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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-benzyl-2-[[4-butyl-5-[(1R)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-cyclopropylethyl]acetamide —— C25H39N5OS
    N-benzyl-2-[[4-butyl-5-[(1R)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-cyclopropylethyl]acetamide
    —— (3S)-1-cyclopentyl-5-oxo-N-(2-phenylsulfanylphenyl)pyrrolidine-3-carboxamide —— C22H24N2O2S
    (3S)-1-cyclopentyl-5-oxo-N-(2-phenylsulfanylphenyl)pyrrolidine-3-carboxamide
    —— N-benzyl-2-[[4-butyl-5-[(1S)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-cyclopropylethyl]acetamide —— C25H39N5OS
    N-benzyl-2-[[4-butyl-5-[(1S)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-cyclopropylethyl]acetamide
    —— 1-[3-(4,6-Dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoylamino]-3-(3-methoxypropyl)-1-methylthiourea —— C16H27N5O2S2
    1-[3-(4,6-Dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoylamino]-3-(3-methoxypropyl)-1-methylthiourea
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[2-[(2-fluorophenyl)methylsulfanyl]ethyl]propanamide —— C19H24FN3OS2
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[2-[(2-fluorophenyl)methylsulfanyl]ethyl]propanamide
    —— N-[(4-methylphenyl)methyl]-2-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propylacetamide —— C24H29N3O2S
    N-[(4-methylphenyl)methyl]-2-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propylacetamide
    —— N-methyl-2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]-N-(thiophen-3-ylmethyl)acetamide —— C19H22N4O2S3
    N-methyl-2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]-N-(thiophen-3-ylmethyl)acetamide
    —— N-methyl-2-[[4-[[(2R)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]-N-(thiophen-3-ylmethyl)acetamide —— C19H22N4O2S3
    N-methyl-2-[[4-[[(2R)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]-N-(thiophen-3-ylmethyl)acetamide
    —— 2-[(2S)-2-phenylpropyl]-5-[3-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)propylsulfanyl]-1,3,4-oxadiazole —— C20H20N4O2S2
    2-[(2S)-2-phenylpropyl]-5-[3-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)propylsulfanyl]-1,3,4-oxadiazole
    —— 2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1S)-1-thiophen-2-ylethyl]acetamide —— C16H15N3O2S2
    2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1S)-1-thiophen-2-ylethyl]acetamide
    —— N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C15H17N3O4S2
    N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 2-[(2R)-2-phenylpropyl]-5-[3-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)propylsulfanyl]-1,3,4-oxadiazole —— C20H20N4O2S2
    2-[(2R)-2-phenylpropyl]-5-[3-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)propylsulfanyl]-1,3,4-oxadiazole
    —— N-benzyl-N-[(1R)-1-cyclopropylethyl]-2-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H26N4O2S
    N-benzyl-N-[(1R)-1-cyclopropylethyl]-2-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-benzyl-2-[[4-butyl-5-[(1R)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-cyclopropylethyl]acetamide —— C25H39N5OS
    N-benzyl-2-[[4-butyl-5-[(1R)-1-(dimethylamino)propyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-cyclopropylethyl]acetamide
    —— 1-(4-Acetylpiperazin-1-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C16H18N4O3S
    1-(4-Acetylpiperazin-1-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— N-[(4-methylphenyl)methyl]-2-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propylacetamide —— C24H29N3O2S
    N-[(4-methylphenyl)methyl]-2-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propylacetamide
    —— N-benzyl-N-[(1S)-1-cyclopropylethyl]-2-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H26N4O2S
    N-benzyl-N-[(1S)-1-cyclopropylethyl]-2-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 2-Methyl-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C12H10N4O2S
    2-Methyl-5-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— (2S)-N-(furan-2-ylmethyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C16H15N3O3S
    (2S)-N-(furan-2-ylmethyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— N-hexyl-2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H28N4O2S2
    N-hexyl-2-[[4-[[(2S)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-(furan-2-ylmethyl)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylacetamide —— C13H13N5O2S2
    N-(furan-2-ylmethyl)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylacetamide
    —— 1-[1-(Furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylethanone —— C19H19N5O2S2
    1-[1-(Furan-2-ylmethyl)-2,5-dimethylpyrrol-3-yl]-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylethanone
    —— N-hexyl-2-[[4-[[(2R)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C19H28N4O2S2
    N-hexyl-2-[[4-[[(2R)-oxolan-2-yl]methyl]-5-thiophen-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C13H16N4O3S3
    N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2S)-N-cyclohexyl-N-ethyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C17H24N4OS2
    (2S)-N-cyclohexyl-N-ethyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (2S)-N-cyclopropyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C12H14N4OS2
    (2S)-N-cyclopropyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 3-propylsulfanyl-5-thiophen-2-yl-1H-1,2,4-triazole —— C9H11N3S2
    3-propylsulfanyl-5-thiophen-2-yl-1H-1,2,4-triazole
    —— (2R)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanenitrile —— C9H8N4S2
    (2R)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanenitrile
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-N-propyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C15H20N4O3S3
    N-[(3S)-1,1-dioxothiolan-3-yl]-N-propyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 6-Amino-5-[2-[(4-benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-1-cyclopropylpyrimidine-2,4-dione —— C19H20N6O3S
    6-Amino-5-[2-[(4-benzyl-5-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-1-cyclopropylpyrimidine-2,4-dione
    —— 2-(4-fluorophenyl)-4-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazole —— C16H11FN4S3
    2-(4-fluorophenyl)-4-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-thiazole
    —— N-[(1R)-1-(2-chlorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H15ClN4OS2
    N-[(1R)-1-(2-chlorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-propyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C15H20N4O3S3
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-propyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 4-[(2S)-oxolane-2-carbonyl]-N-(2-phenylsulfanylethyl)piperazine-1-carbothioamide —— C18H25N3O2S2
    4-[(2S)-oxolane-2-carbonyl]-N-(2-phenylsulfanylethyl)piperazine-1-carbothioamide
    —— 3-[(1R)-1-phenylethyl]sulfanyl-5-thiophen-2-yl-1H-1,2,4-triazole —— C14H13N3S2
    3-[(1R)-1-phenylethyl]sulfanyl-5-thiophen-2-yl-1H-1,2,4-triazole
    —— N-[(1S)-1-(2,4-difluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H14F2N4OS2
    N-[(1S)-1-(2,4-difluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 2-(furan-2-yl)-5-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,4-oxadiazole —— C13H9N5O2S2
    2-(furan-2-yl)-5-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3,4-oxadiazole
    —— 4-[(2R)-oxolane-2-carbonyl]-N-(2-phenylsulfanylethyl)piperazine-1-carbothioamide —— C18H25N3O2S2
    4-[(2R)-oxolane-2-carbonyl]-N-(2-phenylsulfanylethyl)piperazine-1-carbothioamide
    —— (2S)-N-(1-cyanocyclohexyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H19N5OS2
    (2S)-N-(1-cyanocyclohexyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (2R)-1-(4-ethylpiperazin-1-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C15H21N5OS2
    (2R)-1-(4-ethylpiperazin-1-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— (2R)-N-[(1S,2S)-2-methylcyclohexyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C16H22N4OS2
    (2R)-N-[(1S,2S)-2-methylcyclohexyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C14H17N5OS2
    N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2S)-N-[2-(4-fluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C17H17FN4OS2
    (2S)-N-[2-(4-fluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(4-fluorophenyl)methyl]-N-methyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H15FN4OS2
    N-[(4-fluorophenyl)methyl]-N-methyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2R)-2-[[5-benzyl-4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]propanenitrile —— C15H18N4OS
    (2R)-2-[[5-benzyl-4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]propanenitrile
    —— N-methyl-N-(4-methylcyclohexyl)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylacetamide —— C16H23N5OS2
    N-methyl-N-(4-methylcyclohexyl)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylacetamide
    —— (2S)-1-(4-ethylpiperazin-1-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one —— C15H21N5OS2
    (2S)-1-(4-ethylpiperazin-1-yl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propan-1-one
    —— (E)-3-[5-chloro-3-methyl-1-(2-methylpropyl)pyrazol-4-yl]-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]prop-2-enamide —— C22H33ClN6OS
    (E)-3-[5-chloro-3-methyl-1-(2-methylpropyl)pyrazol-4-yl]-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]prop-2-enamide
    —— [(2S)-1-(1-adamantyl)-1-oxopropan-2-yl] 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoate —— C23H32N2O3S
    [(2S)-1-(1-adamantyl)-1-oxopropan-2-yl] 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoate
    —— 2-(1-oxidopyridin-1-ium-2-yl)oxy-N-(2-phenylsulfanylethyl)acetamide —— C15H16N2O3S
    2-(1-oxidopyridin-1-ium-2-yl)oxy-N-(2-phenylsulfanylethyl)acetamide