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有机硫化合物

有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在,在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特,在药物设计、合成化学以及材料制备方面扮演着重要角色。

1. 结构与分类

有机硫化合物可以按硫的连接方式分为饱和和不饱和类,如二硫化物、噻吩衍生物、砜等。常见的结构类型有:

  • 二硫化物:含-S-S-键的化合物。
  • 硫醚(Thiols):含有-R-S-H或-R-S-R 基团的化合物。
  • 磺酸酯(Sulfonates)与磺酸盐(Sulfonates):带有-SO3H基团的化合物,广泛应用于合成和制药领域。
  • 噻吩及其衍生物:具有环状结构的有机硫化物。
2. 生物学活性

许多有机硫化合物在生物学上有重要功能或应用潜力。例如:

  • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
  • 硫代葡萄糖苷(Glycosinolate)是十字花科植物中的一种天然存在物质,具有生物活性。
3. 合成方法

有机硫化合物可通过多种途径合成:

  • 亲核取代反应:使用含硫试剂与卤化物进行反应。
  • 自由基加成法:采用氧化剂引发自由基形成,通过烯烃与H2S、R-S-H等反应制备。
  • 金属催化转化:利用钯、铜等催化剂促进特定硫化过程。
4. 应用领域

有机硫化合物的应用广泛:

  • 医药领域:用于开发抗菌剂、抗病毒药物及抗癌药物等。
  • 农学研究:某些有机硫化合物作为生物农药的有效成分,能够抑制病害的发生。
  • 材料科学与技术:在导电聚合物和塑料添加剂中有重要应用。
5. 环境与安全性

