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有机硫化合物

有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在,在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特,在药物设计、合成化学以及材料制备方面扮演着重要角色。

1. 结构与分类

有机硫化合物可以按硫的连接方式分为饱和和不饱和类,如二硫化物、噻吩衍生物、砜等。常见的结构类型有:

  • 二硫化物:含-S-S-键的化合物。
  • 硫醚(Thiols):含有-R-S-H或-R-S-R 基团的化合物。
  • 磺酸酯(Sulfonates)与磺酸盐(Sulfonates):带有-SO3H基团的化合物,广泛应用于合成和制药领域。
  • 噻吩及其衍生物:具有环状结构的有机硫化物。
2. 生物学活性

许多有机硫化合物在生物学上有重要功能或应用潜力。例如:

  • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
  • 硫代葡萄糖苷(Glycosinolate)是十字花科植物中的一种天然存在物质,具有生物活性。
3. 合成方法

有机硫化合物可通过多种途径合成:

  • 亲核取代反应:使用含硫试剂与卤化物进行反应。
  • 自由基加成法:采用氧化剂引发自由基形成,通过烯烃与H2S、R-S-H等反应制备。
  • 金属催化转化:利用钯、铜等催化剂促进特定硫化过程。
4. 应用领域

有机硫化合物的应用广泛:

  • 医药领域:用于开发抗菌剂、抗病毒药物及抗癌药物等。
  • 农学研究:某些有机硫化合物作为生物农药的有效成分,能够抑制病害的发生。
  • 材料科学与技术:在导电聚合物和塑料添加剂中有重要应用。
5. 环境与安全性

尽管有机硫化合物具有许多潜在益处,但其生产和使用也可能对环境造成影响。因此,在设计和合成这些化合物时需要考虑可持续性和环保性因素。

以上是对有机硫化合物的简单介绍,包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

中文名称 英文名称 CAS号 化学式 结构式图片
—— 2-(4-chlorophenyl)sulfanyl-5-nitro-N-prop-2-enylbenzamide —— C16H13ClN2O3S
2-(4-chlorophenyl)sulfanyl-5-nitro-N-prop-2-enylbenzamide
—— (7R)-3-(2-cyclohexylethyl)-N,6-dimethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxamide —— C15H23N5OS
(7R)-3-(2-cyclohexylethyl)-N,6-dimethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxamide
—— 2-[2-(4-Fluorophenyl)sulfanylethyl]-5,6-dimethyl-3-oxopyridazine-4-carbonitrile —— C15H14FN3OS
2-[2-(4-Fluorophenyl)sulfanylethyl]-5,6-dimethyl-3-oxopyridazine-4-carbonitrile
—— 2-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-5-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C18H18N6O2S
2-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-5-[(4-propan-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,4-oxadiazole
—— (7S)-3-(2-cyclohexylethyl)-N,6-dimethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxamide —— C15H23N5OS
(7S)-3-(2-cyclohexylethyl)-N,6-dimethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carboxamide
—— 6-Tert-butyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-amine —— C9H15N3S
6-Tert-butyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-amine
—— 1-[(3S)-3,5-dithiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-(1-ethyltetrazol-5-yl)sulfanylethanone —— C16H16N6OS3
1-[(3S)-3,5-dithiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-(1-ethyltetrazol-5-yl)sulfanylethanone
—— (2S)-2-[[5-[cyclopropyl(propanoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide —— C16H20N4O3S2
(2S)-2-[[5-[cyclopropyl(propanoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide
—— N-benzyl-2-[3-[2-[benzyl(methyl)amino]-2-oxoethyl]sulfanyl-1,2,4-triazol-4-yl]-N-methylacetamide —— C22H25N5O2S
N-benzyl-2-[3-[2-[benzyl(methyl)amino]-2-oxoethyl]sulfanyl-1,2,4-triazol-4-yl]-N-methylacetamide
—— (2R)-2-[[5-[cyclopropyl(propanoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide —— C16H20N4O3S2
(2R)-2-[[5-[cyclopropyl(propanoyl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)propanamide
—— N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[[5-(furan-2-ylmethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H17FN4O2S2
N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[[5-(furan-2-ylmethylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
—— (2S)-2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-cycloheptylpropanamide —— C18H22ClN3O2S
(2S)-2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-cycloheptylpropanamide
—— 7-[[5-(Furan-2-ylmethylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C15H13N5O2S3
7-[[5-(Furan-2-ylmethylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
—— 2-Methyl-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5-phenylthieno[2,3-d]pyrimidine —— C16H12N4S3
2-Methyl-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5-phenylthieno[2,3-d]pyrimidine
—— Tert-butyl 2-[[5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate —— C14H15BrN2O3S
Tert-butyl 2-[[5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate
—— N-(3-chlorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine —— C14H8ClN5S3
N-(3-chlorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine
—— 1-(1-Ethyl-2,5-dimethylpyrrol-3-yl)-2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C18H22N4O2S
1-(1-Ethyl-2,5-dimethylpyrrol-3-yl)-2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]ethanone
—— 5-[[5-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H12N6O2S2
5-[[5-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
—— (2S)-2-(2-chlorophenyl)sulfanyl-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]propanamide —— C14H15ClN2O3S2
(2S)-2-(2-chlorophenyl)sulfanyl-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]propanamide
—— (2S)-2-(2-chlorophenyl)sulfanyl-N-[(4-methylphenyl)methyl]propanamide —— C17H18ClNOS
(2S)-2-(2-chlorophenyl)sulfanyl-N-[(4-methylphenyl)methyl]propanamide
—— (2S)-N-[(2-chlorophenyl)methyl]-2-(2-chlorophenyl)sulfanylpropanamide —— C16H15Cl2NOS
(2S)-N-[(2-chlorophenyl)methyl]-2-(2-chlorophenyl)sulfanylpropanamide
—— N'-[2-(2-chlorophenyl)sulfanylacetyl]-2-(4-methyl-1,3-thiazol-2-yl)acetohydrazide —— C14H14ClN3O2S2
N'-[2-(2-chlorophenyl)sulfanylacetyl]-2-(4-methyl-1,3-thiazol-2-yl)acetohydrazide
—— (2R)-2-(2-chlorophenyl)sulfanyl-N-cycloheptylpropanamide —— C16H22ClNOS
(2R)-2-(2-chlorophenyl)sulfanyl-N-cycloheptylpropanamide
—— 4-Methyl-4-(2-methyl-1,3-dithiolan-2-yl)pentanenitrile —— C10H17NS2
4-Methyl-4-(2-methyl-1,3-dithiolan-2-yl)pentanenitrile
—— (2S)-2-(4-chlorophenyl)sulfanyl-N-(propan-2-ylcarbamoyl)propanamide —— C13H17ClN2O2S
