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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[5-(Butylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-7-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one —— C13H16N6OS3
    2-[[5-(Butylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-7-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
    —— 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]acetamide —— C19H19ClN4O2S
    2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[4-(dimethylamino)phenyl]methyl]acetamide
    —— (2R)-N-[(4-methylphenyl)methyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C19H19N3O2S
    (2R)-N-[(4-methylphenyl)methyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— methyl N-[(2R)-2-[[5-(butylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoyl]carbamate —— C11H18N4O3S2
    methyl N-[(2R)-2-[[5-(butylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoyl]carbamate
    —— methyl N-[(2R)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoyl]carbamate —— C13H13N3O4S
    methyl N-[(2R)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoyl]carbamate
    —— (2S)-N-[(4-fluorophenyl)methyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H16FN3O2S
    (2S)-N-[(4-fluorophenyl)methyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C17H21N3O4S2
    (2S)-N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— N-[(1R)-1-cyclopropylethyl]-2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H22N4OS2
    N-[(1R)-1-cyclopropylethyl]-2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 3-[4-Ethyl-5-[2-[(4-fluorophenyl)methylamino]-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide —— C16H20FN5O2S
    3-[4-Ethyl-5-[2-[(4-fluorophenyl)methylamino]-2-oxoethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide
    —— 2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(3-methylthiophen-2-yl)methyl]acetamide —— C19H22N4OS3
    2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(3-methylthiophen-2-yl)methyl]acetamide
    —— 3-[4-Ethyl-5-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide —— C11H16F3N5O2S
    3-[4-Ethyl-5-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]propanamide
    —— N-[(1S)-1-cyclopropylethyl]-2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H22N4OS2
    N-[(1S)-1-cyclopropylethyl]-2-[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 3-[5-[2-(2,5-Dimethyl-1-propan-2-ylpyrrol-3-yl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide —— C18H27N5O2S
    3-[5-[2-(2,5-Dimethyl-1-propan-2-ylpyrrol-3-yl)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]propanamide
    —— (2S)-N-[(2-chlorophenyl)methyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H16ClN3O2S
    (2S)-N-[(2-chlorophenyl)methyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (E)-2-[4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-3-hydroxy-N-methylbut-2-enamide —— C14H12F3N3O3S
    (E)-2-[4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-3-hydroxy-N-methylbut-2-enamide
    —— ethyl 5-[(2S)-2-[4-(difluoromethylsulfanyl)anilino]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C19H22F2N2O3S
    ethyl 5-[(2S)-2-[4-(difluoromethylsulfanyl)anilino]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— N-[[(5R,7R)-3-chloro-1-adamantyl]methyl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide —— C18H23ClN2O2S
    N-[[(5R,7R)-3-chloro-1-adamantyl]methyl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide
    —— methyl 5-[(2R)-2-[4-(difluoromethylsulfanyl)anilino]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C18H20F2N2O3S
    methyl 5-[(2R)-2-[4-(difluoromethylsulfanyl)anilino]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— (2S)-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N,N-dimethylpropanamide —— C13H14ClN3O2S
    (2S)-2-[[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N,N-dimethylpropanamide
    —— 2-[[5-(4-Methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(5-methylthiophen-2-yl)ethanone —— C16H15N3OS3
    2-[[5-(4-Methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(5-methylthiophen-2-yl)ethanone
    —— Ethyl 2-[2-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3-thiazol-4-yl]acetate —— C16H17N3O4S2
    Ethyl 2-[2-[[5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3-thiazol-4-yl]acetate
    —— N-[[(5S,7S)-3-chloro-1-adamantyl]methyl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide —— C18H23ClN2O2S
    N-[[(5S,7S)-3-chloro-1-adamantyl]methyl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylacetamide
    —— 2-[[5-(2-Methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(5-methylthiophen-2-yl)ethanone —— C16H15N3OS3
    2-[[5-(2-Methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-(5-methylthiophen-2-yl)ethanone
    —— N-[2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]acetamide —— C12H12FN3O2S
