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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-phenyl-5-[(1S)-1-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,3,4-oxadiazole —— C18H17N5OS2
    2-phenyl-5-[(1S)-1-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,3,4-oxadiazole
    —— 3-[(5-Methyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate —— C6H7N2O3S-
    3-[(5-Methyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate
    —— 2-[[5-(4-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetic acid —— C10H7BrN2O3S
    2-[[5-(4-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetic acid
    —— N-[(2-fluorophenyl)methyl]-N-methyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C19H19FN4OS2
    N-[(2-fluorophenyl)methyl]-N-methyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (5E)-5-[(5-chloro-2-hydroxyphenyl)methylidene]-3-methyl-2-(3-methylsulfanylphenyl)imino-1,3-thiazolidin-4-one —— C18H15ClN2O2S2
    (5E)-5-[(5-chloro-2-hydroxyphenyl)methylidene]-3-methyl-2-(3-methylsulfanylphenyl)imino-1,3-thiazolidin-4-one
    —— N-ethyl-N-[(3-fluorophenyl)methyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C20H21FN4OS2
    N-ethyl-N-[(3-fluorophenyl)methyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— [(2R)-1-oxo-1-(propan-2-ylamino)propan-2-yl] 2-(2-fluorophenyl)sulfanylacetate —— C14H18FNO3S
    [(2R)-1-oxo-1-(propan-2-ylamino)propan-2-yl] 2-(2-fluorophenyl)sulfanylacetate
    —— 2-phenyl-5-[(1R)-1-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,3,4-oxadiazole —— C18H17N5OS2
    2-phenyl-5-[(1R)-1-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethyl]-1,3,4-oxadiazole
    —— N-[(1R)-1-(4-bromophenyl)ethyl]-2-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C18H19BrN4OS2
    N-[(1R)-1-(4-bromophenyl)ethyl]-2-[[4-(2-thiophen-2-ylethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— (1S,2S)-2-(4-fluorophenyl)-N-[3-[4-(2-methylpropyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propyl]cyclopropane-1-carboxamide —— C20H27FN4OS
    (1S,2S)-2-(4-fluorophenyl)-N-[3-[4-(2-methylpropyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]propyl]cyclopropane-1-carboxamide
    —— (5E)-3-methyl-2-(3-methylsulfanylphenyl)imino-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one —— C16H14N2OS3
    (5E)-3-methyl-2-(3-methylsulfanylphenyl)imino-5-(thiophen-2-ylmethylidene)-1,3-thiazolidin-4-one
    —— (2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate —— C12H11N2O3S-
    (2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate
    —— N-butyl-N-ethyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H24N4OS2
    N-butyl-N-ethyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoic acid —— C10H9N3O3S
    (2R)-2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoic acid
    —— (5E)-5-[(5-bromofuran-2-yl)methylidene]-3-methyl-2-(3-methylsulfanylphenyl)imino-1,3-thiazolidin-4-one —— C16H13BrN2O2S2
    (5E)-5-[(5-bromofuran-2-yl)methylidene]-3-methyl-2-(3-methylsulfanylphenyl)imino-1,3-thiazolidin-4-one
    —— 2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2-methylphenyl)methyl]acetamide —— C20H22N4OS2
    2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2-methylphenyl)methyl]acetamide
    —— N-(2-cyanopropan-2-yl)-N-methyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H19N5OS2
    N-(2-cyanopropan-2-yl)-N-methyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[(1R)-1-(furan-2-yl)ethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H18N4O2S2
    N-[(1R)-1-(furan-2-yl)ethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 4-oxo-N-(2-phenylsulfanylethyl)-4-thiophen-2-ylbutanamide —— C16H17NO2S2
    4-oxo-N-(2-phenylsulfanylethyl)-4-thiophen-2-ylbutanamide
    —— (5E)-5-[(4-fluorophenyl)methylidene]-3-methyl-2-(3-methylsulfanylphenyl)imino-1,3-thiazolidin-4-one —— C18H15FN2OS2
    (5E)-5-[(4-fluorophenyl)methylidene]-3-methyl-2-(3-methylsulfanylphenyl)imino-1,3-thiazolidin-4-one
    —— N-[(1S)-1-(furan-2-yl)ethyl]-2-(2-methylphenyl)sulfanylacetamide —— C15H17NO2S
    N-[(1S)-1-(furan-2-yl)ethyl]-2-(2-methylphenyl)sulfanylacetamide
    —— (2S)-4-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile —— C23H19N5OS3
    (2S)-4-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile
    —— N-butyl-N-ethyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H24N4OS2
    N-butyl-N-ethyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-4-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile —— C23H19N5OS3
    (2R)-4-[[4-cyclopropyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-oxo-2-(4-phenyl-1,3-thiazol-2-yl)butanenitrile
    —— N-[(1S)-1-cyclopropylethyl]-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H20N4OS2
    N-[(1S)-1-cyclopropylethyl]-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1R)-1-(furan-2-yl)ethyl]propanamide —— C16H21N3O2S
