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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 1-(5-Tert-butyl-1,2-oxazol-3-yl)-3-[4-(3-methylphenyl)sulfanylphenyl]urea —— C21H23N3O2S
    1-(5-Tert-butyl-1,2-oxazol-3-yl)-3-[4-(3-methylphenyl)sulfanylphenyl]urea
    —— 3-(2-chloro-phenylsulfanyl)-6-methanesulfonyl-benzo[b]thiophene-2-carbonitrile —— C16H10ClNO2S3
    3-(2-chloro-phenylsulfanyl)-6-methanesulfonyl-benzo[b]thiophene-2-carbonitrile
    —— 3-methyl-8-(2-methylfuran-3-yl)sulfanyl-5-(1-oxidopyridin-1-ium-2-yl)-3,4-dihydro-2H-naphthalen-1-one —— C21H19NO3S
    3-methyl-8-(2-methylfuran-3-yl)sulfanyl-5-(1-oxidopyridin-1-ium-2-yl)-3,4-dihydro-2H-naphthalen-1-one
    —— 1-(Cyclobutylmethyl)-6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-pyrimidine-2,4-dione 301297-46-1 C19H24N2O2S
    1-(Cyclobutylmethyl)-6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-pyrimidine-2,4-dione
    —— (1S,8R)-8-amino-7-oxo-4-[(E)-3-(2H-triazol-4-ylsulfanyl)prop-1-enyl]-2-thiabicyclo[4.2.0]oct-4-ene-5-carboxylic acid —— C13H14N4O3S2
    (1S,8R)-8-amino-7-oxo-4-[(E)-3-(2H-triazol-4-ylsulfanyl)prop-1-enyl]-2-thiabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
    —— 3-Chloro-4-(2,4,6-trichlorophenyl)sulfanylaniline —— C12H7Cl4NS
    3-Chloro-4-(2,4,6-trichlorophenyl)sulfanylaniline
    —— 3-(4-methyl-anilino)-5-(3,4-difluoro-benzylthio)-1,2,4-triazole 334538-95-3 C16H14F2N4S
    3-(4-methyl-anilino)-5-(3,4-difluoro-benzylthio)-1,2,4-triazole
    —— 3-[(6S)-1-azabicyclo[3.2.1]octan-6-yl]-4-(4,4,4-trifluorobutylsulfanyl)-1,2,5-thiadiazole —— C13H18F3N3S2
    3-[(6S)-1-azabicyclo[3.2.1]octan-6-yl]-4-(4,4,4-trifluorobutylsulfanyl)-1,2,5-thiadiazole
    —— 3-(3-trifluoromethylthio-phenylimino)-3H-[1,2,4]-thiadiazolo[4,3-a]pyridine 148257-32-3 C13H8F3N3S2
    3-(3-trifluoromethylthio-phenylimino)-3H-[1,2,4]-thiadiazolo[4,3-a]pyridine
    —— 4-[2-[2-(5-Aminopyridin-2-yl)sulfanylethoxy]ethylsulfanyl]phenol —— C15H18N2O2S2
    4-[2-[2-(5-Aminopyridin-2-yl)sulfanylethoxy]ethylsulfanyl]phenol
    —— 3-(5-chlorothiophen-2-yl)sulfanyl-N-(4-methylphenyl)-1H-1,2,4-triazol-5-amine —— C13H11ClN4S2
    3-(5-chlorothiophen-2-yl)sulfanyl-N-(4-methylphenyl)-1H-1,2,4-triazol-5-amine
    —— 3-chloro-4-(2-chloro-4-nitro-phenylsulfanyl)-aniline 19574-06-2 C12H8Cl2N2O2S
    3-chloro-4-(2-chloro-4-nitro-phenylsulfanyl)-aniline
    —— 8-Phenyl-3-thiophen-2-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[3,4-b][1,3]thiazepine —— C16H15N3S2
    8-Phenyl-3-thiophen-2-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[3,4-b][1,3]thiazepine
    —— 8-(Furan-2-ylmethylsulfanyl)-5-methyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine —— C12H9F3N4OS
    8-(Furan-2-ylmethylsulfanyl)-5-methyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
    —— 2-[5-Methylsulfanyl-4-(4-methyl-1,3-thiazol-2-yl)thiophen-2-yl]-2-oxoethanimidamide —— C11H11N3OS3
