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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(3R)-5-(furan-2-yl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone —— C17H17N5O2S2
    2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(3R)-5-(furan-2-yl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-(3-chloro-4-fluorophenyl)sulfanyl-N-[(2S)-2-cyano-3-methylbutan-2-yl]acetamide —— C14H16ClFN2OS
    2-(3-chloro-4-fluorophenyl)sulfanyl-N-[(2S)-2-cyano-3-methylbutan-2-yl]acetamide
    —— (2R)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C20H20ClN5O2S
    (2R)-1-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— 2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(3S)-5-(furan-2-yl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone —— C17H17N5O2S2
    2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(3S)-5-(furan-2-yl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
    —— (3S)-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-1-thiophen-2-ylsulfonylpiperidine-3-carboxamide —— C20H22N4O3S3
    (3S)-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-1-thiophen-2-ylsulfonylpiperidine-3-carboxamide
    —— (3R)-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-1-thiophen-2-ylsulfonylpiperidine-3-carboxamide —— C20H22N4O3S3
    (3R)-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-1-thiophen-2-ylsulfonylpiperidine-3-carboxamide
    —— (2R)-2-[(5,6-dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)methylsulfanyl]-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]propanamide —— C22H23N5O2S3
    (2R)-2-[(5,6-dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)methylsulfanyl]-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]propanamide
    —— 2-[(3R)-1,1-dioxo-2,3-dihydrothiophen-3-yl]-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]acetamide —— C16H17N3O3S2
    2-[(3R)-1,1-dioxo-2,3-dihydrothiophen-3-yl]-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]acetamide
    —— (2S)-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C20H20ClN5O2S
    (2S)-1-[(3S)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— (3R)-1-cyclopropyl-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-5-oxopyrrolidine-3-carboxamide —— C18H20N4O2S
    (3R)-1-cyclopropyl-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-5-oxopyrrolidine-3-carboxamide
    —— (3R)-6-chloro-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-3,4-dihydro-2H-chromene-3-carboxamide —— C20H18ClN3O2S
    (3R)-6-chloro-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-3,4-dihydro-2H-chromene-3-carboxamide
    —— (3S)-1-cyclopropyl-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-5-oxopyrrolidine-3-carboxamide —— C18H20N4O2S
    (3S)-1-cyclopropyl-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-5-oxopyrrolidine-3-carboxamide
    —— (3S)-6-chloro-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-3,4-dihydro-2H-chromene-3-carboxamide —— C20H18ClN3O2S
    (3S)-6-chloro-N-[4-(1-methylimidazol-2-yl)sulfanylphenyl]-3,4-dihydro-2H-chromene-3-carboxamide
    —— 3-[(2-Chlorophenyl)methylsulfanyl]-5-(2-methoxyethyl)-1,2,4-triazol-4-amine —— C12H15ClN4OS
    3-[(2-Chlorophenyl)methylsulfanyl]-5-(2-methoxyethyl)-1,2,4-triazol-4-amine
    —— 6-(4-bromophenyl)-3-(2-methoxyethyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C13H13BrN4OS
    6-(4-bromophenyl)-3-(2-methoxyethyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— (2S)-N-tert-butyl-2-[[4-cyclopropyl-5-(4-methylpiperidin-1-yl)-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C18H31N5OS