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1R)-1-(furan-2-yl)ethyl]propanamide
    —— 2-[(3S)-1,1-dioxothiolan-3-yl]-N-(2-phenylsulfanylethyl)acetamide —— C14H19NO3S2
    2-[(3S)-1,1-dioxothiolan-3-yl]-N-(2-phenylsulfanylethyl)acetamide
    —— N-[(1S)-1-(furan-2-yl)ethyl]-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrobenzamide —— C16H15N5O4S
    N-[(1S)-1-(furan-2-yl)ethyl]-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrobenzamide
    —— N-[(1R)-1-(furan-2-yl)ethyl]-2-(2-methylphenyl)sulfanylacetamide —— C15H17NO2S
    N-[(1R)-1-(furan-2-yl)ethyl]-2-(2-methylphenyl)sulfanylacetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-[(1S)-1-(furan-2-yl)ethyl]acetamide —— C15H16BrNO2S
    2-(4-bromo-2-methylphenyl)sulfanyl-N-[(1S)-1-(furan-2-yl)ethyl]acetamide
    —— (1R)-5-ethoxy-1-methyl-3-methylsulfanyl-1-oxo-1λ6-thia-2-azacyclohexa-1,3,5-triene-4-carbonitrile —— C9H12N2O2S2
    (1R)-5-ethoxy-1-methyl-3-methylsulfanyl-1-oxo-1λ6-thia-2-azacyclohexa-1,3,5-triene-4-carbonitrile
    —— 1-(3-chlorophenyl)-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea —— C16H16ClN3OS2
    1-(3-chlorophenyl)-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea
    —— 2-[[5-[(4-fluorophenyl)methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide —— C17H17FN4OS3
    2-[[5-[(4-fluorophenyl)methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide
    —— 1-(3-Chlorophenyl)-3-[(2-phenylsulfanylacetyl)amino]thiourea —— C15H14ClN3OS2
    1-(3-Chlorophenyl)-3-[(2-phenylsulfanylacetyl)amino]thiourea
    —— Methyl 3-[[5-[(4-fluorophenyl)methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]propanoate —— C13H14FN3O2S2
    Methyl 3-[[5-[(4-fluorophenyl)methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]propanoate
    —— 2-[[5-[(4-fluorophenyl)methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide —— C17H17FN4O2S2
    2-[[5-[(4-fluorophenyl)methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide
    —— N-[(4-fluorophenyl)methyl]-5-[[(2S)-oxan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H18FN3OS2
    N-[(4-fluorophenyl)methyl]-5-[[(2S)-oxan-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 1-[(2R)-1-methoxypropan-2-yl]-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea —— C14H21N3O2S2
    1-[(2R)-1-methoxypropan-2-yl]-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea
    —— N-(2-ethylphenyl)-5-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H16N4OS2
    N-(2-ethylphenyl)-5-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 1-(4-Acetylpiperazin-1-yl)-2-[[5-(2-ethyl-6-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone —— C19H25N5O2S2
    1-(4-Acetylpiperazin-1-yl)-2-[[5-(2-ethyl-6-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanone
    —— 1-[(2S)-1-methoxypropan-2-yl]-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea —— C14H21N3O2S2
    1-[(2S)-1-methoxypropan-2-yl]-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea
    —— 2-[2-[(2R)-2-(2-fluorophenyl)-1,3-thiazolidin-3-yl]-2-oxoethyl]sulfanylpyridine-3-carbonitrile —— C17H14FN3OS2
    2-[2-[(2R)-2-(2-fluorophenyl)-1,3-thiazolidin-3-yl]-2-oxoethyl]sulfanylpyridine-3-carbonitrile
    —— 2-[2-(2,5-Dimethyl-1-pyridin-2-ylpyrrol-3-yl)-2-oxoethyl]sulfanylpyridine-3-carbonitrile —— C19H16N4OS
    2-[2-(2,5-Dimethyl-1-pyridin-2-ylpyrrol-3-yl)-2-oxoethyl]sulfanylpyridine-3-carbonitrile
    —— N-(2-chloro-4,6-dimethylphenyl)-5-methylsulfanyl-1,3,4-thiadiazol-2-amine —— C11H12ClN3S2
    N-(2-chloro-4,6-dimethylphenyl)-5-methylsulfanyl-1,3,4-thiadiazol-2-amine
    —— (2R)-3-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-methylpropanenitrile —— C12H11FN4S2
    (2R)-3-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-methylpropanenitrile
    —— N-(4-fluorophenyl)-5-[[(2S)-4-(2-methylpropyl)morpholin-4-ium-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C17H24FN4OS2+
    N-(4-fluorophenyl)-5-[[(2S)-4-(2-methylpropyl)morpholin-4-ium-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-[[5-(2-ethyl-6-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(5-methylfuran-2-yl)methyl]acetamide —— C20H24N4O2S2
    2-[[5-(2-ethyl-6-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(5-methylfuran-2-yl)methyl]acetamide
    —— 1-[[2-(4-bromophenyl)sulfanylacetyl]amino]-3-[(2S)-1-methoxypropan-2-yl]thiourea —— C13H18BrN3O2S2
    1-[[2-(4-bromophenyl)sulfanylacetyl]amino]-3-[(2S)-1-methoxypropan-2-yl]thiourea
    —— N-(2-ethyl-6-methylphenyl)-5-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C16H18N4OS2
    N-(2-ethyl-6-methylphenyl)-5-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(4-fluorophenyl)-5-[(3-thiophen-3-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H10FN5OS3
    N-(4-fluorophenyl)-5-[(3-thiophen-3-yl-1,2,4-oxadiazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine