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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[[(2R)-2,3-dihydro-1-benzothiophene-2-carbonyl]amino]methyl]-N,N-dimethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide —— C19H23N5O2S
    2-[[[(2R)-2,3-dihydro-1-benzothiophene-2-carbonyl]amino]methyl]-N,N-dimethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxamide
    —— 2-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfanyl)pyridine-3-carboxylate —— C14H10NO4S-
    2-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfanyl)pyridine-3-carboxylate
    —— 2-(2,4-Difluorophenyl)sulfanylacetate —— C8H5F2O2S-
    2-(2,4-Difluorophenyl)sulfanylacetate
    —— 3-(3,4-Difluorophenyl)sulfanylpropanoate —— C9H7F2O2S-
    3-(3,4-Difluorophenyl)sulfanylpropanoate
    —— 2-(4-Chlorophenyl)sulfanylcyclohexene-1-carboxylate —— C13H12ClO2S-
    2-(4-Chlorophenyl)sulfanylcyclohexene-1-carboxylate
    —— 1-[(1S)-1-chloro-2,2,2-trifluoroethyl]sulfanyl-4-methylbenzene —— C9H8ClF3S
    1-[(1S)-1-chloro-2,2,2-trifluoroethyl]sulfanyl-4-methylbenzene
    —— 3-(4,6-Dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoate —— C10H13N2O2S-
    3-(4,6-Dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoate
    —— 2-(4-Methylphenyl)sulfanylcyclohexene-1-carboxylate —— C14H15O2S-
    2-(4-Methylphenyl)sulfanylcyclohexene-1-carboxylate
    —— 2-[[4-benzyl-5-[(1R)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C21H31N5O2S
    2-[[4-benzyl-5-[(1R)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 2-[(2S)-2,3-dibromopropyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile —— C11H12Br2N2S
    2-[(2S)-2,3-dibromopropyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile
    —— 1-[(6S)-6-hydroxy-4-(2-phenylsulfanylethyl)-1,4-diazepan-1-yl]ethanone —— C15H22N2O2S
    1-[(6S)-6-hydroxy-4-(2-phenylsulfanylethyl)-1,4-diazepan-1-yl]ethanone
    —— 1-[(6R)-6-hydroxy-4-(2-phenylsulfanylethyl)-1,4-diazepan-1-yl]ethanone —— C15H22N2O2S
    1-[(6R)-6-hydroxy-4-(2-phenylsulfanylethyl)-1,4-diazepan-1-yl]ethanone
    —— N-(furan-2-ylmethyl)-2-((3-phenyl-1,2,4-thiadiazol-5-yl)thio)acetamide —— C15H13N3O2S2
    N-(furan-2-ylmethyl)-2-((3-phenyl-1,2,4-thiadiazol-5-yl)thio)acetamide
    —— N-benzyl-2-((3-(o-tolyl)-1,2,4-thiadiazol-5-yl)thio)acetamide —— C18H17N3OS2
    N-benzyl-2-((3-(o-tolyl)-1,2,4-thiadiazol-5-yl)thio)acetamide
    —— N-(furan-2-ylmethyl)-2-[[3-(2-methylphenyl)-1,2,4-thiadiazol-5-yl]sulfanyl]acetamide —— C16H15N3O2S2
    N-(furan-2-ylmethyl)-2-[[3-(2-methylphenyl)-1,2,4-thiadiazol-5-yl]sulfanyl]acetamide
    —— [(1R)-1-[5-[2-(2-hydroxyethylazaniumyl)ethylsulfanyl]-4-(2-morpholin-4-ium-4-ylethyl)-1,2,4-triazol-3-yl]propyl]-dimethylazanium —— C17H37N6O2S+3
    [(1R)-1-[5-[2-(2-hydroxyethylazaniumyl)ethylsulfanyl]-4-(2-morpholin-4-ium-4-ylethyl)-1,2,4-triazol-3-yl]propyl]-dimethylazanium
    —— (5-Bromoimidazo[2,1-b][1,3]thiazol-6-yl)methyl (5-phenyl-1,3,4-oxadiazol-2-yl) sulfide —— C14H9BrN4OS2
    (5-Bromoimidazo[2,1-b][1,3]thiazol-6-yl)methyl (5-phenyl-1,3,4-oxadiazol-2-yl) sulfide
    —— (3-Methylimidazo[2,1-B][1,3]thiazol-6-YL)methyl (5-phenyl-1,3,4-oxadiazol-2-YL) sulfide —— C15H12N4OS2
    (3-Methylimidazo[2,1-B][1,3]thiazol-6-YL)methyl (5-phenyl-1,3,4-oxadiazol-2-YL) sulfide
    —— (2S)-N-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]-2-pyrazol-1-ylbutanamide —— C12H17N5OS2
