乙烯基硫脲 | 1483-58-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫脲类
• 中文名称: 乙烯基硫脲
• 英文名称: ethylenethiourea
• 英文别名: allylthiourea；vinylthiourea；N-Vinyl-thioharnstoff；Ethylenthioharnstoff；Ethenylthiourea
• CAS: 1483-58-5
• 化学式: C₃H₆N₂S
• mdl: MFCD06496374
• 分子量: 102.16
• InChiKey: PVTGORQEZYKPDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.1
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  乙烯基硫脲 、 氯化镧 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Adi, M. B.; Murty, A. S. R., Current Science, 1978, vol. 47, p. 539 - 541

  摘要：

  DOI：
• 作为产物：
  描述：

  异硫氰酸乙烯 在 氨 作用下， 以 乙醚 为溶剂， 生成 乙烯基硫脲
  参考文献：
  名称：

  Thioureas and Isothiuronium Salts. Monomeric Derivatives

  摘要：

  DOI：

  10.1021/jo01017a052

文献信息

• A Novel Synthesis and Antimicrobial Studies of 3-(4-Substitutedthiocarbamidophenyl)-N, N-dimethyl-3-Pyridin-2-yl-propan-1-amine
  作者：DIPAK TAYADE、Rahim Shekar、Rahim Shekar

  DOI：10.13005/ojc/280152

  日期：2012.3.18

  pharmaceutical, medicinal and drug chemistry. Considering all these facts into consideration it was thought interesting to synthesize 3-(4-substitutedthiocarbamidophenyl)-N, N-dimethyl-3-pyridin-2-yl-propan-1-amine by interacting 3-(4-chlorophenyl)-N, N-dimethyl-3-pyridin-2-yl-propan-1-amine with various thiourea in isopropanol medium .The justification and identification of the structure of these newly synthesized

  杂环和含杂环药物表现出显着和显着的药物吸收，传递和药物作用；因此，他们在制药，医学，农业和药物科学中建立了自己的身份和重要性。硫酰氨基和苯甲酰氨基杂环化合物在工业，制药，药物和药物化学中显示出各种意义和应用。考虑到所有这些事实，认为通过与3-（4-氯苯基）-N相互作用来合成3-（4-取代的硫代氨基甲酰基苯基）-N，N-二甲基-3-吡啶-2--2-基-丙烷-1-胺是有趣的。 N-二甲基-3-吡啶-2-基-1-丙烷-1-胺与各种硫脲在异丙醇介质中的关系。在化学表征的基础上，建立了这些新合成化合物的理由和鉴定，
• Sonar, M. H.; Murty, A. S. R., Journal of the Indian Chemical Society, 1985, vol. 62, p. 60 - 61
  作者：Sonar, M. H.、Murty, A. S. R.

  DOI：——

  日期：——
• Mishra, L. K.; Bhushan, Himanshu; Jha, N. K., Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1981, vol. 20, # 4, p. 415 - 417
  作者：Mishra, L. K.、Bhushan, Himanshu、Jha, N. K.

  DOI：——

  日期：——
• I 2 -Imidazoline Binding Site Affinity of a Structurally Different Type of Ligands
  作者：Christophe Dardonville、Isabel Rozas、Luis F Callado、J.Javier Meana

  DOI：10.1016/s0968-0896(01)00420-5

  日期：2002.5

  Two families of compounds with affinity towards the I-2 imidazoline binding sites are reported. The first is a family of compounds structurally related to agmatine with two guanidine or 2-aminoimidazoline groups at each end of an aliphatic chain of six, eight, nine or 12 methylene groups. Second, and following the model of clonidine, we propose another family of compounds also with two guanidine or 2-aminoimidazoline groups at each end of a chain consisting of two phenyl rings connected by groups such as CH2, CO, NH and SO2, The affinity of the compounds towards the I-2 imidazoline binding sites was then evaluated in human brain tissues. In order to determine their pharmacological selectivity versus alpha(2)-adrenoceptors. the affinity for these receptors was also evaluated for the compounds with the highest affinities at I-2 imidazoline binding sites. The results obtained show that many of the compounds exhibit a considerable affinity towards the I-2 imidazoline binding sites. The aliphatic derivatives, in particular, present a very interesting selectivity for the I-2 imidazoline binding sites versus the alpha(2) adrenoceptors. To better understand these findings, mono-guanidinium analogues of the aliphatic derivatives were synthesised and tested showing poor affinity for I-2 imidazoline binding sites. The importance of these results lies in the novelty of the chemical structures studied (dicationic aliphatic compounds particularly) because they are significantly different to those of the I-2 imidazoline binding site ligands reported to date. (C) 2002 Published by Elsevier Science Ltd.
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Sc: MVol.D4, 1.9.1, page 85 - 86
  作者：

  DOI：——

  日期：——