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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-(5-Hydroxy-4,4-dimethyl-pentane-1sulfinyl)-2,2-dimethyl-pentan-1-ol —— C14H30O3S
    5-(5-Hydroxy-4,4-dimethyl-pentane-1sulfinyl)-2,2-dimethyl-pentan-1-ol
    —— [3-(5-Methyl-2-nitrophenyl)sulfanylphenyl]methanamine —— C14H14N2O2S
    [3-(5-Methyl-2-nitrophenyl)sulfanylphenyl]methanamine
    —— 1-Pyridin-2-ylsulfanylbutan-2-ol —— C9H13NOS
    1-Pyridin-2-ylsulfanylbutan-2-ol
    —— 5-[(2,6-difluorophenyl)methylsulfanyl]-1H-1,2,4-triazole —— C9H7F2N3S
    5-[(2,6-difluorophenyl)methylsulfanyl]-1H-1,2,4-triazole
    —— 5-[(5-chlorothiophen-2-yl)methylsulfanyl]-1H-1,2,4-triazole —— C7H6ClN3S2
    5-[(5-chlorothiophen-2-yl)methylsulfanyl]-1H-1,2,4-triazole
    —— 2-(4-methylphenyl)sulfanyl-N-[3-[[(3S)-oxolan-3-yl]methoxy]propyl]acetamide —— C17H25NO3S
    2-(4-methylphenyl)sulfanyl-N-[3-[[(3S)-oxolan-3-yl]methoxy]propyl]acetamide
    —— N-[3-[[(3R)-oxolan-3-yl]methoxy]propyl]-2-phenylsulfanylacetamide —— C16H23NO3S
    N-[3-[[(3R)-oxolan-3-yl]methoxy]propyl]-2-phenylsulfanylacetamide
    —— N-[3-[[(3S)-oxolan-3-yl]methoxy]propyl]-2-phenylsulfanylacetamide —— C16H23NO3S
    N-[3-[[(3S)-oxolan-3-yl]methoxy]propyl]-2-phenylsulfanylacetamide
    —— ethyl 2-[[(4R,9R,14R,19R)-3,10,13,20,26-pentazatetracyclo[20.3.1.04,9.014,19]hexacosa-1(25),22(26),23-trien-24-yl]sulfanyl]acetate —— C25H41N5O2S
    ethyl 2-[[(4R,9R,14R,19R)-3,10,13,20,26-pentazatetracyclo[20.3.1.04,9.014,19]hexacosa-1(25),22(26),23-trien-24-yl]sulfanyl]acetate
    —— ethyl 3-[2-(N,N-dimethylsulfonylamino)phenyl]sulfanyl-6-(3-pyridylmethoxy)benzo[b]thiophene-2-carboxylate —— C25H24N2O7S4
    ethyl 3-[2-(N,N-dimethylsulfonylamino)phenyl]sulfanyl-6-(3-pyridylmethoxy)benzo[b]thiophene-2-carboxylate
    —— N-[(1S)-2-methyl-1-(5-methyl-1H-1,2,4-triazol-3-yl)propyl]-2-phenylsulfanylacetamide —— C15H20N4OS
    N-[(1S)-2-methyl-1-(5-methyl-1H-1,2,4-triazol-3-yl)propyl]-2-phenylsulfanylacetamide
    —— N-[(2R,3S)-2-hydroxy-2,3-dimethylpentyl]-2-phenylsulfanylacetamide —— C15H23NO2S
    N-[(2R,3S)-2-hydroxy-2,3-dimethylpentyl]-2-phenylsulfanylacetamide
    —— N-[(1R)-2-methyl-1-(5-methyl-1H-1,2,4-triazol-3-yl)propyl]-2-phenylsulfanylacetamide —— C15H20N4OS
    N-[(1R)-2-methyl-1-(5-methyl-1H-1,2,4-triazol-3-yl)propyl]-2-phenylsulfanylacetamide
    —— N-[(2R,3R)-2-hydroxy-2,3-dimethylpentyl]-2-phenylsulfanylacetamide —— C15H23NO2S
    N-[(2R,3R)-2-hydroxy-2,3-dimethylpentyl]-2-phenylsulfanylacetamide
    —— N-[(2S)-2-methyl-3-(2-methyl-1,3-dioxolan-2-yl)propyl]-2-phenylsulfanylacetamide —— C16H23NO3S
    N-[(2S)-2-methyl-3-(2-methyl-1,3-dioxolan-2-yl)propyl]-2-phenylsulfanylacetamide
    —— N-[(2S,3R)-2-hydroxy-2,3-dimethylpentyl]-2-phenylsulfanylacetamide —— C15H23NO2S
    N-[(2S,3R)-2-hydroxy-2,3-dimethylpentyl]-2-phenylsulfanylacetamide
    —— N-[(2R)-2-methyl-3-(2-methyl-1,3-dioxolan-2-yl)propyl]-2-phenylsulfanylacetamide —— C16H23NO3S
    N-[(2R)-2-methyl-3-(2-methyl-1,3-dioxolan-2-yl)propyl]-2-phenylsulfanylacetamide
    —— N-[(2S,3S)-2-hydroxy-2,3-dimethylpentyl]-2-phenylsulfanylacetamide —— C15H23NO2S
    N-[(2S,3S)-2-hydroxy-2,3-dimethylpentyl]-2-phenylsulfanylacetamide
    —— N-benzyl-2-[5-[[2-[(4-fluorophenyl)methylsulfanyl]-1-methyl-4-oxopyrimidin-5-yl]methyl]-2-oxopyrimidin-1-yl]-N-methylacetamide —— C27H26FN5O3S
