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有机硫化合物

有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在,在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特,在药物设计、合成化学以及材料制备方面扮演着重要角色。

1. 结构与分类

有机硫化合物可以按硫的连接方式分为饱和和不饱和类,如二硫化物、噻吩衍生物、砜等。常见的结构类型有:

  • 二硫化物:含-S-S-键的化合物。
  • 硫醚(Thiols):含有-R-S-H或-R-S-R 基团的化合物。
  • 磺酸酯(Sulfonates)与磺酸盐(Sulfonates):带有-SO3H基团的化合物,广泛应用于合成和制药领域。
  • 噻吩及其衍生物:具有环状结构的有机硫化物。
2. 生物学活性

许多有机硫化合物在生物学上有重要功能或应用潜力。例如:

  • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
  • 硫代葡萄糖苷(Glycosinolate)是十字花科植物中的一种天然存在物质,具有生物活性。
3. 合成方法

有机硫化合物可通过多种途径合成:

  • 亲核取代反应:使用含硫试剂与卤化物进行反应。
  • 自由基加成法:采用氧化剂引发自由基形成,通过烯烃与H2S、R-S-H等反应制备。
  • 金属催化转化:利用钯、铜等催化剂促进特定硫化过程。
4. 应用领域

有机硫化合物的应用广泛:

  • 医药领域:用于开发抗菌剂、抗病毒药物及抗癌药物等。
  • 农学研究:某些有机硫化合物作为生物农药的有效成分,能够抑制病害的发生。
  • 材料科学与技术:在导电聚合物和塑料添加剂中有重要应用。
5. 环境与安全性

