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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (4R)-5-acetyl-6-methyl-4-(3-methylthiophen-2-yl)-2-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-3-carbonitrile —— C21H20N2OS3
    (4R)-5-acetyl-6-methyl-4-(3-methylthiophen-2-yl)-2-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-3-carbonitrile
    —— 6-[(3R)-3-(aminomethyl)pyrrolidin-1-yl]-2-butylsulfanylpyrimidin-4-amine —— C13H23N5S
    6-[(3R)-3-(aminomethyl)pyrrolidin-1-yl]-2-butylsulfanylpyrimidin-4-amine
    —— N-(1-cyanocyclohexyl)-2-(2,4-dimethylphenyl)sulfanyl-N-methylacetamide —— C18H24N2OS
    N-(1-cyanocyclohexyl)-2-(2,4-dimethylphenyl)sulfanyl-N-methylacetamide
    —— (4S)-3-acetyl-2-methyl-4-phenyl-6-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-5-carbonitrile —— C22H20N2OS2
    (4S)-3-acetyl-2-methyl-4-phenyl-6-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-5-carbonitrile
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-(4-methylcyclohexyl)acetamide —— C17H25NOS
    2-(2,4-dimethylphenyl)sulfanyl-N-(4-methylcyclohexyl)acetamide
    —— 2-methyl-5-[3-[4-[(3S)-piperidin-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole —— C13H20N6S2
    2-methyl-5-[3-[4-[(3S)-piperidin-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole
    —— 2-methyl-5-[3-[4-[(3R)-piperidin-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole —— C13H20N6S2
    2-methyl-5-[3-[4-[(3R)-piperidin-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole
    —— 1-[2,5-Dimethyl-1-(2,2,2-trifluoroethyl)pyrrol-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C18H16F3N3O2S
    1-[2,5-Dimethyl-1-(2,2,2-trifluoroethyl)pyrrol-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— (2S)-N-benzyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H17N3O2S
    (2S)-N-benzyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C16H19NOS2
    2-(2,5-dimethylphenyl)sulfanyl-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— 2-butylsulfanyl-6-[(3S)-3-(methylsulfonylmethyl)piperidin-1-yl]pyrimidin-4-amine —— C15H26N4O2S2
    2-butylsulfanyl-6-[(3S)-3-(methylsulfonylmethyl)piperidin-1-yl]pyrimidin-4-amine
    —— N-(1-cyanocyclopentyl)-2-{[3-(thiophen-2-yl)-1H-1,2,4-triazol-5-yl]sulfanyl}acetamide —— C14H15N5OS2
    N-(1-cyanocyclopentyl)-2-{[3-(thiophen-2-yl)-1H-1,2,4-triazol-5-yl]sulfanyl}acetamide
    —— 6-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-2-butylsulfanylpyrimidin-4-amine —— C13H23N5S
    6-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-2-butylsulfanylpyrimidin-4-amine
    —— 1-thiophen-2-yl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C12H9N3OS3
    1-thiophen-2-yl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 2-butylsulfanyl-6-[(3R)-3-(methylsulfonylmethyl)piperidin-1-yl]pyrimidin-4-amine —— C15H26N4O2S2
    2-butylsulfanyl-6-[(3R)-3-(methylsulfonylmethyl)piperidin-1-yl]pyrimidin-4-amine
    —— N-cyclohexyl-N-ethyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H22N4OS2
    N-cyclohexyl-N-ethyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H15FN4OS2
    N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2S)-N-(furan-2-ylmethyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C14H14N4O2S2
    (2S)-N-(furan-2-ylmethyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(2R)-3-methylbutan-2-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C13H18N4OS2
    N-[(2R)-3-methylbutan-2-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N,N-bis(prop-2-enyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C14H16N4OS2
    N,N-bis(prop-2-enyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— ethyl (2R)-2-phenyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetate —— C16H15N3O2S2
    ethyl (2R)-2-phenyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetate
    —— N-[[(3S)-1-(2-methoxyethyl)pyrrolidin-3-yl]methyl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine —— C18H31N5OS
    N-[[(3S)-1-(2-methoxyethyl)pyrrolidin-3-yl]methyl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine
    —— N-[[(3R)-1-(2-methoxyethyl)pyrrolidin-3-yl]methyl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine —— C18H31N5OS
    N-[[(3R)-1-(2-methoxyethyl)pyrrolidin-3-yl]methyl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine
    —— N-(1-cyanocyclohexyl)-2-{[5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide —— C15H17N5OS2
    N-(1-cyanocyclohexyl)-2-{[5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
    —— 2-butylsulfanyl-4-N-[(1S)-1-(1-methylpyrazol-4-yl)ethyl]pyrimidine-4,6-diamine —— C14H22N6S
    2-butylsulfanyl-4-N-[(1S)-1-(1-methylpyrazol-4-yl)ethyl]pyrimidine-4,6-diamine
    —— N-[(1S,2R)-2-methylcyclohexyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C15H20N4OS2
    N-[(1S,2R)-2-methylcyclohexyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 3,5-dimethyl-4-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,2-oxazole —— C12H12N4OS2
    3,5-dimethyl-4-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,2-oxazole
    —— 2-butylsulfanyl-4-N-[(1R)-1-(1-methylpyrazol-4-yl)ethyl]pyrimidine-4,6-diamine —— C14H22N6S
    2-butylsulfanyl-4-N-[(1R)-1-(1-methylpyrazol-4-yl)ethyl]pyrimidine-4,6-diamine
    —— N-propan-2-yl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C11H14N4OS2
    N-propan-2-yl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 3-[2-oxo-2-(1,2,5-trimethylpyrrol-3-yl)ethyl]sulfanyl-4-propyl-1H-1,2,4-triazol-5-one —— C14H20N4O2S
    3-[2-oxo-2-(1,2,5-trimethylpyrrol-3-yl)ethyl]sulfanyl-4-propyl-1H-1,2,4-triazol-5-one
    —— 2-butylsulfanyl-4-N-[[(3S)-1,1-dioxothiolan-3-yl]methyl]pyrimidine-4,6-diamine —— C13H22N4O2S2
    2-butylsulfanyl-4-N-[[(3S)-1,1-dioxothiolan-3-yl]methyl]pyrimidine-4,6-diamine
    —— 3-[2-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl]sulfanyl-4-propyl-1H-1,2,4-triazol-5-one —— C17H26N4O3S
    3-[2-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl]sulfanyl-4-propyl-1H-1,2,4-triazol-5-one
    —— 2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-pentan-2-yl]acetamide —— C12H22N4O2S
    2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-pentan-2-yl]acetamide
    —— 2-butylsulfanyl-4-N-[[(3R)-1,1-dioxothiolan-3-yl]methyl]pyrimidine-4,6-diamine —— C13H22N4O2S2
    2-butylsulfanyl-4-N-[[(3R)-1,1-dioxothiolan-3-yl]methyl]pyrimidine-4,6-diamine
    —— ethyl 2-[2-[2-[[(1R)-1-(2-chlorophenyl)ethyl]amino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate —— C17H19ClN2O3S2
