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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-propan-2-ylpropanamide —— C13H18N4O2S
    (2R)-2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-propan-2-ylpropanamide
    —— (2S)-2-[[4-cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-propan-2-ylpropanamide —— C18H26N4O2S
    (2S)-2-[[4-cyclohexyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-propan-2-ylpropanamide
    —— N-(5-oxo-1-phenyl-4H-pyrazol-3-yl)-2-pyrimidin-2-ylsulfanylacetamide —— C15H13N5O2S
    N-(5-oxo-1-phenyl-4H-pyrazol-3-yl)-2-pyrimidin-2-ylsulfanylacetamide
    —— (2R)-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1S)-1-phenylbutyl]propanamide —— C17H23N3OS3
    (2R)-2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1S)-1-phenylbutyl]propanamide
    —— N-methyl-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide —— C20H21N3O2S
    N-methyl-2-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1R)-1-phenylethyl]acetamide
    —— (2S)-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide —— C15H19N3O2S
    (2S)-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide
    —— N-methyl-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-phenylethyl]acetamide —— C20H21N3O2S
    N-methyl-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S)-1-phenylethyl]acetamide
    —— (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide —— C14H16FN3OS3
    (2R)-2-[[4-(4-fluorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propan-2-ylpropanamide
    —— N-butyl-2-[[5-(furan-2-yl)-4-(2-methylpropyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C16H24N4O2S
    N-butyl-2-[[5-(furan-2-yl)-4-(2-methylpropyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-(furan-2-ylmethyl)-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C15H13N5O2S3
    N-(furan-2-ylmethyl)-5-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— 2-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-5-[(6-methyl-2-propan-2-ylpyrimidin-4-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C21H21N5O2S
    2-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-5-[(6-methyl-2-propan-2-ylpyrimidin-4-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— 4-[[4-Benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-thiazole —— C17H14N4OS2
    4-[[4-Benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-thiazole
    —— 2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide —— C21H20N4O3S
    2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide
    —— 2-(2-Bromophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole —— C14H7BrN4OS2
    2-(2-Bromophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole
    —— 5-(4-fluorophenyl)-4-[1-[[(2S)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylthieno[2,3-d]pyrimidine —— C18H15FN6OS2
    5-(4-fluorophenyl)-4-[1-[[(2S)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylthieno[2,3-d]pyrimidine
    —— 2-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-5-[(4-methyl-1,3-thiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C17H14N4O2S2
    2-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-5-[(4-methyl-1,3-thiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— N-benzyl-2-[(4,5-dicyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-N-propan-2-ylacetamide —— C20H26N4OS
    N-benzyl-2-[(4,5-dicyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-N-propan-2-ylacetamide
    —— 5-(4-fluorophenyl)-4-[1-[[(2R)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylthieno[2,3-d]pyrimidine —— C18H15FN6OS2
    5-(4-fluorophenyl)-4-[1-[[(2R)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylthieno[2,3-d]pyrimidine
    —— N-(3-fluorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine —— C14H8FN5S3
    N-(3-fluorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine
    —— 5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine —— C18H20N4OS3
    5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]-1,3,4-thiadiazol-2-amine
    —— 2-[[4-amino-5-[(2-fluorophenyl)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(2,4-dimethylphenyl)methyl]-N-methylacetamide —— C21H24FN5OS
    2-[[4-amino-5-[(2-fluorophenyl)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(2,4-dimethylphenyl)methyl]-N-methylacetamide
    —— (2R)-N-cycloheptyl-2-[[5-[[(2S)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C17H28N4O2S2
    (2R)-N-cycloheptyl-2-[[5-[[(2S)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2R)-N-cycloheptyl-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C17H28N4O2S2
    (2R)-N-cycloheptyl-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2S)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]propan-1-one —— C18H24N4O3S2
    (2S)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]propan-1-one
    —— N-cyclopropyl-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C10H16N4O2S