    N-[2-[[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]acetamide
    —— 2-(3-chloro-4-fluorophenyl)sulfanyl-N-[[4-(dimethylamino)phenyl]methyl]acetamide —— C17H18ClFN2OS
    2-(3-chloro-4-fluorophenyl)sulfanyl-N-[[4-(dimethylamino)phenyl]methyl]acetamide
    —— 2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one —— C17H21N5O3S2
    2-[[4-(3-methoxypropyl)-5-oxo-1H-1,2,4-triazol-3-yl]sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one
    —— tert-butylsulfanylmethanediamine —— C5H13N2S-
    tert-butylsulfanylmethanediamine
    —— N-[2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)ethyl]acetamide —— C11H18N4OS
    N-[2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)ethyl]acetamide
    —— (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(2-phenylethyl)propanamide —— C19H20N4OS2
    (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(2-phenylethyl)propanamide
    —— 2-[(5-Methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one —— C14H14N4OS4
    2-[(5-Methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one
    —— (2S)-N-tert-butyl-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C17H24N4OS2
    (2S)-N-tert-butyl-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2R)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(thiophen-2-ylmethyl)propanamide —— C18H20N4OS3
    (2R)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(thiophen-2-ylmethyl)propanamide
    —— (2S)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]propanamide —— C15H18N4O3S3
    (2S)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]propanamide
    —— (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-cycloheptylpropanamide —— C18H24N4OS2
    (2R)-2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-cycloheptylpropanamide
    —— (2R)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide —— C20H21FN4OS2
    (2R)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide
    —— (2S)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide —— C20H21FN4OS2
    (2S)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]propanamide
    —— 3-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methyl-4-oxopentan-2-yl)propanamide —— C17H20FN3O3S
    3-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-methyl-4-oxopentan-2-yl)propanamide
    —— methyl N-[(2S)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoyl]carbamate —— C14H16N4O3S2
    methyl N-[(2S)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoyl]carbamate
    —— (2R)-N-tert-butyl-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide —— C16H22N4OS2
    (2R)-N-tert-butyl-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanamide
    —— (2R)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-methylphenyl)methyl]propanamide —— C20H22N4OS2
    (2R)-2-[[5-(3-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(4-methylphenyl)methyl]propanamide
    —— N-(1-adamantylmethyl)-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C17H23F3N4OS
    N-(1-adamantylmethyl)-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— (2R)-N-[(1R,2S)-2-methylcyclohexyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C14H21F3N4OS
    (2R)-N-[(1R,2S)-2-methylcyclohexyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— N-[(2S)-2-(dimethylamino)-2-phenylethyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C16H20F3N5OS
    N-[(2S)-2-(dimethylamino)-2-phenylethyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— (2S)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-3-morpholin-4-ium-4-ylpropan-2-ol —— C15H23N4O2S2+
    (2S)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-3-morpholin-4-ium-4-ylpropan-2-ol
    —— N-(cyclohexylcarbamoyl)-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C13H18F3N5O2S
    N-(cyclohexylcarbamoyl)-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[(1S)-1-(3,4-dimethylphenyl)ethyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C16H19F3N4OS
    N-[(1S)-1-(3,4-dimethylphenyl)ethyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— (3S,4R)-4-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1,1-dioxothiolan-3-ol —— C17H17N3O4S2
    (3S,4R)-4-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1,1-dioxothiolan-3-ol
    —— ethyl 2,4-dimethyl-5-[(2S)-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate —— C16H19F3N4O3S
    ethyl 2,4-dimethyl-5-[(2S)-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate
    —— (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C15H16F4N4OS
    (2R)-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— N-[(2R)-2-(dimethylamino)-2-phenylethyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C16H20F3N5OS
    N-[(2R)-2-(dimethylamino)-2-phenylethyl]-2-[[4-methyl-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide