哌扎西酯-d10盐酸盐 | 14056-67-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 哌扎西酯-d10盐酸盐
• 中文别名: 睾酮3-(O-羧甲基)肟；盐酸匹哌氮酯
• 英文名称: pipazethate hydrochloride
• 英文别名: 10H-pyrido[3,2-b][1,4]benzothiadiazine-10-carboxylic acid 2-(2-piperidinoethoxy)ethyl ester hydrochloride；benzo[b]pyrido[2,3-e][1,4]thiazine-10-carboxylic acid 2-(2-piperidin-1-yl-ethoxy)-ethyl ester; monohydrochloride；pipazethate; monohydrochloride；pipazetate; monohydrochloride；Hydron;2-(2-piperidin-1-ylethoxy)ethyl pyrido[3,2-b][1,4]benzothiazine-10-carboxylate;chloride
• CAS: 14056-67-8；6056-11-7
• 化学式: C₂₁H₂₅N₃O₃S*ClH
• 分子量: 435.975
• InChiKey: FEUBUXUFKHXRKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.75
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  80.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
  申请人：The Scripps Research Institute

  公开号：US10660899B2

  公开（公告）日：2020-05-26

  The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

  本发明提供了用神经递质受体调节剂诱导少突胶质祖细胞向成熟髓鞘细胞命运分化的方法。本发明还提供了通过施用所述神经递质受体调节剂刺激有需要的受试者增加髓鞘化的方法。本发明还提供了使用神经递质受体调节剂治疗脱髓鞘疾病的方法。
• Verfahren zur Herstellung von Pipazetat
  申请人：ASTA Medica Aktiengesellschaft

  公开号：EP0527298B1

  公开（公告）日：1997-07-30
• DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE
  申请人：Schultz Peter

  公开号：US20140038949A1

  公开（公告）日：2014-02-06

  The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.
• US5446148A
  申请人：——

  公开号：US5446148A

  公开（公告）日：1995-08-29
• US5539107A
  申请人：——

  公开号：US5539107A

  公开（公告）日：1996-07-23