    (2S)-N-tert-butyl-2-[[4-cyclopropyl-5-(4-methylpiperidin-1-yl)-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— N-benzyl-2-[[5-[(3S,5S)-3,5-dimethylpiperidin-1-yl]-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-ethylacetamide —— C25H33N5O2S
    N-benzyl-2-[[5-[(3S,5S)-3,5-dimethylpiperidin-1-yl]-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-ethylacetamide
    —— N-benzyl-2-[[5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-ethylacetamide —— C25H33N5O2S
    N-benzyl-2-[[5-[(3R,5R)-3,5-dimethylpiperidin-1-yl]-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-ethylacetamide
    —— (2R)-N-cyclohexyl-2-[[4-cyclopropyl-5-(4-methylpiperidin-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide —— C21H35N5OS
    (2R)-N-cyclohexyl-2-[[4-cyclopropyl-5-(4-methylpiperidin-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide
    —— 3-tert-butyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C14H16N4S
    3-tert-butyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— (2R)-N-tert-butyl-2-[[4-cyclopropyl-5-(4-methylpiperidin-1-yl)-1,2,4-triazol-3-yl]sulfanyl]propanamide —— C18H31N5OS
    (2R)-N-tert-butyl-2-[[4-cyclopropyl-5-(4-methylpiperidin-1-yl)-1,2,4-triazol-3-yl]sulfanyl]propanamide
    —— N-benzyl-2-[[5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-ethylacetamide —— C25H33N5O2S
    N-benzyl-2-[[5-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-ethylacetamide
    —— (2S)-N-cyclohexyl-2-[[4-cyclopropyl-5-(4-methylpiperidin-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide —— C21H35N5OS
    (2S)-N-cyclohexyl-2-[[4-cyclopropyl-5-(4-methylpiperidin-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-methylpropanamide
    —— 2-[[4-cyclopropyl-5-(4-methylpiperidin-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-[(2S)-2-methylmorpholin-4-yl]ethanone —— C18H29N5O2S
    2-[[4-cyclopropyl-5-(4-methylpiperidin-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-[(2S)-2-methylmorpholin-4-yl]ethanone
    —— 2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-methyl-N-[(1S)-1-phenylethyl]acetamide —— C13H17N5OS
    2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-methyl-N-[(1S)-1-phenylethyl]acetamide
    —— 3-Benzylsulfanyl-5-(2-methoxyethyl)-1,2,4-triazol-4-amine —— C12H16N4OS
    3-Benzylsulfanyl-5-(2-methoxyethyl)-1,2,4-triazol-4-amine
    —— N-[(E)-1-(4-bromophenyl)ethylideneamino]-2-[[5-[(4-chloroanilino)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C22H22BrClN6OS
    N-[(E)-1-(4-bromophenyl)ethylideneamino]-2-[[5-[(4-chloroanilino)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 3-Benzylsulfanyl-5-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,2,4-triazol-4-amine —— C13H14N6S3
    3-Benzylsulfanyl-5-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,2,4-triazol-4-amine
    —— 3-propyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-amine —— C7H11N5S
    3-propyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-amine
    —— 4-Amino-3-[(2-chlorophenyl)methylsulfanyl]-6-phenyl-1,2,4-triazin-5-one —— C16H13ClN4OS
    4-Amino-3-[(2-chlorophenyl)methylsulfanyl]-6-phenyl-1,2,4-triazin-5-one
    —— Methyl 2-[[4-amino-5-(4,5-dihydro-1,3-thiazol-2-ylsulfanylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C9H13N5O2S3
    Methyl 2-[[4-amino-5-(4,5-dihydro-1,3-thiazol-2-ylsulfanylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— Ethyl 2-[[4-amino-5-(methoxymethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C8H14N4O3S
    Ethyl 2-[[4-amino-5-(methoxymethyl)-1,2,4-triazol-3-yl]sulfanyl]acetate
    —— 3-Trifluoromethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-ylamine —— C5H4F3N5S
    3-Trifluoromethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-ylamine
    —— 3-[2-(2-amino-2-oxoethyl)sulfanyl-4,6-dimethylpyrimidin-5-yl]-N-[[4-(dimethylamino)phenyl]methyl]-N-methylpropanamide —— C21H29N5O2S
    3-[2-(2-amino-2-oxoethyl)sulfanyl-4,6-dimethylpyrimidin-5-yl]-N-[[4-(dimethylamino)phenyl]methyl]-N-methylpropanamide
    —— 3-tert-butyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-amine —— C8H13N5S
    3-tert-butyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-amine
    —— Methyl 2-[(4-amino-5-propyl-1,2,4-triazol-3-yl)sulfanyl]acetate —— C8H14N4O2S
    Methyl 2-[(4-amino-5-propyl-1,2,4-triazol-3-yl)sulfanyl]acetate
    —— 4-amino-5-[(phenylsulfanyl)methyl]-4H-1,2,4-triazole-3-thiol —— C9H10N4S2
    4-amino-5-[(phenylsulfanyl)methyl]-4H-1,2,4-triazole-3-thiol
    —— 3-benzylthio-4-amino-6-phenyl-1,2,4-triazine-5-one 22285-37-6 C16H14N4OS
    3-benzylthio-4-amino-6-phenyl-1,2,4-triazine-5-one
    —— 6-phenyl-3-(phenylsulfanylmethyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine —— C17H14N4S2
    6-phenyl-3-(phenylsulfanylmethyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— N-benzyl-N-[(2R)-butan-2-yl]-3-(6-methyl-2-methylsulfanyl-4-oxo-1H-pyrimidin-5-yl)propanamide —— C20H27N3O2S
    N-benzyl-N-[(2R)-butan-2-yl]-3-(6-methyl-2-methylsulfanyl-4-oxo-1H-pyrimidin-5-yl)propanamide
    —— (2S)-N-[[4-(dimethylamino)phenyl]methyl]-N-[[(2R)-oxolan-2-yl]methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C23H28N2O2S
    (2S)-N-[[4-(dimethylamino)phenyl]methyl]-N-[[(2R)-oxolan-2-yl]methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— [(2S)-1-[cyclohexyl(1,3-thiazol-2-yl)amino]-1-oxopropan-2-yl] 2-phenylsulfanylacetate —— C20H24N2O3S2
    [(2S)-1-[cyclohexyl(1,3-thiazol-2-yl)amino]-1-oxopropan-2-yl] 2-phenylsulfanylacetate
    —— (2R)-N-[[4-(dimethylamino)phenyl]methyl]-N-[[(2S)-oxolan-2-yl]methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C23H28N2O2S
    (2R)-N-[[4-(dimethylamino)phenyl]methyl]-N-[[(2S)-oxolan-2-yl]methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— (2R)-N-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]-2-(4-nitrophenyl)sulfanylpropanamide —— C18H17N5O3S2
    (2R)-N-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]-2-(4-nitrophenyl)sulfanylpropanamide
    —— (2S)-N-[[4-(dimethylamino)phenyl]methyl]-N-[[(2S)-oxolan-2-yl]methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C23H28N2O2S
    (2S)-N-[[4-(dimethylamino)phenyl]methyl]-N-[[(2S)-oxolan-2-yl]methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— (2S)-N-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]-2-(4-nitrophenyl)sulfanylpropanamide —— C18H17N5O3S2
    (2S)-N-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]-2-(4-nitrophenyl)sulfanylpropanamide
    —— N-benzyl-N-[(2S)-butan-2-yl]-3-(6-methyl-2-methylsulfanyl-4-oxo-1H-pyrimidin-5-yl)propanamide —— C20H27N3O2S
    N-benzyl-N-[(2S)-butan-2-yl]-3-(6-methyl-2-methylsulfanyl-4-oxo-1H-pyrimidin-5-yl)propanamide
    —— (2R)-N-[[4-(dimethylamino)phenyl]methyl]-N-[[(2R)-oxolan-2-yl]methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C23H28N2O2S
    (2R)-N-[[4-(dimethylamino)phenyl]methyl]-N-[[(2R)-oxolan-2-yl]methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-2-(1-ethyltetrazol-5-yl)sulfanyl-N-methylacetamide —— C10H17N5O3S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-2-(1-ethyltetrazol-5-yl)sulfanyl-N-methylacetamide
    —— 2-[(7R)-3-ethyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C14H13N4O2S-
    2-[(7R)-3-ethyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate