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有机硫化合物

有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在,在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特,在药物设计、合成化学以及材料制备方面扮演着重要角色。

1. 结构与分类

有机硫化合物可以按硫的连接方式分为饱和和不饱和类,如二硫化物、噻吩衍生物、砜等。常见的结构类型有:

  • 二硫化物:含-S-S-键的化合物。
  • 硫醚(Thiols):含有-R-S-H或-R-S-R 基团的化合物。
  • 磺酸酯(Sulfonates)与磺酸盐(Sulfonates):带有-SO3H基团的化合物,广泛应用于合成和制药领域。
  • 噻吩及其衍生物:具有环状结构的有机硫化物。
2. 生物学活性

许多有机硫化合物在生物学上有重要功能或应用潜力。例如:

  • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
  • 硫代葡萄糖苷(Glycosinolate)是十字花科植物中的一种天然存在物质,具有生物活性。
3. 合成方法

有机硫化合物可通过多种途径合成:

  • 亲核取代反应:使用含硫试剂与卤化物进行反应。
  • 自由基加成法:采用氧化剂引发自由基形成,通过烯烃与H2S、R-S-H等反应制备。
  • 金属催化转化:利用钯、铜等催化剂促进特定硫化过程。
4. 应用领域

有机硫化合物的应用广泛:

  • 医药领域:用于开发抗菌剂、抗病毒药物及抗癌药物等。
  • 农学研究:某些有机硫化合物作为生物农药的有效成分,能够抑制病害的发生。
  • 材料科学与技术:在导电聚合物和塑料添加剂中有重要应用。
5. 环境与安全性

尽管有机硫化合物具有许多潜在益处,但其生产和使用也可能对环境造成影响。因此,在设计和合成这些化合物时需要考虑可持续性和环保性因素。

以上是对有机硫化合物的简单介绍,包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

中文名称 英文名称 CAS号 化学式 结构式图片
—— (2S)-1-[4-(3-bromophenyl)sulfanylphenyl]butan-2-amine —— C16H18BrNS
(2S)-1-[4-(3-bromophenyl)sulfanylphenyl]butan-2-amine
—— (2R)-1-[1,3-dimethyl-5-(5-methylpyrimidin-2-yl)sulfanylpyrazol-4-yl]propan-2-amine —— C13H19N5S
(2R)-1-[1,3-dimethyl-5-(5-methylpyrimidin-2-yl)sulfanylpyrazol-4-yl]propan-2-amine
—— (2R)-1-[2-methyl-4-(5-methylpyrimidin-2-yl)sulfanylphenyl]propan-2-amine —— C15H19N3S
(2R)-1-[2-methyl-4-(5-methylpyrimidin-2-yl)sulfanylphenyl]propan-2-amine
—— (2R)-1-[3-methyl-4-(3-methylphenyl)sulfanylphenyl]propan-2-amine —— C17H21NS
(2R)-1-[3-methyl-4-(3-methylphenyl)sulfanylphenyl]propan-2-amine
—— (2S)-1-[3-fluoro-4-(3-methylphenyl)sulfanylphenyl]propan-2-amine —— C16H18FNS
(2S)-1-[3-fluoro-4-(3-methylphenyl)sulfanylphenyl]propan-2-amine
—— (2R)-1-[4-bromo-2-(5-methylpyrimidin-2-yl)sulfanylphenyl]propan-2-amine —— C14H16BrN3S
(2R)-1-[4-bromo-2-(5-methylpyrimidin-2-yl)sulfanylphenyl]propan-2-amine
—— (2S)-3-ethyl-N-[(1R)-1-(4-methylsulfanylphenyl)ethyl]pentan-2-amine —— C16H27NS
(2S)-3-ethyl-N-[(1R)-1-(4-methylsulfanylphenyl)ethyl]pentan-2-amine
—— 2-[1-[(2S)-3-ethylpentan-2-yl]tetrazol-5-yl]sulfanylacetic acid —— C10H18N4O2S
2-[1-[(2S)-3-ethylpentan-2-yl]tetrazol-5-yl]sulfanylacetic acid
—— (2S)-1-[3-methyl-4-(3-methylphenyl)sulfanylphenyl]propan-2-amine —— C17H21NS
(2S)-1-[3-methyl-4-(3-methylphenyl)sulfanylphenyl]propan-2-amine
—— (2S)-1-[4-bromo-2-(5-methylpyrimidin-2-yl)sulfanylphenyl]propan-2-amine —— C14H16BrN3S
(2S)-1-[4-bromo-2-(5-methylpyrimidin-2-yl)sulfanylphenyl]propan-2-amine
—— 5-fluoro-N'-hydroxy-2-(3-methoxypropylsulfanyl)benzenecarboximidamide —— C11H15FN2O2S
5-fluoro-N'-hydroxy-2-(3-methoxypropylsulfanyl)benzenecarboximidamide
—— 3-[2-[(2R)-2-aminopropyl]-4-fluorophenyl]sulfanyl-4-methyl-1H-1,2,4-triazol-5-one —— C12H15FN4OS
3-[2-[(2R)-2-aminopropyl]-4-fluorophenyl]sulfanyl-4-methyl-1H-1,2,4-triazol-5-one
—— (2R)-1-[3-fluoro-4-(3-methylphenyl)sulfanylphenyl]propan-2-amine —— C16H18FNS
(2R)-1-[3-fluoro-4-(3-methylphenyl)sulfanylphenyl]propan-2-amine
—— 2-[1-[(2R)-3-ethylpentan-2-yl]tetrazol-5-yl]sulfanylacetic acid —— C10H18N4O2S
2-[1-[(2R)-3-ethylpentan-2-yl]tetrazol-5-yl]sulfanylacetic acid
—— (2R)-1-[5-fluoro-2-(1-methylpyrazol-4-yl)sulfanylphenyl]propan-2-amine —— C13H16FN3S
(2R)-1-[5-fluoro-2-(1-methylpyrazol-4-yl)sulfanylphenyl]propan-2-amine
—— 3-[4-[(2R)-2-aminobutyl]phenyl]sulfanyl-4-methyl-1H-1,2,4-triazol-5-one —— C13H18N4OS
3-[4-[(2R)-2-aminobutyl]phenyl]sulfanyl-4-methyl-1H-1,2,4-triazol-5-one
—— 2-[[5-(2-methylfuran-3-yl)-4-[(Z)-(2,4,5-trimethylphenyl)methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C19H20N4O3S
2-[[5-(2-methylfuran-3-yl)-4-[(Z)-(2,4,5-trimethylphenyl)methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid
—— (2R)-3-ethyl-N-[(1R)-1-(4-methylsulfanylphenyl)ethyl]pentan-2-amine —— C16H27NS
(2R)-3-ethyl-N-[(1R)-1-(4-methylsulfanylphenyl)ethyl]pentan-2-amine
—— (2S)-1-[6-(1-methylpyrazol-4-yl)sulfanylimidazo[2,1-b][1,3]thiazol-5-yl]propan-2-amine —— C12H15N5S2
(2S)-1-[6-(1-methylpyrazol-4-yl)sulfanylimidazo[2,1-b][1,3]thiazol-5-yl]propan-2-amine
—— (2S)-1-[5-fluoro-2-(1-methylpyrazol-4-yl)sulfanylphenyl]propan-2-amine —— C13H16FN3S
(2S)-1-[5-fluoro-2-(1-methylpyrazol-4-yl)sulfanylphenyl]propan-2-amine
—— (2R)-1-[6-(1-methylpyrazol-4-yl)sulfanylimidazo[2,1-b][1,3]thiazol-5-yl]propan-2-amine —— C12H15N5S2
(2R)-1-[6-(1-methylpyrazol-4-yl)sulfanylimidazo[2,1-b][1,3]thiazol-5-yl]propan-2-amine
—— 3-[4-[(2R)-2-aminopropyl]phenyl]sulfanyl-4-methyl-1H-1,2,4-triazol-5-one —— C12H16N4OS
3-[4-[(2R)-2-aminopropyl]phenyl]sulfanyl-4-methyl-1H-1,2,4-triazol-5-one
—— (2S)-3-ethyl-N-[(1S)-1-(4-methylsulfanylphenyl)ethyl]pentan-2-amine —— C16H27NS
(2S)-3-ethyl-N-[(1S)-1-(4-methylsulfanylphenyl)ethyl]pentan-2-amine
—— 2-[[4-[(Z)-(2,5-dimethyl-1-propan-2-ylpyrrol-3-yl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C19H22N5O3S-
2-[[4-[(Z)-(2,5-dimethyl-1-propan-2-ylpyrrol-3-yl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
—— 2-[[4-[(Z)-(5-cyano-1,2-dimethylpyrrol-3-yl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C17H15N6O3S-
2-[[4-[(Z)-(5-cyano-1,2-dimethylpyrrol-3-yl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
