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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 1-(4-chlorophenylamino)-4-[5-(4-pyridyl)-1H-1,2,4-triazolyl-3-ylthio]phthalazine 325781-32-6 C21H14ClN7S
    1-(4-chlorophenylamino)-4-[5-(4-pyridyl)-1H-1,2,4-triazolyl-3-ylthio]phthalazine
    —— 1-(1-Adamantyl)-3-[4-(4-nitrophenyl)sulfanylphenyl]urea —— C23H25N3O3S
    1-(1-Adamantyl)-3-[4-(4-nitrophenyl)sulfanylphenyl]urea
    —— 1-[4-[5-(4-Hydroxyphenyl)sulfanylpentyl]-1,3-thiazolidin-3-yl]-3,3-dimethyl-1-sulfanylidenepentan-2-one —— C21H31NO2S3
    1-[4-[5-(4-Hydroxyphenyl)sulfanylpentyl]-1,3-thiazolidin-3-yl]-3,3-dimethyl-1-sulfanylidenepentan-2-one
    —— Benzyl 4-[[5-[(dimethylamino)methyl]-1,3-thiazol-2-yl]sulfanyl]piperidine-1-carbodithioate —— C19H25N3S4
    Benzyl 4-[[5-[(dimethylamino)methyl]-1,3-thiazol-2-yl]sulfanyl]piperidine-1-carbodithioate
    —— N-(5-tert-butyl-2-methoxyphenyl)-N'-(4-(4-pyridinylthio)phenyl)urea —— C23H25N3O2S
    N-(5-tert-butyl-2-methoxyphenyl)-N'-(4-(4-pyridinylthio)phenyl)urea
    —— 7-(1-aminopropan-2-ylamino)-5-[(3-chloro-2-fluorophenyl)methylsulfanyl]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C15H15ClFN5OS2
    7-(1-aminopropan-2-ylamino)-5-[(3-chloro-2-fluorophenyl)methylsulfanyl]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— (3S,3aR,4S,9bR)-4-hydroxy-9-(hydroxymethyl)-6-methyl-3-(phenylsulfanylmethyl)-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione —— C21H22O5S
    (3S,3aR,4S,9bR)-4-hydroxy-9-(hydroxymethyl)-6-methyl-3-(phenylsulfanylmethyl)-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione
    —— 2-[2-[2-Methyl-3-[(2-methylsulfanylimidazol-1-yl)methyl]phenyl]sulfanylethylsulfanyl]pyrimidine —— C18H20N4S3
    2-[2-[2-Methyl-3-[(2-methylsulfanylimidazol-1-yl)methyl]phenyl]sulfanylethylsulfanyl]pyrimidine
    —— 2-[[2-(4-Morpholinyl)ethyl]amino]-5-(pentylthio)thiazolo[4,5-d]pyrimidin-7(4H)-one 259100-56-6 C16H25N5O2S2
    2-[[2-(4-Morpholinyl)ethyl]amino]-5-(pentylthio)thiazolo[4,5-d]pyrimidin-7(4H)-one
    —— 7-[(2-Hydroxy-1,1-dimethylethyl)amino]-5-[[(2-methyl-4-thiazolyl)methyl]thio] thiazolo[4,5-d]pyrimidin-2(3H)-one —— C14H17N5O2S3
    7-[(2-Hydroxy-1,1-dimethylethyl)amino]-5-[[(2-methyl-4-thiazolyl)methyl]thio] thiazolo[4,5-d]pyrimidin-2(3H)-one
    —— 5-[(3-chlorophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C15H15ClN4O2S2
    5-[(3-chlorophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— 3-[(6R)-1-azabicyclo[3.2.1]octan-6-yl]-4-butylsulfanyl-1,2,5-thiadiazole —— C13H21N3S2
    3-[(6R)-1-azabicyclo[3.2.1]octan-6-yl]-4-butylsulfanyl-1,2,5-thiadiazole
    —— ethyl 2-[(7-nitro-2,3-dioxo-1,4-dihydroquinoxalin-6-yl)sulfanyl]-1H-imidazole-5-carboxylate —— C14H11N5O6S
    ethyl 2-[(7-nitro-2,3-dioxo-1,4-dihydroquinoxalin-6-yl)sulfanyl]-1H-imidazole-5-carboxylate
