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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(Z)-(5-bromo-2-fluorophenyl)methylideneamino]-2-[[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C19H16BrFN4OS3
    N-[(Z)-(5-bromo-2-fluorophenyl)methylideneamino]-2-[[5-[(4-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[(2R)-2-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]propyl]acetamide —— C19H26N6O2S2
    2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[(2R)-2-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]propyl]acetamide
    —— 2-[4-[(1S)-1-(4-methylsulfanylphenyl)ethyl]-1,4-diazepan-1-yl]ethanamine —— C16H27N3S
    2-[4-[(1S)-1-(4-methylsulfanylphenyl)ethyl]-1,4-diazepan-1-yl]ethanamine
    —— 3-[4-[(1S)-1-(4-methylsulfanylphenyl)ethyl]piperazin-1-yl]propan-1-amine —— C16H27N3S
    3-[4-[(1S)-1-(4-methylsulfanylphenyl)ethyl]piperazin-1-yl]propan-1-amine
    —— (3S)-3-piperidin-4-yl-3-(4-propan-2-ylsulfanylphenyl)propan-1-ol —— C17H27NOS
    (3S)-3-piperidin-4-yl-3-(4-propan-2-ylsulfanylphenyl)propan-1-ol
    —— (3R)-3-piperidin-4-yl-3-(4-propan-2-ylsulfanylphenyl)propan-1-ol —— C17H27NOS
    (3R)-3-piperidin-4-yl-3-(4-propan-2-ylsulfanylphenyl)propan-1-ol
    —— 3-[2-(4-Ethylsulfanylphenyl)-1,3-thiazol-4-yl]propanoic acid —— C14H15NO2S2
    3-[2-(4-Ethylsulfanylphenyl)-1,3-thiazol-4-yl]propanoic acid
    —— 2-[4-[(1R)-1-(4-methylsulfanylphenyl)ethyl]-1,4-diazepan-1-yl]ethanamine —— C16H27N3S
    2-[4-[(1R)-1-(4-methylsulfanylphenyl)ethyl]-1,4-diazepan-1-yl]ethanamine
    —— 3-[3-(4-ethylsulfanylphenyl)-1,2-thiazol-5-yl]propanoic acid —— C14H15NO2S2
    3-[3-(4-ethylsulfanylphenyl)-1,2-thiazol-5-yl]propanoic acid
    —— 4-[4-(4-methylsulfanylphenyl)-1,3-thiazol-2-yl]butanoic acid —— C14H15NO2S2
    4-[4-(4-methylsulfanylphenyl)-1,3-thiazol-2-yl]butanoic acid
    —— 2-[4-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]piperazin-1-yl]ethanamine —— C16H27N3S
    2-[4-[(1R)-1-(4-ethylsulfanylphenyl)ethyl]piperazin-1-yl]ethanamine
    —— 2-[4-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]piperazin-1-yl]ethanamine —— C16H27N3S
    2-[4-[(1S)-1-(4-ethylsulfanylphenyl)ethyl]piperazin-1-yl]ethanamine
    —— [(Z)-[1-methyl-5-phenylsulfanyl-3-(trifluoromethyl)pyrazol-4-yl]methylideneamino] benzoate —— C19H14F3N3O2S
    [(Z)-[1-methyl-5-phenylsulfanyl-3-(trifluoromethyl)pyrazol-4-yl]methylideneamino] benzoate
    —— 1-[2-methyl-4-(4-methylsulfanylphenyl)butan-2-yl]-1,4-diazepane —— C17H28N2S
    1-[2-methyl-4-(4-methylsulfanylphenyl)butan-2-yl]-1,4-diazepane
    —— 4-[4-(4-ethylsulfanylphenyl)-1,3-thiazol-2-yl]butan-1-amine —— C15H20N2S2
    4-[4-(4-ethylsulfanylphenyl)-1,3-thiazol-2-yl]butan-1-amine
    —— 6-(4-cyclopentylsulfanylphenyl)-2-methylhexan-2-ol —— C18H28OS
    6-(4-cyclopentylsulfanylphenyl)-2-methylhexan-2-ol