    N-benzyl-2-[5-[[2-[(4-fluorophenyl)methylsulfanyl]-1-methyl-4-oxopyrimidin-5-yl]methyl]-2-oxopyrimidin-1-yl]-N-methylacetamide
    —— N-[(2S)-2-methyl-3-(2-methyl-1,3-dioxolan-2-yl)propyl]-2-(4-methylphenyl)sulfanylacetamide —— C17H25NO3S
    N-[(2S)-2-methyl-3-(2-methyl-1,3-dioxolan-2-yl)propyl]-2-(4-methylphenyl)sulfanylacetamide
    —— N-[[4-(aminomethylideneamino)phenyl]methyl]-2-[2-(5-amino-2-methylsulfanylphenyl)-3-chloro-6-oxo-5-(propan-2-ylamino)pyrazin-1-yl]acetamide —— C24H28ClN7O2S
    N-[[4-(aminomethylideneamino)phenyl]methyl]-2-[2-(5-amino-2-methylsulfanylphenyl)-3-chloro-6-oxo-5-(propan-2-ylamino)pyrazin-1-yl]acetamide
    —— 2-[5-(3-Amino-2,3-dioxopropyl)-7-benzyl-6-ethyl-2-phenylsulfanylpyrrolo[2,3-d]pyrimidin-4-yl]oxyacetic acid —— C26H24N4O5S
    2-[5-(3-Amino-2,3-dioxopropyl)-7-benzyl-6-ethyl-2-phenylsulfanylpyrrolo[2,3-d]pyrimidin-4-yl]oxyacetic acid
    —— N-[(2R)-2-methyl-3-(2-methyl-1,3-dioxolan-2-yl)propyl]-2-(4-methylphenyl)sulfanylacetamide —— C17H25NO3S
    N-[(2R)-2-methyl-3-(2-methyl-1,3-dioxolan-2-yl)propyl]-2-(4-methylphenyl)sulfanylacetamide
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2S)-2-(5-ethylfuran-2-yl)azepan-1-yl]ethanone —— C22H24ClN3O3S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2S)-2-(5-ethylfuran-2-yl)azepan-1-yl]ethanone
    —— 5-[3-[(2R)-2-(5-ethylfuran-2-yl)azepan-1-yl]-3-oxopropyl]-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one —— C21H29N3O3S
    5-[3-[(2R)-2-(5-ethylfuran-2-yl)azepan-1-yl]-3-oxopropyl]-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2R)-2-(5-ethylfuran-2-yl)azepan-1-yl]ethanone —— C22H24ClN3O3S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-[(2R)-2-(5-ethylfuran-2-yl)azepan-1-yl]ethanone
    —— 5-[3-[(2S)-2-(5-ethylfuran-2-yl)azepan-1-yl]-3-oxopropyl]-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one —— C21H29N3O3S
    5-[3-[(2S)-2-(5-ethylfuran-2-yl)azepan-1-yl]-3-oxopropyl]-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one
    —— 2-[[2-[(1R)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole —— C19H23N3O2S2
    2-[[2-[(1R)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-[[2-[(1S)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C19H23N3O2S2
    2-[[2-[(1S)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-[[2-[(1S)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole —— C19H23N3O2S2
    2-[[2-[(1S)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 2-[[2-[(1R)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole —— C19H23N3O2S2
    2-[[2-[(1R)-1-ethoxyethyl]-1,3-thiazol-4-yl]methylsulfanyl]-5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazole
    —— 6,7-Dichloro-2-isopropyl-3-(5-cyclopropylmethylsulfanyl-1,3,4-thiadiazol-2-ylsulfanyl)quinoxaline —— C17H16Cl2N4S3
    6,7-Dichloro-2-isopropyl-3-(5-cyclopropylmethylsulfanyl-1,3,4-thiadiazol-2-ylsulfanyl)quinoxaline
    —— 5-(2-Anilinopyrimidin-4-yl)-4-(4-chlorophenyl)-2-methylsulfanylthiophene-3-carbonitrile —— C22H15ClN4S2
    5-(2-Anilinopyrimidin-4-yl)-4-(4-chlorophenyl)-2-methylsulfanylthiophene-3-carbonitrile
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-[1-[[(3S)-oxolan-3-yl]methyl]piperidin-4-yl]pyridine-3-carboxamide —— C24H31N3O2S
    2-(3,4-dimethylphenyl)sulfanyl-N-[1-[[(3S)-oxolan-3-yl]methyl]piperidin-4-yl]pyridine-3-carboxamide
