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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H21ClN4O2S2
    N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 1-(2,5-dimethyl-1-propylpyrrol-3-yl)-2-[1-[[(2R)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylethanone —— C17H25N5O2S
    1-(2,5-dimethyl-1-propylpyrrol-3-yl)-2-[1-[[(2R)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylethanone
    —— N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[[5-[[(2S)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H21ClN4O2S2
    N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[[5-[[(2S)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 1-(4-fluorophenyl)-3-[[(2S)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea —— C17H18FN3OS2
    1-(4-fluorophenyl)-3-[[(2S)-2-(4-methylphenyl)sulfanylpropanoyl]amino]thiourea
    —— 2-(2,5-difluorophenyl)sulfanyl-N-[(2R)-2-phenylpropyl]acetamide —— C17H17F2NOS
    2-(2,5-difluorophenyl)sulfanyl-N-[(2R)-2-phenylpropyl]acetamide
    —— (2S)-N-[2-(4-chlorophenyl)ethyl]-2-(4-methylphenyl)sulfanylpropanamide —— C18H20ClNOS
    (2S)-N-[2-(4-chlorophenyl)ethyl]-2-(4-methylphenyl)sulfanylpropanamide
    —— 2-(2-chlorophenyl)sulfanyl-N-[(2R)-2-(diethylamino)-2-(furan-2-yl)ethyl]acetamide —— C18H23ClN2O2S
    2-(2-chlorophenyl)sulfanyl-N-[(2R)-2-(diethylamino)-2-(furan-2-yl)ethyl]acetamide
    —— N-[(2R)-2-(diethylamino)-2-(furan-2-yl)ethyl]-2-(2,5-dimethylphenyl)sulfanylacetamide —— C20H28N2O2S
    N-[(2R)-2-(diethylamino)-2-(furan-2-yl)ethyl]-2-(2,5-dimethylphenyl)sulfanylacetamide
    —— 1-(2,5-dimethyl-1-propylpyrrol-3-yl)-2-[1-[[(2S)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylethanone —— C17H25N5O2S
    1-(2,5-dimethyl-1-propylpyrrol-3-yl)-2-[1-[[(2S)-oxolan-2-yl]methyl]tetrazol-5-yl]sulfanylethanone
    —— N-[(2S)-2-(diethylamino)-2-(furan-2-yl)ethyl]-2-(2,5-dimethylphenyl)sulfanylacetamide —— C20H28N2O2S
    N-[(2S)-2-(diethylamino)-2-(furan-2-yl)ethyl]-2-(2,5-dimethylphenyl)sulfanylacetamide
    —— 1-[[2-[(4-Benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]amino]-3-tert-butylthiourea —— C17H24N6OS2
    1-[[2-[(4-Benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]amino]-3-tert-butylthiourea
    —— 1-Tert-butyl-3-[3-(4-chlorophenyl)sulfanylpropanoylamino]thiourea —— C14H20ClN3OS2
    1-Tert-butyl-3-[3-(4-chlorophenyl)sulfanylpropanoylamino]thiourea
    —— ethyl (1R,2E)-2-[[(2R)-2-phenylsulfanylpropanoyl]hydrazinylidene]cyclopentane-1-carboxylate —— C17H22N2O3S
    ethyl (1R,2E)-2-[[(2R)-2-phenylsulfanylpropanoyl]hydrazinylidene]cyclopentane-1-carboxylate
    —— ethyl (1S,2E)-2-[[(2R)-2-phenylsulfanylpropanoyl]hydrazinylidene]cyclopentane-1-carboxylate —— C17H22N2O3S
    ethyl (1S,2E)-2-[[(2R)-2-phenylsulfanylpropanoyl]hydrazinylidene]cyclopentane-1-carboxylate
    —— (5S,7S)-3-chloro-N-(3-phenylsulfanylpropyl)adamantane-1-carboxamide —— C20H26ClNOS
    (5S,7S)-3-chloro-N-(3-phenylsulfanylpropyl)adamantane-1-carboxamide
    —— N'-[2-(4-methylphenyl)sulfanylacetyl]cyclobutanecarbohydrazide —— C14H18N2O2S
    N'-[2-(4-methylphenyl)sulfanylacetyl]cyclobutanecarbohydrazide
    —— N'-[2-(2-fluorophenyl)sulfanylacetyl]-2-[(4-methylphenyl)methylsulfanyl]acetohydrazide —— C18H19FN2O2S2
    N'-[2-(2-fluorophenyl)sulfanylacetyl]-2-[(4-methylphenyl)methylsulfanyl]acetohydrazide
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide —— C13H20N4O3S3
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-cyclopentyl-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide
    —— 2-[(3-chlorophenyl)methylsulfanyl]-N'-[2-(4-methylphenyl)sulfanylacetyl]acetohydrazide —— C18H19ClN2O2S2
    2-[(3-chlorophenyl)methylsulfanyl]-N'-[2-(4-methylphenyl)sulfanylacetyl]acetohydrazide
    —— 5-[(1R)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C12H10FN5OS2
    5-[(1R)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— 3-[(1R)-1-[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-amine —— C12H11ClN6OS
    3-[(1R)-1-[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-amine
    —— (NE)-N-[(2S)-2-pyrimidin-2-ylsulfanylcyclopentylidene]hydroxylamine —— C9H11N3OS
    (NE)-N-[(2S)-2-pyrimidin-2-ylsulfanylcyclopentylidene]hydroxylamine
    —— 3-[(1R)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-amine —— C12H11FN6OS
    3-[(1R)-1-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-amine
    —— (2S)-2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N,N-dimethylpropanamide —— C7H13N5OS
    (2S)-2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N,N-dimethylpropanamide
    —— (NE)-N-[(2R)-2-pyrimidin-2-ylsulfanylcyclopentylidene]hydroxylamine —— C9H11N3OS
    (NE)-N-[(2R)-2-pyrimidin-2-ylsulfanylcyclopentylidene]hydroxylamine