    N-cyclopropyl-2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-(2-chlorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine —— C14H8ClN5S3
    N-(2-chlorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine
    —— 4-[1-[[(2R)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanyl-6-phenylthieno[2,3-d]pyrimidine —— C18H16N6OS2
    4-[1-[[(2R)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanyl-6-phenylthieno[2,3-d]pyrimidine
    —— (2R)-N-[(1S)-1-phenylethyl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)propanamide —— C18H24N4OS
    (2R)-N-[(1S)-1-phenylethyl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)propanamide
    —— N-[(4-fluorophenyl)methyl]-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine —— C15H10FN5S3
    N-[(4-fluorophenyl)methyl]-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine
    —— 5-[(dimethylamino)methyl]-4-methylsulfanyl-1H-pyrrol-3-amine —— C8H15N3S
    5-[(dimethylamino)methyl]-4-methylsulfanyl-1H-pyrrol-3-amine
    —— N-[[(2R)-oxolan-2-yl]methyl]-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine —— C13H13N5OS3
    N-[[(2R)-oxolan-2-yl]methyl]-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine
    —— 1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C17H22N4O3S2
    1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 5-((Isoxazol-5-ylmethyl)thio)-1,3,4-thiadiazol-2-amine —— C6H6N4OS2
    5-((Isoxazol-5-ylmethyl)thio)-1,3,4-thiadiazol-2-amine
    —— 4-cyclopropyl-3-(1,2-oxazol-5-ylmethylsulfanyl)-1H-1,2,4-triazol-5-one —— C9H10N4O2S
    4-cyclopropyl-3-(1,2-oxazol-5-ylmethylsulfanyl)-1H-1,2,4-triazol-5-one
    —— 1-(2,5-dimethyl-1-propan-2-ylpyrrol-3-yl)-2-[1-[[(2R)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylethanone —— C17H25N5O2S
    1-(2,5-dimethyl-1-propan-2-ylpyrrol-3-yl)-2-[1-[[(2R)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylethanone
    —— 2-(Furan-2-yl)-5-[(5-thiophen-2-yl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-oxadiazole —— C14H9N3O3S2
    2-(Furan-2-yl)-5-[(5-thiophen-2-yl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— (2S)-N-[(1R)-1-phenylethyl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)propanamide —— C18H24N4OS
    (2S)-N-[(1R)-1-phenylethyl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)propanamide
    —— 5-(Furan-2-yl)-3-[[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylmethyl]-1,2-oxazole —— C14H11N5O2S2
    5-(Furan-2-yl)-3-[[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylmethyl]-1,2-oxazole
    —— N-(4-fluorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine —— C14H8FN5S3
    N-(4-fluorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine
    —— 2-[(1-Tert-butyltetrazol-5-yl)sulfanylmethyl]-5-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,3,4-oxadiazole —— C18H19N7O2S
    2-[(1-Tert-butyltetrazol-5-yl)sulfanylmethyl]-5-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,3,4-oxadiazole
    —— 1-[2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylacetyl]pyrrolidin-2-one —— C12H10ClF3N2O2S
    1-[2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanylacetyl]pyrrolidin-2-one
    —— ethyl (Z)-3-thiophen-2-yl-2-(3-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)prop-2-enoate —— C17H14N4O2S3
    ethyl (Z)-3-thiophen-2-yl-2-(3-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)prop-2-enoate
    —— ethyl (Z)-3-thiophen-3-yl-2-(3-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)prop-2-enoate —— C17H14N4O2S3
    ethyl (Z)-3-thiophen-3-yl-2-(3-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)prop-2-enoate
    —— ethyl (Z)-2-(3-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-3-thiophen-2-ylprop-2-enoate —— C14H14N4O2S2
    ethyl (Z)-2-(3-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-3-thiophen-2-ylprop-2-enoate
    —— ethyl (Z)-2-(3-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-3-thiophen-3-ylprop-2-enoate —— C14H14N4O2S2
    ethyl (Z)-2-(3-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-3-thiophen-3-ylprop-2-enoate
    —— (2R)-N-cycloheptyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide —— C12H21N5OS
    (2R)-N-cycloheptyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide
    —— (2S)-N-benzyl-N-tert-butyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide —— C16H23N5OS
    (2S)-N-benzyl-N-tert-butyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide
    —— (2S)-N-cycloheptyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide —— C12H21N5OS
    (2S)-N-cycloheptyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide
    —— (2R)-N-benzyl-N-tert-butyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide —— C16H23N5OS
    (2R)-N-benzyl-N-tert-butyl-2-(1-methyltetrazol-5-yl)sulfanylpropanamide
    —— (2R)-2-(2-chlorophenyl)sulfanyl-N-(thiophen-2-ylmethyl)propanamide —— C14H14ClNOS2
    (2R)-2-(2-chlorophenyl)sulfanyl-N-(thiophen-2-ylmethyl)propanamide