尽管有机硫化合物具有许多潜在益处,但其生产和使用也可能对环境造成影响。因此,在设计和合成这些化合物时需要考虑可持续性和环保性因素。

以上是对有机硫化合物的简单介绍,包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

中文名称 英文名称 CAS号 化学式 结构式图片
—— (5S)-3-cyclopropyloxy-5-methylsulfanylcyclohexa-1,3-diene-1-carbaldehyde —— C11H14O2S
(5S)-3-cyclopropyloxy-5-methylsulfanylcyclohexa-1,3-diene-1-carbaldehyde
—— (5S)-3-cyclopropyloxy-1,5-bis(methylsulfanyl)cyclohexa-1,3-diene —— C11H16OS2
(5S)-3-cyclopropyloxy-1,5-bis(methylsulfanyl)cyclohexa-1,3-diene
—— (1S)-1-(3-methylsulfanylphenyl)but-3-en-1-ol —— C11H14OS
(1S)-1-(3-methylsulfanylphenyl)but-3-en-1-ol
—— (1R)-1-(3-methylsulfanylphenyl)but-3-en-1-ol —— C11H14OS
(1R)-1-(3-methylsulfanylphenyl)but-3-en-1-ol
—— (5R)-3-cyclopropyloxy-1,5-bis(methylsulfanyl)cyclohexa-1,3-diene —— C11H16OS2
(5R)-3-cyclopropyloxy-1,5-bis(methylsulfanyl)cyclohexa-1,3-diene
—— (5R)-3-cyclopropyloxy-5-methylsulfanylcyclohexa-1,3-diene-1-carbaldehyde —— C11H14O2S
(5R)-3-cyclopropyloxy-5-methylsulfanylcyclohexa-1,3-diene-1-carbaldehyde
—— (1S)-1-(4-methylsulfanylphenyl)butan-1-ol —— C11H16OS
(1S)-1-(4-methylsulfanylphenyl)butan-1-ol
—— (5S)-3-cyclopropyloxy-5-methoxy-1-methylsulfanylcyclohexa-1,3-diene —— C11H16O2S
(5S)-3-cyclopropyloxy-5-methoxy-1-methylsulfanylcyclohexa-1,3-diene
—— [2-[2-Cyanoethyl(methyl)amino]-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate —— C14H15BrN2O3S
[2-[2-Cyanoethyl(methyl)amino]-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate
—— (1R)-1-(4-methylsulfanylphenyl)butan-1-ol —— C11H16OS
(1R)-1-(4-methylsulfanylphenyl)butan-1-ol
—— (1S)-1-(3-methylsulfanylphenyl)butan-1-ol —— C11H16OS
(1S)-1-(3-methylsulfanylphenyl)butan-1-ol
—— [2-oxo-2-(1H-pyrrol-2-yl)ethyl] 2-(4-bromophenyl)sulfanylacetate —— C14H12BrNO3S
[2-oxo-2-(1H-pyrrol-2-yl)ethyl] 2-(4-bromophenyl)sulfanylacetate
—— [2-[[(1S,2S)-2-methylcyclohexyl]amino]-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate —— C17H22BrNO3S
[2-[[(1S,2S)-2-methylcyclohexyl]amino]-2-oxoethyl] 2-(4-bromophenyl)sulfanylacetate
—— (1R)-1-(3-methylsulfanylphenyl)butan-1-ol —— C11H16OS
(1R)-1-(3-methylsulfanylphenyl)butan-1-ol
—— (1S)-3-(1,3-dioxan-2-yl)-1-(4-methylsulfanylphenyl)propan-1-ol —— C14H20O3S
(1S)-3-(1,3-dioxan-2-yl)-1-(4-methylsulfanylphenyl)propan-1-ol
—— (R)-(1-methylpyrrol-2-yl)-(2-methylsulfanylphenyl)methanol —— C13H15NOS
(R)-(1-methylpyrrol-2-yl)-(2-methylsulfanylphenyl)methanol
—— (1R)-3-(1,3-dioxan-2-yl)-1-(4-methylsulfanylphenyl)propan-1-ol —— C14H20O3S
(1R)-3-(1,3-dioxan-2-yl)-1-(4-methylsulfanylphenyl)propan-1-ol
—— (5R)-3-cyclopropyloxy-5-methoxy-1-methylsulfanylcyclohexa-1,3-diene —— C11H16O2S
(5R)-3-cyclopropyloxy-5-methoxy-1-methylsulfanylcyclohexa-1,3-diene
—— (R)-(2-methylsulfanylphenyl)-thiophen-3-ylmethanol —— C12H12OS2
(R)-(2-methylsulfanylphenyl)-thiophen-3-ylmethanol
—— (S)-(4-ethylsulfanylphenyl)-(5-methylthiophen-2-yl)methanol —— C14H16OS2
(S)-(4-ethylsulfanylphenyl)-(5-methylthiophen-2-yl)methanol
—— (R)-(4-ethylsulfanylphenyl)-(5-methylthiophen-2-yl)methanol —— C14H16OS2
(R)-(4-ethylsulfanylphenyl)-(5-methylthiophen-2-yl)methanol
—— (R)-(4-methylsulfanylphenyl)-thiophen-3-ylmethanol —— C12H12OS2
(R)-(4-methylsulfanylphenyl)-thiophen-3-ylmethanol
—— (S)-(4-methylsulfanylphenyl)-thiophen-3-ylmethanol —— C12H12OS2
(S)-(4-methylsulfanylphenyl)-thiophen-3-ylmethanol
—— (R)-(1-methylpyrrol-2-yl)-(4-methylsulfanylphenyl)methanol —— C13H15NOS
(R)-(1-methylpyrrol-2-yl)-(4-methylsulfanylphenyl)methanol
—— (S)-(2-methylsulfanylphenyl)-thiophen-3-ylmethanol —— C12H12OS2
(S)-(2-methylsulfanylphenyl)-thiophen-3-ylmethanol
—— (S)-(4-ethylsulfanylphenyl)-(1-methylpyrrol-2-yl)methanol —— C14H17NOS
(S)-(4-ethylsulfanylphenyl)-(1-methylpyrrol-2-yl)methanol
—— (R)-(4-ethylsulfanylphenyl)-thiophen-3-ylmethanol —— C13H14OS2
(R)-(4-ethylsulfanylphenyl)-thiophen-3-ylmethanol
—— (S)-(1-methylpyrrol-2-yl)-(2-methylsulfanylphenyl)methanol —— C13H15NOS
(S)-(1-methylpyrrol-2-yl)-(2-methylsulfanylphenyl)methanol
—— (S)-furan-3-yl-(4-methylsulfanylphenyl)methanol —— C12H12O2S
(S)-furan-3-yl-(4-methylsulfanylphenyl)methanol
—— (S)-(4-ethylsulfanylphenyl)-thiophen-3-ylmethanol —— C13H14OS2
(S)-(4-ethylsulfanylphenyl)-thiophen-3-ylmethanol
—— (R)-(2-methylsulfanylphenyl)-pyridin-2-ylmethanol —— C13H13NOS
(R)-(2-methylsulfanylphenyl)-pyridin-2-ylmethanol
—— (S)-(1-methylpyrrol-2-yl)-(4-methylsulfanylphenyl)methanol —— C13H15NOS
(S)-(1-methylpyrrol-2-yl)-(4-methylsulfanylphenyl)methanol
—— (R)-(4-ethylsulfanylphenyl)-(1-methylpyrrol-2-yl)methanol —— C14H17NOS
(R)-(4-ethylsulfanylphenyl)-(1-methylpyrrol-2-yl)methanol
—— (R)-furan-2-yl-(4-methylsulfanylphenyl)methanol —— C12H12O2S
(R)-furan-2-yl-(4-methylsulfanylphenyl)methanol
—— (R)-furan-3-yl-(2-methylsulfanylphenyl)methanol —— C12H12O2S
(R)-furan-3-yl-(2-methylsulfanylphenyl)methanol
—— (R)-(4-ethylsulfanylphenyl)-(5-methylfuran-2-yl)methanol —— C14H16O2S
(R)-(4-ethylsulfanylphenyl)-(5-methylfuran-2-yl)methanol
—— (S)-(5-methylfuran-2-yl)-(2-methylsulfanylphenyl)methanol —— C13H14O2S
(S)-(5-methylfuran-2-yl)-(2-methylsulfanylphenyl)methanol
—— (S)-furan-2-yl-(4-methylsulfanylphenyl)methanol —— C12H12O2S
(S)-furan-2-yl-(4-methylsulfanylphenyl)methanol
—— (S)-(4-ethylsulfanylphenyl)-(furan-2-yl)methanol —— C13H14O2S
(S)-(4-ethylsulfanylphenyl)-(furan-2-yl)methanol
—— (R)-(5-methylfuran-2-yl)-(2-methylsulfanylphenyl)methanol —— C13H14O2S
(R)-(5-methylfuran-2-yl)-(2-methylsulfanylphenyl)methanol
—— (R)-furan-3-yl-(4-methylsulfanylphenyl)methanol —— C12H12O2S
(R)-furan-3-yl-(4-methylsulfanylphenyl)methanol
—— (R)-(4-ethylsulfanylphenyl)-(furan-3-yl)methanol —— C13H14O2S
(R)-(4-ethylsulfanylphenyl)-(furan-3-yl)methanol
—— (R)-(4-(methylthio)phenyl)(pyridin-2-yl)methanol —— C13H13NOS
(R)-(4-(methylthio)phenyl)(pyridin-2-yl)methanol
—— (S)-(4-ethylsulfanylphenyl)-(5-methylfuran-2-yl)methanol —— C14H16O2S
(S)-(4-ethylsulfanylphenyl)-(5-methylfuran-2-yl)methanol
—— (S)-(4-ethylsulfanylphenyl)-(furan-3-yl)methanol —— C13H14O2S
(S)-(4-ethylsulfanylphenyl)-(furan-3-yl)methanol
—— (S)-furan-2-yl-(2-methylsulfanylphenyl)methanol —— C12H12O2S
(S)-furan-2-yl-(2-methylsulfanylphenyl)methanol
—— (S)-furan-3-yl-(2-methylsulfanylphenyl)methanol —— C12H12O2S
(S)-furan-3-yl-(2-methylsulfanylphenyl)methanol
—— (R)-(4-ethylsulfanylphenyl)-pyridin-2-ylmethanol —— C14H15NOS
(R)-(4-ethylsulfanylphenyl)-pyridin-2-ylmethanol
—— (S)-(4-(methylthio)phenyl)(pyridin-2-yl)methanol —— C13H13NOS
(S)-(4-(methylthio)phenyl)(pyridin-2-yl)methanol
—— (S)-(2-methylsulfanylphenyl)-pyridin-2-ylmethanol —— C13H13NOS
(S)-(2-methylsulfanylphenyl)-pyridin-2-ylmethanol