    —— 3-[(6R)-1-azabicyclo[3.2.1]octan-6-yl]-4-butylsulfanyl-1,2,5-thiadiazole;oxalic acid —— C15H23N3O4S2
    3-[(6R)-1-azabicyclo[3.2.1]octan-6-yl]-4-butylsulfanyl-1,2,5-thiadiazole;oxalic acid
    —— 4-[[(2S,4S)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol —— C17H19NO2S2
    4-[[(2S,4S)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol
    —— N-(aminoiminomethyl)-4-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxamide methanesulfonate —— CH4O3S*C14H17N3OS
    N-(aminoiminomethyl)-4-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxamide methanesulfonate
    —— 6-acetyl-2-(3-chlorophenyl)-5-methyl-4-phenylthio-3(2H)-pyridazinone 259192-79-5 C19H15ClN2O2S
    6-acetyl-2-(3-chlorophenyl)-5-methyl-4-phenylthio-3(2H)-pyridazinone
    —— 4-[[(2S,4S)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol;hydrochloride —— C17H20ClNO2S2
    4-[[(2S,4S)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol;hydrochloride
    —— 2-Methyl-6-[[6-[(4-methylpyrimidin-2-yl)sulfanylmethyl]pyridin-2-yl]methylsulfanyl]pyrazine —— C17H17N5S2
    2-Methyl-6-[[6-[(4-methylpyrimidin-2-yl)sulfanylmethyl]pyridin-2-yl]methylsulfanyl]pyrazine
    —— (5E,8E,11E,14E)-1-propylsulfanylicosa-5,8,11,14-tetraene —— C23H40S
    (5E,8E,11E,14E)-1-propylsulfanylicosa-5,8,11,14-tetraene
    —— N-(4-methylphenyl)-3-quinolin-8-ylsulfanyl-1H-1,2,4-triazol-5-amine —— C18H15N5S
    N-(4-methylphenyl)-3-quinolin-8-ylsulfanyl-1H-1,2,4-triazol-5-amine
    —— 5-[(6-nitro-1H-benzimidazol-5-yl)sulfanyl]-1,2,3,4-tetrahydroisoquinoline —— C16H14N4O2S
    5-[(6-nitro-1H-benzimidazol-5-yl)sulfanyl]-1,2,3,4-tetrahydroisoquinoline
    —— 3-chloro-4-(2,4-dichlorophenyl)sulfanyl-N-methylaniline —— C13H10Cl3NS
    3-chloro-4-(2,4-dichlorophenyl)sulfanyl-N-methylaniline
    —— 7-methyl-4-[[5-(methylthio)-1,3,4-thiadiazol-2-yl]thio]thieno[3,2-d]pyrimidine —— C10H8N4S4
    7-methyl-4-[[5-(methylthio)-1,3,4-thiadiazol-2-yl]thio]thieno[3,2-d]pyrimidine
    —— methyl 6-[(4-methylphenyl)thio]thieno[2,3-b]pyridine-2-carboxylate —— C16H13NO2S2
    methyl 6-[(4-methylphenyl)thio]thieno[2,3-b]pyridine-2-carboxylate
    —— 4-(5-Chloro-2,3-dihydro-1-benzothiophen-2-yl)-1-methylpiperidine —— C14H18ClNS
    4-(5-Chloro-2,3-dihydro-1-benzothiophen-2-yl)-1-methylpiperidine
    —— (Z)-tert-butyl-[[5-(3,5-dimethylphenyl)sulfanylfuran-2-yl]methylidene]-hydroxyazanium —— C17H22NO2S+
    (Z)-tert-butyl-[[5-(3,5-dimethylphenyl)sulfanylfuran-2-yl]methylidene]-hydroxyazanium
    —— 2-(2-tert-butylphenyl)sulfanyl-4,5-dichloro-1H-imidazole —— C13H14Cl2N2S
    2-(2-tert-butylphenyl)sulfanyl-4,5-dichloro-1H-imidazole
    —— 3-anilino-5-(3,3-dimethoxy-propylthio)-1,2,4-triazole 334538-59-9 C13H18N4O2S
    3-anilino-5-(3,3-dimethoxy-propylthio)-1,2,4-triazole
    —— 2-[2-(2-Chloro-4-hydroxyphenyl)thioethyl]-1-methylpyrrolidine —— C13H18ClNOS
    2-[2-(2-Chloro-4-hydroxyphenyl)thioethyl]-1-methylpyrrolidine
    —— 6-[(imidazol-2-yl)thio]-3-nitroimidazo[1,2-b]pyridazine —— C9H6N6O2S
    6-[(imidazol-2-yl)thio]-3-nitroimidazo[1,2-b]pyridazine
    —— Ethyl 4'-oxospiro[1,3-dithiolane-2,2'-bicyclo[3.1.0]hexane]-6'-carboxylate —— C11H14O3S2
    Ethyl 4'-oxospiro[1,3-dithiolane-2,2'-bicyclo[3.1.0]hexane]-6'-carboxylate
    —— 1,5-Dideoxy-1,5-imino-2-S-phenyl-2-thio-D-glucitol 160711-00-2 C12H17NO3S
    1,5-Dideoxy-1,5-imino-2-S-phenyl-2-thio-D-glucitol
    —— 3-chloro-4,5-dimethyl-6-allylthiopyridazine —— C9H11ClN2S
    3-chloro-4,5-dimethyl-6-allylthiopyridazine
    —— 2-(3-Butenyl-2-thio)pyrazine —— C8H10N2S
    2-(3-Butenyl-2-thio)pyrazine
    —— 4-[3-(3,3-Dimethyl-4-oxo-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butyraldehyde —— C15H28O2S2
    4-[3-(3,3-Dimethyl-4-oxo-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butyraldehyde
    —— 2-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanylpyridine-3-carbonitrile —— C16H17N3OS
    2-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanylpyridine-3-carbonitrile
    —— 4-methylthio-3-(isoxazol-3-yl)-2-methylbromobenzene 391199-90-9 C11H10BrNOS
    4-methylthio-3-(isoxazol-3-yl)-2-methylbromobenzene
    —— N-phenyl-5-(thiophen-2-ylsulfanylmethyl)-1H-1,2,4-triazol-3-amine —— C13H12N4S2
    N-phenyl-5-(thiophen-2-ylsulfanylmethyl)-1H-1,2,4-triazol-3-amine
    —— 4-[2-(4-Methylphenylsulfanyl)phenyl]-3,6-dihydro-2H-pyridine —— C18H19NS
    4-[2-(4-Methylphenylsulfanyl)phenyl]-3,6-dihydro-2H-pyridine
    —— 5-(thiophen-2-ylmethyl)-3-(thiophen-3-ylmethylsulfanyl)-1H-1,2,4-triazole —— C12H11N3S3
    5-(thiophen-2-ylmethyl)-3-(thiophen-3-ylmethylsulfanyl)-1H-1,2,4-triazole
    —— endo-8-methyl-6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane —— C13H21N3S2
    endo-8-methyl-6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— 3-benzylsulfanyl-5-[(3-methylphenyl)methyl]-1H-1,2,4-triazole —— C17H17N3S
    3-benzylsulfanyl-5-[(3-methylphenyl)methyl]-1H-1,2,4-triazole
    —— 2-amino-4-ethylsulfanyl-6-furan-2-yl-pyrimidine-5-carbonitrile —— C11H10N4OS
    2-amino-4-ethylsulfanyl-6-furan-2-yl-pyrimidine-5-carbonitrile
    —— 2-(4-Pyrazol-1-ylpyrimidin-2-yl)sulfanylacetic acid —— C9H8N4O2S
    2-(4-Pyrazol-1-ylpyrimidin-2-yl)sulfanylacetic acid
    —— 3-[(2,6-difluorophenyl)methylsulfanyl]-1H-1,2,4-triazol-5-amine —— C9H8F2N4S
    3-[(2,6-difluorophenyl)methylsulfanyl]-1H-1,2,4-triazol-5-amine
    —— 1-(2-Hydroxy-ethyl)-3-(3-methyl-cyclohex-2-enylmethyl)-thiourea —— C11H20N2OS
    1-(2-Hydroxy-ethyl)-3-(3-methyl-cyclohex-2-enylmethyl)-thiourea
    —— Diethynylcarbamodithioic acid —— C5H3NS2
    Diethynylcarbamodithioic acid
    —— 3-(2-ethoxyethylsulfanyl)-1H-1,2,4-triazol-5-amine —— C6H12N4OS
    3-(2-ethoxyethylsulfanyl)-1H-1,2,4-triazol-5-amine
    —— Trioctadecylsulfanium —— C54H111S+
    Trioctadecylsulfanium