    2-[5-Methylsulfanyl-4-(4-methyl-1,3-thiazol-2-yl)thiophen-2-yl]-2-oxoethanimidamide
    —— 5-[(2-methyl-3H-benzimidazol-5-yl)sulfanyl]-1,2,3,4-tetrahydroisoquinoline —— C17H17N3S
    5-[(2-methyl-3H-benzimidazol-5-yl)sulfanyl]-1,2,3,4-tetrahydroisoquinoline
    —— 2-[2-Methyl-3-[(2-methylsulfanylimidazol-1-yl)methyl]phenyl]sulfanylethanol —— C14H18N2OS2
    2-[2-Methyl-3-[(2-methylsulfanylimidazol-1-yl)methyl]phenyl]sulfanylethanol
    —— (3R)-6-fluoro-2,2-dimethyl-3-(1,2,4-triazol-1-ylmethyl)-1-benzothiophen-3-ol —— C13H14FN3OS
    (3R)-6-fluoro-2,2-dimethyl-3-(1,2,4-triazol-1-ylmethyl)-1-benzothiophen-3-ol
    —— 2-(1-Ethyltetrazol-5-yl)sulfanyl-5-nitro-1,3-thiazole —— C6H6N6O2S2
    2-(1-Ethyltetrazol-5-yl)sulfanyl-5-nitro-1,3-thiazole
    —— 4,5-dichloro-2-(4-ethylphenyl)sulfanyl-1H-imidazole —— C11H10Cl2N2S
    4,5-dichloro-2-(4-ethylphenyl)sulfanyl-1H-imidazole
    —— 3-Methyl-8-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[3,4-b][1,3]thiazepine —— C13H15N3S
    3-Methyl-8-phenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[3,4-b][1,3]thiazepine
    —— 4-(1,2,3,4-Tetrahydroisoquinolin-5-ylsulfanyl)aniline —— C15H16N2S
    4-(1,2,3,4-Tetrahydroisoquinolin-5-ylsulfanyl)aniline
    —— 2-[(ethoxycarbonyl)methylthio]thiazolo[4,5-b]pyridine 133903-46-5 C10H10N2O2S2
    2-[(ethoxycarbonyl)methylthio]thiazolo[4,5-b]pyridine
    —— 1-(3-Pyridin-2-ylsulfanylpropanoyl)pyrrolidine-2,5-dione —— C12H12N2O3S
    1-(3-Pyridin-2-ylsulfanylpropanoyl)pyrrolidine-2,5-dione
    —— 1-[(1,3-Dimethyl-4,5,6,7-tetrahydrobenzimidazol-3-ium-2-yl)sulfanyl]propan-2-one —— C12H19N2OS+
    1-[(1,3-Dimethyl-4,5,6,7-tetrahydrobenzimidazol-3-ium-2-yl)sulfanyl]propan-2-one
    —— 5-Ethylsulfanyl-1,3-thiazole-2-sulfonamide —— C5H8N2O2S3
    5-Ethylsulfanyl-1,3-thiazole-2-sulfonamide
    —— 5-Phenylsulfanyl-1,3-dihydroindol-2-one —— C14H11NOS
    5-Phenylsulfanyl-1,3-dihydroindol-2-one
    —— N-(4-methylphenyl)-3-prop-2-enylsulfanyl-1H-1,2,4-triazol-5-amine —— C12H14N4S
    N-(4-methylphenyl)-3-prop-2-enylsulfanyl-1H-1,2,4-triazol-5-amine
    —— 1-Hydroxy-6-phenylsulfanylpyridin-2-one —— C11H9NO2S
    1-Hydroxy-6-phenylsulfanylpyridin-2-one
    —— [4-amino-5-(3-methyl-thiophen-2-ylmethyl)-pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester 476302-16-6 C14H17N3O2S2
    [4-amino-5-(3-methyl-thiophen-2-ylmethyl)-pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester
    —— 4-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-methylpyridine-3-carbonitrile —— C17H19N3OS
    4-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-methylpyridine-3-carbonitrile
    —— 4-(5-ethyl-3-methylsulfanyl-1,2-oxazol-4-yl)-N-phenylpyridin-2-amine —— C17H17N3OS
    4-(5-ethyl-3-methylsulfanyl-1,2-oxazol-4-yl)-N-phenylpyridin-2-amine
    —— (Z)-N-[[5-(2-methylpropylsulfanyl)thiadiazol-4-yl]methoxy]-1-azabicyclo[2.2.1]heptan-3-imine —— C13H20N4OS2
    (Z)-N-[[5-(2-methylpropylsulfanyl)thiadiazol-4-yl]methoxy]-1-azabicyclo[2.2.1]heptan-3-imine
    —— 2-[1-(Methylamino)pentan-3-ylsulfanyl]-6-(trifluoromethyl)pyridine-3-carbonitrile —— C13H16F3N3S
    2-[1-(Methylamino)pentan-3-ylsulfanyl]-6-(trifluoromethyl)pyridine-3-carbonitrile
    —— 3-phenylethynyl-4H-5-thia-2,6,9b-triaza-cyclopenta[a]naphthalene —— C17H11N3S
    3-phenylethynyl-4H-5-thia-2,6,9b-triaza-cyclopenta[a]naphthalene
    —— 3-(cyclohexylmethylsulfanyl)-5-[(2-methylphenyl)methyl]-1H-1,2,4-triazole —— C17H23N3S
    3-(cyclohexylmethylsulfanyl)-5-[(2-methylphenyl)methyl]-1H-1,2,4-triazole
    —— 2-[(4,4,3-trifluoro-3-butenyl)thio]thiazolo[4,5-b]-pyridine —— C10H7F3N2S2
    2-[(4,4,3-trifluoro-3-butenyl)thio]thiazolo[4,5-b]-pyridine
    —— 2-[(6,6-Dioxo-1,6-oxathiecan-4-yl)sulfanyl]ethanol —— C10H20O4S2
    2-[(6,6-Dioxo-1,6-oxathiecan-4-yl)sulfanyl]ethanol
    —— 2-[[3-(furan-2-ylmethylsulfanyl)-1H-1,2,4-triazol-5-yl]methyl]pyridine —— C13H12N4OS
    2-[[3-(furan-2-ylmethylsulfanyl)-1H-1,2,4-triazol-5-yl]methyl]pyridine
    —— 4-Benzyl-1-isopropyl-3-methyl-5-methylsulfanyl-1,3-dihydro-imidazol-2-one —— C15H20N2OS
    4-Benzyl-1-isopropyl-3-methyl-5-methylsulfanyl-1,3-dihydro-imidazol-2-one
    —— 2-[2-(2-Butoxyethylsulfonyl)ethylsulfanyl]ethanol —— C10H22O4S2
    2-[2-(2-Butoxyethylsulfonyl)ethylsulfanyl]ethanol
    —— 5-(5-ethylsulfanylpyridin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole —— C13H19N3S
    5-(5-ethylsulfanylpyridin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole
    —— 5-[(3,5-dimethylbenzyl)sulfanyl]-1H-1,2,4-triazol-3-amine —— C11H14N4S
    5-[(3,5-dimethylbenzyl)sulfanyl]-1H-1,2,4-triazol-3-amine
    —— 3-[(3-methylbutyl)thio]-1H-1,2,4-triazol-5-amine —— C7H14N4S
    3-[(3-methylbutyl)thio]-1H-1,2,4-triazol-5-amine
    —— 4-(1H-1,2,4-triazol-5-ylsulfanyl)butane-1-thiol —— C6H11N3S2
    4-(1H-1,2,4-triazol-5-ylsulfanyl)butane-1-thiol
    —— 1-(2-Hydroxy-ethyl)-3-(2-methyl-cyclopent-2-enyl)-thiourea —— C9H16N2OS
    1-(2-Hydroxy-ethyl)-3-(2-methyl-cyclopent-2-enyl)-thiourea
    —— 3-chloro-N-(3,5-dichloro-4-quinolin-3-ylsulfanylphenyl)-5-(trifluoromethyl)benzenesulfonamide —— C22H12Cl3F3N2O2S2
    3-chloro-N-(3,5-dichloro-4-quinolin-3-ylsulfanylphenyl)-5-(trifluoromethyl)benzenesulfonamide
    —— {3-[4-(3-cyclohexyl-1-phenethylureido)phenylsulphanyl]phenyl}acetic acid 735273-77-5 C29H32N2O3S
    {3-[4-(3-cyclohexyl-1-phenethylureido)phenylsulphanyl]phenyl}acetic acid
    —— 3,5-Dichloro-4-[6-(4-fluoro-phenylsulfanyl)-2-oxo-3,4-dihydro-2H-pyrido[3,2-d]pyrimidin-1-yl]-benzoic acid methyl ester —— C21H14Cl2FN3O3S
    3,5-Dichloro-4-[6-(4-fluoro-phenylsulfanyl)-2-oxo-3,4-dihydro-2H-pyrido[3,2-d]pyrimidin-1-yl]-benzoic acid methyl ester
    —— N-[5-(6,7-dimethoxyquinazolin-4-yl)sulfanyl-1,3,4-thiadiazol-2-yl]thiophene-2-carboxamide 664325-13-7 C17H13N5O3S3
    N-[5-(6,7-dimethoxyquinazolin-4-yl)sulfanyl-1,3,4-thiadiazol-2-yl]thiophene-2-carboxamide