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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 3-[5-[2-[Bis(2-methylpropyl)amino]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]propanamide —— C16H29N5O2S
    3-[5-[2-[Bis(2-methylpropyl)amino]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]propanamide
    —— 3-[5-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]propanamide —— C12H13BrN4O2S2
    3-[5-[2-(5-Bromothiophen-2-yl)-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]propanamide
    —— 1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C15H22N4O2S2
    1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 1-(5-Bromothiophen-2-yl)-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C9H8BrN3OS3
    1-(5-Bromothiophen-2-yl)-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— N-[(1S)-1-(1-adamantyl)ethyl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H26N4OS2
    N-[(1S)-1-(1-adamantyl)ethyl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-methyl-5-[(2-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C11H13N3S2
    N-methyl-5-[(2-methylphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-phenylethyl)acetamide —— C13H16N4OS2
    2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-phenylethyl)acetamide
    —— 2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[3-[(4-methylphenyl)methyl]-1,3-thiazol-2-ylidene]acetamide —— C16H17N5OS3
    2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[3-[(4-methylphenyl)methyl]-1,3-thiazol-2-ylidene]acetamide
    —— 1-[1-(Furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C16H18N4O2S2
    1-[1-(Furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 3-[5-[2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]propanamide —— C14H23N5O3S
    3-[5-[2-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]propanamide
    —— 3-[5-[[(4S)-1,3-dioxan-4-yl]methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]propanamide —— C11H18N4O3S
    3-[5-[[(4S)-1,3-dioxan-4-yl]methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]propanamide
    —— 1-[(3S)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C19H19N5O2S2
    1-[(3S)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— N-[2-(4-chlorophenyl)ethyl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C13H15ClN4OS2
    N-[2-(4-chlorophenyl)ethyl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 3-[5-[2-[[4-(Dimethylamino)phenyl]methylamino]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]propanamide —— C17H24N6O2S
    3-[5-[2-[[4-(Dimethylamino)phenyl]methylamino]-2-oxoethyl]sulfanyl-4-methyl-1,2,4-triazol-3-yl]propanamide
    —— N-cyclopropyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C12H18N4O3S3
    N-cyclopropyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 1-[1-[2-(4-Fluorophenyl)ethyl]-2,5-dimethylpyrrol-3-yl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C19H21FN4OS2
    1-[1-[2-(4-Fluorophenyl)ethyl]-2,5-dimethylpyrrol-3-yl]-2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(thiophen-2-ylmethyl)acetamide —— C10H12N4OS3
    2-[[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(thiophen-2-ylmethyl)acetamide
    —— N-[[4-(dimethylamino)phenyl]methyl]-N-methyl-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H27N5O3S
    N-[[4-(dimethylamino)phenyl]methyl]-N-methyl-2-[[5-oxo-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[(2-fluorophenyl)methyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C13H12FN3O2S
    N-[(2-fluorophenyl)methyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(R)-(4-fluorophenyl)-thiophen-2-ylmethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C17H14FN3O2S2
    N-[(R)-(4-fluorophenyl)-thiophen-2-ylmethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— 2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(3-propan-2-yloxypropyl)acetamide —— C12H19N3O3S
    2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(3-propan-2-yloxypropyl)acetamide
    —— [5-(2,5-Dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methyl 3-(4-fluorophenyl)sulfanylpropanoate —— C18H17FN2O4S
    [5-(2,5-Dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methyl 3-(4-fluorophenyl)sulfanylpropanoate
    —— (2S)-2-[[5-(butylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethylpropanamide —— C11H20N4OS2
    (2S)-2-[[5-(butylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-ethylpropanamide
    —— 5-[[(1R)-2,2-dichlorocyclopropyl]methylsulfanyl]-N-prop-2-enyl-1,3,4-thiadiazol-2-amine —— C9H11Cl2N3S2
    5-[[(1R)-2,2-dichlorocyclopropyl]methylsulfanyl]-N-prop-2-enyl-1,3,4-thiadiazol-2-amine
    —— (2S)-N-ethyl-2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C11H17N3OS3
    (2S)-N-ethyl-2-[[5-(2-methylprop-2-enylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— N-[3-(3,5-dimethylpyrazol-1-yl)propyl]-2-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]acetamide —— C20H24N4OS2
    N-[3-(3,5-dimethylpyrazol-1-yl)propyl]-2-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]acetamide
    —— N-[2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethyl]acetamide —— C11H14N4O2S
    N-[2-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]ethyl]acetamide
    —— [(Z)-4-amino-3-cyano-2-oxopent-3-enyl] 3-(4-chlorophenyl)sulfanylpropanoate —— C15H15ClN2O3S
    [(Z)-4-amino-3-cyano-2-oxopent-3-enyl] 3-(4-chlorophenyl)sulfanylpropanoate
    —— 2-[(1R)-1-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole —— C15H17N5OS
    2-[(1R)-1-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole
    —— N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C19H23N3O4S2
    N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 5,6-bis(4-methylphenyl)-3-[[(2S)-oxolan-2-yl]methylsulfanyl]-1,2,4-triazine —— C22H23N3OS
    5,6-bis(4-methylphenyl)-3-[[(2S)-oxolan-2-yl]methylsulfanyl]-1,2,4-triazine
    —— [(2R)-1-[[(1S,2S)-2-methylcyclohexyl]amino]-1-oxopropan-2-yl] 2-(2,5-difluorophenyl)sulfanylacetate —— C18H23F2NO3S
    [(2R)-1-[[(1S,2S)-2-methylcyclohexyl]amino]-1-oxopropan-2-yl] 2-(2,5-difluorophenyl)sulfanylacetate
    —— [5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl]methyl 2-(2,5-difluorophenyl)sulfanylacetate —— C17H11ClF2N2O3S
    [5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl]methyl 2-(2,5-difluorophenyl)sulfanylacetate
    —— (2S)-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-ethylpropanamide —— C18H20N4OS2
    (2S)-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-ethylpropanamide
    —— 2-[(1R)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-5-(4-fluorophenyl)-1,3,4-oxadiazole —— C18H16FN5OS2
    2-[(1R)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-5-(4-fluorophenyl)-1,3,4-oxadiazole
    —— [2-(Cyclopropylamino)-2-oxoethyl] 2-(2,5-difluorophenyl)sulfanylacetate —— C13H13F2NO3S
    [2-(Cyclopropylamino)-2-oxoethyl] 2-(2,5-difluorophenyl)sulfanylacetate
    —— [(1S)-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl] 2-(2,5-difluorophenyl)sulfanylacetate —— C18H14F2N2O3S
    [(1S)-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl] 2-(2,5-difluorophenyl)sulfanylacetate
    —— [2-(Tert-butylamino)-2-oxoethyl] 2-(2,5-difluorophenyl)sulfanylacetate —— C14H17F2NO3S
    [2-(Tert-butylamino)-2-oxoethyl] 2-(2,5-difluorophenyl)sulfanylacetate
    —— [2-[[(1R)-1-(3,4-dimethylphenyl)ethyl]amino]-2-oxoethyl] 2-(2,5-difluorophenyl)sulfanylacetate —— C20H21F2NO3S
    [2-[[(1R)-1-(3,4-dimethylphenyl)ethyl]amino]-2-oxoethyl] 2-(2,5-difluorophenyl)sulfanylacetate
    —— [(2R)-1-(cyclopropylamino)-1-oxopropan-2-yl] 2-(2,5-difluorophenyl)sulfanylacetate —— C14H15F2NO3S
    [(2R)-1-(cyclopropylamino)-1-oxopropan-2-yl] 2-(2,5-difluorophenyl)sulfanylacetate
    —— (2S)-2-[[5,6-bis(4-methylphenyl)-1,2,4-triazin-3-yl]sulfanyl]-N-ethylpropanamide —— C22H24N4OS
    (2S)-2-[[5,6-bis(4-methylphenyl)-1,2,4-triazin-3-yl]sulfanyl]-N-ethylpropanamide
    —— [5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]methyl 2-(2,5-difluorophenyl)sulfanylacetate —— C15H10F2N2O4S
    [5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]methyl 2-(2,5-difluorophenyl)sulfanylacetate
    —— [(1S)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl] 2-(2,5-difluorophenyl)sulfanylacetate —— C18H13F3N2O3S
    [(1S)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl] 2-(2,5-difluorophenyl)sulfanylacetate
    —— (2R)-2-[[5,6-bis(4-methylphenyl)-1,2,4-triazin-3-yl]sulfanyl]-N-ethylpropanamide —— C22H24N4OS
    (2R)-2-[[5,6-bis(4-methylphenyl)-1,2,4-triazin-3-yl]sulfanyl]-N-ethylpropanamide
    —— [(2R)-1-[[(1R,2R)-2-methylcyclohexyl]amino]-1-oxopropan-2-yl] 2-(2,5-difluorophenyl)sulfanylacetate —— C18H23F2NO3S
    [(2R)-1-[[(1R,2R)-2-methylcyclohexyl]amino]-1-oxopropan-2-yl] 2-(2,5-difluorophenyl)sulfanylacetate
    —— [2-[[(1S)-1-(furan-2-yl)ethyl]amino]-2-oxoethyl] 2-(2,5-difluorophenyl)sulfanylacetate —— C16H15F2NO4S
    [2-[[(1S)-1-(furan-2-yl)ethyl]amino]-2-oxoethyl] 2-(2,5-difluorophenyl)sulfanylacetate
    —— (2S)-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N,N-dimethylpropanamide —— C18H20N4OS2
    (2S)-2-[(4-benzyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N,N-dimethylpropanamide
    —— (2R)-2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N,N-dimethylpropanamide —— C9H15N5O2S
    (2R)-2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N,N-dimethylpropanamide
    —— (1R,2S,5R)-2-[4-(difluoromethyl)-6-methylpyrimidin-2-yl]sulfanyl-6,8-dioxabicyclo[3.2.1]octan-4-one —— C12H12F2N2O3S
    (1R,2S,5R)-2-[4-(difluoromethyl)-6-methylpyrimidin-2-yl]sulfanyl-6,8-dioxabicyclo[3.2.1]octan-4-one
    —— 2-[[4-amino-5-[(4-fluorophenyl)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(2S)-5-methylhexan-2-yl]acetamide —— C18H26FN5OS
    2-[[4-amino-5-[(4-fluorophenyl)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(2S)-5-methylhexan-2-yl]acetamide