    —— 3-[(1R)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-amine —— C13H14N6OS
    3-[(1R)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-amine
    —— N'-[2-(2,4-dimethylphenyl)sulfanylacetyl]-2-(3,5-dimethylpyrazol-1-yl)acetohydrazide —— C17H22N4O2S
    N'-[2-(2,4-dimethylphenyl)sulfanylacetyl]-2-(3,5-dimethylpyrazol-1-yl)acetohydrazide
    —— 3-[(1S)-1-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-amine —— C13H14N6OS
    3-[(1S)-1-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1H-1,2,4-triazol-5-amine
    —— (2R)-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide —— C16H22F3N3OS
    (2R)-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
    —— (2R)-N-(2-thiophen-2-ylethyl)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylpropanamide —— C15H17N5OS3
    (2R)-N-(2-thiophen-2-ylethyl)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylpropanamide
    —— 2-[[5-(4-methoxyphenyl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]-3-nitroimidazo[1,2-a]pyridine —— C21H20N6O4S
    2-[[5-(4-methoxyphenyl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]-3-nitroimidazo[1,2-a]pyridine
    —— (2S)-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide —— C16H22F3N3OS
    (2S)-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
    —— (2R)-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide —— C16H22F3N3OS
    (2R)-N-[(1S,2S,3S)-2,3-dimethylcyclohexyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
    —— (2S)-N-cyclohexyl-N-ethyl-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylpropanamide —— C17H25N5OS2
    (2S)-N-cyclohexyl-N-ethyl-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylpropanamide
    —— (2R)-N-cyclohexyl-N-ethyl-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylpropanamide —— C17H25N5OS2
    (2R)-N-cyclohexyl-N-ethyl-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylpropanamide
    —— (2S)-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide —— C16H22F3N3OS
    (2S)-N-[(1R,2S,3S)-2,3-dimethylcyclohexyl]-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
    —— [(2S)-1-(ethylamino)-1-oxopropan-2-yl] 2-(2,5-dimethylphenyl)sulfanylacetate —— C15H21NO3S
    [(2S)-1-(ethylamino)-1-oxopropan-2-yl] 2-(2,5-dimethylphenyl)sulfanylacetate
    —— N'-[2-(4-bromo-2-methylphenyl)sulfanylacetyl]-2-[(3R)-1,1-dioxothiolan-3-yl]acetohydrazide —— C15H19BrN2O4S2
    N'-[2-(4-bromo-2-methylphenyl)sulfanylacetyl]-2-[(3R)-1,1-dioxothiolan-3-yl]acetohydrazide
    —— (3S)-3-[4-methyl-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,2,4-triazol-3-yl]thiolane 1,1-dioxide —— C17H18N4O2S3
    (3S)-3-[4-methyl-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,2,4-triazol-3-yl]thiolane 1,1-dioxide
    —— (3R)-3-[4-methyl-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,2,4-triazol-3-yl]thiolane 1,1-dioxide —— C17H18N4O2S3
    (3R)-3-[4-methyl-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,2,4-triazol-3-yl]thiolane 1,1-dioxide
    —— (3R)-3-[4-methyl-5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,2,4-triazol-3-yl]thiolane 1,1-dioxide —— C18H20N4O2S3
    (3R)-3-[4-methyl-5-[[2-(4-methylphenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,2,4-triazol-3-yl]thiolane 1,1-dioxide
    —— (2R)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C17H20N4O2S
    (2R)-N-[(2S)-2-cyano-3-methylbutan-2-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— N-butyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C18H23N3O4S2
    N-butyl-N-[(3S)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 2-[[5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C15H16BrN3O3S
    2-[[5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-propylacetamide —— C17H21N3O4S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-propylacetamide
    —— (2R)-2-[[5-[[(3R)-1,1-dioxothiolan-3-yl]methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]propanamide —— C18H30N4O3S2
    (2R)-2-[[5-[[(3R)-1,1-dioxothiolan-3-yl]methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]propanamide
    —— (2R)-N-[(1S,2R)-2-methylcyclohexyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H23N3O2S
    (2R)-N-[(1S,2R)-2-methylcyclohexyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (2R)-N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C17H20N4O2S
    (2R)-N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— (2R)-N-(1-cyanocyclohexyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H20N4O2S
    (2R)-N-(1-cyanocyclohexyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— N-[(4-chlorophenyl)methyl]-N-methyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C18H16ClN3O2S
    N-[(4-chlorophenyl)methyl]-N-methyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide