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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[(7R)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole —— C18H21N5OS2
    2-[[(7R)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]-5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazole
    —— 2-(2-Chloro-4-nitrophenyl)sulfanyl-5-(2-methylphenyl)-1,3,4-oxadiazole —— C15H10ClN3O3S
    2-(2-Chloro-4-nitrophenyl)sulfanyl-5-(2-methylphenyl)-1,3,4-oxadiazole
    —— 2-(3-Methylphenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C15H11N3O3S
    2-(3-Methylphenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 2-(2-Methylphenyl)-5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C21H14N4OS2
    2-(2-Methylphenyl)-5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine —— C16H11FN4S4
    4-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine
    —— 2-(3,4-Dimethylphenyl)-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-oxadiazole —— C20H18N4OS2
    2-(3,4-Dimethylphenyl)-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-oxadiazole
    —— 4-[[5-[(4-Methoxyphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]thieno[2,3-d]pyrimidine —— C16H12N4OS4
    4-[[5-[(4-Methoxyphenyl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]thieno[2,3-d]pyrimidine
    —— 5,6-Dimethyl-3-propan-2-yl-2-thieno[2,3-d]pyrimidin-4-ylsulfanylthieno[2,3-d]pyrimidin-4-one —— C17H16N4OS3
    5,6-Dimethyl-3-propan-2-yl-2-thieno[2,3-d]pyrimidin-4-ylsulfanylthieno[2,3-d]pyrimidin-4-one
    —— N-butyl-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine —— C12H13N5S3
    N-butyl-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-thiadiazol-2-amine
    —— 4-[(5-Methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine —— C13H12N4S4
    4-[(5-Methylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
    —— 2-(2,4-Dinitrophenyl)sulfanyl-5-(3-methylphenyl)-1,3,4-oxadiazole —— C15H10N4O5S
    2-(2,4-Dinitrophenyl)sulfanyl-5-(3-methylphenyl)-1,3,4-oxadiazole
    —— 2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-thiophen-2-ylethyl)acetamide —— C19H22N4O2S3
    2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]-N-(2-thiophen-2-ylethyl)acetamide
    —— 2-[(1S)-1-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]-5-phenyl-1,3,4-oxadiazole —— C14H14N4OS3
    2-[(1S)-1-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]-5-phenyl-1,3,4-oxadiazole
    —— [(1R)-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate —— C21H22N2O3S
    [(1R)-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl] 3-(3,4-dimethylphenyl)sulfanylpropanoate
    —— 2-(2-Fluorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole —— C14H7FN4OS2
    2-(2-Fluorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole
    —— 2-(Furan-2-yl)-5-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C19H12N4O2S2
    2-(Furan-2-yl)-5-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 2-[[5-(Butylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile —— C13H13N5O2S2
    2-[[5-(Butylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile
    —— 2-(2-chlorophenyl)-5-[[(7R)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]-1,3,4-oxadiazole —— C19H15ClN4OS2
    2-(2-chlorophenyl)-5-[[(7R)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]-1,3,4-oxadiazole
    —— 2-(4-Fluorophenyl)-5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C20H11FN4OS2
    2-(4-Fluorophenyl)-5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 2-Thiophen-2-yl-5-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C15H12N4OS3
    2-Thiophen-2-yl-5-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 2-[(4-Amino-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanyl]-5-nitrobenzonitrile —— C17H13N5O2S2
    2-[(4-Amino-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)sulfanyl]-5-nitrobenzonitrile
    —— 2-(furan-2-yl)-5-[[(7R)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]-1,3,4-oxadiazole —— C17H14N4O2S2
    2-(furan-2-yl)-5-[[(7R)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]sulfanyl]-1,3,4-oxadiazole
    —— 2-[[5-(2-Chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile —— C15H7ClN4O3S
    2-[[5-(2-Chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile
    —— 2-(2-Methylfuran-3-yl)-5-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C20H14N4O2S2
    2-(2-Methylfuran-3-yl)-5-(2-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 2-[(10-Methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-5-pyridin-3-yl-1,3,4-oxadiazole —— C17H13N5OS2
    2-[(10-Methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-5-pyridin-3-yl-1,3,4-oxadiazole
    —— 2-(2-Fluorophenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C14H8FN3O3S
    2-(2-Fluorophenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 2-[5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-5-(furan-2-yl)-1,3,4-oxadiazole —— C18H9FN4O2S2
    2-[5-(4-Fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl-5-(furan-2-yl)-1,3,4-oxadiazole
    —— 2-(Furan-2-yl)-5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C18H10N4O2S2
    2-(Furan-2-yl)-5-(6-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 2-(2-Methylfuran-3-yl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C13H9N3O4S
    2-(2-Methylfuran-3-yl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 2-(4-Methoxyphenyl)-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-oxadiazole —— C19H16N4O2S2
    2-(4-Methoxyphenyl)-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-oxadiazole
    —— 2-[[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile —— C16H10N4O4S
    2-[[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile
    —— 2-[[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile —— C13H6N4O4S
    2-[[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-5-nitrobenzonitrile
    —— 2-Phenyl-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazole —— C18H14N4OS2
    2-Phenyl-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazole
    —— N-benzyl-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-thiadiazol-2-amine —— C19H17N5S3
    N-benzyl-5-[(10-methyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-yl)sulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-(4-Chlorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole —— C14H7ClN4OS2
    2-(4-Chlorophenyl)-5-thieno[2,3-d]pyrimidin-4-ylsulfanyl-1,3,4-oxadiazole
    —— 5-Nitro-2-[(12-oxo-11-prop-2-enyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-10-yl)sulfanyl]benzonitrile —— C19H14N4O3S2
    5-Nitro-2-[(12-oxo-11-prop-2-enyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-10-yl)sulfanyl]benzonitrile
    —— 5-Nitro-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]benzonitrile —— C15H8N4O3S
    5-Nitro-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]benzonitrile
    —— 4-Methyl-2-[4-(4-methylpiperidin-1-yl)sulfonyl-2-nitrophenyl]sulfanylpyrimidine —— C17H20N4O4S2
    4-Methyl-2-[4-(4-methylpiperidin-1-yl)sulfonyl-2-nitrophenyl]sulfanylpyrimidine
    —— 4-[[(7R)-7-methyl-4-pyrimidin-2-ylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholin-4-ium —— C20H24N5OS2+
    4-[[(7R)-7-methyl-4-pyrimidin-2-ylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholin-4-ium
    —— 2-(3,4-Dimethoxyphenyl)-5-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole —— C18H16N4O3S2
    2-(3,4-Dimethoxyphenyl)-5-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyl-1,3,4-oxadiazole
    —— 2-(1,3-Benzodioxol-5-yl)-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazole —— C19H14N4O3S2
    2-(1,3-Benzodioxol-5-yl)-5-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)-1,3,4-oxadiazole
    —— 2-(4-Chlorophenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole —— C14H8ClN3O3S
    2-(4-Chlorophenyl)-5-(2-nitrophenyl)sulfanyl-1,3,4-oxadiazole
    —— 2-[4-[(3R)-3-methylpiperidin-1-yl]sulfonyl-2-nitrophenyl]sulfanylpyrimidine —— C16H18N4O4S2
    2-[4-[(3R)-3-methylpiperidin-1-yl]sulfonyl-2-nitrophenyl]sulfanylpyrimidine
    —— 2-Methyl-5-phenyl-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine —— C17H12N4S2
    2-Methyl-5-phenyl-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine
    —— 2-(2-Nitro-4-pyrrolidin-1-ylsulfonylphenyl)sulfanylpyrimidine —— C14H14N4O4S2
    2-(2-Nitro-4-pyrrolidin-1-ylsulfonylphenyl)sulfanylpyrimidine
    —— 4-(4-Methylpyrimidin-2-yl)sulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine —— C15H14N4S2
    4-(4-Methylpyrimidin-2-yl)sulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine
    —— 5,6-Dimethyl-2-[(4-methylpiperidin-1-ium-1-yl)methyl]-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine —— C19H24N5S2+
    5,6-Dimethyl-2-[(4-methylpiperidin-1-ium-1-yl)methyl]-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine
    —— 5,6-Dimethyl-2-(phenylsulfanylmethyl)-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine —— C19H16N4S3
    5,6-Dimethyl-2-(phenylsulfanylmethyl)-4-pyrimidin-2-ylsulfanylthieno[2,3-d]pyrimidine
    —— 2-(4-Chloro-2-nitrophenyl)sulfanyl-4-methylpyrimidine —— C11H8ClN3O2S
    2-(4-Chloro-2-nitrophenyl)sulfanyl-4-methylpyrimidine
    —— 4-[[12-(4-Methylpyrimidin-2-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-10-yl]methyl]morpholine —— C19H21N5OS2
    4-[[12-(4-Methylpyrimidin-2-yl)sulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-10-yl]methyl]morpholine