    ethyl 2-[2-[2-[[(1R)-1-(2-chlorophenyl)ethyl]amino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— ethyl (2R)-2-[(6-phenyl-1,2,4-triazin-3-yl)sulfanyl]propanoate —— C14H15N3O2S
    ethyl (2R)-2-[(6-phenyl-1,2,4-triazin-3-yl)sulfanyl]propanoate
    —— ethyl 2-[2-[(2R)-1-oxo-1-[[(2S)-4-phenylbutan-2-yl]amino]propan-2-yl]sulfanyl-1,3-thiazol-4-yl]acetate —— C20H26N2O3S2
    ethyl 2-[2-[(2R)-1-oxo-1-[[(2S)-4-phenylbutan-2-yl]amino]propan-2-yl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— 2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-phenylethyl]acetamide —— C12H15N5OS
    2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-phenylethyl]acetamide
    —— 2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(2S)-pentan-2-yl]acetamide —— C12H22N4O2S
    2-[(5-oxo-4-propyl-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(2S)-pentan-2-yl]acetamide
    —— Ethyl 2-[2-[2-[(1-cyanocyclohexyl)-methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate —— C17H23N3O3S2
    Ethyl 2-[2-[2-[(1-cyanocyclohexyl)-methylamino]-2-oxoethyl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— 2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione —— C5H3N3O2S
    2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione
    —— ethyl 2-[2-[(2R)-1-(cyclohexylmethylamino)-1-oxopropan-2-yl]sulfanyl-1,3-thiazol-4-yl]acetate —— C17H26N2O3S2
    ethyl 2-[2-[(2R)-1-(cyclohexylmethylamino)-1-oxopropan-2-yl]sulfanyl-1,3-thiazol-4-yl]acetate
    —— 3-(3-hydroxypropylsulfanyl)-4H-1,2,4-triazin-5-one —— C6H9N3O2S
    3-(3-hydroxypropylsulfanyl)-4H-1,2,4-triazin-5-one
    —— (4-methoxycyclohexyl)-[(2R)-2-[4-methyl-5-(2-pyrrolidin-1-ium-1-ylethylsulfanyl)-1,2,4-triazol-3-yl]pyrrolidin-1-yl]methanone —— C21H36N5O2S+
    (4-methoxycyclohexyl)-[(2R)-2-[4-methyl-5-(2-pyrrolidin-1-ium-1-ylethylsulfanyl)-1,2,4-triazol-3-yl]pyrrolidin-1-yl]methanone
    —— [(3R)-1-(6-amino-2-butylsulfanylpyrimidin-4-yl)piperidin-3-yl]-(1-methylimidazol-2-yl)methanone —— C18H26N6OS
    [(3R)-1-(6-amino-2-butylsulfanylpyrimidin-4-yl)piperidin-3-yl]-(1-methylimidazol-2-yl)methanone
    —— 3-[(2S)-1-(furan-2-ylmethyl)pyrrolidin-1-ium-2-yl]-4-methyl-5-(2-pyrrolidin-1-ium-1-ylethylsulfanyl)-1,2,4-triazole —— C18H29N5OS+2
    3-[(2S)-1-(furan-2-ylmethyl)pyrrolidin-1-ium-2-yl]-4-methyl-5-(2-pyrrolidin-1-ium-1-ylethylsulfanyl)-1,2,4-triazole
    —— (2S)-2-(4-chlorophenyl)sulfanyl-N-[(2-methylphenyl)methyl]propanamide —— C17H18ClNOS
    (2S)-2-(4-chlorophenyl)sulfanyl-N-[(2-methylphenyl)methyl]propanamide
    —— [(3R,5R)-5-methyl-2-oxooxolan-3-yl] 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylbenzoate —— C20H18N2O4S2
    [(3R,5R)-5-methyl-2-oxooxolan-3-yl] 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylbenzoate
    —— (3S)-1-(4-methylcyclohexyl)-3-(5-methylsulfanyl-4-propan-2-yl-1,2,4-triazol-3-yl)piperidin-1-ium —— C18H33N4S+
    (3S)-1-(4-methylcyclohexyl)-3-(5-methylsulfanyl-4-propan-2-yl-1,2,4-triazol-3-yl)piperidin-1-ium
    —— 4-methyl-3-(2-pyrrolidin-1-ylethylsulfanyl)-5-[(2R)-1-(thiophen-2-ylmethyl)pyrrolidin-2-yl]-1,2,4-triazole —— C18H27N5S2
    4-methyl-3-(2-pyrrolidin-1-ylethylsulfanyl)-5-[(2R)-1-(thiophen-2-ylmethyl)pyrrolidin-2-yl]-1,2,4-triazole