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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(1S)-1-(1-adamantyl)ethyl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide —— C21H32N4OS
    N-[(1S)-1-(1-adamantyl)ethyl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide
    —— N'-acetyl-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetohydrazide —— C11H17N5O2S
    N'-acetyl-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetohydrazide
    —— (2R)-N-(furan-2-ylmethyl)-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)propanamide —— C15H20N4O2S
    (2R)-N-(furan-2-ylmethyl)-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)propanamide
    —— N-(2-benzylsulfanylethyl)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C19H22N4OS3
    N-(2-benzylsulfanylethyl)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-tert-butyl-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide —— C13H22N4OS
    N-tert-butyl-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)acetamide
    —— (9aS)-3-cyclohexyl-7,8,9,9a-tetrahydro-6H-[1,2,4]triazolo[4,3-b][4,1,2]benzothiadiazine —— C14H20N4S
    (9aS)-3-cyclohexyl-7,8,9,9a-tetrahydro-6H-[1,2,4]triazolo[4,3-b][4,1,2]benzothiadiazine
    —— (2R)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2S)-4-phenylbutan-2-yl]propanamide —— C16H22N4OS
    (2R)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2S)-4-phenylbutan-2-yl]propanamide
    —— [2-[4-(2,5-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] 2-fluorobenzoate —— C23H20FNO3S
    [2-[4-(2,5-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] 2-fluorobenzoate
    —— N-[(1S)-1-(2-bromophenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C13H15BrN4OS
    N-[(1S)-1-(2-bromophenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 2-chloropyridine-3-carboxylate —— C20H15ClN2O3S
    [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 2-chloropyridine-3-carboxylate
    —— 1-[2,5-Dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C14H15N5OS2
    1-[2,5-Dimethyl-1-(1,3-thiazol-2-yl)pyrrol-3-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— (2R)-N-(1-adamantyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H24N4OS
    (2R)-N-(1-adamantyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(1S)-1-(2,4-difluorophenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C13H14F2N4OS
    N-[(1S)-1-(2,4-difluorophenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 2-(Furan-2-yl)-5-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C10H9N5O2S
    2-(Furan-2-yl)-5-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— 2-(3-Bromophenyl)-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazole —— C13H11BrN4S2
    2-(3-Bromophenyl)-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazole
    —— 4-[(4-Methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-2-thiophen-2-yl-1,3-oxazole —— C11H10N4OS2
    4-[(4-Methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-2-thiophen-2-yl-1,3-oxazole
    —— (2S)-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C19H18ClN5O2S
    (2S)-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— N-[(1R)-1-(3,4-dimethylphenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C15H20N4OS
    N-[(1R)-1-(3,4-dimethylphenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-[(1S)-1-(3,4-dimethylphenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C15H20N4OS
    N-[(1S)-1-(3,4-dimethylphenyl)ethyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2R)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C19H18ClN5O2S
    (2R)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C19H20N4OS2
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2R)-N-[(1S,2S)-2-methylcyclohexyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C13H22N4OS
    (2R)-N-[(1S,2S)-2-methylcyclohexyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 2-(4-Chlorophenyl)-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazole —— C13H11ClN4S2
    2-(4-Chlorophenyl)-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazole
    —— N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C19H20N4OS2
    N-[4-(3,4-dimethylphenyl)sulfanylphenyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2S)-N-(1-adamantyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H24N4OS
    (2S)-N-(1-adamantyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 1-[2,5-dimethyl-1-[(1S)-1-phenylethyl]pyrrol-3-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C19H22N4OS
    1-[2,5-dimethyl-1-[(1S)-1-phenylethyl]pyrrol-3-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— (2R)-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C19H18ClN5O2S
    (2R)-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— 2-[[5-[2-(dimethylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dimethylacetamide —— C10H16N4O2S3
    2-[[5-[2-(dimethylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dimethylacetamide
    —— 2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-2-phenylpropyl]acetamide —— C14H18N4OS
    2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-2-phenylpropyl]acetamide
    —— (2R)-N-cyclopropyl-2-[[5-[(2R)-1-(cyclopropylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C14H20N4O2S3
    (2R)-N-cyclopropyl-2-[[5-[(2R)-1-(cyclopropylamino)-1-oxopropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— 1-[(2R)-2,3-dihydroxypropyl]-3-[2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfanyl]phenyl]-1-methylurea —— C16H22N4O3S
    1-[(2R)-2,3-dihydroxypropyl]-3-[2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfanyl]phenyl]-1-methylurea
    —— N-(3-methylphenyl)-5-(3-phenylpropylsulfanyl)-1,3,4-thiadiazol-2-amine —— C18H19N3S2
    N-(3-methylphenyl)-5-(3-phenylpropylsulfanyl)-1,3,4-thiadiazol-2-amine
    —— N-(3-methylphenyl)-5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C17H17N3S2
    N-(3-methylphenyl)-5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(3-methylphenyl)-5-[(2-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C17H17N3S2
    N-(3-methylphenyl)-5-[(2-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— (2R)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]cyclohexan-1-one —— C15H17N3OS2
    (2R)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]cyclohexan-1-one
    —— 4-[[5-(3-Methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-thiophen-2-ylbutan-1-one —— C17H17N3OS3
    4-[[5-(3-Methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-thiophen-2-ylbutan-1-one
    —— 5-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-N-(3-methylphenyl)-1,3,4-thiadiazol-2-amine —— C17H16ClN3S2
    5-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-N-(3-methylphenyl)-1,3,4-thiadiazol-2-amine
    —— N-methyl-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-methylphenyl)methyl]acetamide —— C20H22N4OS2
    N-methyl-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-methylphenyl)methyl]acetamide
    —— N-(3-methylphenyl)-5-[(2-thiophen-2-yl-1,3-oxazol-4-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C17H14N4OS3
    N-(3-methylphenyl)-5-[(2-thiophen-2-yl-1,3-oxazol-4-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— (2R)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-pyrrolidin-1-ylpropan-1-one —— C16H20N4OS2
    (2R)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-pyrrolidin-1-ylpropan-1-one
    —— (2R)-N-benzyl-N-methyl-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C20H22N4OS2
    (2R)-N-benzyl-N-methyl-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— N-[(2R)-1-methoxypropan-2-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C14H17N3O3S
    N-[(2R)-1-methoxypropan-2-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 1-(5-Phenyl-3,4-dihydropyrazol-2-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C19H16N4O2S
    1-(5-Phenyl-3,4-dihydropyrazol-2-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— 2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(1H-pyrrol-2-yl)ethanone —— C14H11N3O2S
    2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(1H-pyrrol-2-yl)ethanone
    —— N-(2-cyanoethyl)-N-methyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C14H14N4O2S
    N-(2-cyanoethyl)-N-methyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]cyclohexan-1-one —— C14H14N2O2S
    (2R)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]cyclohexan-1-one
    —— N-[(2S)-butan-2-yl]-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C18H23N3O4S2
    N-[(2S)-butan-2-yl]-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-1-(1-adamantyl)-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]propan-1-one —— C17H22F3N3OS
    (2R)-1-(1-adamantyl)-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]propan-1-one
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-methyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H20N4O3S3
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-methyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-(4-methylphenyl)-4-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazol-2-amine —— C17H15N5S3
    N-(4-methylphenyl)-4-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazol-2-amine