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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 1-[3-(4-Fluorophenyl)sulfanylpropanoylamino]-3-pentylthiourea —— C15H22FN3OS2
    1-[3-(4-Fluorophenyl)sulfanylpropanoylamino]-3-pentylthiourea
    —— 1-[[2-(2-Methylphenyl)sulfanylacetyl]amino]-3-pentylthiourea —— C15H23N3OS2
    1-[[2-(2-Methylphenyl)sulfanylacetyl]amino]-3-pentylthiourea
    —— N-[(1S)-1-(4-bromophenyl)ethyl]-3-(4-fluorophenyl)sulfanylpropanamide —— C17H17BrFNOS
    N-[(1S)-1-(4-bromophenyl)ethyl]-3-(4-fluorophenyl)sulfanylpropanamide
    —— N-[(1R)-1-(2-bromophenyl)ethyl]-3-(4-fluorophenyl)sulfanylpropanamide —— C17H17BrFNOS
    N-[(1R)-1-(2-bromophenyl)ethyl]-3-(4-fluorophenyl)sulfanylpropanamide
    —— [2-[butyl-[(3S)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 3-(4-chlorophenyl)sulfanylpropanoate —— C19H26ClNO5S2
    [2-[butyl-[(3S)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 3-(4-chlorophenyl)sulfanylpropanoate
    —— N-[(1R)-1-(4-chlorophenyl)ethyl]-2-(2-methylphenyl)sulfanylacetamide —— C17H18ClNOS
    N-[(1R)-1-(4-chlorophenyl)ethyl]-2-(2-methylphenyl)sulfanylacetamide
    —— [2-[butyl-[(3R)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 3-(4-chlorophenyl)sulfanylpropanoate —— C19H26ClNO5S2
    [2-[butyl-[(3R)-1,1-dioxothiolan-3-yl]amino]-2-oxoethyl] 3-(4-chlorophenyl)sulfanylpropanoate
    —— N-[2-(4-chlorophenyl)ethyl]-2-(2-methylphenyl)sulfanylacetamide —— C17H18ClNOS
    N-[2-(4-chlorophenyl)ethyl]-2-(2-methylphenyl)sulfanylacetamide
    —— N-[2-(4-chlorophenyl)ethyl]-2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H15Cl2N3O2S
    N-[2-(4-chlorophenyl)ethyl]-2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— [2-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl] 3-phenylsulfanylpropanoate —— C21H27NO4S
    [2-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl] 3-phenylsulfanylpropanoate
    —— [2-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl] 3-phenylsulfanylpropanoate —— C21H27NO4S
    [2-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl] 3-phenylsulfanylpropanoate
    —— 2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-cyclopentylacetamide —— C15H20BrNOS
    2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-cyclopentylacetamide
    —— 1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[[4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C21H22ClN5O3S
    1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[[4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— [2-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl] 3-(4-fluorophenyl)sulfanylpropanoate —— C21H26FNO4S
    [2-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl] 3-(4-fluorophenyl)sulfanylpropanoate
    —— [2-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl] 3-(4-fluorophenyl)sulfanylpropanoate —— C21H26FNO4S
    [2-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-oxoethyl] 3-(4-fluorophenyl)sulfanylpropanoate
    —— 1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[[4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone —— C21H22ClN5O3S
    1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[[4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]ethanone
    —— 2-(2,5-difluorophenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]acetamide —— C16H14F3NOS
    2-(2,5-difluorophenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]acetamide
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[2-(4-fluorophenyl)ethyl]propanamide —— C18H22FN3OS
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[2-(4-fluorophenyl)ethyl]propanamide
    —— (2S)-N-(1-cyanocyclohexyl)-2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-methylpropanamide —— C20H25N5OS2
    (2S)-N-(1-cyanocyclohexyl)-2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-methylpropanamide
    —— [2-[(2-chloro-6-fluorophenyl)methyl-methylamino]-2-oxoethyl] (2R)-2-phenylsulfanylpropanoate —— C19H19ClFNO3S
    [2-[(2-chloro-6-fluorophenyl)methyl-methylamino]-2-oxoethyl] (2R)-2-phenylsulfanylpropanoate
    —— 2-[(2R)-1-(1-methylpiperidin-4-yl)-4-[(2-methylsulfanylpyrimidin-5-yl)methyl]piperazin-2-yl]ethanol —— C18H31N5OS
    2-[(2R)-1-(1-methylpiperidin-4-yl)-4-[(2-methylsulfanylpyrimidin-5-yl)methyl]piperazin-2-yl]ethanol
    —— [2-[(2-chloro-6-fluorophenyl)methyl-methylamino]-2-oxoethyl] (2S)-2-phenylsulfanylpropanoate —— C19H19ClFNO3S
    [2-[(2-chloro-6-fluorophenyl)methyl-methylamino]-2-oxoethyl] (2S)-2-phenylsulfanylpropanoate
    —— (Z)-3-amino-2-(2-pyrimidin-2-ylsulfanylacetyl)but-2-enenitrile —— C10H10N4OS
    (Z)-3-amino-2-(2-pyrimidin-2-ylsulfanylacetyl)but-2-enenitrile
    —— 1-[2,5-Dimethyl-1-(2,2,2-trifluoroethyl)pyrrol-3-yl]-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylethanone —— C16H16F3N5OS2
    1-[2,5-Dimethyl-1-(2,2,2-trifluoroethyl)pyrrol-3-yl]-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylethanone
    —— 2-Cyclopropyl-5-(5,6-dimethyl-2-thiophen-2-ylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C17H14N4OS3
    2-Cyclopropyl-5-(5,6-dimethyl-2-thiophen-2-ylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— (2R)-4-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C17H15N5OS3
    (2R)-4-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— 2-[[4-butyl-5-[(1R)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide —— C19H31N5OS2
    2-[[4-butyl-5-[(1R)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide
    —— 2-[[4-butyl-5-[(1S)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide —— C19H31N5OS2
    2-[[4-butyl-5-[(1S)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide
    —— (2R)-N-(1-cyanocyclohexyl)-2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-methylpropanamide —— C20H25N5OS2
    (2R)-N-(1-cyanocyclohexyl)-2-[(4-cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-methylpropanamide
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-(pyridin-2-ylmethyl)propanamide —— C16H20N4OS
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-(pyridin-2-ylmethyl)propanamide
    —— N,N-dibenzyl-2-(1-cyclopropyltetrazol-5-yl)sulfanylacetamide —— C20H21N5OS
    N,N-dibenzyl-2-(1-cyclopropyltetrazol-5-yl)sulfanylacetamide
    —— 2-Cyclopropyl-5-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C18H14N4OS2
    2-Cyclopropyl-5-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 4-(1-Cyclopropyltetrazol-5-yl)sulfanyl-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine 878260-71-0 C16H11FN6S2
    4-(1-Cyclopropyltetrazol-5-yl)sulfanyl-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine
    —— 2-[[5-(cyclopropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethylacetamide —— C13H20N4O3S3
    2-[[5-(cyclopropylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]-N-ethylacetamide
    —— 1-(5-Phenyl-3,4-dihydropyrazol-2-yl)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylethanone —— C17H16N6OS2
    1-(5-Phenyl-3,4-dihydropyrazol-2-yl)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylethanone
    —— N-cyclopropyl-N-[5-[2-oxo-2-(5-phenyl-3,4-dihydropyrazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]propanamide —— C19H21N5O2S2
    N-cyclopropyl-N-[5-[2-oxo-2-(5-phenyl-3,4-dihydropyrazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]propanamide
    —— 4-(1-Cyclopropyltetrazol-5-yl)sulfanyl-6-(4-methoxyphenyl)thieno[3,2-d]pyrimidine —— C17H14N6OS2
    4-(1-Cyclopropyltetrazol-5-yl)sulfanyl-6-(4-methoxyphenyl)thieno[3,2-d]pyrimidine
    —— 4-(1-Cyclopropyltetrazol-5-yl)sulfanyl-2,5,6-trimethylthieno[2,3-d]pyrimidine —— C13H14N6S2
    4-(1-Cyclopropyltetrazol-5-yl)sulfanyl-2,5,6-trimethylthieno[2,3-d]pyrimidine
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-(4-methylpiperazin-1-yl)propanamide —— C15H25N5OS
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-(4-methylpiperazin-1-yl)propanamide
    —— 2-[(1R)-1-(1-cyclopropyltetrazol-5-yl)sulfanylethyl]-5-thiophen-2-yl-1,3,4-oxadiazole —— C12H12N6OS2
    2-[(1R)-1-(1-cyclopropyltetrazol-5-yl)sulfanylethyl]-5-thiophen-2-yl-1,3,4-oxadiazole
    —— 2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone —— C16H23N3O2S3
    2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone
    —— 2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone —— C16H23N3O2S3
    2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]ethanone
    —— N-[(1R)-1-(4-chlorophenyl)ethyl]-2-[[4-(2-phenylethyl)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C25H25ClN4OS2
    N-[(1R)-1-(4-chlorophenyl)ethyl]-2-[[4-(2-phenylethyl)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 2-(2-methylphenyl)sulfanyl-N-(4-methylpiperazin-4-ium-1-yl)acetamide —— C14H22N3OS+
    2-(2-methylphenyl)sulfanyl-N-(4-methylpiperazin-4-ium-1-yl)acetamide
    —— 2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-(4-methylpiperazin-4-ium-1-yl)acetamide —— C15H23BrN3OS+
    2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-(4-methylpiperazin-4-ium-1-yl)acetamide
    —— 7-[[5-(Cyclopropylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C13H13N5OS3
    7-[[5-(Cyclopropylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 2-[[(4R)-1,3-dioxan-4-yl]methylsulfanyl]-5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazole —— C16H20N2O3S2
    2-[[(4R)-1,3-dioxan-4-yl]methylsulfanyl]-5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazole
    —— 2-[(4,5-Dicyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-1-(2,5-dimethylthiophen-3-yl)ethanone —— C16H19N3OS2
    2-[(4,5-Dicyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-1-(2,5-dimethylthiophen-3-yl)ethanone
    —— N-[(S)-(4-fluorophenyl)-thiophen-2-ylmethyl]-2-pyrimidin-2-ylsulfanylacetamide —— C17H14FN3OS2
    N-[(S)-(4-fluorophenyl)-thiophen-2-ylmethyl]-2-pyrimidin-2-ylsulfanylacetamide
    —— N-(3-phenylsulfanylpropyl)-2-pyrimidin-2-ylsulfanylacetamide —— C15H17N3OS2
    N-(3-phenylsulfanylpropyl)-2-pyrimidin-2-ylsulfanylacetamide