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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— [2-[(2-Methylphenyl)methylamino]-2-oxoethyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate —— C21H25NO3S
    [2-[(2-Methylphenyl)methylamino]-2-oxoethyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate
    —— [2-oxo-2-(2-phenylsulfanylanilino)ethyl] 2-[(1S)-cyclopent-2-en-1-yl]acetate —— C21H21NO3S
    [2-oxo-2-(2-phenylsulfanylanilino)ethyl] 2-[(1S)-cyclopent-2-en-1-yl]acetate
    —— N-(3-chlorophenyl)-5-[(5-methyl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C13H11ClN4OS2
    N-(3-chlorophenyl)-5-[(5-methyl-1,2-oxazol-3-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— (5-phenyl-1,3,4-oxadiazol-2-yl)methyl (1'S,5'R)-spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxylate —— C21H24N2O3S2
    (5-phenyl-1,3,4-oxadiazol-2-yl)methyl (1'S,5'R)-spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxylate
    —— 1-[(3-methyl-4-methylsulfanylphenyl)methyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C16H22N2O2S
    1-[(3-methyl-4-methylsulfanylphenyl)methyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— 1-(2,5-Dimethylthiophen-3-yl)-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C16H14FN3OS3
    1-(2,5-Dimethylthiophen-3-yl)-2-[[5-(3-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— [2-(ethoxycarbonylamino)-2-oxoethyl] (1'S,5'R)-spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxylate —— C17H25NO5S2
    [2-(ethoxycarbonylamino)-2-oxoethyl] (1'S,5'R)-spiro[1,3-dithiolane-2,9'-bicyclo[3.3.1]nonane]-3'-carboxylate
    —— (2S)-N-(1-cyanocyclohexyl)-2-(2,5-difluorophenyl)sulfanyl-N-methylpropanamide —— C17H20F2N2OS
    (2S)-N-(1-cyanocyclohexyl)-2-(2,5-difluorophenyl)sulfanyl-N-methylpropanamide
    —— 1-[2-(4-fluorophenyl)sulfanylethyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C15H19FN2O2S
    1-[2-(4-fluorophenyl)sulfanylethyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— (2R)-N-(1-cyanocyclohexyl)-2-(2,5-difluorophenyl)sulfanyl-N-methylpropanamide —— C17H20F2N2OS
    (2R)-N-(1-cyanocyclohexyl)-2-(2,5-difluorophenyl)sulfanyl-N-methylpropanamide
    —— (2R)-2-(2,5-difluorophenyl)sulfanyl-N-(thiophen-2-ylmethyl)propanamide —— C14H13F2NOS2
    (2R)-2-(2,5-difluorophenyl)sulfanyl-N-(thiophen-2-ylmethyl)propanamide
    —— 1-[2-(4-fluorophenyl)sulfanylethyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C15H19FN2O2S
    1-[2-(4-fluorophenyl)sulfanylethyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— 1-[(3-methyl-4-methylsulfanylphenyl)methyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C16H22N2O2S
    1-[(3-methyl-4-methylsulfanylphenyl)methyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— (2S)-2-(2,5-difluorophenyl)sulfanyl-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]propanamide —— C14H14F2N2O3S2
    (2S)-2-(2,5-difluorophenyl)sulfanyl-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]propanamide