    (2S)-N-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]-2-pyrazol-1-ylbutanamide
    —— (2R)-N-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]-2-pyrazol-1-ylbutanamide —— C12H17N5OS2
    (2R)-N-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]-2-pyrazol-1-ylbutanamide
    —— 2-[4-[[(2R)-oxan-2-yl]methyl]phenyl]sulfanylacetamide —— C14H19NO2S
    2-[4-[[(2R)-oxan-2-yl]methyl]phenyl]sulfanylacetamide
    —— 2-[4-[[(2S)-oxan-2-yl]methyl]phenyl]sulfanylacetamide —— C14H19NO2S
    2-[4-[[(2S)-oxan-2-yl]methyl]phenyl]sulfanylacetamide
    —— (3R)-1-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]-3-prop-2-enylpiperidine-3-carboxylic acid —— C17H22N4O3S
    (3R)-1-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]-3-prop-2-enylpiperidine-3-carboxylic acid
    —— (3S)-1-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]-3-prop-2-enylpiperidine-3-carboxylic acid —— C17H22N4O3S
    (3S)-1-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]-3-prop-2-enylpiperidine-3-carboxylic acid
    —— 3-[5-[(2S)-2,3-dihydro-1-benzothiophene-2-carbonyl]-4,6,7,8-tetrahydropyrazolo[1,5-a][1,4]diazepin-2-yl]propanoic acid —— C19H21N3O3S
    3-[5-[(2S)-2,3-dihydro-1-benzothiophene-2-carbonyl]-4,6,7,8-tetrahydropyrazolo[1,5-a][1,4]diazepin-2-yl]propanoic acid
    —— Ethyl 6-chloro-2-methyl-4-(2-morpholin-4-ium-4-ylacetyl)thieno[2,3-b][1,4]benzothiazine-3-carboxylate —— C20H22ClN2O4S2+
    Ethyl 6-chloro-2-methyl-4-(2-morpholin-4-ium-4-ylacetyl)thieno[2,3-b][1,4]benzothiazine-3-carboxylate
    —— 3-[5-[(2R)-2,3-dihydro-1-benzothiophene-2-carbonyl]-4,6,7,8-tetrahydropyrazolo[1,5-a][1,4]diazepin-2-yl]propanoic acid —— C19H21N3O3S
    3-[5-[(2R)-2,3-dihydro-1-benzothiophene-2-carbonyl]-4,6,7,8-tetrahydropyrazolo[1,5-a][1,4]diazepin-2-yl]propanoic acid
    —— 1,3-dimethyl-5-((4-methylbenzyl)thio)-7-(thiophen-2-yl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C20H18N4O2S2
    1,3-dimethyl-5-((4-methylbenzyl)thio)-7-(thiophen-2-yl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— (2S)-N-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-ylmethyl)-2-pyrazol-1-ylbutanamide —— C13H17N5OS
    (2S)-N-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-ylmethyl)-2-pyrazol-1-ylbutanamide
    —— 5-[(2S)-butan-2-yl]sulfanyl-1,3-dimethyl-7-thiophen-2-ylpyrimido[4,5-d]pyrimidine-2,4-dione —— C16H18N4O2S2
    5-[(2S)-butan-2-yl]sulfanyl-1,3-dimethyl-7-thiophen-2-ylpyrimido[4,5-d]pyrimidine-2,4-dione
    —— 7-ethyl-5-((3-fluorobenzyl)thio)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C17H17FN4O2S
    7-ethyl-5-((3-fluorobenzyl)thio)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 5-((2,5-dimethylbenzyl)thio)-7-(furan-2-yl)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C21H20N4O3S
    5-((2,5-dimethylbenzyl)thio)-7-(furan-2-yl)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 5-(cyclopentylthio)-1,3-dimethyl-7-(thiophen-2-yl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C17H18N4O2S2
    5-(cyclopentylthio)-1,3-dimethyl-7-(thiophen-2-yl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 7-cyclopropyl-5-((4-fluorobenzyl)thio)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C18H17FN4O2S
    7-cyclopropyl-5-((4-fluorobenzyl)thio)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 7-cyclopropyl-5-((2-fluorobenzyl)thio)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C18H17FN4O2S
    7-cyclopropyl-5-((2-fluorobenzyl)thio)-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 5-[(2R)-butan-2-yl]sulfanyl-7-cyclopropyl-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione —— C15H20N4O2S
    5-[(2R)-butan-2-yl]sulfanyl-7-cyclopropyl-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione
    —— methyl (2R)-2-(7-ethyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylpropanoate —— C14H18N4O4S
    methyl (2R)-2-(7-ethyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylpropanoate
    —— methyl (2R)-2-(1,3,7-trimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylbutanoate —— C14H18N4O4S
    methyl (2R)-2-(1,3,7-trimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylbutanoate
    —— 5-(ethylthio)-1,3-dimethyl-7-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C16H16N4O2S
    5-(ethylthio)-1,3-dimethyl-7-phenylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 5-((4-fluorobenzyl)thio)-1,3-dimethyl-7-(thiophen-2-yl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C19H15FN4O2S2
    5-((4-fluorobenzyl)thio)-1,3-dimethyl-7-(thiophen-2-yl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— 5-[(2R)-butan-2-yl]sulfanyl-1,3-dimethyl-7-thiophen-2-ylpyrimido[4,5-d]pyrimidine-2,4-dione —— C16H18N4O2S2
    5-[(2R)-butan-2-yl]sulfanyl-1,3-dimethyl-7-thiophen-2-ylpyrimido[4,5-d]pyrimidine-2,4-dione
    —— 7-Cyclopropyl-5-[(3-fluorophenyl)methylsulfanyl]-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione —— C18H17FN4O2S
    7-Cyclopropyl-5-[(3-fluorophenyl)methylsulfanyl]-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione
    —— N-[[(2R)-oxolan-2-yl]methyl]-2-(1,3,7-trimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetamide —— C16H21N5O4S
    N-[[(2R)-oxolan-2-yl]methyl]-2-(1,3,7-trimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetamide
    —— N-cyclopentyl-2-((2,6,8-trimethyl-5,7-dioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl)thio)acetamide —— C16H21N5O3S
    N-cyclopentyl-2-((2,6,8-trimethyl-5,7-dioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl)thio)acetamide
    —— methyl (2R)-2-(7-cyclopropyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylpropanoate —— C15H18N4O4S
    methyl (2R)-2-(7-cyclopropyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylpropanoate
    —— 5-[(4-Fluorophenyl)methylsulfanyl]-1,3-dimethyl-7-propylpyrimido[4,5-d]pyrimidine-2,4-dione —— C18H19FN4O2S
    5-[(4-Fluorophenyl)methylsulfanyl]-1,3-dimethyl-7-propylpyrimido[4,5-d]pyrimidine-2,4-dione
    —— 5-[(4-Chlorophenyl)methylsulfanyl]-1,3-dimethyl-7-propan-2-ylpyrimido[4,5-d]pyrimidine-2,4-dione —— C18H19ClN4O2S
    5-[(4-Chlorophenyl)methylsulfanyl]-1,3-dimethyl-7-propan-2-ylpyrimido[4,5-d]pyrimidine-2,4-dione
    —— 7-(furan-2-yl)-1,3-dimethyl-5-((3-methylbenzyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione —— C20H18N4O3S
    7-(furan-2-yl)-1,3-dimethyl-5-((3-methylbenzyl)thio)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione
    —— methyl (2S)-2-(7-cyclopropyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylpropanoate —— C15H18N4O4S
    methyl (2S)-2-(7-cyclopropyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylpropanoate
    —— 5-[(2-Fluorophenyl)methylsulfanyl]-1,3,7-trimethylpyrimido[4,5-d]pyrimidine-2,4-dione —— C16H15FN4O2S
    5-[(2-Fluorophenyl)methylsulfanyl]-1,3,7-trimethylpyrimido[4,5-d]pyrimidine-2,4-dione