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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— methyl (1S,3R,6S)-3-(4-chlorophenyl)sulfanyl-2,4-dioxo-6-phenylcyclohexane-1-carboxylate —— C20H17ClO4S
    methyl (1S,3R,6S)-3-(4-chlorophenyl)sulfanyl-2,4-dioxo-6-phenylcyclohexane-1-carboxylate
    —— (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]pentanedinitrile —— C15H15N5S2
    (2R)-2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanylmethyl]pentanedinitrile
    —— 2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C18H23N3O3S2
    2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— (2S)-1-(4-ethylpiperazin-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one —— C20H28N4O2S2
    (2S)-1-(4-ethylpiperazin-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one
    —— (2R)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one —— C20H29N4O2S2+
    (2R)-1-(4-ethylpiperazin-4-ium-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propan-1-one
    —— 3,3-dimethyl-1-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]butan-2-one —— C17H22N2O2S2
    3,3-dimethyl-1-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]butan-2-one
    —— 2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C13H15N3O2S2
    2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 1-(azepan-1-yl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C19H25N3O2S2
    1-(azepan-1-yl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C13H15N3O2S2
    2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide —— C14H19N5OS2
    2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide
    —— 2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]-1-morpholin-4-ylethanone —— C17H21N3O3S2
    2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]-1-morpholin-4-ylethanone
    —— 1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C19H25N3O3S2
    1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— (2S)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanenitrile —— C14H15N3OS2
    (2S)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]propanenitrile
    —— 2-benzylsulfanyl-5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazole —— C18H18N2OS2
    2-benzylsulfanyl-5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazole
    —— 1-(4-acetylpiperazin-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C19H24N4O3S2
    1-(4-acetylpiperazin-1-yl)-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— tert-butyl 2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetate —— C17H22N2O3S2
    tert-butyl 2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetate
    —— 5-[[5-(2,5-Dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C11H11N5O2S2
    5-[[5-(2,5-Dimethylfuran-3-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— [(2R)-1-oxo-1-(thiophen-2-ylmethylamino)propan-2-yl] 3-(4-chlorophenyl)sulfanylpropanoate —— C17H18ClNO3S2
    [(2R)-1-oxo-1-(thiophen-2-ylmethylamino)propan-2-yl] 3-(4-chlorophenyl)sulfanylpropanoate
    —— N,N-dimethyl-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C15H19N3O2S2
    N,N-dimethyl-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(4-fluorophenyl)methyl]-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C20H20FN3O2S2
    N-[(4-fluorophenyl)methyl]-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N,N-bis(2-methoxyethyl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H27N3O4S2
    N,N-bis(2-methoxyethyl)-2-[[5-[(5R)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N'-acetyl-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetohydrazide —— C15H18N4O3S2
    N'-acetyl-2-[[5-[(5S)-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetohydrazide
    —— [(2R)-1-[[(3R)-1,1-dioxothiolan-3-yl]-methylamino]-1-oxopropan-2-yl] 3-(4-chlorophenyl)sulfanylpropanoate —— C17H22ClNO5S2
    [(2R)-1-[[(3R)-1,1-dioxothiolan-3-yl]-methylamino]-1-oxopropan-2-yl] 3-(4-chlorophenyl)sulfanylpropanoate
    —— (2S)-2-[[5,6-bis(4-methylphenyl)-1,2,4-triazin-3-yl]sulfanyl]-N-tert-butylpropanamide —— C24H28N4OS
    (2S)-2-[[5,6-bis(4-methylphenyl)-1,2,4-triazin-3-yl]sulfanyl]-N-tert-butylpropanamide
    —— N-[(1S)-1-[(1R,2S,4S)-2-bicyclo[2.2.1]hept-5-enyl]ethyl]-3-methylsulfonylpropan-1-amine —— C13H23NO2S
    N-[(1S)-1-[(1R,2S,4S)-2-bicyclo[2.2.1]hept-5-enyl]ethyl]-3-methylsulfonylpropan-1-amine
    —— [(2R)-1-(cycloheptylamino)-1-oxopropan-2-yl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate —— C18H27N3O3S
    [(2R)-1-(cycloheptylamino)-1-oxopropan-2-yl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate
    —— [(2S)-1-[(4-methylphenyl)methylamino]-1-oxopropan-2-yl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate —— C19H23N3O3S
    [(2S)-1-[(4-methylphenyl)methylamino]-1-oxopropan-2-yl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate
    —— N-[(1R)-1-[(1R,2S,4S)-2-bicyclo[2.2.1]hept-5-enyl]ethyl]-3-methylsulfonylpropan-1-amine —— C13H23NO2S
    N-[(1R)-1-[(1R,2S,4S)-2-bicyclo[2.2.1]hept-5-enyl]ethyl]-3-methylsulfonylpropan-1-amine
    —— (1S,2S,3S,4S)-3-[(2-phenylsulfanylphenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid —— C21H19NO3S
    (1S,2S,3S,4S)-3-[(2-phenylsulfanylphenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
    —— N-[(1S)-1-[(1R,2R,4S)-2-bicyclo[2.2.1]hept-5-enyl]ethyl]-3-methylsulfonylpropan-1-amine —— C13H23NO2S
    N-[(1S)-1-[(1R,2R,4S)-2-bicyclo[2.2.1]hept-5-enyl]ethyl]-3-methylsulfonylpropan-1-amine
    —— (2R)-N-(3-methylsulfonylpropyl)nonan-2-amine —— C13H29NO2S
    (2R)-N-(3-methylsulfonylpropyl)nonan-2-amine
    —— [(2R)-1-oxo-1-(prop-2-enylamino)propan-2-yl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate —— C14H19N3O3S
    [(2R)-1-oxo-1-(prop-2-enylamino)propan-2-yl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate
    —— [(2R)-1-[[(3R)-1,1-dioxothiolan-3-yl]amino]-1-oxopropan-2-yl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate —— C15H21N3O5S2
    [(2R)-1-[[(3R)-1,1-dioxothiolan-3-yl]amino]-1-oxopropan-2-yl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate
    —— 2-(Pyrimidin-2-ylsulfanylmethyl)-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one —— C15H14N4OS2
    2-(Pyrimidin-2-ylsulfanylmethyl)-6,7,8,9-tetrahydropyrimido[2,1-b][1,3]benzothiazol-4-one
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1R)-2-methyl-1-thiophen-2-ylpropyl]propanamide —— C18H25N3OS2
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1R)-2-methyl-1-thiophen-2-ylpropyl]propanamide
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1S)-2-methyl-1-thiophen-2-ylpropyl]propanamide —— C18H25N3OS2
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1S)-2-methyl-1-thiophen-2-ylpropyl]propanamide
    —— (2R)-N-[(2-chlorophenyl)methyl]-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C18H19ClN4OS2
    (2R)-N-[(2-chlorophenyl)methyl]-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (2S)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methylpropyl)propanamide —— C15H22N4OS2
    (2S)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methylpropyl)propanamide
    —— 2-(4-methylphenyl)sulfanyl-N-[(1R)-2-methyl-1-thiophen-2-ylpropyl]acetamide —— C17H21NOS2
    2-(4-methylphenyl)sulfanyl-N-[(1R)-2-methyl-1-thiophen-2-ylpropyl]acetamide
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]propanamide —— C18H24N4O2S
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]propanamide
    —— (2R)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-propylpropanamide —— C14H20N4OS2
    (2R)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-propylpropanamide
    —— 2-(2-methylphenyl)sulfanyl-N-[(1S)-2-methyl-1-thiophen-2-ylpropyl]acetamide —— C17H21NOS2
    2-(2-methylphenyl)sulfanyl-N-[(1S)-2-methyl-1-thiophen-2-ylpropyl]acetamide
    —— (1S,2S,3S,4R)-3-[(2-phenylsulfanylphenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid —— C21H19NO3S
    (1S,2S,3S,4R)-3-[(2-phenylsulfanylphenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
    —— (2S)-N-(3-methylsulfonylpropyl)nonan-2-amine —— C13H29NO2S
    (2S)-N-(3-methylsulfonylpropyl)nonan-2-amine
    —— (2R)-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C15H20N4O3S3
    (2R)-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (1S,2S,3R,4R)-3-[(2-phenylsulfanylphenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid —— C21H19NO3S
    (1S,2S,3R,4R)-3-[(2-phenylsulfanylphenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
    —— (2R)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-prop-2-enylpropanamide —— C14H18N4OS2
    (2R)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-prop-2-enylpropanamide
    —— (2R)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methylpropyl)propanamide —— C15H22N4OS2
    (2R)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methylpropyl)propanamide
    —— 2-(4-bromophenyl)sulfanyl-N-[(1R)-2-methyl-1-thiophen-2-ylpropyl]acetamide —— C16H18BrNOS2
    2-(4-bromophenyl)sulfanyl-N-[(1R)-2-methyl-1-thiophen-2-ylpropyl]acetamide
    —— (1S,2S,3R,4S)-3-[(2-phenylsulfanylphenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid —— C21H19NO3S
    (1S,2S,3R,4S)-3-[(2-phenylsulfanylphenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid