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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— methyl (1R<sup>*</sup>,6S<sup>*</sup>,8S<sup>*</sup>)-8-methylsulfonyl-2-oxa-7-thiabicyclo<4.2.0>octane-8-acetate 7,7-dioxide 144632-67-7 C10H16O7S2
    methyl (1R<sup>*</sup>,6S<sup>*</sup>,8S<sup>*</sup>)-8-methylsulfonyl-2-oxa-7-thiabicyclo<4.2.0>octane-8-acetate 7,7-dioxide
    —— 5-Chloro-2-(p-tolylthio)-3-oxatricyclo<5.2.1.0<sup>2,6</sup>>dec-8-en-4-one —— C16H15ClO2S
    5-Chloro-2-(p-tolylthio)-3-oxatricyclo<5.2.1.0<sup>2,6</sup>>dec-8-en-4-one
    —— Ethyl-carbamic acid (4aS,9aR)-1,4a-dimethyl-1,2,3,4,4a,9a-hexahydro-benzo[4,5]thieno[2,3-b]pyridin-6-yl ester —— C16H22N2O2S
    Ethyl-carbamic acid (4aS,9aR)-1,4a-dimethyl-1,2,3,4,4a,9a-hexahydro-benzo[4,5]thieno[2,3-b]pyridin-6-yl ester
    —— 2-Methyl-5-[(6-phenyl-1,2,4-triazin-3-yl)methylsulfanyl]-1,3,4-thiadiazole —— C13H11N5S2
    2-Methyl-5-[(6-phenyl-1,2,4-triazin-3-yl)methylsulfanyl]-1,3,4-thiadiazole
    —— (1'R,4'S,5'R,6'R)-5'-chloro-6'-phenylsulfanylspiro[1,3-dioxolane-2,2'-7-oxabicyclo[2.2.1]heptane] —— C14H15ClO3S
    (1'R,4'S,5'R,6'R)-5'-chloro-6'-phenylsulfanylspiro[1,3-dioxolane-2,2'-7-oxabicyclo[2.2.1]heptane]
    —— (4-Benzyl-5-methylsulfanyl-1,2,4-triazol-3-yl)carbamodithioic acid —— C11H12N4S3
    (4-Benzyl-5-methylsulfanyl-1,2,4-triazol-3-yl)carbamodithioic acid
    —— 3-[2-[2-(1,3-Dioxolan-2-yl)ethyl]-1,3-dithian-2-yl]pyridine —— C14H19NO2S2
    3-[2-[2-(1,3-Dioxolan-2-yl)ethyl]-1,3-dithian-2-yl]pyridine
    —— 2-[[2-amino-4-([18F]fluoromethyl)phenyl]thio]-N,N-dimethylbenzenemethanamine —— C16H19FN2S
    2-[[2-amino-4-([18F]fluoromethyl)phenyl]thio]-N,N-dimethylbenzenemethanamine
    —— Methyl 2-((4-methyl-1,2,4-triazol-3-yl)thio)acetoacetate (aminocarbonyl)hydrazone —— C9H14N6O3S
    Methyl 2-((4-methyl-1,2,4-triazol-3-yl)thio)acetoacetate (aminocarbonyl)hydrazone
    —— 3-(3-Methyl-imidazo[1,2-b]pyridazin-6-ylsulfanyl)-propane-1-sulfonic acid amide —— C10H14N4O2S2
    3-(3-Methyl-imidazo[1,2-b]pyridazin-6-ylsulfanyl)-propane-1-sulfonic acid amide
    —— (Z,3S,4S)-2-hydroxy-3-methyl-4-phenylsulfanyloct-1-ene-1-diazonium —— C15H21N2OS+
    (Z,3S,4S)-2-hydroxy-3-methyl-4-phenylsulfanyloct-1-ene-1-diazonium
    —— 2-Fluoro-3,3,5,5-tetramethyl-2-phenylsulfanylcyclohexan-1-one —— C16H21FOS
    2-Fluoro-3,3,5,5-tetramethyl-2-phenylsulfanylcyclohexan-1-one
    —— (1S,2R,6R,7R)-2-(p-Tolylthio)-3-oxatricyclo<5.2.1.0<sup>2,6</sup>>dec-8-en-4-one —— C16H16O2S
    (1S,2R,6R,7R)-2-(p-Tolylthio)-3-oxatricyclo<5.2.1.0<sup>2,6</sup>>dec-8-en-4-one
    —— N,N-dimethyl-N-({3-[4-(methylsulfanyl)benzyl]-4-pyridinyl}methyl)amine 662150-41-6 C16H20N2S
    N,N-dimethyl-N-({3-[4-(methylsulfanyl)benzyl]-4-pyridinyl}methyl)amine
    —— 5-ethylthio-2-(1-methyl-4-nitro-2-pyrrolyl)-1,3,4-thiadiazole —— C9H10N4O2S2
    5-ethylthio-2-(1-methyl-4-nitro-2-pyrrolyl)-1,3,4-thiadiazole
    —— 4-Isopropyl-2-methyl-5-(3,4-dimethylphenylthio)-1-[(4-pyridyl)methyl]-1H-pyrrole-3-methanol —— C23H28N2OS
    4-Isopropyl-2-methyl-5-(3,4-dimethylphenylthio)-1-[(4-pyridyl)methyl]-1H-pyrrole-3-methanol
    —— N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-5-(4-chlorophenylsulfanyl)-thiophene-2-carboxamide —— C18H19ClN2OS2
    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-5-(4-chlorophenylsulfanyl)-thiophene-2-carboxamide
    —— 4-cyclohexylthio-3-isopropyl-1-methyl-5-{ [ (pyridin-4-ylmethyl)amino]methyl}-1,3-dihydro-2-imidazolone —— C20H30N4OS
    4-cyclohexylthio-3-isopropyl-1-methyl-5-{ [ (pyridin-4-ylmethyl)amino]methyl}-1,3-dihydro-2-imidazolone
    —— N-(3-phenylsulfanylphenyl)-4-(1,3-thiazol-2-yl)pyrimidin-2-amine —— C19H14N4S2
    N-(3-phenylsulfanylphenyl)-4-(1,3-thiazol-2-yl)pyrimidin-2-amine
    —— N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-5-(4-fluorophenyl)sulfanyl-1,3,4-thiadiazole-2-carboxamide —— C16H17FN4OS2
    N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-5-(4-fluorophenyl)sulfanyl-1,3,4-thiadiazole-2-carboxamide
    —— (2S,4R)-2-amino-4-(3,5-dichloropyridin-2-yl)sulfanyl-4-(3-fluorophenyl)butan-1-ol —— C15H15Cl2FN2OS
    (2S,4R)-2-amino-4-(3,5-dichloropyridin-2-yl)sulfanyl-4-(3-fluorophenyl)butan-1-ol
    —— 4-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-(difluoromethoxy)pyridine-3-carbonitrile —— C17H17F2N3O2S
    4-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-(difluoromethoxy)pyridine-3-carbonitrile
    —— 2,2,3,3,3-Pentafluoropropyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate —— C12H9F5N4O2S
    2,2,3,3,3-Pentafluoropropyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate
    —— 4-(5-methyl-3-pyridin-3-ylsulfanyl-1,2-oxazol-4-yl)-N-phenylpyrimidin-2-amine —— C19H15N5OS
    4-(5-methyl-3-pyridin-3-ylsulfanyl-1,2-oxazol-4-yl)-N-phenylpyrimidin-2-amine
    —— 4-[(3,5-Dichlorophenyl)sulfanyl]-5-ethyl-1-(2-hydroxyethyl)-1H-pyrazole-3-carboxamide —— C14H15Cl2N3O2S
    4-[(3,5-Dichlorophenyl)sulfanyl]-5-ethyl-1-(2-hydroxyethyl)-1H-pyrazole-3-carboxamide
    —— N-[(E)-1,3-dihydroxyoctadec-4-en-2-yl]ethanethioamide —— C20H39NO2S
    N-[(E)-1,3-dihydroxyoctadec-4-en-2-yl]ethanethioamide
    —— 2-[5-(3,5-Dimethyl-phenylsulfanyl)-1-isopropyl-3-methyl-1H-pyrazol-4-ylmethyl]-pyridine 412326-34-2 C21H25N3S
    2-[5-(3,5-Dimethyl-phenylsulfanyl)-1-isopropyl-3-methyl-1H-pyrazol-4-ylmethyl]-pyridine
    —— [5-(3,5-Dichlorophenyl)sulfanyl-3-(hydroxymethyl)-1-propan-2-ylpyrazol-4-yl]methanol —— C14H16Cl2N2O2S
    [5-(3,5-Dichlorophenyl)sulfanyl-3-(hydroxymethyl)-1-propan-2-ylpyrazol-4-yl]methanol
    —— 3-(4-Fluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carbonitrile —— C16H11FN2O2S2
    3-(4-Fluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carbonitrile
    —— 5-(2-Aminopyridin-4-yl)-4-(4-methylphenyl)-2-methylsulfanylthiophene-3-carbonitrile —— C18H15N3S2
    5-(2-Aminopyridin-4-yl)-4-(4-methylphenyl)-2-methylsulfanylthiophene-3-carbonitrile
    —— 3-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-5-chloropyridine-2-carbonitrile —— C16H16ClN3OS
    3-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-5-chloropyridine-2-carbonitrile
    —— (1R,2R)-N-(cyanomethyl)-2-[[4-(dimethylamino)phenyl]sulfanylmethyl]cyclohexane-1-carboxamide —— C18H25N3OS
    (1R,2R)-N-(cyanomethyl)-2-[[4-(dimethylamino)phenyl]sulfanylmethyl]cyclohexane-1-carboxamide
    —— 2-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-ethylpyridine-3-carbonitrile —— C18H21N3OS
    2-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-ethylpyridine-3-carbonitrile
    —— N-(4-fluoro-2-methylphenyl)-4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)pyrimidin-2-amine —— C16H15FN4OS
    N-(4-fluoro-2-methylphenyl)-4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)pyrimidin-2-amine
    —— (5R,6R)-N-(cyanomethyl)-5-[(4-fluorophenyl)sulfanylmethyl]spiro[2.4]heptane-6-carboxamide —— C17H19FN2OS
    (5R,6R)-N-(cyanomethyl)-5-[(4-fluorophenyl)sulfanylmethyl]spiro[2.4]heptane-6-carboxamide
    —— Methyl 4-chloro-8-methyl-3-phenylsulfanyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate —— C16H18ClNO2S
    Methyl 4-chloro-8-methyl-3-phenylsulfanyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate
    —— 3-(6-Phenylsulfanylpyridin-3-yl)-3,9-diazabicyclo[4.2.1]nonane —— C18H21N3S
    3-(6-Phenylsulfanylpyridin-3-yl)-3,9-diazabicyclo[4.2.1]nonane
    —— Methyl 3-[4-amino-5-(thiophen-2-ylmethyl)pyrimidin-2-yl]sulfanylpropanoate —— C13H15N3O2S2
    Methyl 3-[4-amino-5-(thiophen-2-ylmethyl)pyrimidin-2-yl]sulfanylpropanoate
    —— Ethyl 2-[4-(4-nitropyrazol-1-yl)pyrimidin-2-yl]sulfanylacetate —— C11H11N5O4S
    Ethyl 2-[4-(4-nitropyrazol-1-yl)pyrimidin-2-yl]sulfanylacetate
    —— N-(pyridin-4-ylmethyl)-5a,9a-dihydro-[1,4]benzoxathiino[3,2-b]pyridin-7-amine —— C17H15N3OS
    N-(pyridin-4-ylmethyl)-5a,9a-dihydro-[1,4]benzoxathiino[3,2-b]pyridin-7-amine
    —— 4-[3-(4-Hydroxy-3,3-dimethyl-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butan-1-ol —— C15H32O2S2
    4-[3-(4-Hydroxy-3,3-dimethyl-butylsulfanyl)-propylsulfanyl]-2,2-dimethyl-butan-1-ol
    —— 2-[[3-[(5-methylthiophen-2-yl)methylsulfanyl]-1H-1,2,4-triazol-5-yl]methyl]pyridine —— C14H14N4S2
    2-[[3-[(5-methylthiophen-2-yl)methylsulfanyl]-1H-1,2,4-triazol-5-yl]methyl]pyridine
    —— 3-[(3R)-1-azabicyclo[2.2.1]heptan-3-yl]-4-pentylsulfanyl-1,2,5-thiadiazole —— C13H21N3S2
    3-[(3R)-1-azabicyclo[2.2.1]heptan-3-yl]-4-pentylsulfanyl-1,2,5-thiadiazole
    —— Ethyl 2-[4-(4-methylpyrazol-1-yl)pyrimidin-2-yl]sulfanylacetate —— C12H14N4O2S
    Ethyl 2-[4-(4-methylpyrazol-1-yl)pyrimidin-2-yl]sulfanylacetate
    —— 3-(furan-2-ylmethylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-1,2,4-triazole —— C12H11N3OS2
    3-(furan-2-ylmethylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-1,2,4-triazole
    —— 1-(2-Hydroxy-ethyl)-3-(2-ethyl-cyclohex-1-enylmethyl)-thiourea 455256-14-1 C12H22N2OS
    1-(2-Hydroxy-ethyl)-3-(2-ethyl-cyclohex-1-enylmethyl)-thiourea
    —— exo-3-(3-methylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.1]heptane —— C9H13N3S2
    exo-3-(3-methylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.1]heptane
    —— 2-(1,2,2,5,5-Pentamethylimidazol-4-yl)sulfanylethanol —— C10H20N2OS
    2-(1,2,2,5,5-Pentamethylimidazol-4-yl)sulfanylethanol
    —— 1-[(2S)-2-ethylcyclohexyl]-3-(2-hydroxyethyl)thiourea —— C11H22N2OS
    1-[(2S)-2-ethylcyclohexyl]-3-(2-hydroxyethyl)thiourea
    —— 1-(2-Hydroxy-ethyl)-3-(2-methyl-cyclohex-1-enylmethyl)-thiourea —— C11H20N2OS
    1-(2-Hydroxy-ethyl)-3-(2-methyl-cyclohex-1-enylmethyl)-thiourea