(2S)-2-(4-chlorophenyl)sulfanyl-N-(propan-2-ylcarbamoyl)propanamide
—— (2E)-2-cyano-3-(4-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}thiophen-2-yl)prop-2-enethioamide —— C11H10N6S3
(2E)-2-cyano-3-(4-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}thiophen-2-yl)prop-2-enethioamide
—— 4-{[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}thiophene-2-carbaldehyde —— C8H7N3OS3
4-{[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}thiophene-2-carbaldehyde
—— methyl (2E)-3-(4-{[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}thiophen-2-yl)-2-cyanoprop-2-enoate —— C12H10N4O2S3
methyl (2E)-3-(4-{[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}thiophen-2-yl)-2-cyanoprop-2-enoate
—— ethyl (2E)-3-(4-{[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}thiophen-2-yl)-2-cyanoprop-2-enoate —— C13H12N4O2S3
ethyl (2E)-3-(4-{[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}thiophen-2-yl)-2-cyanoprop-2-enoate
—— (2R)-N'-[2-(2-fluorophenyl)sulfanylacetyl]-2-(4-methylphenyl)sulfanylpropanehydrazide —— C18H19FN2O2S2
(2R)-N'-[2-(2-fluorophenyl)sulfanylacetyl]-2-(4-methylphenyl)sulfanylpropanehydrazide
—— 1-(3-methylbutyl)-3-[[(2S)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea —— C16H25N3OS2
1-(3-methylbutyl)-3-[[(2S)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea
—— 1-(3-methylbutyl)-3-[[(2R)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea —— C16H25N3OS2
1-(3-methylbutyl)-3-[[(2R)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea
—— (E)-N'-[2-(4-methylphenyl)sulfanylacetyl]-3-(5-methylthiophen-2-yl)prop-2-enehydrazide —— C17H18N2O2S2
(E)-N'-[2-(4-methylphenyl)sulfanylacetyl]-3-(5-methylthiophen-2-yl)prop-2-enehydrazide
—— (2R)-N'-[2-(3,5-dimethylpyrazol-1-yl)acetyl]-2-(4-methylphenyl)sulfanylpropanehydrazide —— C17H22N4O2S
(2R)-N'-[2-(3,5-dimethylpyrazol-1-yl)acetyl]-2-(4-methylphenyl)sulfanylpropanehydrazide
—— 1-[(2S)-1-methoxypropan-2-yl]-3-[[(2S)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea —— C15H23N3O2S2
1-[(2S)-1-methoxypropan-2-yl]-3-[[(2S)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea
—— 1-(4-chlorophenyl)-3-[[(2S)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea —— C17H18ClN3OS2
1-(4-chlorophenyl)-3-[[(2S)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea
—— (2R)-N'-[2-(1-adamantyl)acetyl]-2-(4-methylphenyl)sulfanylpropanehydrazide —— C22H30N2O2S
(2R)-N'-[2-(1-adamantyl)acetyl]-2-(4-methylphenyl)sulfanylpropanehydrazide
—— 1-(4-chlorophenyl)-3-[[(2R)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea —— C17H18ClN3OS2
1-(4-chlorophenyl)-3-[[(2R)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea
—— 1-[(2S)-1-methoxypropan-2-yl]-3-[[(2R)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea —— C15H23N3O2S2
1-[(2S)-1-methoxypropan-2-yl]-3-[[(2R)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea
—— (2S)-N-[(3-chlorophenyl)methyl]-2-(4-methylphenyl)sulfanylpropanamide —— C17H18ClNOS
(2S)-N-[(3-chlorophenyl)methyl]-2-(4-methylphenyl)sulfanylpropanamide
—— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(2S)-2-phenylpropyl]propanamide —— C19H25N3OS
3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(2S)-2-phenylpropyl]propanamide
—— 1-Tert-butyl-3-[3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoylamino]thiourea —— C15H25N5OS2
1-Tert-butyl-3-[3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoylamino]thiourea
—— 1-tert-butyl-3-[[(2S)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea —— C15H23N3OS2
1-tert-butyl-3-[[(2S)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea
—— 1-tert-butyl-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea —— C14H21N3OS2
1-tert-butyl-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea
—— 1-Tert-butyl-3-[3-(3,4-dimethylphenyl)sulfanylpropanoylamino]thiourea —— C16H25N3OS2
1-Tert-butyl-3-[3-(3,4-dimethylphenyl)sulfanylpropanoylamino]thiourea
—— 1-Tert-butyl-3-[[2-(2-methylphenyl)sulfanylacetyl]amino]thiourea —— C14H21N3OS2
1-Tert-butyl-3-[[2-(2-methylphenyl)sulfanylacetyl]amino]thiourea
—— 1-Tert-butyl-3-[(2-phenylsulfanylacetyl)amino]thiourea —— C13H19N3OS2
1-Tert-butyl-3-[(2-phenylsulfanylacetyl)amino]thiourea
—— 1-tert-butyl-3-[[(2S)-2-phenylsulfanylpropanoyl]amino]thiourea —— C14H21N3OS2
1-tert-butyl-3-[[(2S)-2-phenylsulfanylpropanoyl]amino]thiourea
—— 1-Tert-butyl-3-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]amino]thiourea —— C15H18FN5O2S2
1-Tert-butyl-3-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]amino]thiourea
—— 1-Tert-butyl-3-[[2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]amino]thiourea —— C15H18ClN5O2S2
1-Tert-butyl-3-[[2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]amino]thiourea