    —— 1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C15H19FN2O2S
    1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(1S,2S,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— 1-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]-3-[(1-phenylsulfanylcyclopropyl)methyl]urea —— C17H22N2O2S
    1-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]-3-[(1-phenylsulfanylcyclopropyl)methyl]urea
    —— 1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea —— C15H19FN2O2S
    1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(1S,2R,4S)-7-oxabicyclo[2.2.1]heptan-2-yl]urea
    —— [2-[2-(4-methylphenyl)sulfanylethylamino]-2-oxoethyl] (E)-3-(5-methylthiophen-2-yl)prop-2-enoate —— C19H21NO3S2
    [2-[2-(4-methylphenyl)sulfanylethylamino]-2-oxoethyl] (E)-3-(5-methylthiophen-2-yl)prop-2-enoate
    —— (2R)-4-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C18H15N3OS3
    (2R)-4-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— (2R)-4-[(5-butylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C14H16N4OS4
    (2R)-4-[(5-butylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— (2S)-4-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile —— C18H15N3OS3
    (2S)-4-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]-2-(4-methyl-1,3-thiazol-2-yl)-3-oxobutanenitrile
    —— (2R)-N-(1-adamantyl)-2-(3,4-difluorophenyl)sulfanylpropanamide —— C19H23F2NOS
    (2R)-N-(1-adamantyl)-2-(3,4-difluorophenyl)sulfanylpropanamide
    —— N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-(3,4-difluorophenyl)sulfanylacetamide —— C14H16F2N2OS
    N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-(3,4-difluorophenyl)sulfanylacetamide
    —— (1R,3S)-3-(2-methylsulfonylethylcarbamoyl)cyclohexane-1-carboxylic acid —— C11H19NO5S
    (1R,3S)-3-(2-methylsulfonylethylcarbamoyl)cyclohexane-1-carboxylic acid
    —— (1R,3R)-3-(2-methylsulfonylethylcarbamoyl)cyclohexane-1-carboxylic acid —— C11H19NO5S
    (1R,3R)-3-(2-methylsulfonylethylcarbamoyl)cyclohexane-1-carboxylic acid
    —— (1S,3R)-3-(2-methylsulfonylethylcarbamoyl)cyclohexane-1-carboxylic acid —— C11H19NO5S
    (1S,3R)-3-(2-methylsulfonylethylcarbamoyl)cyclohexane-1-carboxylic acid
    —— (1S,3S)-3-(2-methylsulfonylethylcarbamoyl)cyclohexane-1-carboxylic acid —— C11H19NO5S
    (1S,3S)-3-(2-methylsulfonylethylcarbamoyl)cyclohexane-1-carboxylic acid
    —— N-benzyl-2-(3,4-difluorophenyl)sulfanylacetamide —— C15H13F2NOS
    N-benzyl-2-(3,4-difluorophenyl)sulfanylacetamide
    —— 1-Ethyl-3-(2-phenylsulfanylethylcarbamothioylamino)thiourea —— C12H18N4S3
    1-Ethyl-3-(2-phenylsulfanylethylcarbamothioylamino)thiourea
    —— 1-[(2-Chlorophenyl)methyl]-3-(2-phenylsulfanylethyl)thiourea —— C16H17ClN2S2
    1-[(2-Chlorophenyl)methyl]-3-(2-phenylsulfanylethyl)thiourea
    —— 1-[2-(4-Chlorophenyl)sulfanylethyl]-3-(cyclopropanecarbonylamino)thiourea —— C13H16ClN3OS2
    1-[2-(4-Chlorophenyl)sulfanylethyl]-3-(cyclopropanecarbonylamino)thiourea
    —— methyl N-(2-phenylsulfanylethylcarbamothioylamino)carbamate —— C11H15N3O2S2
    methyl N-(2-phenylsulfanylethylcarbamothioylamino)carbamate
    —— 1-[3-(Dimethylamino)propyl]-3-[2-(4-methylphenyl)sulfanylethyl]thiourea —— C15H25N3S2
    1-[3-(Dimethylamino)propyl]-3-[2-(4-methylphenyl)sulfanylethyl]thiourea
    —— 1-Benzyl-3-[2-(4-chlorophenyl)sulfanylethyl]-1-methylthiourea —— C17H19ClN2S2
    1-Benzyl-3-[2-(4-chlorophenyl)sulfanylethyl]-1-methylthiourea
    —— N-[2-(4-chlorophenyl)sulfanylethyl]morpholine-4-carbothioamide —— C13H17ClN2OS2
    N-[2-(4-chlorophenyl)sulfanylethyl]morpholine-4-carbothioamide
    —— 1-[2-(4-Chlorophenyl)sulfanylethyl]-3-[2-(dimethylamino)ethyl]thiourea —— C13H20ClN3S2
    1-[2-(4-Chlorophenyl)sulfanylethyl]-3-[2-(dimethylamino)ethyl]thiourea
    —— 4-ethyl-N-(2-phenylsulfanylethyl)piperazine-1-carbothioamide —— C15H23N3S2
    4-ethyl-N-(2-phenylsulfanylethyl)piperazine-1-carbothioamide
    —— (2R,6S)-N-[2-(4-chlorophenyl)sulfanylethyl]-2,6-dimethylmorpholine-4-carbothioamide —— C15H21ClN2OS2
    (2R,6S)-N-[2-(4-chlorophenyl)sulfanylethyl]-2,6-dimethylmorpholine-4-carbothioamide
    —— 1-[2-(4-Chlorophenyl)sulfanylethyl]-3-(2,2,6,6-tetramethylpiperidin-4-yl)thiourea —— C18H28ClN3S2
    1-[2-(4-Chlorophenyl)sulfanylethyl]-3-(2,2,6,6-tetramethylpiperidin-4-yl)thiourea
    —— ethyl N-[2-(4-chlorophenyl)sulfanylethylcarbamothioylamino]carbamate —— C12H16ClN3O2S2
    ethyl N-[2-(4-chlorophenyl)sulfanylethylcarbamothioylamino]carbamate
    —— 1-[(1S)-1-phenylethyl]-3-(2-phenylsulfanylethyl)thiourea —— C17H20N2S2
    1-[(1S)-1-phenylethyl]-3-(2-phenylsulfanylethyl)thiourea
    —— (2R,6R)-N-[2-(4-chlorophenyl)sulfanylethyl]-2,6-dimethylmorpholine-4-carbothioamide —— C15H21ClN2OS2
    (2R,6R)-N-[2-(4-chlorophenyl)sulfanylethyl]-2,6-dimethylmorpholine-4-carbothioamide
    —— 5-Ethylsulfanylthiophen-2-ol —— C6H8OS2
    5-Ethylsulfanylthiophen-2-ol
    —— (2R)-2-(2-bromophenyl)-2-pyrimidin-4-ylsulfanylethanamine —— C12H12BrN3S
    (2R)-2-(2-bromophenyl)-2-pyrimidin-4-ylsulfanylethanamine
    —— (1S,2S)-1-(3-methylphenyl)-1-pyrimidin-4-ylsulfanylbutan-2-amine —— C15H19N3S
    (1S,2S)-1-(3-methylphenyl)-1-pyrimidin-4-ylsulfanylbutan-2-amine
    —— (1R,2S)-1-pyridin-3-yl-1-pyrimidin-4-ylsulfanylbutan-2-amine —— C13H16N4S
    (1R,2S)-1-pyridin-3-yl-1-pyrimidin-4-ylsulfanylbutan-2-amine
    —— 2-benzylsulfanyl-5-fluoro-N'-hydroxybenzenecarboximidamide —— C14H13FN2OS
    2-benzylsulfanyl-5-fluoro-N'-hydroxybenzenecarboximidamide
    —— (1S,2R)-1-(3-bromophenyl)-1-pyrimidin-4-ylsulfanylbutan-2-amine —— C14H16BrN3S
    (1S,2R)-1-(3-bromophenyl)-1-pyrimidin-4-ylsulfanylbutan-2-amine
    —— (2R)-2-(2,4-difluorophenyl)sulfanyl-N-(2-thiophen-2-ylethyl)propanamide —— C15H15F2NOS2
    (2R)-2-(2,4-difluorophenyl)sulfanyl-N-(2-thiophen-2-ylethyl)propanamide
    —— 3-(3,4-difluorophenyl)sulfanyl-N-[(4-fluorophenyl)methyl]propanamide —— C16H14F3NOS
    3-(3,4-difluorophenyl)sulfanyl-N-[(4-fluorophenyl)methyl]propanamide