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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 4-hydroxy-3-phenylthiobutanonitrile 108078-46-2 C10H11NOS
    4-hydroxy-3-phenylthiobutanonitrile
    —— 4-((4-nitrophenyl)thio)pyridine 746630-21-7 C11H8N2O2S
    4-((4-nitrophenyl)thio)pyridine
    —— (2-chlorophenyl)(4-nitrophenyl)sulfane 33667-99-1 C12H8ClNO2S
    (2-chlorophenyl)(4-nitrophenyl)sulfane
    —— [(p-tolylthio)methyl]diphenylphosphine oxide 31238-58-1 C20H19OPS
    [(p-tolylthio)methyl]diphenylphosphine oxide
    —— 4-hydroxy-3-p-tolylthiobutanonitrile 108078-48-4 C11H13NOS
    4-hydroxy-3-p-tolylthiobutanonitrile
    —— [(1-chloro-2,2,2-trifluoroethyl)sulfanyl](ethoxy)methanethione 845523-76-4 C5H6ClF3OS2
    [(1-chloro-2,2,2-trifluoroethyl)sulfanyl](ethoxy)methanethione
    —— 3-anilino-5-(α-methylbenzylthio)-1,2,4-triazole 334538-56-6 C16H16N4S
    3-anilino-5-(α-methylbenzylthio)-1,2,4-triazole
    —— ethyl N-[(2S)-1-[[2-(4-chlorophenyl)sulfanylacetyl]amino]-4-methylpentan-2-yl]carbamate —— C17H25ClN2O3S
    ethyl N-[(2S)-1-[[2-(4-chlorophenyl)sulfanylacetyl]amino]-4-methylpentan-2-yl]carbamate
    —— (5R,6S)-6-(3-isohexylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane 162184-39-6 C15H25N3S2
    (5R,6S)-6-(3-isohexylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— ethyl N-[(2R)-1-[[2-(4-chlorophenyl)sulfanylacetyl]amino]-4-methylpentan-2-yl]carbamate —— C17H25ClN2O3S
    ethyl N-[(2R)-1-[[2-(4-chlorophenyl)sulfanylacetyl]amino]-4-methylpentan-2-yl]carbamate
    —— Ethyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate —— C11H12N4O2S
    Ethyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate
    —— N-[(2R)-2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-2-(2,4-dimethylphenyl)sulfanylpyridine-3-carboxamide —— C24H26N2O4S
    N-[(2R)-2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-2-(2,4-dimethylphenyl)sulfanylpyridine-3-carboxamide
    —— N-(3-fluorophenyl)-4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)pyrimidin-2-amine —— C15H13FN4OS
    N-(3-fluorophenyl)-4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)pyrimidin-2-amine
    —— endo-2-methyl-6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane —— C13H21N3S2
    endo-2-methyl-6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— methyl 3-[4-[6-(3,5-di-t-butyl-4-hydroxyphenylthio)-1-methyl-1H-benzimidazol-2-ylmethoxy]phenyl]-2-(4-fluorobenzyloxy)propionate —— C40H45FN2O5S
    methyl 3-[4-[6-(3,5-di-t-butyl-4-hydroxyphenylthio)-1-methyl-1H-benzimidazol-2-ylmethoxy]phenyl]-2-(4-fluorobenzyloxy)propionate
    —— 2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-phenyl]-cyclopropanecarboxylic acid [3-(2-oxo-pyrrolidin-1-yl)-propyl]-amide —— C26H30Cl2N2O2S
    2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-phenyl]-cyclopropanecarboxylic acid [3-(2-oxo-pyrrolidin-1-yl)-propyl]-amide
    —— N-[(2S)-1-[(3S,5R)-3,5-dimethylpiperidin-1-yl]propan-2-yl]-2-(4-fluorophenyl)sulfanylacetamide —— C18H27FN2OS
    N-[(2S)-1-[(3S,5R)-3,5-dimethylpiperidin-1-yl]propan-2-yl]-2-(4-fluorophenyl)sulfanylacetamide
    —— N-[(2S)-1-[(3S,5S)-3,5-dimethylpiperidin-1-yl]propan-2-yl]-2-(4-fluorophenyl)sulfanylacetamide —— C18H27FN2OS
    N-[(2S)-1-[(3S,5S)-3,5-dimethylpiperidin-1-yl]propan-2-yl]-2-(4-fluorophenyl)sulfanylacetamide
    —— 1,2-Diethyl-3-[5-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]pyrimidin-4-yl]guanidine —— C17H20N8OS
    1,2-Diethyl-3-[5-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]pyrimidin-4-yl]guanidine
    —— 3-[[(3R)-1-azabicyclo[2.2.1]heptan-3-yl]oxy]-4-(3,3,3-trifluoropropylsulfanyl)-1,2,5-thiadiazole —— C11H14F3N3OS2
    3-[[(3R)-1-azabicyclo[2.2.1]heptan-3-yl]oxy]-4-(3,3,3-trifluoropropylsulfanyl)-1,2,5-thiadiazole
    —— N-hydroxy-4-(4-pyridin-4-ylsulfanylphenyl)sulfonyloxane-4-carboxamide —— C17H18N2O5S2
    N-hydroxy-4-(4-pyridin-4-ylsulfanylphenyl)sulfonyloxane-4-carboxamide
    —— 2-(2,4-Dichlorophenyl)sulfanyl-4-(3-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile —— C21H17Cl2N3S
    2-(2,4-Dichlorophenyl)sulfanyl-4-(3-methyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
    —— N-(diaminomethylidene)-3-methylsulfanyl-8,9-dihydro-7H-benzo[7]annulene-6-carboxamide;methanesulfonic acid —— C15H21N3O4S2
    N-(diaminomethylidene)-3-methylsulfanyl-8,9-dihydro-7H-benzo[7]annulene-6-carboxamide;methanesulfonic acid
    —— 5-[(2-fluorophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C15H15FN4O2S2
    5-[(2-fluorophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— 4-[[(2R,4S)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol —— C17H19NO2S2
    4-[[(2R,4S)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol
    —— 2-(2,6-dimethylphenyl)sulfanyl-6-imidazol-1-yl-1H-benzimidazole —— C18H16N4S
    2-(2,6-dimethylphenyl)sulfanyl-6-imidazol-1-yl-1H-benzimidazole
    —— 5-(thiophen-2-ylmethyl)-3-(thiophen-2-ylmethylsulfanyl)-1H-1,2,4-triazole —— C12H11N3S3
    5-(thiophen-2-ylmethyl)-3-(thiophen-2-ylmethylsulfanyl)-1H-1,2,4-triazole
    —— (Z)-cyclopentyl-hydroxy-[[5-(4-methoxyphenyl)sulfanylfuran-2-yl]methylidene]azanium —— C17H20NO3S+
    (Z)-cyclopentyl-hydroxy-[[5-(4-methoxyphenyl)sulfanylfuran-2-yl]methylidene]azanium
    —— 3-(6-Pyridin-2-ylsulfanylpyridin-3-yl)-3,10-diazabicyclo[4.3.1]decane —— C18H22N4S
    3-(6-Pyridin-2-ylsulfanylpyridin-3-yl)-3,10-diazabicyclo[4.3.1]decane
    —— 3,3,3-Trifluoropropyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate —— C12H11F3N4O2S
    3,3,3-Trifluoropropyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate
    —— 2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(4-ethylphenyl)ethyl]acetamide —— C24H28N4OS
    2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(4-ethylphenyl)ethyl]acetamide
    —— 2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C18H22N4O3S2
    2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— 2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-N-methylacetamide —— C23H25FN4OS
    2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-N-methylacetamide
    —— 2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]-N-methylacetamide —— C23H25FN4OS
    2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]-N-methylacetamide
    —— 2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide —— C18H22N4O3S2
    2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(3R)-1,1-dioxothiolan-3-yl]acetamide
    —— 2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[[(2R)-4-(2-methylpropyl)morpholin-2-yl]methyl]acetamide —— C23H33N5O2S
    2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[[(2R)-4-(2-methylpropyl)morpholin-2-yl]methyl]acetamide
