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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-({5-[(E)-{2-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]hydrazinylidene}methyl]furan-2-yl}sulfanyl)-1H-benzimidazole —— C23H25N9O3S
    2-({5-[(E)-{2-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]hydrazinylidene}methyl]furan-2-yl}sulfanyl)-1H-benzimidazole
    —— [(1S)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate —— C17H17N5O3S
    [(1S)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate
    —— [(1R)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate —— C17H17N5O3S
    [(1R)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate
    —— 2-(2-methylphenyl)sulfanyl-N-[(E)-3-phenylprop-2-ynylideneamino]acetamide —— C18H16N2OS
    2-(2-methylphenyl)sulfanyl-N-[(E)-3-phenylprop-2-ynylideneamino]acetamide
    —— N-[(E)-[2-(4-chlorophenyl)sulfanyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylideneamino]-4-nitrobenzamide —— C22H14ClN5O4S
    N-[(E)-[2-(4-chlorophenyl)sulfanyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]methylideneamino]-4-nitrobenzamide
    —— 3-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)propyl (2R)-2,3-dihydro-1-benzothiophene-2-carboxylate —— C19H17N3O3S
    3-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)propyl (2R)-2,3-dihydro-1-benzothiophene-2-carboxylate
    —— (Z)-3-amino-2-[2-[(4-amino-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetyl]but-2-enenitrile —— C12H12N6OS2
    (Z)-3-amino-2-[2-[(4-amino-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]acetyl]but-2-enenitrile
    —— (Z)-3-amino-2-[2-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]but-2-enenitrile —— C9H9F3N6OS
    (Z)-3-amino-2-[2-[[4-amino-5-(trifluoromethyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]but-2-enenitrile
    —— N-[(E)-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylideneamino]-2-(2-methylphenoxy)acetamide —— C21H18N4O3S
    N-[(E)-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylideneamino]-2-(2-methylphenoxy)acetamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(E)-(4-ethylphenyl)methylideneamino]acetamide —— C17H17ClN2OS
    2-(4-chlorophenyl)sulfanyl-N-[(E)-(4-ethylphenyl)methylideneamino]acetamide
    —— 2-fluoro-N-[2-({4-[(E)-{2-[(4-fluorophenyl)carbonyl]hydrazinylidene}methyl]-2-nitrophenyl}sulfanyl)-1,3-benzothiazol-6-yl]benzamide —— C28H17F2N5O4S2
    2-fluoro-N-[2-({4-[(E)-{2-[(4-fluorophenyl)carbonyl]hydrazinylidene}methyl]-2-nitrophenyl}sulfanyl)-1,3-benzothiazol-6-yl]benzamide
    —— 6-methyl-2-[(E)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile —— C23H20N4O2S2
    6-methyl-2-[(E)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carbonitrile
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(E)-(4-fluorophenyl)methylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C19H14ClFN8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(E)-(4-fluorophenyl)methylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— N-[(E)-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylideneamino]-2,3-dihydro-1,4-benzodioxine-3-carboxamide —— C19H16N6O5S
    N-[(E)-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylideneamino]-2,3-dihydro-1,4-benzodioxine-3-carboxamide
    —— N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]-2-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide —— C18H14BrClN4O2S3
    N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]-2-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide
    —— [(1S)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 3-phenylsulfanylpropanoate —— C18H17N3O3S
    [(1S)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 3-phenylsulfanylpropanoate
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methylphenyl)sulfanyl]methyl}-N'-[(E)-(2,4,6-trimethylphenyl)methylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C23H24N8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methylphenyl)sulfanyl]methyl}-N'-[(E)-(2,4,6-trimethylphenyl)methylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— 2-({5-[(2-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(1E)-1-(2-chlorophenyl)ethylidene]acetohydrazide —— C19H16Cl2N4OS3
    2-({5-[(2-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(1E)-1-(2-chlorophenyl)ethylidene]acetohydrazide
    —— [(1R)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 3-phenylsulfanylpropanoate —— C18H17N3O3S
    [(1R)-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethyl] 3-phenylsulfanylpropanoate
    —— [2-[methyl-[(1R)-1-phenylethyl]amino]-2-oxoethyl] (2S)-2,3-dihydro-1-benzothiophene-2-carboxylate —— C20H21NO3S
    [2-[methyl-[(1R)-1-phenylethyl]amino]-2-oxoethyl] (2S)-2,3-dihydro-1-benzothiophene-2-carboxylate
    —— N-[(E)-[4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylideneamino]-4-hydroxybutanamide —— C18H16N4O4S2
    N-[(E)-[4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylideneamino]-4-hydroxybutanamide
    —— N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]pyridine-3-carboxamide —— C17H14N6O3S
    N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]pyridine-3-carboxamide
    —— 2-[(2E)-2-{2-[(4-chlorophenyl)sulfanyl]benzylidene}hydrazinyl]-4,6-di(pyrrolidin-1-yl)-1,3,5-triazine —— C24H26ClN7S
    2-[(2E)-2-{2-[(4-chlorophenyl)sulfanyl]benzylidene}hydrazinyl]-4,6-di(pyrrolidin-1-yl)-1,3,5-triazine
    —— [2-[methyl-[(1R)-1-phenylethyl]amino]-2-oxoethyl] (2R)-2,3-dihydro-1-benzothiophene-2-carboxylate —— C20H21NO3S
    [2-[methyl-[(1R)-1-phenylethyl]amino]-2-oxoethyl] (2R)-2,3-dihydro-1-benzothiophene-2-carboxylate
    —— [(E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]thiourea —— C11H10N4OS2
    [(E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]thiourea
    —— N-[(E)-(5-quinolin-8-ylsulfanylfuran-2-yl)methylideneamino]furan-2-carboxamide —— C19H13N3O3S
    N-[(E)-(5-quinolin-8-ylsulfanylfuran-2-yl)methylideneamino]furan-2-carboxamide
    —— [2-[methyl-[(1S)-1-phenylethyl]amino]-2-oxoethyl] (2S)-2,3-dihydro-1-benzothiophene-2-carboxylate —— C20H21NO3S
    [2-[methyl-[(1S)-1-phenylethyl]amino]-2-oxoethyl] (2S)-2,3-dihydro-1-benzothiophene-2-carboxylate
    —— 3,5,6-trichloro-N-[(E)-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylideneamino]pyridin-2-amine —— C15H10Cl3N7O2S
    3,5,6-trichloro-N-[(E)-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylideneamino]pyridin-2-amine
    —— 3-(2-bromophenyl)sulfanyl-N-[(1R)-1-phenylethyl]propanamide —— C17H18BrNOS
    3-(2-bromophenyl)sulfanyl-N-[(1R)-1-phenylethyl]propanamide
    —— N'~1~-{(E)-1-[5-(1,3-benzothiazol-2-ylsulfanyl)-2-furyl]methylidene}-2-nitrobenzohydrazide —— C19H12N4O4S2
    N'~1~-{(E)-1-[5-(1,3-benzothiazol-2-ylsulfanyl)-2-furyl]methylidene}-2-nitrobenzohydrazide
    —— 3-(2-bromophenyl)sulfanyl-N-[(1S)-1-phenylethyl]propanamide —— C17H18BrNOS
    3-(2-bromophenyl)sulfanyl-N-[(1S)-1-phenylethyl]propanamide
    —— 2-[(E)-(2,4-dichlorophenyl)methylideneamino]oxy-N-(2-phenylsulfanylphenyl)acetamide —— C21H16Cl2N2O2S
    2-[(E)-(2,4-dichlorophenyl)methylideneamino]oxy-N-(2-phenylsulfanylphenyl)acetamide
    —— 2-dodecylsulfanyl-1-N-[(2S)-4-methylpentan-2-yl]-4-N-phenylbenzene-1,4-diamine —— C30H48N2S
    2-dodecylsulfanyl-1-N-[(2S)-4-methylpentan-2-yl]-4-N-phenylbenzene-1,4-diamine
    —— 2-dodecylsulfanyl-1-N-[(2R)-4-methylpentan-2-yl]-4-N-phenylbenzene-1,4-diamine —— C30H48N2S
    2-dodecylsulfanyl-1-N-[(2R)-4-methylpentan-2-yl]-4-N-phenylbenzene-1,4-diamine
    —— 2-({4-allyl-5-[(4-chloroanilino)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N'-(4-fluorobenzylidene)propanohydrazide —— C22H22ClFN6OS
    2-({4-allyl-5-[(4-chloroanilino)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N'-(4-fluorobenzylidene)propanohydrazide
    —— 2-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(1E)-1-(pyridin-4-yl)ethylidene]acetohydrazide —— C18H16ClN5OS3
    2-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(1E)-1-(pyridin-4-yl)ethylidene]acetohydrazide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(E)-cyclohex-3-en-1-ylmethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C19H19ClN8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(E)-cyclohex-3-en-1-ylmethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— N-benzyl-2-({(E)-[5-nitro-2-(pyrimidin-2-ylsulfanyl)phenyl]methylidene}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide —— C27H23N5O3S2
    N-benzyl-2-({(E)-[5-nitro-2-(pyrimidin-2-ylsulfanyl)phenyl]methylidene}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
    —— 3-(Phenylsulfanyl)-N'-[(E)-{4-[(E)-{[3-(phenylsulfanyl)propanamido]imino}methyl]phenyl}methylidene]propanehydrazide —— C26H26N4O2S2
    3-(Phenylsulfanyl)-N'-[(E)-{4-[(E)-{[3-(phenylsulfanyl)propanamido]imino}methyl]phenyl}methylidene]propanehydrazide
    —— 2-((4-Chlorophenyl)sulfanyl)nicotinaldehyde O-(3,4-dichlorobenzyl)oxime —— C19H13Cl3N2OS
    2-((4-Chlorophenyl)sulfanyl)nicotinaldehyde O-(3,4-dichlorobenzyl)oxime
    —— (E)-({2-[(4-chlorophenyl)sulfanyl]pyridin-3-yl}methylidene)(methoxy)amine —— C13H11ClN2OS
    (E)-({2-[(4-chlorophenyl)sulfanyl]pyridin-3-yl}methylidene)(methoxy)amine
    —— 2-[(2E)-2-(4-bromobenzylidene)-1-methylhydrazinyl]-4-[4-(phenylsulfanyl)phenyl]-1,3-thiazole —— C23H18BrN3S2
    2-[(2E)-2-(4-bromobenzylidene)-1-methylhydrazinyl]-4-[4-(phenylsulfanyl)phenyl]-1,3-thiazole
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-N'-[(1E)-1-(pyridin-2-yl)ethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C16H16N12O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-N'-[(1E)-1-(pyridin-2-yl)ethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— N-[(E)-[5-(1,3-benzothiazol-2-ylsulfanyl)furan-2-yl]methylideneamino]furan-2-carboxamide —— C17H11N3O3S2
    N-[(E)-[5-(1,3-benzothiazol-2-ylsulfanyl)furan-2-yl]methylideneamino]furan-2-carboxamide
    —— 2-(4-methyl-6-morpholin-4-ylpyrimidin-2-yl)sulfanyl-N-[(E)-1-phenylhexylideneamino]acetamide —— C23H31N5O2S
    2-(4-methyl-6-morpholin-4-ylpyrimidin-2-yl)sulfanyl-N-[(E)-1-phenylhexylideneamino]acetamide
    —— 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[(E)-(5-methylfuran-2-yl)methylideneamino]acetamide —— C14H16N4O2S
    2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[(E)-(5-methylfuran-2-yl)methylideneamino]acetamide
    —— 3-butyl-5-[(1R)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,2,4-oxadiazole —— C16H21N5OS2
    3-butyl-5-[(1R)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,2,4-oxadiazole
    —— ethyl (2E)-2-[(5E)-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-3-[2-oxo-2-[[(2S)-oxolan-2-yl]methylamino]ethyl]-1,3-thiazolidin-2-ylidene]acetate —— C22H26N2O5S2
    ethyl (2E)-2-[(5E)-5-[(4-methylsulfanylphenyl)methylidene]-4-oxo-3-[2-oxo-2-[[(2S)-oxolan-2-yl]methylamino]ethyl]-1,3-thiazolidin-2-ylidene]acetate
    —— 3-butyl-5-[(1S)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,2,4-oxadiazole —— C16H21N5OS2
    3-butyl-5-[(1S)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,2,4-oxadiazole
    —— 2-(3,4-difluorophenyl)sulfanyl-1-[(1S)-1-phenyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]ethanone —— C21H18F2N2OS
    2-(3,4-difluorophenyl)sulfanyl-1-[(1S)-1-phenyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]ethanone