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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— [2-oxo-2-(2-phenylethylamino)ethyl] (2S)-2-(4-chlorophenyl)sulfanylpropanoate —— C19H20ClNO3S
    [2-oxo-2-(2-phenylethylamino)ethyl] (2S)-2-(4-chlorophenyl)sulfanylpropanoate
    —— N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]-2-phenylsulfanylacetamide —— C13H14N2O3S2
    N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]-2-phenylsulfanylacetamide
    —— 1-[1-[(3S)-1,1-dioxothiolan-3-yl]-2,5-dimethylpyrrol-3-yl]-2-phenylsulfanylethanone —— C18H21NO3S2
    1-[1-[(3S)-1,1-dioxothiolan-3-yl]-2,5-dimethylpyrrol-3-yl]-2-phenylsulfanylethanone
    —— 2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-propan-2-ylacetamide —— C8H13N3OS3
    2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-propan-2-ylacetamide
    —— N-(1-adamantyl)-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C15H21N3OS3
    N-(1-adamantyl)-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]-2-phenylsulfanylacetamide —— C13H17NO3S2
    N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]-2-phenylsulfanylacetamide
    —— (5-phenyl-1,3,4-oxadiazol-2-yl)methyl (2R)-2-(4-chlorophenyl)sulfanylpropanoate —— C18H15ClN2O3S
    (5-phenyl-1,3,4-oxadiazol-2-yl)methyl (2R)-2-(4-chlorophenyl)sulfanylpropanoate
    —— N-benzyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-phenylsulfanylacetamide —— C19H21NO3S2
    N-benzyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-phenylsulfanylacetamide
    —— 2-(2-Bromophenyl)-5-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C12H9BrN4OS3
    2-(2-Bromophenyl)-5-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H14ClN3OS3
    N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H14ClN3OS3
    N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 2-[(5-Methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C5H7N3OS3
    2-[(5-Methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-N-cyclopropyl-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C9H13N3OS3
    (2R)-N-cyclopropyl-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (6S)-5-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methyl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylic acid —— C19H19N3O3S
    (6S)-5-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methyl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylic acid
    —— N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-phenylsulfanylacetamide —— C13H17NO3S2
    N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-phenylsulfanylacetamide
    —— (2S)-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C6H9N3OS3
    (2S)-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (5-oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methyl (2S)-2-(4-chlorophenyl)sulfanylpropanoate —— C16H13ClN2O3S2
    (5-oxo-[1,3]thiazolo[3,2-a]pyrimidin-7-yl)methyl (2S)-2-(4-chlorophenyl)sulfanylpropanoate
    —— 1-[1-(Furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C16H17N3O2S3
    1-[1-(Furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— N-(6-amino-2,4-dioxo-1-propylpyrimidin-5-yl)-N-(2-methoxyethyl)-2-phenylsulfanylacetamide —— C18H24N4O4S
    N-(6-amino-2,4-dioxo-1-propylpyrimidin-5-yl)-N-(2-methoxyethyl)-2-phenylsulfanylacetamide
    —— [(3R)-3-cyano-4-imino-2-oxopentyl] (2S)-2-(4-chlorophenyl)sulfanylpropanoate —— C15H15ClN2O3S
    [(3R)-3-cyano-4-imino-2-oxopentyl] (2S)-2-(4-chlorophenyl)sulfanylpropanoate
    —— [2-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxoethyl] (2R)-2-(4-chlorophenyl)sulfanylpropanoate —— C19H20ClNO4S
    [2-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxoethyl] (2R)-2-(4-chlorophenyl)sulfanylpropanoate
    —— N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide —— C20H20N2O3S
    N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide
    —— (6R)-5-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methyl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylic acid —— C19H19N3O3S
    (6R)-5-[[5-(4-methylphenyl)sulfanylfuran-2-yl]methyl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylic acid
    —— 1-(1-Ethyl-2,5-dimethylpyrrol-3-yl)-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C19H21N3O2S
    1-(1-Ethyl-2,5-dimethylpyrrol-3-yl)-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H19N3O4S2
    N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H19N3O4S2
    N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(4-fluorophenyl)methyl]-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-methylacetamide —— C17H17FN4O2S
    N-[(4-fluorophenyl)methyl]-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-methylacetamide
    —— N-[[(2S)-butan-2-yl]carbamoyl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H20N4O3S
    N-[[(2S)-butan-2-yl]carbamoyl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— dimethyl-[(1R)-2-[[2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]amino]-1-phenylethyl]azanium —— C21H25N4O2S+
    dimethyl-[(1R)-2-[[2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]amino]-1-phenylethyl]azanium
    —— N-cyclohexyl-2-[[4-cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C20H28N4O2S
    N-cyclohexyl-2-[[4-cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[[(1S,2S)-2-methylcyclohexyl]carbamoyl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H24N4O3S
    N-[[(1S,2S)-2-methylcyclohexyl]carbamoyl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-2-[(4-cyclohexyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]propanamide —— C20H27FN4OS
    (2R)-2-[(4-cyclohexyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]propanamide
    —— (3S)-3-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one —— C11H11N3O3S
    (3S)-3-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one
    —— 1-[2-[[4-Cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]pyrrolidin-2-one —— C18H22N4O3S
    1-[2-[[4-Cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]pyrrolidin-2-one
    —— 2-[[4-cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide —— C21H23FN4O2S
    2-[[4-cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide
    —— N-[(2R)-2-(dimethylamino)-2-phenylethyl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C21H24N4O2S
    N-[(2R)-2-(dimethylamino)-2-phenylethyl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[4-cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S,2R)-2-methylcyclohexyl]acetamide —— C21H30N4O2S
    2-[[4-cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S,2R)-2-methylcyclohexyl]acetamide
    —— N-[(4-chlorophenyl)methyl]-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-methylacetamide —— C17H17ClN4O2S
    N-[(4-chlorophenyl)methyl]-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-methylacetamide
    —— N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C17H17ClN4O2S
    N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 1-(2,5-Dimethyl-1-propan-2-ylpyrrol-3-yl)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C18H22N4O2S
    1-(2,5-Dimethyl-1-propan-2-ylpyrrol-3-yl)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— 2-[[4-Cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-(1-ethyl-2,5-dimethylpyrrol-3-yl)ethanone —— C22H28N4O2S
    2-[[4-Cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-(1-ethyl-2,5-dimethylpyrrol-3-yl)ethanone
    —— methyl (2R)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate —— C13H14N2O3S
    methyl (2R)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate
    —— 2-[[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-(4-methylphenyl)-1,3,4-oxadiazole —— C19H14ClN3OS2
    2-[[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-(4-methylphenyl)-1,3,4-oxadiazole
    —— N-[(1S)-1-(1-adamantyl)ethyl]-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C21H28N4O2S
    N-[(1S)-1-(1-adamantyl)ethyl]-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[(2S)-butan-2-yl]-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H25N3O4S2
    N-[(2S)-butan-2-yl]-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— (2S)-N-(cyclohexylcarbamoyl)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C19H24N4O3S
    (2S)-N-(cyclohexylcarbamoyl)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— ethyl 5-[(2R)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C19H22N4O4S
    ethyl 5-[(2R)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C13H16N4O4S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— (2R)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]propanamide —— C17H24N4O2S
    (2R)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]propanamide
    —— N-(2-cyanoethyl)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-methylacetamide —— C13H15N5O2S
    N-(2-cyanoethyl)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-methylacetamide