—— 2-[[4-[(Z)-(4-ethylphenyl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C18H18N4O3S
2-[[4-[(Z)-(4-ethylphenyl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
—— 2-[[4-[(Z)-[(1S)-cyclohex-3-en-1-yl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C16H18N4O3S
2-[[4-[(Z)-[(1S)-cyclohex-3-en-1-yl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
—— 2-[[4-[(Z)-(4-chlorophenyl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C16H12ClN4O3S-
2-[[4-[(Z)-(4-chlorophenyl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
—— 2-[[4-[(Z)-(4-fluorophenyl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C16H12FN4O3S-
2-[[4-[(Z)-(4-fluorophenyl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
—— 2-[[4-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C20H23N5O3S
2-[[4-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
—— 2-[[5-(2-methylfuran-3-yl)-4-[(Z)-pyridin-2-ylmethylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C15H13N5O3S
2-[[5-(2-methylfuran-3-yl)-4-[(Z)-pyridin-2-ylmethylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid
—— 2-[[5-(2-methylfuran-3-yl)-4-[(Z)-pyridin-3-ylmethylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C15H13N5O3S
2-[[5-(2-methylfuran-3-yl)-4-[(Z)-pyridin-3-ylmethylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetic acid
—— 2-[[4-[(Z)-(3,4-difluorophenyl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid —— C16H12F2N4O3S
2-[[4-[(Z)-(3,4-difluorophenyl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid
—— 2-[[5-(2-methylfuran-3-yl)-4-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetate —— C17H15N4O3S2-
2-[[5-(2-methylfuran-3-yl)-4-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-1,2,4-triazol-3-yl]sulfanyl]acetate
—— (2R)-N',N'-dimethyl-2-(4-methylphenyl)sulfanylpropanehydrazide —— C12H18N2OS
(2R)-N',N'-dimethyl-2-(4-methylphenyl)sulfanylpropanehydrazide
—— 2-[[4-[(Z)-(2-chlorophenyl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C16H12ClN4O3S-
2-[[4-[(Z)-(2-chlorophenyl)methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
—— 2-[[4-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C20H22N5O3S-
2-[[4-[(Z)-[4-(diethylamino)phenyl]methylideneamino]-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
—— 2-[(4-benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N',N'-dimethylacetohydrazide —— C14H19N5OS
2-[(4-benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N',N'-dimethylacetohydrazide
—— (2R)-N',N'-dimethyl-2-phenylsulfanylpropanehydrazide —— C11H16N2OS
(2R)-N',N'-dimethyl-2-phenylsulfanylpropanehydrazide
—— (2S)-N',N'-dimethyl-2-phenylsulfanylpropanehydrazide —— C11H16N2OS
(2S)-N',N'-dimethyl-2-phenylsulfanylpropanehydrazide
—— 2-(2,4-dimethylphenyl)sulfanyl-N',N'-dimethylacetohydrazide —— C12H18N2OS
2-(2,4-dimethylphenyl)sulfanyl-N',N'-dimethylacetohydrazide
—— 2-(3,4-dimethylphenyl)sulfanyl-N',N'-dimethylacetohydrazide —— C12H18N2OS
2-(3,4-dimethylphenyl)sulfanyl-N',N'-dimethylacetohydrazide
—— (Z)-3-amino-2-[2-[[4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]but-2-enenitrile —— C14H15N5OS2
(Z)-3-amino-2-[2-[[4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]but-2-enenitrile
—— 1-[(2S)-1-methoxypropan-2-yl]-3-[(Z)-(4-methylsulfanylphenyl)methylideneamino]thiourea —— C13H19N3OS2
1-[(2S)-1-methoxypropan-2-yl]-3-[(Z)-(4-methylsulfanylphenyl)methylideneamino]thiourea
—— (2R)-2-(2-methoxyphenoxy)-N-(2-phenylsulfanylphenyl)propanamide —— C22H21NO3S
(2R)-2-(2-methoxyphenoxy)-N-(2-phenylsulfanylphenyl)propanamide
—— 4-(4-methoxyphenyl)sulfanyl-3-nitro-N-propan-2-ylbenzenesulfonamide —— C16H18N2O5S2
4-(4-methoxyphenyl)sulfanyl-3-nitro-N-propan-2-ylbenzenesulfonamide
—— 1-[4-(4-Methoxyphenyl)sulfanyl-3-nitrophenyl]sulfonylpyrrolidine —— C17H18N2O5S2
1-[4-(4-Methoxyphenyl)sulfanyl-3-nitrophenyl]sulfonylpyrrolidine
—— 4-[[4-(4-Methoxyphenyl)sulfanyl-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl]methyl]morpholin-4-ium —— C20H24N3O2S2+
4-[[4-(4-Methoxyphenyl)sulfanyl-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl]methyl]morpholin-4-ium
—— 2-[[5-(Cyclopropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(2,5-dichlorothiophen-3-yl)ethanone —— C11H9Cl2N3OS3
2-[[5-(Cyclopropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(2,5-dichlorothiophen-3-yl)ethanone
—— (2R)-2-(2-phenylsulfanylethyl)piperidine —— C13H19NS
(2R)-2-(2-phenylsulfanylethyl)piperidine