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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[(4-chlorophenyl)methyl]-N-methylacetamide —— C14H16ClN5O2S
    2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[(4-chlorophenyl)methyl]-N-methylacetamide
    —— 2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(thiophen-2-ylmethyl)acetamide —— C11H13N5O2S2
    2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(thiophen-2-ylmethyl)acetamide
    —— 2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide —— C8H10F3N5O2S
    2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-1-[4-[[(2S)-oxolan-2-yl]methyl]piperazin-1-yl]ethanone —— C18H25BrN2O2S
    2-(4-bromo-2-methylphenyl)sulfanyl-1-[4-[[(2S)-oxolan-2-yl]methyl]piperazin-1-yl]ethanone
    —— 3-[[2-(4-Fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-methyl-1,2,4-triazol-4-amine —— C13H12FN5S2
    3-[[2-(4-Fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-5-methyl-1,2,4-triazol-4-amine
    —— (2S)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]propanamide —— C13H22N4OS2
    (2S)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]propanamide
    —— 2-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(3-phenylpropyl)acetamide —— C14H16F3N5OS
    2-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(3-phenylpropyl)acetamide
    —— 2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[(1S)-1-(4-ethylphenyl)ethyl]acetamide —— C16H21N5O2S
    2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[(1S)-1-(4-ethylphenyl)ethyl]acetamide
    —— 2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(tert-butylcarbamoyl)acetamide —— C11H18N6O3S
    2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-(tert-butylcarbamoyl)acetamide
    —— (2S)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]propanamide —— C13H22N4OS2
    (2S)-2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]propanamide
    —— 2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(3-chlorophenyl)ethyl]acetamide —— C13H16ClN5OS
    2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(3-chlorophenyl)ethyl]acetamide
    —— 2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(3-chlorophenyl)ethyl]acetamide —— C13H16ClN5OS
    2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(3-chlorophenyl)ethyl]acetamide
    —— 2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethanone —— C11H19N5O2S
    2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethanone
    —— 2-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(4-chlorophenyl)methyl]-N-methylacetamide —— C13H13ClF3N5OS
    2-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(4-chlorophenyl)methyl]-N-methylacetamide
    —— 3-Methyl-5-[(5-methyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,2,4-triazol-4-amine —— C7H10N6OS
    3-Methyl-5-[(5-methyl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,2,4-triazol-4-amine
    —— (2S)-N-(1-adamantyl)-2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H25N5OS
    (2S)-N-(1-adamantyl)-2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 2-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide —— C12H11F4N5OS
    2-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide
    —— 3-Methyl-5-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,2,4-triazol-4-amine —— C10H10N6OS2
    3-Methyl-5-[(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)methylsulfanyl]-1,2,4-triazol-4-amine
    —— 2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]ethanone —— C18H17ClN6O2S
    2-[(4-amino-5-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-(4-methylphenyl)sulfanyl-N-piperidin-1-ylacetamide —— C14H20N2OS
    2-(4-methylphenyl)sulfanyl-N-piperidin-1-ylacetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-piperidin-1-ylacetamide —— C14H19BrN2OS
    2-(4-bromo-2-methylphenyl)sulfanyl-N-piperidin-1-ylacetamide
    —— 2-(4-fluorophenyl)sulfanyl-N-piperidin-1-ylacetamide —— C13H17FN2OS
    2-(4-fluorophenyl)sulfanyl-N-piperidin-1-ylacetamide
    —— 4-amino-2-[(1S)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1H-pyrimidin-6-one —— C15H15N5O2S
    4-amino-2-[(1S)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1H-pyrimidin-6-one
    —— N-cycloheptyl-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide —— C17H27N3OS
    N-cycloheptyl-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide
    —— 2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide —— C14H16FN3OS
    2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfanyl]-N-[(4-fluorophenyl)methyl]acetamide
    —— (2S)-2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]propanamide —— C12H21N5OS
    (2S)-2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]propanamide
    —— (2S)-2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]propanamide —— C12H21N5OS
    (2S)-2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S,2S)-2-methylcyclohexyl]propanamide
    —— 2-[(1R,2R,4R)-2-bicyclo[2.2.1]heptanyl]-N-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]acetamide —— C18H22N4OS
    2-[(1R,2R,4R)-2-bicyclo[2.2.1]heptanyl]-N-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]acetamide
    —— 2-[(1R,2S,4R)-2-bicyclo[2.2.1]heptanyl]-N-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]acetamide —— C18H22N4OS
    2-[(1R,2S,4R)-2-bicyclo[2.2.1]heptanyl]-N-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]acetamide
    —— 6-Amino-1-cyclopropyl-5-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]pyrimidine-2,4-dione —— C12H14N6O3S
    6-Amino-1-cyclopropyl-5-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]pyrimidine-2,4-dione
    —— (2R)-N-[(2R)-4-phenylbutan-2-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C19H22N4OS2
    (2R)-N-[(2R)-4-phenylbutan-2-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (Z)-3-amino-2-[2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetyl]but-2-enenitrile —— C17H19N5O2S2
    (Z)-3-amino-2-[2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetyl]but-2-enenitrile
    —— 2-(4-fluorophenyl)-5-[(1R)-1-(4-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12F2N2OS
    2-(4-fluorophenyl)-5-[(1R)-1-(4-fluorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 1-(1-Cyclopropyl-2,5-dimethylpyrrol-3-yl)-2-(1-propan-2-yltetrazol-5-yl)sulfanylethanone —— C15H21N5OS
    1-(1-Cyclopropyl-2,5-dimethylpyrrol-3-yl)-2-(1-propan-2-yltetrazol-5-yl)sulfanylethanone
    —— (Z)-3-amino-2-[2-[[4-[[(2R)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetyl]but-2-enenitrile —— C17H19N5O2S2
    (Z)-3-amino-2-[2-[[4-[[(2R)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetyl]but-2-enenitrile
    —— N-benzyl-2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfanyl]acetamide —— C14H17N3OS
    N-benzyl-2-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfanyl]acetamide
    —— 4,5,6-trimethyl-2-[2-oxo-2-[(2R)-2-thiophen-2-ylpyrrolidin-1-yl]ethyl]sulfanylpyridine-3-carbonitrile —— C19H21N3OS2
    4,5,6-trimethyl-2-[2-oxo-2-[(2R)-2-thiophen-2-ylpyrrolidin-1-yl]ethyl]sulfanylpyridine-3-carbonitrile
    —— [(3R,4S)-4-hydroxy-1,1-dioxothiolan-3-yl]-[2-(4-methylphenyl)sulfanylethyl]azanium —— C13H20NO3S2+
    [(3R,4S)-4-hydroxy-1,1-dioxothiolan-3-yl]-[2-(4-methylphenyl)sulfanylethyl]azanium
    —— N-(1-cyano-4-methylcyclohexyl)-2-[(4,5-dicyclopropyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-methylacetamide —— C19H27N5OS
    N-(1-cyano-4-methylcyclohexyl)-2-[(4,5-dicyclopropyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-methylacetamide
    —— 6-Amino-1-cyclopropyl-5-[2-(2,5-difluorophenyl)sulfanylacetyl]pyrimidine-2,4-dione —— C15H13F2N3O3S
    6-Amino-1-cyclopropyl-5-[2-(2,5-difluorophenyl)sulfanylacetyl]pyrimidine-2,4-dione
    —— 2-(1-benzyltetrazol-5-yl)sulfanyl-1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]ethanone —— C16H21N5O2S
    2-(1-benzyltetrazol-5-yl)sulfanyl-1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]ethanone
    —— 2-[(4,5-Dicyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-1-thiophen-2-ylethanone —— C14H15N3OS2
    2-[(4,5-Dicyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-1-thiophen-2-ylethanone
    —— (2S)-N-(cyclohexylmethyl)-2-[[5-[4-(diethylamino)phenyl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C22H32N4O2S
    (2S)-N-(cyclohexylmethyl)-2-[[5-[4-(diethylamino)phenyl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— N-[[(2S)-oxolan-2-yl]methyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C13H16N4O2S2
    N-[[(2S)-oxolan-2-yl]methyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylethanone —— C18H23N5O2S2
    1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylethanone
    —— (Z)-3-amino-2-[2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]but-2-enenitrile —— C14H12N4O2S
    (Z)-3-amino-2-[2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]but-2-enenitrile
    —— 1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylethanone —— C18H23N5O2S2
    1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylethanone
    —— 5-(4-Methylphenyl)-4-(1-methyltetrazol-5-yl)sulfanylthieno[2,3-d]pyrimidine 920689-78-7 C15H12N6S2
    5-(4-Methylphenyl)-4-(1-methyltetrazol-5-yl)sulfanylthieno[2,3-d]pyrimidine
    —— 2-[[4-Benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-(1-ethyl-2,5-dimethylpyrrol-3-yl)ethanone —— C23H24N4O2S
    2-[[4-Benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-(1-ethyl-2,5-dimethylpyrrol-3-yl)ethanone
    —— 1-Methyl-2-[2-nitro-4-(trifluoromethylsulfonyl)phenyl]sulfanylimidazole —— C11H8F3N3O4S2
    1-Methyl-2-[2-nitro-4-(trifluoromethylsulfonyl)phenyl]sulfanylimidazole