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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-4-ium-1-yl)propan-1-one —— C21H33N4O2S+
    (2R)-2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(4-ethylpiperazin-4-ium-1-yl)propan-1-one
    —— 2-(1-Adamantyl)-5-(2-phenylethylsulfanyl)-1,3,4-oxadiazole —— C20H24N2OS
    2-(1-Adamantyl)-5-(2-phenylethylsulfanyl)-1,3,4-oxadiazole
    —— 2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-benzyl-N-propan-2-ylacetamide —— C24H31N3O2S
    2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-benzyl-N-propan-2-ylacetamide
    —— 2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[(1S)-1-(4-ethylphenyl)ethyl]acetamide —— C19H20N5OS+
    2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[(1S)-1-(4-ethylphenyl)ethyl]acetamide
    —— (2S)-2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-2-phenylpropyl]propanamide —— C24H31N3O2S
    (2S)-2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-2-phenylpropyl]propanamide
    —— 2-[[5-(1-Adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetonitrile —— C14H17N3OS
    2-[[5-(1-Adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetonitrile
    —— N-[(1R)-1-(1-adamantyl)ethyl]-2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanylacetamide —— C21H26N5OS+
    N-[(1R)-1-(1-adamantyl)ethyl]-2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanylacetamide
    —— (3R)-3-[[5-[(2-bromo-4-fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide —— C15H17BrFN3O2S2
    (3R)-3-[[5-[(2-bromo-4-fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide
    —— 2-(1-Adamantyl)-5-[(3-methylphenyl)methylsulfanyl]-1,3,4-oxadiazole —— C20H24N2OS
    2-(1-Adamantyl)-5-[(3-methylphenyl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-[(1R)-1-(4-ethylphenyl)ethyl]acetamide —— C19H19N5OS
    2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-[(1R)-1-(4-ethylphenyl)ethyl]acetamide
    —— 2-(4-chlorophenyl)-5-[[5-(4-methylpiperidin-1-yl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3,4-oxadiazole —— C22H27ClN6O2S
    2-(4-chlorophenyl)-5-[[5-(4-methylpiperidin-1-yl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3,4-oxadiazole
    —— 2-(1-Adamantyl)-5-[(4-methylphenyl)methylsulfanyl]-1,3,4-oxadiazole —— C20H24N2OS
    2-(1-Adamantyl)-5-[(4-methylphenyl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-(4-chlorophenyl)-5-[[5-(4-methylpiperidin-1-yl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3,4-oxadiazole —— C22H27ClN6O2S
    2-(4-chlorophenyl)-5-[[5-(4-methylpiperidin-1-yl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3,4-oxadiazole
    —— 2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C19H27N3O3S
    2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— 4-methyl-1-[5-[(4-methylphenyl)methylsulfanyl]-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]piperidine —— C21H30N4OS
    4-methyl-1-[5-[(4-methylphenyl)methylsulfanyl]-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]piperidine
    —— 2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-benzyl-N-ethylacetamide —— C23H29N3O2S
    2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-benzyl-N-ethylacetamide
    —— 2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S,2R)-2-methylcyclohexyl]acetamide —— C21H31N3O2S
    2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(1S,2R)-2-methylcyclohexyl]acetamide
    —— 2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-4-phenylbutan-2-yl]acetamide —— C24H31N3O2S
    2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(2R)-4-phenylbutan-2-yl]acetamide
    —— 2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]acetamide —— C17H14FN5OS
    2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]acetamide
    —— 2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-butylacetamide —— C18H27N3O2S
    2-[[5-(1-adamantyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-butylacetamide
    —— 2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-methyl-N-[(1R)-1-phenylethyl]acetamide —— C18H17N5OS
    2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-methyl-N-[(1R)-1-phenylethyl]acetamide
    —— 2-(1-Adamantyl)-5-[(2-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazole —— C19H21ClN2OS
    2-(1-Adamantyl)-5-[(2-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N,N-dimethylacetamide —— C11H11N5OS
    2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N,N-dimethylacetamide
    —— (3S)-3-[[5-[(2-bromo-4-fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide —— C15H17BrFN3O2S2
    (3S)-3-[[5-[(2-bromo-4-fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide
    —— 2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[(1R)-1-phenylbutyl]acetamide —— C19H20N5OS+
    2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[(1R)-1-phenylbutyl]acetamide
    —— 2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N,N-di(propan-2-yl)acetamide —— C15H19N5OS
    2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N,N-di(propan-2-yl)acetamide
    —— (2R)-2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[2-(cyclohexen-1-yl)ethyl]propanamide —— C18H22N5OS+
    (2R)-2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[2-(cyclohexen-1-yl)ethyl]propanamide
    —— (2S)-2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-cyclopentylpropanamide —— C15H17N5OS
    (2S)-2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-cyclopentylpropanamide
    —— 2-amino-6-[2-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanylpyridin-1-ium-3,5-dicarbonitrile —— C15H18N5O2S+
    2-amino-6-[2-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-oxoethyl]sulfanylpyridin-1-ium-3,5-dicarbonitrile
    —— 2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[(2S)-4-phenylbutan-2-yl]acetamide —— C19H20N5OS+
    2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[(2S)-4-phenylbutan-2-yl]acetamide
    —— 2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N,N-diethylacetamide —— C13H15N5OS
    2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N,N-diethylacetamide
    —— 2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[(2S)-butan-2-yl]acetamide —— C13H16N5OS+
    2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[(2S)-butan-2-yl]acetamide
    —— 2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-benzyl-N-propan-2-ylacetamide —— C19H19N5OS
    2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-benzyl-N-propan-2-ylacetamide
    —— 2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[(1R)-1-(2-chlorophenyl)ethyl]acetamide —— C17H15ClN5OS+
    2-(6-amino-3,5-dicyanopyridin-1-ium-2-yl)sulfanyl-N-[(1R)-1-(2-chlorophenyl)ethyl]acetamide
    —— 2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-[(1S)-1-(3-chlorophenyl)ethyl]acetamide —— C17H14ClN5OS
    2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-[(1S)-1-(3-chlorophenyl)ethyl]acetamide
    —— 2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-[(2S)-4-phenylbutan-2-yl]acetamide —— C19H19N5OS
    2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-[(2S)-4-phenylbutan-2-yl]acetamide
    —— ethyl (4S)-6-amino-5-cyano-2-[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanylmethyl]-4-(4-methylsulfanylphenyl)-4H-pyran-3-carboxylate —— C28H28N4O3S2
    ethyl (4S)-6-amino-5-cyano-2-[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanylmethyl]-4-(4-methylsulfanylphenyl)-4H-pyran-3-carboxylate
    —— ethyl (4R)-6-amino-5-cyano-2-[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanylmethyl]-4-(4-methylsulfanylphenyl)-4H-pyran-3-carboxylate —— C28H28N4O3S2
    ethyl (4R)-6-amino-5-cyano-2-[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanylmethyl]-4-(4-methylsulfanylphenyl)-4H-pyran-3-carboxylate
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[3-(2,4-dimethylphenyl)propyl]propanamide —— C21H29N3OS
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[3-(2,4-dimethylphenyl)propyl]propanamide
    —— 3-[2-(2-amino-2-oxoethyl)sulfanyl-4,6-dimethylpyrimidin-5-yl]-N-methyl-N-[(1R)-1-phenylethyl]propanamide —— C20H26N4O2S
    3-[2-(2-amino-2-oxoethyl)sulfanyl-4,6-dimethylpyrimidin-5-yl]-N-methyl-N-[(1R)-1-phenylethyl]propanamide
    —— N-(1-adamantyl)-2-(3-chloro-4-fluorophenyl)sulfanylacetamide —— C18H21ClFNOS
    N-(1-adamantyl)-2-(3-chloro-4-fluorophenyl)sulfanylacetamide
    —— 2-(3-chloro-4-fluorophenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]acetamide —— C16H14ClF2NOS
    2-(3-chloro-4-fluorophenyl)sulfanyl-N-[2-(4-fluorophenyl)ethyl]acetamide
    —— 2-(3-chloro-4-fluorophenyl)sulfanyl-N-(1-cyanocyclohexyl)-N-methylacetamide —— C16H18ClFN2OS
    2-(3-chloro-4-fluorophenyl)sulfanyl-N-(1-cyanocyclohexyl)-N-methylacetamide
    —— 3-[2-(2-amino-2-oxoethyl)sulfanyl-4,6-dimethylpyrimidin-5-yl]-N-methyl-N-[(1S)-1-phenylethyl]propanamide —— C20H26N4O2S
    3-[2-(2-amino-2-oxoethyl)sulfanyl-4,6-dimethylpyrimidin-5-yl]-N-methyl-N-[(1S)-1-phenylethyl]propanamide
    —— (2S)-N-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-N-propan-2-yl-2,3-dihydro-1-benzothiophene-2-carboxamide —— C21H20ClN3O2S
    (2S)-N-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-N-propan-2-yl-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— 2-(3-chloro-4-fluorophenyl)sulfanyl-N-[(1S,2R)-2-methylcyclohexyl]acetamide —— C15H19ClFNOS
    2-(3-chloro-4-fluorophenyl)sulfanyl-N-[(1S,2R)-2-methylcyclohexyl]acetamide
    —— (2R)-N-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-N-propan-2-yl-2,3-dihydro-1-benzothiophene-2-carboxamide —— C21H20ClN3O2S
    (2R)-N-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-N-propan-2-yl-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— 2-(3-chloro-4-fluorophenyl)sulfanyl-N-[(2R)-2-cyano-3-methylbutan-2-yl]acetamide —— C14H16ClFN2OS
    2-(3-chloro-4-fluorophenyl)sulfanyl-N-[(2R)-2-cyano-3-methylbutan-2-yl]acetamide
    —— (2S)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C20H20ClN5O2S
    (2S)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— (2R)-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C20H20ClN5O2S
    (2R)-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one