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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 3-Methyl-7-[(2,3,4,5,6-pentafluorophenyl)sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C14H7F5N2OS2
    3-Methyl-7-[(2,3,4,5,6-pentafluorophenyl)sulfanylmethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 2-[4-(Furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-1-(4-methylpiperazin-4-ium-1-yl)ethanone —— C16H18F3N4O2S+
    2-[4-(Furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-1-(4-methylpiperazin-4-ium-1-yl)ethanone
    —— [(1S)-1-[5-[(2-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylpropyl]azanium —— C13H17FN3OS+
    [(1S)-1-[5-[(2-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylpropyl]azanium
    —— 5-[5-[(4-Fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]pentylazanium —— C14H19FN3OS+
    5-[5-[(4-Fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]pentylazanium
    —— (2S)-N-[(Z)-butan-2-ylideneamino]-2-(4-chlorophenyl)sulfanylpropanamide —— C13H17ClN2OS
    (2S)-N-[(Z)-butan-2-ylideneamino]-2-(4-chlorophenyl)sulfanylpropanamide
    —— (2R)-N-cyclopropyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C14H15N3O2S
    (2R)-N-cyclopropyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (4R)-3-acetyl-2-methyl-6-(phenylsulfanylmethylsulfanyl)-4-thiophen-2-yl-3,4-dihydropyridine-5-carbonitrile —— C20H18N2OS3
    (4R)-3-acetyl-2-methyl-6-(phenylsulfanylmethylsulfanyl)-4-thiophen-2-yl-3,4-dihydropyridine-5-carbonitrile
    —— (2R)-N-benzyl-2-(2,4-dimethylphenyl)sulfanylpropanamide —— C18H21NOS
    (2R)-N-benzyl-2-(2,4-dimethylphenyl)sulfanylpropanamide
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C14H15N3O4S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— (4S)-5-acetyl-6-methyl-4-(3-methylthiophen-2-yl)-2-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-3-carbonitrile —— C21H20N2OS3
    (4S)-5-acetyl-6-methyl-4-(3-methylthiophen-2-yl)-2-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-3-carbonitrile
    —— N-[(3-chlorophenyl)methyl]-2-(2,4-dimethylphenyl)sulfanylacetamide —— C17H18ClNOS
    N-[(3-chlorophenyl)methyl]-2-(2,4-dimethylphenyl)sulfanylacetamide
    —— N-cyclohexyl-2-(2,5-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C20H29NO3S2
    N-cyclohexyl-2-(2,5-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— N-benzyl-2-(2,4-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C21H25NO3S2
    N-benzyl-2-(2,4-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— (2R)-2-(2,4-dimethylphenyl)sulfanyl-N-(furan-2-ylmethyl)propanamide —— C16H19NO2S
    (2R)-2-(2,4-dimethylphenyl)sulfanyl-N-(furan-2-ylmethyl)propanamide
    —— N-(1-adamantyl)-2-(2,4-dimethylphenyl)sulfanylacetamide —— C20H27NOS
    N-(1-adamantyl)-2-(2,4-dimethylphenyl)sulfanylacetamide
    —— N-benzyl-2-(2,4-dimethylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide —— C21H25NO3S2
    N-benzyl-2-(2,4-dimethylphenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide
    —— 2-[(2-Bromophenyl)methylsulfanyl]-5-phenyl-1,3,4-oxadiazole —— C15H11BrN2OS
    2-[(2-Bromophenyl)methylsulfanyl]-5-phenyl-1,3,4-oxadiazole
    —— 2-(2,5-Dimethylphenyl)sulfanyl-1-(5-phenyl-3,4-dihydropyrazol-2-yl)ethanone —— C19H20N2OS
    2-(2,5-Dimethylphenyl)sulfanyl-1-(5-phenyl-3,4-dihydropyrazol-2-yl)ethanone
    —— (2R)-2-(2,5-dimethylphenyl)sulfanyl-N-(furan-2-ylmethyl)propanamide —— C16H19NO2S
    (2R)-2-(2,5-dimethylphenyl)sulfanyl-N-(furan-2-ylmethyl)propanamide
    —— 7-[(2,4-Dimethylphenyl)sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C16H16N2OS2
    7-[(2,4-Dimethylphenyl)sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— N-[(2R)-3-methylbutan-2-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C15H19N3O2S
    N-[(2R)-3-methylbutan-2-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]acetamide —— C18H20FNOS
    2-(2,5-dimethylphenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]acetamide
    —— N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H15FN4OS2
    N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 3-(2-methylpropylsulfanyl)-5-thiophen-2-yl-1H-1,2,4-triazole —— C10H13N3S2
    3-(2-methylpropylsulfanyl)-5-thiophen-2-yl-1H-1,2,4-triazole
    —— (3R)-3-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]oxolan-2-one —— C10H9N3O2S2
    (3R)-3-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]oxolan-2-one
    —— 2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetonitrile —— C8H6N4S2
    2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetonitrile
    —— 3-[(4-fluorophenyl)methylsulfanyl]-5-thiophen-2-yl-1H-1,2,4-triazole —— C13H10FN3S2
    3-[(4-fluorophenyl)methylsulfanyl]-5-thiophen-2-yl-1H-1,2,4-triazole
    —— N-(1-cyanocyclohexyl)-2-(3,4-dimethylphenyl)sulfanylacetamide —— C17H22N2OS
    N-(1-cyanocyclohexyl)-2-(3,4-dimethylphenyl)sulfanylacetamide
    —— 5-((3,3-Dimethyl-2-oxobutyl)thio)-4-propyl-2,4-dihydro-3h-1,2,4-triazol-3-one —— C11H19N3O2S
    5-((3,3-Dimethyl-2-oxobutyl)thio)-4-propyl-2,4-dihydro-3h-1,2,4-triazol-3-one
    —— N-(1-adamantyl)-2-(3,4-dimethylphenyl)sulfanylacetamide —— C20H27NOS
    N-(1-adamantyl)-2-(3,4-dimethylphenyl)sulfanylacetamide
    —— 7-[(3,4-Dimethylphenyl)sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C16H16N2OS2
    7-[(3,4-Dimethylphenyl)sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 1-(1-adamantyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C18H21N3OS2
    1-(1-adamantyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-(4-methylcyclohexyl)acetamide —— C17H25NOS
    2-(3,4-dimethylphenyl)sulfanyl-N-(4-methylcyclohexyl)acetamide
    —— N-[(1R,2S)-2-methylcyclohexyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C15H20N4OS2
    N-[(1R,2S)-2-methylcyclohexyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2R)-N-[2-(cyclohexen-1-yl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C17H22N4OS2
    (2R)-N-[2-(cyclohexen-1-yl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(2R)-3-methylbutan-2-yl]-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C12H22N4O2S
    N-[(2R)-3-methylbutan-2-yl]-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— ethyl 2-[2-[2-[[(1S)-1-cyano-1-cyclopropylethyl]amino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate —— C15H19N3O3S2
    ethyl 2-[2-[2-[[(1S)-1-cyano-1-cyclopropylethyl]amino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— 2-(3-chlorophenyl)sulfanyl-N-[(1R,2S)-2-methylcyclohexyl]acetamide —— C15H20ClNOS
    2-(3-chlorophenyl)sulfanyl-N-[(1R,2S)-2-methylcyclohexyl]acetamide
    —— (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H21FN4O2S
    (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (2S)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H21FN4O2S
    (2S)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(1R)-1-(1-adamantyl)ethyl]-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C19H30N4O2S
    N-[(1R)-1-(1-adamantyl)ethyl]-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-thiophen-2-ylethyl]acetamide —— C13H18N4O2S2
    2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-thiophen-2-ylethyl]acetamide
    —— Ethyl 2-[2-[2-(benzylamino)-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate —— C16H18N2O3S2
    Ethyl 2-[2-[2-(benzylamino)-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— N-tert-butyl-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C11H20N4O2S
    N-tert-butyl-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— ethyl 2-[2-[(2S)-1-(cyclopentylamino)-1-oxopropan-2-yl]sulfanyl-1,3-thiazol-4-yl]acetate —— C15H22N2O3S2
    ethyl 2-[2-[(2S)-1-(cyclopentylamino)-1-oxopropan-2-yl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— N-(1-adamantyl)-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C17H26N4O2S
    N-(1-adamantyl)-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 4-propyl-3-benzylthio-Δ<sup>2</sup>-1,2,4-triazolin-5-one —— C12H15N3OS
    4-propyl-3-benzylthio-Δ<sup>2</sup>-1,2,4-triazolin-5-one
    —— ethyl 2-[2-[2-[[(1R)-1-(1-adamantyl)ethyl]amino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate —— C21H30N2O3S2
    ethyl 2-[2-[2-[[(1R)-1-(1-adamantyl)ethyl]amino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— 2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C13H18N4O2S2
    2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— ethyl 2-[2-[2-oxo-2-[[(1R)-1-thiophen-2-ylethyl]amino]ethyl]sulfanyl-1,3-thiazol-4-yl]acetate —— C15H18N2O3S3
    ethyl 2-[2-[2-oxo-2-[[(1R)-1-thiophen-2-ylethyl]amino]ethyl]sulfanyl-1,3-thiazol-4-yl]acetate