H23N5O2S2
    N-(cyclohexen-1-yl)-N-(2-methoxyethyl)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylacetamide
    —— 2-[(3S)-1,1-dioxothiolan-3-yl]-N'-[2-(2,4,6-trimethylphenyl)sulfanylacetyl]acetohydrazide —— C17H24N2O4S2
    2-[(3S)-1,1-dioxothiolan-3-yl]-N'-[2-(2,4,6-trimethylphenyl)sulfanylacetyl]acetohydrazide
    —— (3R)-3-[4-prop-2-enyl-5-(1,3-thiazol-4-ylmethylsulfanyl)-1,2,4-triazol-3-yl]thiolane 1,1-dioxide —— C13H16N4O2S3
    (3R)-3-[4-prop-2-enyl-5-(1,3-thiazol-4-ylmethylsulfanyl)-1,2,4-triazol-3-yl]thiolane 1,1-dioxide
    —— N-[4-(1H-benzimidazol-2-ylsulfanyl)phenyl]-2-(2-ethoxyphenoxy)acetamide —— C23H21N3O3S
    N-[4-(1H-benzimidazol-2-ylsulfanyl)phenyl]-2-(2-ethoxyphenoxy)acetamide
    —— N-[4-(1H-benzimidazol-2-ylsulfanyl)phenyl]-2-(3-methylphenoxy)acetamide —— C22H19N3O2S
    N-[4-(1H-benzimidazol-2-ylsulfanyl)phenyl]-2-(3-methylphenoxy)acetamide
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(5-propan-2-ylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C12H19N3O3S4
    N-[(3S)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(5-propan-2-ylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 4-[(4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-2-[(Z)-2-phenylethenyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine —— C22H21N5S2
    4-[(4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-2-[(Z)-2-phenylethenyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
    —— (5Z)-3-[2-(4-chlorophenyl)sulfanylethyl]-5-(pyridin-2-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one —— C17H13ClN2OS3
    (5Z)-3-[2-(4-chlorophenyl)sulfanylethyl]-5-(pyridin-2-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one