尽管有机硫化合物具有许多潜在益处,但其生产和使用也可能对环境造成影响。因此,在设计和合成这些化合物时需要考虑可持续性和环保性因素。

以上是对有机硫化合物的简单介绍,包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

中文名称 英文名称 CAS号 化学式 结构式图片
—— N-(2-methylpropyl)-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C13H22N4O3S
N-(2-methylpropyl)-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
—— 3-[2-(2,5-dichlorothiophen-3-yl)-2-oxoethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C13H13Cl2N3O3S2
3-[2-(2,5-dichlorothiophen-3-yl)-2-oxoethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
—— (2S)-2-[[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide —— C10H16N4O2S3
(2S)-2-[[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide
—— (2R)-2-[[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-cyclopropylpropanamide —— C10H14N4O2S3
(2R)-2-[[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-cyclopropylpropanamide
—— N-(2-methoxyethyl)-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C12H20N4O4S
N-(2-methoxyethyl)-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
—— ethyl N-[2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]acetyl]carbamate —— C11H18N4O5S
ethyl N-[2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]acetyl]carbamate
—— (2S)-N-methyl-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C11H18N4O3S
(2S)-N-methyl-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide
—— (2S)-N-cyclopropyl-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C13H20N4O3S
(2S)-N-cyclopropyl-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide
—— (2S)-2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C9H16N4O3S
(2S)-2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide
—— (2S)-N,N-dimethyl-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C12H20N4O3S
(2S)-N,N-dimethyl-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide
—— (2S)-2-[[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-cyclopropylpropanamide —— C10H14N4O2S3
(2S)-2-[[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-cyclopropylpropanamide
—— 2-[[5-(2-Morpholin-4-yl-2-oxoethyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C10H14N4O3S3
2-[[5-(2-Morpholin-4-yl-2-oxoethyl)sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
—— (2R)-2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide —— C10H18N4O3S
(2R)-2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide
—— 2-[[5-[2-(Methylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C7H10N4O2S3
2-[[5-[2-(Methylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
—— (2S)-2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]-N-propan-2-ylpropanamide —— C12H22N4O3S
(2S)-2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]-N-propan-2-ylpropanamide
—— N-tert-butyl-2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C12H22N4O3S
N-tert-butyl-2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
—— (2R)-N-cyclopropyl-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C13H20N4O3S
(2R)-N-cyclopropyl-2-[[5-oxo-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide
—— 2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]-N-propan-2-ylacetamide —— C11H20N4O3S
2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]-N-propan-2-ylacetamide
—— 3-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C15H23N5O4S
3-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]sulfanyl-4-[[(2S)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
—— methyl N-[2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetyl]carbamate —— C11H16N4O5S
methyl N-[2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetyl]carbamate
—— (2R)-N,N-dimethyl-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C12H20N4O3S
(2R)-N,N-dimethyl-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]propanamide
—— 2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]-N-methylacetamide —— C9H16N4O3S
2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]-N-methylacetamide
—— 2-[[5-[2-(Cyclopropylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C9H12N4O2S3
2-[[5-[2-(Cyclopropylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
—— N-(2-methoxyethyl)-2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C11H20N4O4S
N-(2-methoxyethyl)-2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
—— [(1S)-1-[5-[2-(methoxycarbonylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium —— C11H19N4O4S+
[(1S)-1-[5-[2-(methoxycarbonylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium
—— (2S)-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)propanamide —— C13H24N4O3S
(2S)-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)propanamide
—— dimethyl-[(1R)-1-[5-[(2R)-1-oxo-1-(propan-2-ylamino)propan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium —— C13H25N4O2S+
dimethyl-[(1R)-1-[5-[(2R)-1-oxo-1-(propan-2-ylamino)propan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium
—— 3-[4,6-dimethyl-2-(methylsulfanyl)pyrimidin-5-yl]-N-[(2-fluorophenyl)methyl]propanamide —— C17H20FN3OS
3-[4,6-dimethyl-2-(methylsulfanyl)pyrimidin-5-yl]-N-[(2-fluorophenyl)methyl]propanamide
—— (2R)-N-cyclopropyl-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C13H22N4O2S
(2R)-N-cyclopropyl-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
—— dimethyl-[(1S)-1-[5-[(2R)-1-oxo-1-(prop-2-enylamino)propan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium —— C13H23N4O2S+
dimethyl-[(1S)-1-[5-[(2R)-1-oxo-1-(prop-2-enylamino)propan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium
—— (2R)-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-ethylpropanamide —— C12H22N4O2S
(2R)-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-ethylpropanamide
—— dimethyl-[(1R)-1-[5-[(2S)-1-(methylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium —— C11H21N4O2S+
dimethyl-[(1R)-1-[5-[(2S)-1-(methylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium
—— (2S)-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-prop-2-enylpropanamide —— C13H22N4O2S
(2S)-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-prop-2-enylpropanamide
—— 2-[[5-[(1R)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide —— C13H22N4O4S2
2-[[5-[(1R)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide
—— (2R)-2-[[5-[(1R)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)propanamide —— C13H24N4O3S
(2R)-2-[[5-[(1R)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)propanamide
—— [(1S)-1-[5-[(2S)-1-(cyclopropylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium —— C13H23N4O2S+
[(1S)-1-[5-[(2S)-1-(cyclopropylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium
—— [(1R)-1-[5-[(2R)-1-(cyclopropylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium —— C13H23N4O2S+
[(1R)-1-[5-[(2R)-1-(cyclopropylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium
—— (2S)-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-ethylpropanamide —— C12H22N4O2S
(2S)-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-ethylpropanamide
—— [(1S)-1-[5-[2-(cyclopropylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium —— C12H21N4O2S+
[(1S)-1-[5-[2-(cyclopropylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium
—— dimethyl-[(1S)-1-[5-[(2S)-1-oxo-1-(prop-2-enylamino)propan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium —— C13H23N4O2S+
dimethyl-[(1S)-1-[5-[(2S)-1-oxo-1-(prop-2-enylamino)propan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium
—— dimethyl-[(1S)-1-[5-[(2S)-1-oxo-1-(propan-2-ylamino)propan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium —— C13H25N4O2S+
dimethyl-[(1S)-1-[5-[(2S)-1-oxo-1-(propan-2-ylamino)propan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium
—— (2S)-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C10H18N4O2S
(2S)-2-[[5-[(1S)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
—— dimethyl-[(1R)-1-[5-[(2S)-1-oxo-1-(propan-2-ylamino)propan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium —— C13H25N4O2S+
dimethyl-[(1R)-1-[5-[(2S)-1-oxo-1-(propan-2-ylamino)propan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]azanium
—— (2S)-2-[[5-[(1R)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)propanamide —— C13H24N4O3S
(2S)-2-[[5-[(1R)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methoxyethyl)propanamide
—— [(1S)-1-[5-[(2R)-1-(cyclopropylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium —— C13H23N4O2S+
[(1S)-1-[5-[(2R)-1-(cyclopropylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium
—— (2S)-2-[[5-[(1R)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-prop-2-enylpropanamide —— C13H22N4O2S
(2S)-2-[[5-[(1R)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-prop-2-enylpropanamide
—— [(1R)-1-[5-[2-(2-methoxyethylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium —— C12H23N4O3S+
[(1R)-1-[5-[2-(2-methoxyethylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium
—— [(1R)-1-[5-[2-(cyclopropylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium —— C12H21N4O2S+
[(1R)-1-[5-[2-(cyclopropylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium
—— [(1S)-1-[5-[2-(tert-butylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium —— C13H25N4O2S+
[(1S)-1-[5-[2-(tert-butylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]propyl]-dimethylazanium
—— (2R)-2-[[5-[(1R)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide —— C13H24N4O2S
(2R)-2-[[5-[(1R)-1-(dimethylamino)propyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide