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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-methylpropan-1-amine;2-methylpropylcarbamothioic S-acid 64221-28-9 C4H11N*C5H11NOS
    2-methylpropan-1-amine;2-methylpropylcarbamothioic S-acid
    —— [5-(3,5-dichloro-phenylsulphanyl)-1-ethyl-3-methyl-1H-pyrazol-4-yl]-methanol 412327-42-5 C13H14Cl2N2OS
    [5-(3,5-dichloro-phenylsulphanyl)-1-ethyl-3-methyl-1H-pyrazol-4-yl]-methanol
    —— [5-(3,5-dichlorophenylthio)-1-isopropyl-3-methyl-1H-pyrazol-4-yl]-phenyl-methanol 412327-18-5 C20H20Cl2N2OS
    [5-(3,5-dichlorophenylthio)-1-isopropyl-3-methyl-1H-pyrazol-4-yl]-phenyl-methanol
    —— tert-butyl 4-hydroxy-1-((phenylthio)methyl)butylcarbamate 1199814-14-6 C16H25NO3S
    tert-butyl 4-hydroxy-1-((phenylthio)methyl)butylcarbamate
    —— 3-[(4-nitrophenyl)thio]benzoic acid 264224-08-0 C13H9NO4S
    3-[(4-nitrophenyl)thio]benzoic acid
    —— 3-[(4-aminophenyl)thio]benzoic acid 264224-09-1 C13H11NO2S
    3-[(4-aminophenyl)thio]benzoic acid
    —— 2-[(3-Chlorophenyl)sulfanyl]propanoic acid 99586-85-3 C9H9ClO2S
    2-[(3-Chlorophenyl)sulfanyl]propanoic acid
    —— N-[5-(4-sulfamoyl-phenyl-sulfanyl)-1,3,4-thiadiazol-2-yl]benzamide 1095154-96-3 C15H12N4O3S3
    N-[5-(4-sulfamoyl-phenyl-sulfanyl)-1,3,4-thiadiazol-2-yl]benzamide
    —— (2,4-Dimethyl-phenylsulfanyl)-phenyl-acetic acid 18626-51-2 C16H16O2S
    (2,4-Dimethyl-phenylsulfanyl)-phenyl-acetic acid
    —— 4-[5-(4-bromophenylamino)-[1,3,4]thiadiazol-2-ylsulfanyl]-benzenesulfonylchloride 1076689-59-2 C14H9BrClN3O2S3
    4-[5-(4-bromophenylamino)-[1,3,4]thiadiazol-2-ylsulfanyl]-benzenesulfonylchloride
    —— 4-(5-p-tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-benzenesulfonylchloride 1076689-63-8 C15H12ClN3O2S3
    4-(5-p-tolylamino-[1,3,4]thiadiazol-2-ylsulfanyl)-benzenesulfonylchloride
    —— 6-fluoro-3-(phenylsulfanyl)-2-pyrazinecarbonitrile 356783-57-8 C11H6FN3S
    6-fluoro-3-(phenylsulfanyl)-2-pyrazinecarbonitrile
    —— 4,4'-Sulfanediylbis(2-butylphenol) 89520-07-0 C20H26O2S
    4,4'-Sulfanediylbis(2-butylphenol)
    —— 5-(2-Phenylsulfanylphenyl)-1,3,4-oxadiazol-2-amine 945031-04-9 C14H11N3OS
    5-(2-Phenylsulfanylphenyl)-1,3,4-oxadiazol-2-amine
    —— 9-methyl-6-(1-methyl-1H-tetrazol-5-ylthio)-9H-purine 1384277-42-2 C8H8N8S
    9-methyl-6-(1-methyl-1H-tetrazol-5-ylthio)-9H-purine
    —— 2-(2,6-Difluorophenyl)-4,5-dihydro-4-[4-[(1-methylethyl)thio]phenyl]oxazole 153234-00-5 C18H17F2NOS
    2-(2,6-Difluorophenyl)-4,5-dihydro-4-[4-[(1-methylethyl)thio]phenyl]oxazole
    —— 4-(5-benzoylamino-1,3,4-thiadiazol-2-ylsulfanyl)benzenesulfonyl chloride 1095154-94-1 C15H10ClN3O3S3
    4-(5-benzoylamino-1,3,4-thiadiazol-2-ylsulfanyl)benzenesulfonyl chloride
    —— (+/-)-2-[[2-[[2-(2-Hydroxyethoxy)ethyl]amino]-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol 259102-66-4 C19H25N5O3S2
    (+/-)-2-[[2-[[2-(2-Hydroxyethoxy)ethyl]amino]-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol
    —— 2-Amino-5-(pentylthio)thiazolo[4,5-d]pyrimidin-7-ol 259100-48-6 C10H14N4OS2
    2-Amino-5-(pentylthio)thiazolo[4,5-d]pyrimidin-7-ol
    —— 2-Sulfanylbutane-1,4-diol 64131-52-8 C4H10O2S
    2-Sulfanylbutane-1,4-diol
    —— 6-(1-methyl-1H-tetrazol-5-ylthio)-9H-purine 1384277-41-1 C7H6N8S
    6-(1-methyl-1H-tetrazol-5-ylthio)-9H-purine
    —— 9-(cyclohexylmethyl)-6-(1-methyl-1H-tetrazol-5-ylthio)-9H-purine 1384277-50-2 C14H18N8S
    9-(cyclohexylmethyl)-6-(1-methyl-1H-tetrazol-5-ylthio)-9H-purine
    —— 4-[5-(4-chlorosulfonylphenylsulfanyl)-[1,3,4]thiadiazol-2-ylamino]-benzenesulfonylchloride 1076689-68-3 C14H9Cl2N3O4S4
    4-[5-(4-chlorosulfonylphenylsulfanyl)-[1,3,4]thiadiazol-2-ylamino]-benzenesulfonylchloride
    —— 7-(3-aminopropyl)thioimidazo[5,1-b]thiazole 352305-63-6 C8H11N3S2
    7-(3-aminopropyl)thioimidazo[5,1-b]thiazole
    —— methyl 2-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxylate 251554-43-5 C14H16O2S
    methyl 2-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxylate
    —— methyl 4-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxylate 251554-45-7 C14H16O2S
    methyl 4-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxylate
    —— 2-Amino-4-(4-methylphenyl)sulfanylphenol;hydrochloride 87660-25-1 C13H14ClNOS
    2-Amino-4-(4-methylphenyl)sulfanylphenol;hydrochloride
    —— Bis(2-chloroethylthiomethyl)ether 63918-90-1 C6H12Cl2OS2
    Bis(2-chloroethylthiomethyl)ether
    —— 5-Methoxy-4-oxo-2-[(phenylthio)methyl]-N-[(tetrahydro-2-furanyl)methyl]-1(4H)-pyridineacetamide 946343-60-8 C20H24N2O4S
    5-Methoxy-4-oxo-2-[(phenylthio)methyl]-N-[(tetrahydro-2-furanyl)methyl]-1(4H)-pyridineacetamide
    —— ethyl 2-{2-chloro-4-fluoro-5-(5-trifluoromethyl-3-pyridazinon-2-yl)phenylthio}propionate 188489-19-2 C16H13ClF4N2O3S
    ethyl 2-{2-chloro-4-fluoro-5-(5-trifluoromethyl-3-pyridazinon-2-yl)phenylthio}propionate
    —— iso-butyl(2-phenylthiocyclopentyl)Amine 1055126-61-8 C15H23NS
    iso-butyl(2-phenylthiocyclopentyl)Amine
    —— (2-Ethoxyphenyl)[2-trifluoromethyl-4-formyl phenyl]sulfide 280752-73-0 C16H13F3O2S
    (2-Ethoxyphenyl)[2-trifluoromethyl-4-formyl phenyl]sulfide
    —— n-propyl(2-phenylthiocyclopentyl)amine 648419-43-6 C14H21NS
    n-propyl(2-phenylthiocyclopentyl)amine
    —— (3-imidazol-1-ylpropyl)-(2-phenylthiocyclopentyl)amine 648419-46-9 C17H23N3S
    (3-imidazol-1-ylpropyl)-(2-phenylthiocyclopentyl)amine
    —— N-Boc-2-(2,2,2-trifluoroethylthio)benzylamine 342816-51-7 C14H18F3NO2S
    N-Boc-2-(2,2,2-trifluoroethylthio)benzylamine
    —— 1-Methyl-1-amino-thiobuttersaeureamid 16256-17-0 C5H12N2S
    1-Methyl-1-amino-thiobuttersaeureamid
    —— bis(2-methyl-3-furyl) sulfide 93240-55-2 C10H10O2S
    bis(2-methyl-3-furyl) sulfide
    —— Prop-2-ene-1-thiolate 81649-93-6 C3H5S
    Prop-2-ene-1-thiolate
    —— 2-hydroxyethyl cycloheptyl sulfide 333782-92-6 C9H18OS
    2-hydroxyethyl cycloheptyl sulfide
    —— 3-(1H-1,2,4-triazol-3-yl-sulfanyl)pentane-2,4-dione 1241892-46-5 C7H9N3O2S
    3-(1H-1,2,4-triazol-3-yl-sulfanyl)pentane-2,4-dione
    —— 2-bromo-1-(pyridin-2-ylthio)ethane 333782-45-9 C7H8BrNS
    2-bromo-1-(pyridin-2-ylthio)ethane
    —— 1-Cyclopropylsulfanylmethyl-4-methylsulfanyl-benzene 481679-61-2 C11H14S2
    1-Cyclopropylsulfanylmethyl-4-methylsulfanyl-benzene
    —— 3-cyano-4-(4-fluorophenyl)-2-methylthiothiophene 116526-51-3 C12H8FNS2
    3-cyano-4-(4-fluorophenyl)-2-methylthiothiophene
    —— N-(2,3-dimethoxybenzyl)-5-{[4-(dimethylamino)phenyl]thio}-8-hydroxy-1,6-naphthyridine-7-carboxamide 410544-53-5 C26H26N4O4S
    N-(2,3-dimethoxybenzyl)-5-{[4-(dimethylamino)phenyl]thio}-8-hydroxy-1,6-naphthyridine-7-carboxamide
    —— 3-chloro-4-(4-pyridinylsulfanyl)aniline 33974-29-7 C11H9ClN2S
    3-chloro-4-(4-pyridinylsulfanyl)aniline
    —— 1,4-bis-(2-chloro-ethylsulfanyl)-benzene 860687-35-0 C10H12Cl2S2
    1,4-bis-(2-chloro-ethylsulfanyl)-benzene
    —— N-[2-amino-6-(4-pyridinyl)-4-pyrimidinyl]-N-[3-fluoro-4-(4-pyridinylsulfanyl)phenyl]amine 570415-37-1 C20H15FN6S
    N-[2-amino-6-(4-pyridinyl)-4-pyrimidinyl]-N-[3-fluoro-4-(4-pyridinylsulfanyl)phenyl]amine
    —— 3-(2-Bromophenyl)-1-methyl-7-methylsulfanyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine 691864-65-0 C13H11BrN4OS
    3-(2-Bromophenyl)-1-methyl-7-methylsulfanyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine
    —— benzyl 4'-(3-benzyloxyphenylthio)-2'-chlorodihydrocinnamate 509088-88-4 C29H25ClO3S
    benzyl 4'-(3-benzyloxyphenylthio)-2'-chlorodihydrocinnamate
    —— Ethyl 2'-chloro-4'-(3-trifluoromethylphenylthio)dihydrocinnamate 509088-83-9 C18H16ClF3O2S
    Ethyl 2'-chloro-4'-(3-trifluoromethylphenylthio)dihydrocinnamate