    —— 2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[[(2S)-4-(2-methylpropyl)morpholin-2-yl]methyl]acetamide —— C23H33N5O2S
    2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[[(2S)-4-(2-methylpropyl)morpholin-2-yl]methyl]acetamide
    —— (3R)-3-[[5-[[2-[(4-chlorophenyl)methyl]-1,3-thiazol-4-yl]methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide —— C19H21ClN4O2S3
    (3R)-3-[[5-[[2-[(4-chlorophenyl)methyl]-1,3-thiazol-4-yl]methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide
    —— (3S)-3-[[5-[[2-[(4-chlorophenyl)methyl]-1,3-thiazol-4-yl]methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide —— C19H21ClN4O2S3
    (3S)-3-[[5-[[2-[(4-chlorophenyl)methyl]-1,3-thiazol-4-yl]methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]thiolane 1,1-dioxide
    —— 2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(4-ethylphenyl)ethyl]acetamide —— C24H28N4OS
    2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R)-1-(4-ethylphenyl)ethyl]acetamide
    —— 2-[(4-chlorophenyl)methyl]-4-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-thiazole —— C22H21ClN4OS3
    2-[(4-chlorophenyl)methyl]-4-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-thiazole
    —— (3S)-3-[5-[[2-[(4-chlorophenyl)methyl]-1,3-thiazol-4-yl]methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]thiolane 1,1-dioxide —— C18H19ClN4O2S3
    (3S)-3-[5-[[2-[(4-chlorophenyl)methyl]-1,3-thiazol-4-yl]methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]thiolane 1,1-dioxide
    —— 2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-butyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide —— C22H30N4O3S2
    2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-N-butyl-N-[(3S)-1,1-dioxothiolan-3-yl]acetamide
    —— (3R)-3-[5-[[2-[(4-chlorophenyl)methyl]-1,3-thiazol-4-yl]methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]thiolane 1,1-dioxide —— C18H19ClN4O2S3
    (3R)-3-[5-[[2-[(4-chlorophenyl)methyl]-1,3-thiazol-4-yl]methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]thiolane 1,1-dioxide
    —— 3-[(5R,6R)-1-azabicyclo[3.2.1]octan-6-yl]-4-[5-[[4-[(5R,6R)-1-azabicyclo[3.2.1]octan-6-yl]-1,2,5-thiadiazol-3-yl]sulfanyl]-3-methylpentyl]sulfanyl-1,2,5-thiadiazole —— C24H36N6S4
    3-[(5R,6R)-1-azabicyclo[3.2.1]octan-6-yl]-4-[5-[[4-[(5R,6R)-1-azabicyclo[3.2.1]octan-6-yl]-1,2,5-thiadiazol-3-yl]sulfanyl]-3-methylpentyl]sulfanyl-1,2,5-thiadiazole
    —— 3,5-dichloro-N-[3-chloro-4-[(6-methyl-1,3-benzothiazol-2-yl)sulfanyl]phenyl]benzenesulfonamide —— C20H13Cl3N2O2S3
    3,5-dichloro-N-[3-chloro-4-[(6-methyl-1,3-benzothiazol-2-yl)sulfanyl]phenyl]benzenesulfonamide
    —— (2R)-2-amino-3-(3-hydroxypropylsulfanyl)propanal —— C6H13NO2S
    (2R)-2-amino-3-(3-hydroxypropylsulfanyl)propanal
    —— 2-[[5-(2-Ethyl-5-methylpyrazol-3-yl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]-5-nitro-1,3-thiazole —— C15H19N7O3S2
    2-[[5-(2-Ethyl-5-methylpyrazol-3-yl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]-5-nitro-1,3-thiazole
    —— 2-(1-Benzylsulfonylpyrrolidin-2-yl)sulfanylphenol —— C17H19NO3S2
    2-(1-Benzylsulfonylpyrrolidin-2-yl)sulfanylphenol
    —— [(2R)-2,3-dihydro-1-benzothiophen-2-yl]-[4-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]piperazin-1-yl]methanone —— C19H23N3O2S
    [(2R)-2,3-dihydro-1-benzothiophen-2-yl]-[4-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]piperazin-1-yl]methanone