    —— 1-[4-(4-ethylsulfanylphenyl)-2-methylbutan-2-yl]piperazine —— C17H28N2S
    1-[4-(4-ethylsulfanylphenyl)-2-methylbutan-2-yl]piperazine
    —— 3-[4-(4-propan-2-ylsulfanylphenyl)-1,3-thiazol-2-yl]propan-1-amine —— C15H20N2S2
    3-[4-(4-propan-2-ylsulfanylphenyl)-1,3-thiazol-2-yl]propan-1-amine
    —— 1-piperazin-1-yl-3-(4-propan-2-ylsulfanylphenyl)propan-1-one —— C16H24N2OS
    1-piperazin-1-yl-3-(4-propan-2-ylsulfanylphenyl)propan-1-one
    —— 3-[5-(4-propan-2-ylsulfanylphenyl)-1,3,4-oxadiazol-2-yl]propanoic acid —— C14H16N2O3S
    3-[5-(4-propan-2-ylsulfanylphenyl)-1,3,4-oxadiazol-2-yl]propanoic acid
    —— 6-(4-cyclopentylsulfanylphenyl)-2-methylhexan-2-amine —— C18H29NS
    6-(4-cyclopentylsulfanylphenyl)-2-methylhexan-2-amine
    —— 3-chloro-5-(4-cyclopentylsulfanylphenyl)-1,2,4-triazine —— C14H14ClN3S
    3-chloro-5-(4-cyclopentylsulfanylphenyl)-1,2,4-triazine
    —— [5-(4-cyclopentylsulfanylphenyl)-1,3,4-thiadiazol-2-yl]methanamine —— C14H17N3S2
    [5-(4-cyclopentylsulfanylphenyl)-1,3,4-thiadiazol-2-yl]methanamine
    —— 2-[3-methyl-5-(4-propan-2-ylsulfanylphenyl)-1,2-oxazol-4-yl]acetic acid —— C15H17NO3S
    2-[3-methyl-5-(4-propan-2-ylsulfanylphenyl)-1,2-oxazol-4-yl]acetic acid
    —— 3-[5-(4-propan-2-ylsulfanylphenyl)-1,2-oxazol-3-yl]propanoic acid —— C15H17NO3S
    3-[5-(4-propan-2-ylsulfanylphenyl)-1,2-oxazol-3-yl]propanoic acid
    —— 3-[5-(4-ethylsulfanylphenyl)-3-methyl-1,2-oxazol-4-yl]propanoic acid —— C15H17NO3S
    3-[5-(4-ethylsulfanylphenyl)-3-methyl-1,2-oxazol-4-yl]propanoic acid
    —— N-[(Z)-[3-bromo-4-(dimethylamino)phenyl]methylideneamino]-2-pyrimidin-2-ylsulfanylacetamide —— C15H16BrN5OS
    N-[(Z)-[3-bromo-4-(dimethylamino)phenyl]methylideneamino]-2-pyrimidin-2-ylsulfanylacetamide
    —— 2-(4-methylsulfanylphenyl)imidazo[2,1-b][1,3,4]thiadiazole-6-carboxylic acid —— C12H9N3O2S2
    2-(4-methylsulfanylphenyl)imidazo[2,1-b][1,3,4]thiadiazole-6-carboxylic acid
    —— (6E)-4-chloro-6-[[2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfanyl]anilino]methylidene]cyclohexa-2,4-dien-1-one —— C18H16ClN3OS
    (6E)-4-chloro-6-[[2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfanyl]anilino]methylidene]cyclohexa-2,4-dien-1-one
    —— (2R)-N-[(Z)-(4-bromophenyl)methylideneamino]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylpropanamide —— C16H17BrN4OS
    (2R)-N-[(Z)-(4-bromophenyl)methylideneamino]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylpropanamide
    —— 2-[2-(4-methylsulfanylphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl]ethanamine —— C13H14N4S2
    2-[2-(4-methylsulfanylphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl]ethanamine
    —— [2-(4-cyclopentylsulfanylphenyl)-1,3-thiazol-4-yl]methanamine —— C15H18N2S2
    [2-(4-cyclopentylsulfanylphenyl)-1,3-thiazol-4-yl]methanamine
    —— 2-(4-propan-2-ylsulfanylphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-amine —— C13H14N4S2
    2-(4-propan-2-ylsulfanylphenyl)imidazo[2,1-b][1,3,4]thiadiazol-6-amine
    —— 2-[4-(1,4-diazepan-1-yl)phenyl]-5-methylsulfanyl-1,3,4-oxadiazole —— C14H18N4OS
    2-[4-(1,4-diazepan-1-yl)phenyl]-5-methylsulfanyl-1,3,4-oxadiazole
    —— (2R,4R)-2-(4-methylsulfanylphenyl)-4-piperidin-4-ylcyclopentan-1-one —— C17H23NOS
    (2R,4R)-2-(4-methylsulfanylphenyl)-4-piperidin-4-ylcyclopentan-1-one
    —— [4-(4-cyclopentylsulfanylphenyl)thiophen-3-yl]methanamine —— C16H19NS2
    [4-(4-cyclopentylsulfanylphenyl)thiophen-3-yl]methanamine
    —— 2-[3-(4-methylsulfanylphenyl)imidazo[5,1-b][1,3]thiazol-5-yl]ethanamine —— C14H15N3S2
    2-[3-(4-methylsulfanylphenyl)imidazo[5,1-b][1,3]thiazol-5-yl]ethanamine
    —— (2R,4S)-2-(4-methylsulfanylphenyl)-4-piperidin-4-ylcyclopentan-1-one —— C17H23NOS
    (2R,4S)-2-(4-methylsulfanylphenyl)-4-piperidin-4-ylcyclopentan-1-one
    —— (2S,4R)-2-(4-methylsulfanylphenyl)-4-piperidin-4-ylcyclopentan-1-one —— C17H23NOS
    (2S,4R)-2-(4-methylsulfanylphenyl)-4-piperidin-4-ylcyclopentan-1-one
    —— (2S,4S)-2-(4-methylsulfanylphenyl)-4-piperidin-4-ylcyclopentan-1-one —— C17H23NOS
    (2S,4S)-2-(4-methylsulfanylphenyl)-4-piperidin-4-ylcyclopentan-1-one
    —— 3-(4-propan-2-ylsulfanylphenyl)imidazo[5,1-b][1,3]thiazol-5-amine —— C14H15N3S2
    3-(4-propan-2-ylsulfanylphenyl)imidazo[5,1-b][1,3]thiazol-5-amine
    —— 2-[4-(4-ethylsulfanylphenyl)-6-methyl-1,3,5-triazin-2-yl]acetic acid —— C14H15N3O2S
    2-[4-(4-ethylsulfanylphenyl)-6-methyl-1,3,5-triazin-2-yl]acetic acid
    —— 3-(4-propan-2-ylsulfanylphenyl)imidazo[2,1-b][1,3]thiazol-6-amine —— C14H15N3S2
    3-(4-propan-2-ylsulfanylphenyl)imidazo[2,1-b][1,3]thiazol-6-amine
    —— 2-[5-(4-cyclopentylsulfanylphenyl)-1,3,4-oxadiazol-2-yl]ethanamine —— C15H19N3OS
    2-[5-(4-cyclopentylsulfanylphenyl)-1,3,4-oxadiazol-2-yl]ethanamine
    —— 5-(4-cyclopentylsulfanylphenyl)-1,2-oxazole-4-carboxylic acid —— C15H15NO3S
    5-(4-cyclopentylsulfanylphenyl)-1,2-oxazole-4-carboxylic acid
    —— [5-(4-cyclopentylsulfanylphenyl)-3-methyl-1,2-oxazol-4-yl]methanamine —— C16H20N2OS
    [5-(4-cyclopentylsulfanylphenyl)-3-methyl-1,2-oxazol-4-yl]methanamine
    —— 2-[5-(4-cyclopentylsulfanylphenyl)-1,2-oxazol-3-yl]ethanamine —— C16H20N2OS
    2-[5-(4-cyclopentylsulfanylphenyl)-1,2-oxazol-3-yl]ethanamine
    —— 5-(4-cyclopentylsulfanylphenyl)thiophene-2-carbaldehyde —— C16H16OS2
    5-(4-cyclopentylsulfanylphenyl)thiophene-2-carbaldehyde
    —— 2-[4-methyl-6-(4-propan-2-ylsulfanylphenyl)-1,3,5-triazin-2-yl]ethanamine —— C15H20N4S
    2-[4-methyl-6-(4-propan-2-ylsulfanylphenyl)-1,3,5-triazin-2-yl]ethanamine
    —— 2-[3-(4-propan-2-ylsulfanylphenyl)pyrazin-2-yl]acetic acid —— C15H16N2O2S
    2-[3-(4-propan-2-ylsulfanylphenyl)pyrazin-2-yl]acetic acid