    —— 2-(3-bromopyridin-2-yl)sulfanyl-N-[(1S)-3-methyl-1-phenylbutyl]acetamide —— C18H21BrN2OS
    2-(3-bromopyridin-2-yl)sulfanyl-N-[(1S)-3-methyl-1-phenylbutyl]acetamide
    —— N-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-ylmethyl)-2-[(2S)-4-propan-2-ylmorpholin-2-yl]acetamide —— C15H24N4O2S
    N-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-ylmethyl)-2-[(2S)-4-propan-2-ylmorpholin-2-yl]acetamide
    —— 2-(3-bromopyridin-2-yl)sulfanyl-N-[(1R)-3-methyl-1-phenylbutyl]acetamide —— C18H21BrN2OS
    2-(3-bromopyridin-2-yl)sulfanyl-N-[(1R)-3-methyl-1-phenylbutyl]acetamide
    —— 2-[(1R)-1-(3-bromopyridin-2-yl)sulfanylethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole —— C16H14BrN3OS
    2-[(1R)-1-(3-bromopyridin-2-yl)sulfanylethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-[1-[[(3R)-oxolan-3-yl]methyl]piperidin-4-yl]pyridine-3-carboxamide —— C24H31N3O2S
    2-(3,4-dimethylphenyl)sulfanyl-N-[1-[[(3R)-oxolan-3-yl]methyl]piperidin-4-yl]pyridine-3-carboxamide
    —— 2-[(1S)-1-(3-bromopyridin-2-yl)sulfanylethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole —— C16H14BrN3OS
    2-[(1S)-1-(3-bromopyridin-2-yl)sulfanylethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole
    —— 2-[(6-methylpyridin-3-yl)methyl]-5-(8-phenyloctylsulfanyl)-1H-pyrimidin-6-one —— C25H31N3OS
    2-[(6-methylpyridin-3-yl)methyl]-5-(8-phenyloctylsulfanyl)-1H-pyrimidin-6-one
    —— 3-[5-[3-Fluoro-5-(4-methoxyoxan-4-yl)phenyl]sulfanyl-2-(methylamino)phenyl]propanoic acid —— C22H26FNO4S
    3-[5-[3-Fluoro-5-(4-methoxyoxan-4-yl)phenyl]sulfanyl-2-(methylamino)phenyl]propanoic acid
    —— N-[4-[4-[(2,2-dimethylcyclopropanecarbonyl)amino]phenyl]sulfanylphenyl]-2,2-dimethylcyclopropane-1-carboxamide —— C24H28N2O2S
    N-[4-[4-[(2,2-dimethylcyclopropanecarbonyl)amino]phenyl]sulfanylphenyl]-2,2-dimethylcyclopropane-1-carboxamide
    —— (6S)-8-chloro-6-(4-methylpiperazin-1-yl)-5,6-dihydropyrrolo[2,1-b][1,3]benzothiazepine;dihydrochloride —— C17H22Cl3N3S
    (6S)-8-chloro-6-(4-methylpiperazin-1-yl)-5,6-dihydropyrrolo[2,1-b][1,3]benzothiazepine;dihydrochloride
    —— 5-(6,7-difluoroquinazolin-4-yl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine —— C15H13F2N5OS2
    5-(6,7-difluoroquinazolin-4-yl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine
    —— 5-(6,7-difluoroquinazolin-4-yl)sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine —— C15H13F2N5OS2
    5-(6,7-difluoroquinazolin-4-yl)sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine
    —— 5-(4'-Cyanobenzyl)-1-[2-(3"methylphenylthio)pyrid-5-ylmethyl)imidazole —— C24H20N4S
    5-(4'-Cyanobenzyl)-1-[2-(3"methylphenylthio)pyrid-5-ylmethyl)imidazole
    —— 7-[[2-Hydroxy-1-(hydroxymethyl)ethyl]amino]-5-[[(2-methyl-4-thiazolyl)methyl] thio]thiazolo[4,5-d]pyrimidin-2(3H)-one —— C13H15N5O3S3
    7-[[2-Hydroxy-1-(hydroxymethyl)ethyl]amino]-5-[[(2-methyl-4-thiazolyl)methyl] thio]thiazolo[4,5-d]pyrimidin-2(3H)-one
    —— 5-[(2,3-difluorophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C15H14F2N4O2S2
    5-[(2,3-difluorophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— N-[[(5S)-3-[5-(5-aminopyridin-2-yl)sulfanylpyridin-3-yl]-2-oxo-1,3-oxazolidin-5-yl]methyl]ethanethioamide —— C16H17N5O2S2
    N-[[(5S)-3-[5-(5-aminopyridin-2-yl)sulfanylpyridin-3-yl]-2-oxo-1,3-oxazolidin-5-yl]methyl]ethanethioamide